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  1. Article ; Online: Outcome of buttress plate-nail construct used for reconstruction of broken lateral wall in intertrochanteric fractures

    Saurabh Jain / Satish Rohra / Harshwardhan Dawar / Bhupendra Kushwah / Adit Agrawal

    Chinese Journal of Traumatology, Vol 26, Iss 4, Pp 223-

    2023  Volume 227

    Abstract: Purpose: Intramedullary implants are well accepted fixation of all types of intertrochanteric (IT) fractures, both stable and unstable types. Intramedullary nails have an ability to effectively support the posteromedial part, but fail to buttress the ... ...

    Abstract Purpose: Intramedullary implants are well accepted fixation of all types of intertrochanteric (IT) fractures, both stable and unstable types. Intramedullary nails have an ability to effectively support the posteromedial part, but fail to buttress the broken lateral wall requiring lateral augmentation. The aim of this study was to evaluate the outcome of proximal femoral nail augmented with trochanteric buttress plate for broken lateral wall with IT fractures, which was fixed to the femur through hip screw and anti-rotation screw nail. Methods: Of 30 patients, 20 had Jensen-Evan type III and 10 had type V fractures. Patients with IT fracture of broken lateral wall and aged more than 18 years, in whom satisfactory reduction was achieved by closed methods, were included in the study. Patients with pathologic or open fractures, polytrauma, prior hip surgery, non-ambulatory prior to surgery, and those who refused to participate were excluded. The operative time, blood loss, radiation exposure, quality of reduction, functional outcome, and union time were evaluated. All data were coded and recorded in Microsoft Excel spread sheet program. SPSS 20.0 was used for data analysis and normality of the continuous data was checked using Kolmogorv Smirnov test. Results: The mean age of patients in the study was 60.3 years. The mean duration of surgery (min), mean intra-operative blood loss (mL) and mean number of exposures were 91.86 ± 12.8 (range 70 – 122), 144.8 ± 3.6 (range 116 – 208), and 56.6 (range 38 – 112), respectively. The mean union time was 11.6 weeks and the mean Harris hip score was 94.1. Conclusion: Lateral trochanteric wall in IT fractures is significantly important, and needs to be reconstructed adequately. Nail-plate construct of trochanteric buttress plate fixed with hip screw and anti-rotation screw of proximal femoral nail can be successfully used to augment, fix or buttress the lateral trochanteric wall giving excellent to good results of early union and reduction.
    Keywords Intertrochanteric fracture ; Lateral trochanteric wall ; Intramedullary nail ; Proximal femoral nail ; Trochanteric buttress plate ; Medicine (General) ; R5-920
    Subject code 690
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Outcome of buttress plate-nail construct used for reconstruction of broken lateral wall in intertrochanteric fractures.

    Jain, Saurabh / Rohra, Satish / Dawar, Harshwardhan / Kushwah, Bhupendra / Agrawal, Adit

    Chinese journal of traumatology = Zhonghua chuang shang za zhi

    2023  Volume 26, Issue 4, Page(s) 223–227

    Abstract: Purpose: Intramedullary implants are well accepted fixation of all types of intertrochanteric (IT) fractures, both stable and unstable types. Intramedullary nails have an ability to effectively support the posteromedial part, but fail to buttress the ... ...

    Abstract Purpose: Intramedullary implants are well accepted fixation of all types of intertrochanteric (IT) fractures, both stable and unstable types. Intramedullary nails have an ability to effectively support the posteromedial part, but fail to buttress the broken lateral wall requiring lateral augmentation. The aim of this study was to evaluate the outcome of proximal femoral nail augmented with trochanteric buttress plate for broken lateral wall with IT fractures, which was fixed to the femur through hip screw and anti-rotation screw nail.
    Methods: Of 30 patients, 20 had Jensen-Evan type III and 10 had type V fractures. Patients with IT fracture of broken lateral wall and aged more than 18 years, in whom satisfactory reduction was achieved by closed methods, were included in the study. Patients with pathologic or open fractures, polytrauma, prior hip surgery, non-ambulatory prior to surgery, and those who refused to participate were excluded. The operative time, blood loss, radiation exposure, quality of reduction, functional outcome, and union time were evaluated. All data were coded and recorded in Microsoft Excel spread sheet program. SPSS 20.0 was used for data analysis and normality of the continuous data was checked using Kolmogorv Smirnov test.
    Results: The mean age of patients in the study was 60.3 years. The mean duration of surgery (min), mean intra-operative blood loss (mL) and mean number of exposures were 91.86 ± 12.8 (range 70 - 122), 144.8 ± 3.6 (range 116 - 208), and 56.6 (range 38 - 112), respectively. The mean union time was 11.6 weeks and the mean Harris hip score was 94.1.
    Conclusion: Lateral trochanteric wall in IT fractures is significantly important, and needs to be reconstructed adequately. Nail-plate construct of trochanteric buttress plate fixed with hip screw and anti-rotation screw of proximal femoral nail can be successfully used to augment, fix or buttress the lateral trochanteric wall giving excellent to good results of early union and reduction.
    MeSH term(s) Humans ; Middle Aged ; Bone Nails ; Treatment Outcome ; Retrospective Studies ; Hip Fractures/surgery ; Bone Screws ; Fracture Fixation, Intramedullary/methods
    Language English
    Publishing date 2023-03-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 2276839-7
    ISSN 1008-1275
    ISSN 1008-1275
    DOI 10.1016/j.cjtee.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An update on applications and limitations of direct oral anticoagulants

