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Article ; Online: The usage of population and disease registries as pre-screening tools for clinical trials, a systematic review.

Foucher, Juliette / Azizi, Louisa / Öijerstedt, Linn / Kläppe, Ulf / Ingre, Caroline

2024 Volume 13, Issue 1, Page(s) 111

Abstract: Objective: This systematic review aims to outline the use of population and disease registries for clinical trial pre-screening.: Materials and methods: The search was conducted in the time period of January 2014 to December 2022 in three databases: ... ...

Abstract	Objective: This systematic review aims to outline the use of population and disease registries for clinical trial pre-screening. Materials and methods: The search was conducted in the time period of January 2014 to December 2022 in three databases: MEDLINE, Embase, and Web of Science Core Collection. References were screened using the Rayyan software, firstly based on titles and abstracts only, and secondly through full text review. Quality of the included studies was assessed using the List of Included Studies and quality Assurance in Review tool, enabling inclusion of publications of only moderate to high quality. Results: The search originally identified 1430 citations, but only 24 studies were included, reporting the use of population and/or disease registries for trial pre-screening. Nine disease domains were represented, with 54% of studies using registries based in the USA, and 62.5% of the studies using national registries. Half of the studies reported usage for drug trials, and over 478,679 patients were identified through registries in this review. Main advantages of the pre-screening methodology were reduced financial burden and time reduction. Discussion and conclusion: The use of registries for trial pre-screening increases reproducibility of the pre-screening process across trials and sites, allowing for implementation and improvement of a quality assurance process. Pre-screening strategies seem under-reported, and we encourage more trials to use and describe their pre-screening processes, as there is a need for standardized methodological guidelines.
MeSH term(s)	Humans ; Registries ; Clinical Trials as Topic ; Patient Selection ; Reproducibility of Results
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-024-02533-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Building resilience: analysis of health care leaders' perspectives on the Covid-19 response in Region Stockholm.

Savage, Carl / Tragl, Leonard / Castillo, Moa Malmqvist / Azizi, Louisa / Hasson, Henna / Sundberg, Carl Johan / Mazzocato, Pamela

BMC health services research

2024 Volume 24, Issue 1, Page(s) 408

Abstract: Background: The Covid-19 pandemic has tested health care organizations worldwide. Responses have demonstrated great variation and Sweden has been an outlier in terms of both strategy and how it was enacted, making it an interesting case for further ... ...

Abstract	Background: The Covid-19 pandemic has tested health care organizations worldwide. Responses have demonstrated great variation and Sweden has been an outlier in terms of both strategy and how it was enacted, making it an interesting case for further study. The aim of this study was to explore how health care leaders experienced the challenges and responses that emerged during the initial wave of the Covid-19 pandemic, and to analyze these experiences through an organizational resilience lens. Methods: A qualitative interview study with 12 senior staff members who worked directly with or supervised pandemic efforts. Transcripts were analyzed using traditional content analysis and the codes directed to the Integrated Resilience Attributes Framework to understand what contributed to or hindered organizational resilience, i.e. how organizations achieve their goals by utilizing existing resources during crises. Results/findings: Organizational resilience was found at the micro (situated) and meso (structural) system levels as individuals and organizations dealt with acute shortages and were forced to rapidly adapt through individual sacrifices, resource management, process management, and communications and relational capacity. Poor systemic resilience related to misaligned responses and a lack of learning from previous experiences, negatively impacted the anticipatory phase and placed greater pressure on individuals and organizations to respond. Conventional crisis leadership could hamper innovation, further cement chronic challenges, and generate a moral tension between centralized directives and clinical microsystem experiences. Conclusions: The pandemic tested the resilience of the health care system, placing undue pressure on micro and meso systems responses. With improved learning capabilities, some of this pressure may be mitigated as it could raise the anticipatory resilience potential, i.e. with better health systems learning, we may need fewer heroes. How crisis leadership could better align decision-making with frontline needs and temper short-term acute needs with a longer-term infinite mindset is worth further study.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Resilience, Psychological ; Pandemics ; Leadership ; Delivery of Health Care
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10886-4
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Article ; Online: Skin microvascular reactivity correlates to clinical microangiopathy in type 1 diabetes: A pilot study.

