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  1. Article ; Online: Multi-drug Treatment for COVID-19-induced Acute Respiratory Distress Syndrome

    Ohe, Masashi

    Turkish journal of pharmaceutical sciences

    2022  Volume 19, Issue 1, Page(s) 101–103

    Abstract: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), broke out in late 2019 to become a serious global threat to human health. In the absence of specific treatments for COVID-19, treatment options ... ...

    Abstract Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), broke out in late 2019 to become a serious global threat to human health. In the absence of specific treatments for COVID-19, treatment options are being examined. Recently, the anti-SARS-CoV-2 activities of tetracyclines, macrolide antibiotics, and ivermectin (IVM), have attracted considerable attention for their potential as a single or multi-drug treatment regimen. Moreover, tetracyclines, macrolide antibiotics, and IVM possess anti-inflammatory and immunomodulatory effects to reduce the production of cytokines. COVID-19 is characterized by early exponential viral replication, cytokine storm-associated organ damage, including acute respiratory distress syndrome (ARDS) and thrombosis. Considering anti-inflammatory and immunomodulatory effects of the aforementioned drugs and corticosteroids, early treatment with doxycycline, azithromycin, IVM, and corticosteroids is thought to be the most promising option for combating COVID-19-induced ARDS.
    Language English
    Publishing date 2022-03-14
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2238484-4
    ISSN 2148-6247 ; 2148-6247
    ISSN (online) 2148-6247
    ISSN 2148-6247
    DOI 10.4274/tjps.galenos.2021.63060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case of lupus nephritis treated with clarithromycin, tacrolimus, and glucocorticoids

    Masashi Ohe

    Kaohsiung Journal of Medical Sciences, Vol 32, Iss 9, Pp 484-

    2016  Volume 485

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Multidrug treatment for COVID-19.

    Ohe, Masashi / Furuya, Ken / Goudarzi, Houman

    Drug discoveries & therapeutics

    2021  Volume 15, Issue 1, Page(s) 39–41

    Abstract: An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which began in Wuhan, China in December 2019, has rapidly spread all over the world. The World Health Organization characterized the disease caused by SARS-CoV-2 ( ... ...

    Abstract An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which began in Wuhan, China in December 2019, has rapidly spread all over the world. The World Health Organization characterized the disease caused by SARS-CoV-2 (COVID-19) as a pandemic in March 2020. In the absence of specific treatments for the virus, treatment options are being examined. Drug repurposing is a process of identifying new therapeutic uses for approved drugs. It is an effective strategy to discover drug molecules with new therapeutic indications. This strategy is time-saving, low-cost, and has a minimal risk of failure. Several existing approved drugs such as chloroquine, hydroxychloroquine, doxycycline, azithromycin, and ivermectin are currently in use because of their efficacy in inhibiting COVID-19. Multidrug therapy, such as a combination of hydroxychloroquine and azithromycin, a combination of doxycycline and ivermectin, or a combination of ivermectin, doxycycline, and azithromycin, has been successfully administered. Multidrug therapy is efficacious because the mechanisms of action of these drugs differ. Moreover, multidrug therapy may prevent the emergence of drug-resistant SARS-CoV-2.
    MeSH term(s) Azithromycin/therapeutic use ; COVID-19/drug therapy ; Doxycycline/therapeutic use ; Drug Repositioning ; Drug Therapy, Combination/methods ; Humans ; Hydroxychloroquine/therapeutic use ; Ivermectin/therapeutic use ; Treatment Outcome
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Ivermectin (70288-86-7) ; Azithromycin (83905-01-5) ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2021-02-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2021.01005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tetracycline plus macrolide: A potential therapeutic regimen for COVID-19?

    Ohe, Masashi / Furuya, Ken / Goudarzi, Houman

    Bioscience trends

    2020  Volume 14, Issue 6, Page(s) 467–468

    Abstract: The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that struck in late 2019 and early 2020 is a serious threat to human health. Since there are no approved drugs that satisfactorily treat this condition, all ... ...

    Abstract The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that struck in late 2019 and early 2020 is a serious threat to human health. Since there are no approved drugs that satisfactorily treat this condition, all efforts at drug design and/or clinical trials are warranted and reasonable. Drug repurposing is a well-known strategy that seeks to deploy existing licensed drugs for newer indications and that provides the quickest possible transition from the bench to the bedside to meet therapeutic needs. At present, several existing licensed drugs such as chloroquine, hydroxychloroquine, methylprednisolone, dexamethasone, and remdesivir have been used because of their potential efficacy in inhibiting COVID-19. Recently, antibiotics such as tetracyclines and macrolides have been reported to be effective against COVID-19. A combination of tetracyclines and macrolides may be a potential treatment for COVID-19 because there are some differences in the mechanism of action of tetracyclines and macrolides.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; COVID-19/drug therapy ; Drug Therapy, Combination ; Humans ; Macrolides/therapeutic use ; Tetracycline/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Macrolides ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2020-12-27
    Publishing country Japan
    Document type Letter
    ZDB-ID 2543899-2
    ISSN 1881-7823 ; 1881-7815
    ISSN (online) 1881-7823
    ISSN 1881-7815
    DOI 10.5582/bst.2020.03443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Successful treatment of angioimmunoblastic T-cell lymphoma with clarithromycin.