    Sharon Wei / Aanchal Sawhney / Harshwardhan Khandait / Amit Meda / Vasu Gupta / Rohit Jain

    The Egyptian Journal of Internal Medicine, Vol 35, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract A major advancement in the field of medicine has been the introduction and usage of direct oral anticoagulants (DOACs) such as dabigatran (Pradaxa), apixaban (Eliquis), and rivaroxaban (Xarelto). DOACs have been increasing in popularity for ... ...

    Abstract Abstract A major advancement in the field of medicine has been the introduction and usage of direct oral anticoagulants (DOACs) such as dabigatran (Pradaxa), apixaban (Eliquis), and rivaroxaban (Xarelto). DOACs have been increasing in popularity for mainstay anticoagulation pharmacotherapy and are being preferred by physicians over warfarin due to their rapid onset, fewer drug and food interactions, and lack of frequent blood monitoring. DOACs have been indicated in the management of thromboembolic conditions and have been extensively researched in various medical trials and studies before the approval of dabigatran (Pradaxa) in 2010 by the FDA. DOACs, like warfarin, are associated with a risk of bleeding, requiring clearance of the drug from the bloodstream or administration of reversal agents. It is important for physicians to familiarize themselves with the various types of DOACs and their dosages, along with their advantages and disadvantages in comparison to other non-DAOC classes of medications before incorporating them into their patient management plans.
    Keywords DOACs ; Apixaban ; Nonvalvular atrial fibrillation ; Rivaroxaban ; Factor Xa ; Warfarin ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Clinical profile and surgical outcomes in children with posterior lenticonus.

    Jain, Divya Harshwardhan / Agarkar, Sumita / Dhillon, Hennaav Kaur

    Oman journal of ophthalmology

    2021  Volume 14, Issue 1, Page(s) 38–41

    Abstract: Aims: The purpose of this study is to describe the clinical profile of children presenting with posterior lenticonus. We also report on visual outcomes following surgery in these patients.: Subjects and methods: Medical records of patients with a ... ...

    Abstract Aims: The purpose of this study is to describe the clinical profile of children presenting with posterior lenticonus. We also report on visual outcomes following surgery in these patients.
    Subjects and methods: Medical records of patients with a diagnosis of posterior lenticonus between January 2000 and December 2016 were reviewed. Data collected included demographic details, preoperative, intraoperative details like type of intraocular lens (IOL) and surgery, and amblyopia therapy. Only the patients with a follow-up of at least 6 months from the time of presentation were included in the analysis.
    Results: Forty-eight eyes with posterior lenticonus with at least 6 months of follow-up were studied. Twelve (25%) eyes had a preoperative posterior capsule (PC) dehiscence as seen on slit-lamp biomicroscopy or on ultrasonography. The mean presenting visual acuity in all eyes was 1.034 ± 0.56 logarithm of the minimum angle of resolution (logMAR) units. The mean final visual acuity in these patients was 0.57 ± 0.5 logMAR units. Postoperative visual acuity was found to have a borderline positive correlation with the presence of preoperative strabismus (
    Conclusion: Visual acuity improves following surgery with IOL implantation in children with posterior lenticonus and cataract. With the availability of foldable lenses and improved surgical techniques, it is possible to place the IOL in bag despite a preexisting posterior capsular dehiscence. Children with posterior lenticonus who present with strabismus are likely to have poorer visual outcomes.
    Language English
    Publishing date 2021-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/ojo.OJO_215_2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does augmentation of intramedullary nails by a buttress plate effectively restore lateral wall integrity in intertrochanteric fractures.

