LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 125

Search options

  1. Article: Editorial: Human brain banking - Bridging brain health and precision neurology.

    Huang, Yue / Li, Qiao-Xin / Cao, Ling-Xiao / Wang, Gang / Chan, Daniel Kam Yin / Bettencourt, Conceicao / Milward, Adrienne E

    Frontiers in neurology

    2023  Volume 14, Page(s) 1322200

    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1322200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Epigenome-wide association study of peripheral immune cell populations in Parkinson's disease.

    Andersen, Maren Stolp / Leikfoss, Ingvild Sørum / Brorson, Ina Skaara / Cappelletti, Chiara / Bettencourt, Conceicao / Toft, Mathias / Pihlstrøm, Lasse

    NPJ Parkinson's disease

    2023  Volume 9, Issue 1, Page(s) 149

    Abstract: Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide ... ...

    Abstract Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide DNA methylation in isolated populations of CD14
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-023-00594-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Evaluation of Removable Partial Denture Metal Frameworks Produced by Digital Methods—A Systematic Review

    Pedro Conceição / Jaime Portugal / Cristina Bettencourt Neves

    Applied Sciences, Vol 13, Iss 10824, p

    2023  Volume 10824

    Abstract: 1) Introduction: This review aimed to synthesize the significant literature addressing digital techniques for producing removable partial denture (RPD) metal frameworks, focusing on oral fit outcomes. (2) Material and Methods: A systematic review of the ...

    Abstract (1) Introduction: This review aimed to synthesize the significant literature addressing digital techniques for producing removable partial denture (RPD) metal frameworks, focusing on oral fit outcomes. (2) Material and Methods: A systematic review of the Web of Science and Pubmed databases was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. The selection was for original articles in English containing relevant data on RPD metal frameworks produced with digital techniques, including study characteristics, digital techniques, and fit assessment methods and outcomes. (3) Results: From the 967 search studies, 405 were duplications, and 521 were excluded after screening against set criteria. A manual search included 21 studies resulting in 62 papers for review. Extra-oral was more frequently used than intra-oral scanning. The computer-assisted design was the most applied digital technique. Additive manufacturing was preferred to milling for direct and indirect fabrication of frameworks. Fit assessments were based on qualitative measures, but quantitative evaluation showed acceptable clinical fit for RPDs made by digital protocols. (4) Conclusions: The combination of direct metal additive manufacturing with conventional impression was the most used protocol and included better qualitative and quantitative fit outcomes than the other digital protocols.
    Keywords removable partial denture ; framework production ; digital ; CAD-CAM ; fit accuracy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 001
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Paroxysmal Movement Disorder and Epilepsy Caused by a De Novo Truncating Mutation in

    Efthymiou, Stephanie / Salpietro, Vincenzo / Bettencourt, Conceicao / Houlden, Henry

    Journal of pediatric genetics

    2018  Volume 7, Issue 3, Page(s) 114–116

    Abstract: Mutations ... ...

    Abstract Mutations in
    Language English
    Publishing date 2018-06-14
    Publishing country Germany
    Document type Journal Article
    ISSN 2146-4596
    ISSN 2146-4596
    DOI 10.1055/s-0038-1651526
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field.

    Fullerton, Josie / Bettencourt, Conceicao / Daniels, Michael / Mclean, Fiona / Simpson, Susan / Smith, Adam / Woodling, Nathan / Kerr, Fiona

    AMRC open research

    2023  Volume 4, Page(s) 22

    Abstract: Background: Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one or ... ...

    Abstract Background: Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one or more mentors beyond their direct manager) have proven to be successful in providing support and expanding career development opportunities. However, many programmes are limited to pools of mentors and mentees within one institute or geographical area, highlighting that cross-regional connections may be a missed opportunity in many mentorship schemes.
    Methods: Here, we aimed to address this limitation through our pilot cross-regional mentorship scheme, creating reciprocal mentor-mentee pairings between two pre-established networks of Alzheimer's Research UK (ARUK) Network-associated researchers. We carefully created 21 mentor-mentee pairings between the Scotland and University College London (UCL) networks in 2021, with surveys conducted to assess mentor/mentee satisfaction with the programme.
    Results: Participants reported very high satisfaction with the nature of the pairings and the mentors' contribution to the career development of mentees; a majority also reported that the mentorship scheme increased their connections outside of their home network. Our assessment of this pilot programme is that it supports the utility of cross-regional mentorship schemes for ECR development. At the same time, we highlight the limitations of our programme and recommend areas for improvement in future programmes, including greater consideration of support for minoritized groups and the need for additional training for mentors.
    Conclusions: In conclusion, our pilot scheme generated successful and novel mentor-mentee pairings across pre-existing networks; both of which reported high satisfaction with pairings, ECR career and personal development, and the formation of new cross-network connections. This pilot may serve as a model for other networks of biomedical researchers, where existing networks within medical research charities can act as a scaffold to build new cross-regional career development opportunities for researchers.
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ISSN 2517-6900
    ISSN (online) 2517-6900
    DOI 10.12688/amrcopenres.13091.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration.