    Ohe, Masashi / Hashino, Satoshi

    Blood research

    2016  Volume 51, Issue 2, Page(s) 139–142

    Language English
    Publishing date 2016-06-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2016.51.2.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case of follicular lymphoma accompanied with chylous ascites.

    Ohe, Masashi / Baba, Masaru / Shida, Haruki / Furuya, Ken / Kogawa, Katsuhisa

    Blood research

    2019  Volume 54, Issue 3, Page(s) 163

    Language English
    Publishing date 2019-09-25
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2019.54.3.163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: Brigatinib in Japanese patients with tyrosine kinase inhibitor-naive ALK-positive non-small cell lung cancer: first results from the phase 2 J-ALTA study.

    Sugawara, Shunichi / Kondo, Masashi / Yokoyama, Toshihide / Kumagai, Toru / Nishio, Makoto / Goto, Koichi / Nakagawa, Kazuhiko / Seto, Takashi / Yamamoto, Nobuyuki / Kudou, Kentarou / Asato, Takayuki / Zhang, Pingkuan / Ohe, Yuichiro

    International journal of clinical oncology

    2023  Volume 28, Issue 5, Page(s) 724–725

    Language English
    Publishing date 2023-01-12
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-022-02286-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4828: Show issues Location:
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  8. Article ; Online: Reply to J. L. Derks et al.

    Kenmotsu, Hirotsugu / Niho, Seiji / Tsuboi, Masahiro / Wakabayashi, Masashi / Eba, Junko / Asamura, Hisao / Ohe, Yuichiro / Watanabe, Shun-Ichi

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 13, Page(s) 1509–1510

    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.00107
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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  9. Article ; Online: Successful additional clarithromycin and tacrolimus treatment for hypereosinophilia associated with eosinophilic granulomatosis with polyangiitis.

    Ohe, Masashi / Shida, Haruki / Horita, Tetsuya / Furuya, Ken

    Translational and clinical pharmacology

    2018  Volume 26, Issue 2, Page(s) 60–63

    Abstract: A 41-year-old man suffering from eosinophilic granulomatosis with polyangiitis (EPGA), diagnosed at another clinic on the basis of American College of Rheumatology Criteria, with a history of bronchial asthma, eosinophilia, mononeuritis multiplex, and ... ...

    Abstract A 41-year-old man suffering from eosinophilic granulomatosis with polyangiitis (EPGA), diagnosed at another clinic on the basis of American College of Rheumatology Criteria, with a history of bronchial asthma, eosinophilia, mononeuritis multiplex, and non-fixed pulmonary infiltrates, was admitted to our department for further treatment. The patient complained of chest pain that started recently. An echocardiogram identified myocardial thickening and decreased wall motion, based on which the patient was diagnosed as having EPGA with myocarditis. The patient was successfully treated using glucocorticoids, such as methyl prednisolone (PSL) and PSL in combination with cyclophosphamide (CPM). However, CPM administration was discontinued afterwards because of the risk of bone marrow toxicity, the increased eosinophilic count (EOC) that we considered as an index of disease activity. Subsequently, the patient received additional clarithromycin (CAM) and tacrolimus (TAC) treatment considering their immunomodulatory effects. As a result, the EOC decreased and the PSL dosage could be reduced. This case shows that additional CAM and TAC treatment may be beneficial in some cases of EPGA.
    Language English
    Publishing date 2018-06-18
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2861878-6
    ISSN 2383-5427 ; 2289-0882
    ISSN (online) 2383-5427
    ISSN 2289-0882
    DOI 10.12793/tcp.2018.26.2.60
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  10. Article ; Online: A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels.

    Ohe, Masashi / Bohgaki, Toshiyuki

    Bulletin of the Hospital for Joint Disease (2013)

    2015  Volume 73, Issue 3, Page(s) 213–216

    Abstract: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. The mainstays of treatment are glucocorticoids (GCs) and non-steroidal anti-inflammatory drugs, although most cases are refractory to these conventional ... ...

    Abstract Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. The mainstays of treatment are glucocorticoids (GCs) and non-steroidal anti-inflammatory drugs, although most cases are refractory to these conventional therapies. Immunosuppressants,such as methotrexate (MTX), cyclosporine A, tumor necrosis factor-α blockers, an interleukin (IL)-1 blocker, and an IL-6, receptor blocker, have been suggested in previous reports for the treatment of steroid-resistant AOSD. We report herein the case of an AOSD patient who was successfully treated with tacrolimus, another immunosuppressant, in combination with GC and MTX. Blood concentrations of tacrolimus were monitored because of the narrow therapeutic window.
    MeSH term(s) Adult ; Aged, 80 and over ; Drug Monitoring/methods ; Drug Therapy, Combination ; Female ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/blood ; Immunosuppressive Agents/therapeutic use ; Methotrexate/therapeutic use ; Still's Disease, Adult-Onset/blood ; Still's Disease, Adult-Onset/drug therapy ; Tacrolimus/blood ; Tacrolimus/therapeutic use
    Chemical Substances Glucocorticoids ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390411-8
    ISSN 2328-5273 ; 1936-9727 ; 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    ISSN (online) 2328-5273 ; 1936-9727
    ISSN 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.233: Show issues Location:
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