    Jain, Saurabh / Dawar, Harshwardhan / Khare, Harshit / Kumar, Malay / Ajmera, Anand

    International orthopaedics

    2022  Volume 46, Issue 10, Page(s) 2365–2371

    Abstract: Background: Recent studies have proved the importance of intact lateral trochanteric wall, thus buttressing/fixing the broken lateral trochanteric wall irrespective of the implant, is likely to improve the alignment and outcome. We compared the outcome ... ...

    Abstract Background: Recent studies have proved the importance of intact lateral trochanteric wall, thus buttressing/fixing the broken lateral trochanteric wall irrespective of the implant, is likely to improve the alignment and outcome. We compared the outcome of lateral wall buttressing by trochanteric buttress plate (TBP) supplemented to proximal femoral nailing versus proximal femoral nailing alone in patients of broken lateral wall intertrochanteric fractures.
    Material and method: Sixty patients of intertrochanteric factures (IT) of femur with broken lateral wall were randomized into group A or B and were treated with either proximal femoral nail (PFN) alone or proximal femoral nail augmented with trochanteric buttress plate (PFN + TBP), respectively. The TBP plate used was primarily fixed to proximal femur via 8 mm hip screw and 6.4 mm antirotation screw of the PFN. Operative time, blood loss, radiation exposure, quality of reduction, functional outcome, union time, and complications were compared.
    Result: The mean age was 60.03 + 7.60 (range 42 to 70 years), with male to female ratio of 4:1 and left to right ratio of approximately 1:1. The mean follow up in the series was 16.2 months (range 13 to 36 months). Mean duration of surgery, mean intra-operative blood loss, and mean number of exposures in group A (PFN alone) were 64.88 + 12.24 min (48 to 88), 93 + 1.18 ml (60 to 120), and 32.13 (24 to 46) and in group B (PFN with TBP plate) were 91.86 + 12.78 min (70 to 122 min), 144.8 + 3.6 ml (116 to 208 ml), and 56.6 (38 to 112), respectively. Twenty-five patients and 28 patients in groups A and B respectively achieved score of 4 Chang quality reduction. Mean union time was 13.4 weeks in group A whereas in group B was 11.6 weeks. Mean HHS score in group A was 87.86 with 90% patients in comparison to 94.13 and 97% cases having excellent to good results in group B. In group A, 24 patients, while 29 patients in group B, had excellent to good results. Four patients had hip pain, four had impingement of screws, two had screw migration, three had Z/reverse effect, and four patients had shortening of more than 1 cm in group A. In group B, only one patient had impingement and none of the patient had hip pain, infection, implant failure, Z effect, or shortening.
    Conclusion: The lateral trochanteric wall in IT fractures is significantly important, and when the lateral wall is broken, it can lead to poor results. TBP plate which is applied laterally on femur along with nail and fixing the plate with hip screw and antirotational screw provides faster union, early weight bearing, better reduction, and so better hip functions. TBP can be used successfully to augment, fix, or buttress the lateral trochanteric wall giving excellent to good results but at the cost of surgical time, blood loss, and radiation exposure.
    MeSH term(s) Adult ; Aged ; Bone Nails ; Bone Screws ; Female ; Fracture Fixation, Intramedullary/methods ; Hip Fractures/etiology ; Hip Fractures/surgery ; Humans ; Male ; Middle Aged ; Pain/etiology ; Treatment Outcome
    Language English
    Publishing date 2022-07-11
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-022-05488-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Migraine and heart: A reality check.

    Valecha, Jayesh / Khandait, Harshwardhan / Sk, Anagha / Gupta, Vasu / Kumawat, Sunita / Anamika, Fnu / Jain, Rohit / Dua, Dharti

    Global cardiology science & practice

    2023  Volume 2023, Issue 3, Page(s) e202320

    Abstract: Migraine is a common neurological disorder affecting 12% of the global population. The common risk factors are adolescent age, genetics, and female sex, and are triggered by hormonal fluctuations, emotional stress, sensory overload, weather changes, ... ...