    Fodder, Katherine / de Silva, Rohan / Warner, Thomas T / Bettencourt, Conceição

    Acta neuropathologica communications

    2023  Volume 11, Issue 1, Page(s) 106

    Abstract: Neurodegenerative diseases encompass a heterogeneous group of conditions characterised by the progressive degeneration of the structure and function of the central or peripheral nervous systems. The pathogenic mechanisms underlying these diseases are not ...

    Abstract Neurodegenerative diseases encompass a heterogeneous group of conditions characterised by the progressive degeneration of the structure and function of the central or peripheral nervous systems. The pathogenic mechanisms underlying these diseases are not fully understood. However, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in Alzheimer's disease (AD), inclusions of hyperphosphorylated microtubule-binding tau in AD and other tauopathies, or inclusions containing α-synuclein in Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Various pathogenic mechanisms are thought to contribute to disease, and an increasing number of studies implicate dysfunction of oligodendrocytes (the myelin producing cells of the central nervous system) and myelin loss. Aberrant DNA methylation, the most widely studied epigenetic modification, has been associated with many neurodegenerative diseases, including AD, PD, DLB and MSA, and recent findings highlight aberrant DNA methylation in oligodendrocyte/myelin-related genes. Here we briefly review the evidence showing that changes to oligodendrocytes and myelin are key in neurodegeneration, and explore the relevance of DNA methylation in oligodendrocyte (dys)function. As DNA methylation is reversible, elucidating its involvement in pathogenic mechanisms of neurodegenerative diseases and in dysfunction of specific cell-types such as oligodendrocytes may bring opportunities for therapeutic interventions for these diseases.
    MeSH term(s) Humans ; DNA Methylation ; Oligodendroglia ; Myelin Sheath ; Epigenesis, Genetic ; Alzheimer Disease/genetics ; Parkinson Disease ; Multiple System Atrophy ; Plaque, Amyloid
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-023-01607-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2.

    Nazish, Iqra / Mamais, Adamantios / Mallach, Anna / Bettencourt, Conceicao / Kaganovich, Alice / Warner, Thomas / Hardy, John / Lewis, Patrick A / Pocock, Jennifer / Cookson, Mark R / Bandopadhyay, Rina

    Cells

    2023  Volume 13, Issue 1

    Abstract: Mutations in the leucine-rich repeat kinase 2 ( ...

    Abstract Mutations in the leucine-rich repeat kinase 2 (
    MeSH term(s) Humans ; Animals ; Mice ; Microglia ; Zymosan/pharmacology ; Genome-Wide Association Study ; Toll-Like Receptor 2/genetics ; Parkinson Disease/genetics ; Gene Expression ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
    Chemical Substances Zymosan (9010-72-4) ; Toll-Like Receptor 2 ; LRRK2 protein, human (EC 2.7.11.1) ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1)
    Language English
    Publishing date 2023-12-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13010053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Creating connections

    Michael Daniels / Adam Smith / Conceicao Bettencourt / Susan Simpson / Fiona Mclean / Fiona Kerr / Nathan Woodling / Josie Fullerton

    Health Open Research, Vol

    developing an online space for cross-regional mentorship and network building in the dementia research field [version 2; peer review: 2 approved]

    2023  Volume 4

    Abstract: Background Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one or ... ...

    Abstract Background Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one or more mentors beyond their direct manager) have proven to be successful in providing support and expanding career development opportunities. However, many programmes are limited to pools of mentors and mentees within one institute or geographical area, highlighting that cross-regional connections may be a missed opportunity in many mentorship schemes. Methods Here, we aimed to address this limitation through our pilot cross-regional mentorship scheme, creating reciprocal mentor-mentee pairings between two pre-established networks of Alzheimer’s Research UK (ARUK) Network-associated researchers. We carefully created 21 mentor-mentee pairings between the Scotland and University College London (UCL) networks in 2021, with surveys conducted to assess mentor/mentee satisfaction with the programme. Results Participants reported very high satisfaction with the nature of the pairings and the mentors’ contribution to the career development of mentees; a majority also reported that the mentorship scheme increased their connections outside of their home network. Our assessment of this pilot programme is that it supports the utility of cross-regional mentorship schemes for ECR development. At the same time, we highlight the limitations of our programme and recommend areas for improvement in future programmes, including greater consideration of support for minoritized groups and the need for additional training for mentors. Conclusions In conclusion, our pilot scheme generated successful and novel mentor-mentee pairings across pre-existing networks; both of which reported high satisfaction with pairings, ECR career and personal development, and the formation of new cross-network connections. This pilot may serve as a model for other networks of biomedical researchers, where ...
    Keywords mentoring ; mentorship ; early career researchers ; dementia ; Alzheimer’s disease ; eng ; Medicine ; R
    Subject code 300
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.