Tehrani, Sara / Bergen, Karin / Azizi, Louisa / Jörneskog, Gun

Diabetes & vascular disease research

2020 Volume 17, Issue 3, Page(s) 1479164120928303

Abstract: Aim: The aim of this study was to investigate the correlation between skin microvascular reactivity and clinical microangiopathy in patients with type 1 diabetes.: Methods: We included 61 patients with type 1 diabetes, that is, 31 patients with and ... ...

Abstract	Aim: The aim of this study was to investigate the correlation between skin microvascular reactivity and clinical microangiopathy in patients with type 1 diabetes. Methods: We included 61 patients with type 1 diabetes, that is, 31 patients with and 30 without clinical microangiopathy, and 31 healthy controls. A microangiopathy scoring system was introduced for comparison of data between patients with microangiopathy. Responses to iontophoresis of acetylcholine and sodium nitroprusside were assessed by laser Doppler imaging. Results: Patients with microangiopathy had reduced acetylcholine- and sodium nitroprusside-mediated flux in forearm skin microcirculation compared to healthy controls ( Conclusion: We conclude that skin microvascular reactivity is associated with clinical microangiopathy in patients with type 1 diabetes. Impaired skin microvascular function in type 1 diabetes seems to be multifactorial and involves both endothelial-dependent and endothelial-independent pathways. We introduce a novel microangiopathy score that could easily be used in a clinical setting for comparison of patients with various degrees of microangiopathy.
MeSH term(s)	Administration, Cutaneous ; Adult ; Aged ; Blood Flow Velocity ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/physiopathology ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/etiology ; Diabetic Angiopathies/physiopathology ; Female ; Forearm ; Humans ; Iontophoresis ; Laser-Doppler Flowmetry ; Male ; Microcirculation/drug effects ; Microscopic Angioscopy ; Middle Aged ; Pilot Projects ; Predictive Value of Tests ; Risk Factors ; Skin/blood supply ; Vasodilation/drug effects ; Vasodilator Agents/administration & dosage
Chemical Substances	Vasodilator Agents
Language	English
Publishing date	2020-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2250793-0
ISSN	1752-8984 ; 1479-1641
ISSN (online)	1752-8984
ISSN	1479-1641
DOI	10.1177/1479164120928303
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Zs.A 6378: Show issues

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article ; Online: CK20 positivity in hepatocellular carcinoma: a potential diagnostic pitfall in liver biopsy.

Mourra, Najat / Azizi, Louisa

Applied immunohistochemistry & molecular morphology : AIMM

2013 Volume 21, Issue 1, Page(s) 94–95

MeSH term(s)	Adenocarcinoma/secondary ; Aged, 80 and over ; Biopsy ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/secondary ; Colonic Neoplasms/pathology ; Diagnosis, Differential ; Diagnostic Errors/prevention & control ; Female ; Glypicans/immunology ; Glypicans/metabolism ; Humans ; Immunohistochemistry ; Keratin-20/immunology ; Keratin-20/metabolism ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Neoplasm Metastasis
Chemical Substances	Glypicans ; Keratin-20
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0b013e31824c4c4a
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Zs.A 3783: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Surgical Treatment of Corneal Shield Ulcer in Vernal Keratoconjunctivitis: A Systematic Review.

Azizi, Samim / Subhi, Yousif / Rasmussen, Marie Louise Roed

Journal of personalized medicine

2023 Volume 13, Issue 7

Abstract: Background: Vernal keratoconjunctivitis (VKC) severely affects the quality of life of affected patients. The development of a shield ulcer is considered one of the most severe late-stage complications, which when untreated leads to irreversible vision ... ...