    Abstract Migraine is a common neurological disorder affecting 12% of the global population. The common risk factors are adolescent age, genetics, and female sex, and are triggered by hormonal fluctuations, emotional stress, sensory overload, weather changes, alcohol consumption, fasting, cheese, chocolate, smoked fish, yeast extract, cured meats, artificial sweeteners, food preservatives containing nitrates and nitrites, and sleep disturbances. Migraine with aura is associated with an increased risk of cardiovascular disease events, such as myocardial infarction, angina pectoris, and cardiac arrhythmias, and has recently been added to the QRISK3 cardiovascular disease prediction score. Population-based cohort studies have shown a significant association of migraine with aura and cardiac arrhythmias, most importantly atrial fibrillation. Patients suffering from migraine with aura are at an increased risk for cardiac arrhythmias; thus, it is essential to screen these patients for undiagnosed cardiovascular disorders.
    Language English
    Publishing date 2023-08-01
    Publishing country Qatar
    Document type Journal Article ; Review
    ZDB-ID 2738381-7
    ISSN 2305-7823
    ISSN 2305-7823
    DOI 10.21542/gcsp.2023.20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Optic Nerve Sheath Meningocele With Optic Disc Pit: A Rare Finding.

    Jain, Divya Harshwardhan / Noronha, Veena Olma / Mukherjee, Bipasha

    Ophthalmic plastic and reconstructive surgery

    2019  Volume 35, Issue 3, Page(s) e85

    MeSH term(s) Adolescent ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Meningocele/diagnosis ; Optic Disk/abnormalities ; Optic Disk/diagnostic imaging ; Optic Nerve Diseases/diagnosis ; Tomography, Optical Coherence
    Language English
    Publishing date 2019-03-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/IOP.0000000000001270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rare association of optic disk pits with myelinated retinal nerves.

    Jain, Divya Harshwardhan / Natarajan, Kavitha Kalavani

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2017  Volume 21, Issue 5, Page(s) 429–430

    Abstract: We report the case of a 9-year-old girl who presented for a routine change of glasses. On slit-lamp examination, no abnormality was detected; however, dilated fundus examination revealed profuse myelination of the retinal nerves around the disk of the ... ...

    Abstract We report the case of a 9-year-old girl who presented for a routine change of glasses. On slit-lamp examination, no abnormality was detected; however, dilated fundus examination revealed profuse myelination of the retinal nerves around the disk of the right eye along with an optic disk pit inferotemporally. The left eye fundus also had an optic disk pit inferotemporally but no associated myelination. Visual acuity was 6/9 in each eye, and the patient had no other ocular or systemic complaints. To our knowledge, cooccurrence of myelinated retinal nerves and optic disk pits in the same eye, has not been previously reported.
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2017.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 and Hematology-What Do We Know So Far?

    Khandait, Harshwardhan / Gandotra, Garima / Sachdeva, Sonali / Kramer, Courtney A / Nye, Derek / Golamari, Reshma / Jain, Rohit

    SN comprehensive clinical medicine

    2020  Volume 2, Issue 12, Page(s) 2631–2636

    Abstract: The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of the novel coronavirus disease 2019 (COVID 19), was reported to the World Health Organization in late 2019. This disease quickly evolved into a public health concern ... ...

    Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of the novel coronavirus disease 2019 (COVID 19), was reported to the World Health Organization in late 2019. This disease quickly evolved into a public health concern and was declared a pandemic on March 11, 2020. COVID-19's high transmission rate and potential to cause a spectrum of systemic diseases makes it imperative for researchers and clinicians worldwide to collaborate and develop a strategy to manage and contain this disease. Studies have shown a wide range of hematological abnormalities and virus-related coagulopathies in affected patients, resulting in an increased propensity to develop serious thrombotic complications or disseminated intravascular coagulation (DIC) in severe cases. The fatal implications of coagulopathy in the form of pulmonary embolism (PE), myocardial infarction (MI), and cerebral infarction compelled us to study in-depth the pathophysiology and treatment options related to COVID-19. This analysis reviews published reports on patients with confirmed SARS-COV-2 infection and associated coagulopathy, defined as abnormalities in the coagulation parameters prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin time, fibrinogen, fibrin degradation products, and D-dimer. In this review, we present the hematological manifestations of COVID-19, focusing on virus-associated coagulopathy and relevant pathophysiology, clinical outcomes, and treatment.
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00607-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MRI in rabies encephalitis.

    Jain, Harshwardhan / Deshpande, Anirudda / Favaz, Ali M / Rajagopal, K V

    BMJ case reports

    2013  Volume 2013

    MeSH term(s) Autopsy ; Diffusion Magnetic Resonance Imaging/methods ; Disease Progression ; Encephalitis, Viral/etiology ; Encephalitis, Viral/pathology ; Fatal Outcome ; Humans ; Rabies/complications ; Rabies/pathology ; Rabies/virology ; Severity of Illness Index
    Language English
    Publishing date 2013-10-30
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-201825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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