    Nazish, Iqra / Mamais, Adamantios / Mallach, Anna / Bettencourt, Conceicao / Kaganovich, Alice / Warner, Tom / Hardy, John / Lewis, Patrick A / Pocock, Jennifer / Cookson, Mark R / Bandopadhyay, Rina

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Introduction: Mutations in the Leucine Rich Repeat Kinase 2 (: Methods: Here, we investigated the effects of zymosan, a TLR2 agonist and the potent and specific LRRK2 kinase inhibitor MLi-2 on gene expression in microglia from : Results: We ... ...

    Abstract Introduction: Mutations in the Leucine Rich Repeat Kinase 2 (
    Methods: Here, we investigated the effects of zymosan, a TLR2 agonist and the potent and specific LRRK2 kinase inhibitor MLi-2 on gene expression in microglia from
    Results: We observed both overlapping and distinct zymosan and MLi-2 mediated gene expression profiles in microglia. At least two candidate Genome-Wide Association (GWAS) hits for PD, CathepsinB (
    Discussion: Overall, these results suggest that microglial LRRK2 may contribute to PD pathogenesis through altered inflammatory pathways. Our findings should encourage future investigations of these putative avenues in the context of PD pathogenesis.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.14.557532
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung.

    Verma, Amrita / Ebanks, Kirsten / Fok, Chi-Yee / Lewis, Patrick A / Bettencourt, Conceicao / Bandopadhyay, Rina

    Brain research

    2021  Volume 1765, Page(s) 147503

    Abstract: Mutations in LRRK2 are the most frequent cause of familial Parkinson's disease (PD), with common LRRK2 non-coding variants also acting as risk factors for idiopathic PD. Currently, therapeutic agents targeting LRRK2 are undergoing advanced clinical ... ...

    Abstract Mutations in LRRK2 are the most frequent cause of familial Parkinson's disease (PD), with common LRRK2 non-coding variants also acting as risk factors for idiopathic PD. Currently, therapeutic agents targeting LRRK2 are undergoing advanced clinical trials in humans, however, it is important to understand the wider implications of LRRK2 targeted treatments given that LRRK2 is expressed in diverse tissues including the brain, kidney and lungs. This presents challenges to treatment in terms of effects on peripheral organ functioning, thus, protein interactors of LRRK2 could be targeted in lieu to optimize therapeutic effects. Herein an in-silico analysis of LRRK2 direct interactors in brain tissue from various brain regionswas conducted along with a comparative analysis of the LRRK2 interactome in the brain, kidney, and lung tissues. This was carried out based on curated protein-protein interaction (PPI) data from protein interaction databases such as HIPPIE, human gene/protein expression databases and Gene ontology (GO) enrichment analysis using Bingo. Seven targets (MAP2K6, MATK, MAPT, PAK6, SH3GL2, CDC42EP3 and CHGB) were found to be viable objectives for LRRK2 based investigations for PD that would have minimal impact on optimal functioning within peripheral organs. Specifically, MAPT, CHGB, PAK6, and SH3GL2 interacted with LRRK2 in the brain and kidney but not in lung tissue whilst LRRK2-MAP2K6 interacted only in the cerebellum and MATK-LRRK2 interaction was absent in kidney tissues. CDC42EP3 expression levels were low in brain tissues compared to kidney/lung. The results of this computational analysis suggest new avenues for experimental investigations towards LRRK2-targeted therapeutics.
    MeSH term(s) Brain/cytology ; Brain/metabolism ; Computer Simulation ; Databases, Genetic ; Gene Expression/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Kidney/cytology ; Kidney/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Lung/cytology ; Lung/metabolism ; Mutation/genetics ; Organ Specificity/genetics ; Protein Serine-Threonine Kinases/genetics ; Transcriptome/genetics
    Chemical Substances LRRK2 protein, human (EC 2.7.11.1) ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-04-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2021.147503
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top