Abstract	Background: Vernal keratoconjunctivitis (VKC) severely affects the quality of life of affected patients. The development of a shield ulcer is considered one of the most severe late-stage complications, which when untreated leads to irreversible vision loss. In this systematic review, we outlined the results of surgical treatments of corneal shield ulcers in VKC. Methods: We searched 12 literature databases on 3 April 2023 for studies of patients with VKC in which shield ulcers were treated by any surgical treatment. Treatment results were reviewed qualitatively. Assessments of the risk of bias of individual studies were made using the Clinical Appraisal Skills Programme. Results: Ten studies with 398 patients with VKC were eligible for the qualitative review. Two categories of surgical approaches were described: supratarsal corticosteroid injection and debridement with or without amniotic membrane transplantation. Almost all patients experienced resolution or improvement of their shield ulcers, regardless of treatment modality. Time to healing was faster with surgical debridement. A small proportion experienced recurrence and side effects. Conclusions: Surgical treatment for shield ulcers in VKC seems highly effective, but careful post-operative treatment and follow-ups are necessary due to the risk of recurrence and potential side effects.
Language	English
Publishing date	2023-07-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13071092
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Article: Strain Characterisation for Measuring Bioefficacy of ITNs Treated with Two Active Ingredients (Dual-AI ITNs): Developing a Robust Protocol by Building Consensus.

Insects

2022 Volume 13, Issue 5

Abstract: Durability monitoring of insecticide-treated nets (ITNs) containing a pyrethroid in combination with a second active ingredient (AI) must be adapted so that the insecticidal bioefficacy of each AI can be monitored independently. An effective way to do ... ...

Abstract	Durability monitoring of insecticide-treated nets (ITNs) containing a pyrethroid in combination with a second active ingredient (AI) must be adapted so that the insecticidal bioefficacy of each AI can be monitored independently. An effective way to do this is to measure rapid knock down of a pyrethroid-susceptible strain of mosquitoes to assess the bioefficacy of the pyrethroid component and to use a pyrethroid-resistant strain to measure the bioefficacy of the second ingredient. To allow robust comparison of results across tests within and between test facilities, and over time, protocols for bioefficacy testing must include either characterisation of the resistant strain, standardisation of the mosquitoes used for bioassays, or a combination of the two. Through a series of virtual meetings, key stakeholders and practitioners explored different approaches to achieving these goals. Via an iterative process we decided on the preferred approach and produced a protocol consisting of characterising mosquitoes used for bioefficacy testing before and after a round of bioassays, for example at each time point in a durability monitoring study. We present the final protocol and justify our approach to establishing a standard methodology for durability monitoring of ITNs containing pyrethroid and a second AI.
Language	English
Publishing date	2022-05-06
Publishing country	Switzerland
Document type	Guideline
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects13050434
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Article ; Online: Strain Characterisation for Measuring Bioefficacy of ITNs Treated with Two Active Ingredients (Dual-AI ITNs)

Insects, Vol 13, Iss 434, p

Developing a Robust Protocol by Building Consensus

2022 Volume 434

Abstract	Durability monitoring of insecticide-treated nets (ITNs) containing a pyrethroid in combination with a second active ingredient (AI) must be adapted so that the insecticidal bioefficacy of each AI can be monitored independently. An effective way to do this is to measure rapid knock down of a pyrethroid-susceptible strain of mosquitoes to assess the bioefficacy of the pyrethroid component and to use a pyrethroid-resistant strain to measure the bioefficacy of the second ingredient. To allow robust comparison of results across tests within and between test facilities, and over time, protocols for bioefficacy testing must include either characterisation of the resistant strain, standardisation of the mosquitoes used for bioassays, or a combination of the two. Through a series of virtual meetings, key stakeholders and practitioners explored different approaches to achieving these goals. Via an iterative process we decided on the preferred approach and produced a protocol consisting of characterising mosquitoes used for bioefficacy testing before and after a round of bioassays, for example at each time point in a durability monitoring study. We present the final protocol and justify our approach to establishing a standard methodology for durability monitoring of ITNs containing pyrethroid and a second AI.
Keywords	insecticide-treated nets (ITN) ; pyrethroid ; mosquito ; strain characterisation ; insecticide resistance ; method development ; Science ; Q
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MR imaging features of nongynaecologic cystic lesions of the pelvis.

Loock, Mélanie Térébus / Fornès, Paul / Soyer, Philippe / Rousset, Pascal / Azizi, Louisa / Hoeffel, Christine

Clinical imaging

2013 Volume 37, Issue 2, Page(s) 211–218

Abstract: Objective: The purpose of our article is to review the magnetic resonance imaging (MRI) features of nongynaecologic cystic lesions of the pelvis.: Conclusion: The rising use of MRI for pelvic exploration will result in an increase in incidental ... ...

Abstract	Objective: The purpose of our article is to review the magnetic resonance imaging (MRI) features of nongynaecologic cystic lesions of the pelvis. Conclusion: The rising use of MRI for pelvic exploration will result in an increase in incidental detection of pelvic cystic cysts. Pelvic cysts of non gynecologic origin are less frequent than gynecologic cysts. However, they account for a wide range of abnormalities, and radiologists must be aware of their features and characteristics.
MeSH term(s)	Chordoma/diagnosis ; Contrast Media ; Cysts/diagnosis ; Humans ; Lymphatic Vessel Tumors/diagnosis ; Lymphocele/diagnosis ; Magnetic Resonance Imaging/methods ; Meningocele/diagnosis ; Neoplasms, Germ Cell and Embryonal/diagnosis ; Pelvis ; Peritoneal Diseases/diagnosis
Chemical Substances	Contrast Media
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2012.04.023
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Zs.A 1469: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Non-contrast 3D MR lymphography of retroperitoneal lymphatic aneurysmal dilatation: a continuous spectrum of change from normal variants to cystic lymphangioma.

Derhy, Sarah / El Mouhadi, Sanaâ / Ruiz, Ana / Azizi, Louisa / Menu, Yves / Arrivé, Lionel

Insights into imaging

2013 Volume 4, Issue 6, Page(s) 753–758

Abstract: Objective: Our objective was to demonstrate the characteristic features of retroperitoneal lymphatic aneurysmal dilatation with three-dimensional (3D) magnetic resonance (MR) lymphography.: Conclusion: Three-dimensional MR lymphography demonstrates ... ...

Abstract	Objective: Our objective was to demonstrate the characteristic features of retroperitoneal lymphatic aneurysmal dilatation with three-dimensional (3D) magnetic resonance (MR) lymphography. Conclusion: Three-dimensional MR lymphography demonstrates that retroperitoneal lymphatic aneurysmal dilatation exhibits a continuous spectrum of change from normal variants to lymphatic aneurysmal dilatation and so-called cystic lymphangioma. Main message: • Non-contrast MR lymphography with very heavily T2-weighted fast spin echo sequences is a useful non-invasive technique without the need of contrast medium injection to obtain a unique evaluation of the lymphatic system • To prove the lymphatic origin of a cystic formation, it is essential to demonstrate the communication with retroperitoneal lymphatic vessels • 3D MR lymphography demonstrates that retroperitoneal lymphatic aneurysmal dilatation exhibits a continuous spectrum of change from normal variants to lymphatic aneurysmal dilatation and so-called cystic lymphangioma.
Language	English
Publishing date	2013-10-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1007/s13244-013-0290-4
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Article: Treatment of Anti-GAD65 Autoimmune Encephalitis With Methylprednisolone.

Azizi, Shayan / Vadlamuri, Diamler L / Cannizzaro, Louis A

The Ochsner journal

2021 Volume 21, Issue 3, Page(s) 312–315

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-06
Publishing country	United States
Document type	Case Reports
ISSN	1524-5012
ISSN	1524-5012
DOI	10.31486/toj.20.0096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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