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  1. Article ; Online: Monotherapy or Combination Therapy for Septic Shock? A Debate on Steroids.

    Tsolaki, Vasiliki / Siempos, Ilias I

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202401-0175ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.80: Show issues Location:
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  2. Article ; Online: Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help?

    Torres, Lisa K / Siempos, Ilias I

    Thorax

    2024  Volume 79, Issue 3, Page(s) 200–201

    MeSH term(s) Humans ; Ferritins ; Phenotype ; Respiratory Distress Syndrome
    Chemical Substances Ferritins (9007-73-2)
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-221131
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  3. Article ; Online: Innovation in Enrichment: Is Persistence Enough?

    Schenck, Edward J / Siempos, Ilias I

    Critical care medicine

    2024  Volume 52, Issue 5, Page(s) 853–856

    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006239
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    Zs.A 1261: Show issues Location:
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  4. Article ; Online: Right ventricular free wall longitudinal strain during weaning from mechanical ventilation using high-flow or conventional oxygen treatment: a pilot study.

    Xourgia, Eleni / Koronaios, Apostolos / Kotanidou, Anastasia / Siempos, Ilias I / Routsi, Christina

    The ultrasound journal

    2024  Volume 16, Issue 1, Page(s) 17

    Language English
    Publishing date 2024-02-27
    Publishing country Italy
    Document type Letter
    ZDB-ID 2965029-X
    ISSN 2524-8987 ; 2036-3176
    ISSN (online) 2524-8987
    ISSN 2036-3176
    DOI 10.1186/s13089-024-00358-5
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  5. Article ; Online: EARLY TRAJECTORY OF VENOUS EXCESS ULTRASOUND SCORE IS ASSOCIATED WITH CLINICAL OUTCOMES OF GENERAL ICU PATIENTS.

    Trigkidis, Kyriakos K / Siempos, Ilias I / Kotanidou, Anastasia / Zakynthinos, Spyros / Routsi, Christina / Kokkoris, Stelios

    Shock (Augusta, Ga.)

    2024  Volume 61, Issue 3, Page(s) 400–405

    Abstract: Abstract: Background: Systemic venous congestion, assessed by the venous excess ultrasound (VExUS) score, has been associated with adverse effects, including acute kidney injury (AKI), in patients with cardiac disease. In general intensive care unit ( ... ...

    Abstract Abstract: Background: Systemic venous congestion, assessed by the venous excess ultrasound (VExUS) score, has been associated with adverse effects, including acute kidney injury (AKI), in patients with cardiac disease. In general intensive care unit (ICU) patients, the association between VExUS score and outcomes is understudied. We aimed to investigate the association between the trajectory of VExUS score within the first 3 days of ICU admission and the composite clinical outcome of major adverse kidney events within 30 days (MAKE30). Methods: In this prospective observational study, including patients consecutively admitted to the ICU, VExUS score was calculated within 24 h after ICU admission (day 1) and at 48 to 72 h (day 3). D-VExUS was calculated as the difference between the VExUS score on day 3 minus that on day 1. Development of AKI within 7 days and all-cause mortality within 30 days were recorded. Results: A total of 89 patients (62% men; median age, 62 years; median Acute Physiology and Chronic Health Evaluation II score, 24) were included. Sixty (67%) patients developed AKI within 7 days, and 17 (19%) patients died within 30 days after ICU admission. D-VExUS was associated with MAKE30, even after adjustment for confounders (hazard ratio, 2.07; 95% confidence interval, 1.17-3.66; P = 0.01). VExUS scores on days 1 or 3 were not associated with MAKE30. Also, VExUS scores on day 1 or on day 3 and D-VExUS were not associated with development of AKI or mortality. Conclusions: In a general ICU cohort, early trajectory of VExUS score, but not individual VExUS scores at different time points, was associated with the patient-centered MAKE30 outcome. Dynamic changes rather than snapshot measurements may unmask the adverse effects of systemic venous congestion on important clinical outcomes.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Hyperemia ; Intensive Care Units ; Critical Care ; Prospective Studies ; Acute Kidney Injury
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000002321
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    Zs.A 3985: Show issues Location:
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  6. Article ; Online: Lost in a number: concealed heterogeneity within the sequential organ failure assessment (SOFA) score.

    Dusaj, Neville / Papoutsi, Eleni / Hoffman, Katherine L / Siempos, Ilias I / Schenck, Edward James

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 6

    MeSH term(s) Humans ; Organ Dysfunction Scores ; Multiple Organ Failure/diagnosis ; Severity of Illness Index ; Prognosis ; Retrospective Studies ; ROC Curve ; Intensive Care Units
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04782-2
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    Zs.A 5517: Show issues Location:
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  7. Article ; Online: Association between ventilatory ratio and mortality persists in patients with ARDS requiring prolonged mechanical ventilation.

    Papoutsi, Eleni / Giannakoulis, Vassilis G / Routsi, Christina / Kotanidou, Anastasia / Siempos, Ilias I

    Intensive care medicine

    2023  Volume 49, Issue 7, Page(s) 876–877

    MeSH term(s) Humans ; Respiration, Artificial ; Intensive Care Units ; Hospital Mortality ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07107-7
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    Zs.A 1089: Show issues Location:
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  8. Article ; Online: Association between driving pressure and mortality may depend on timing since onset of acute respiratory distress syndrome.

    Papoutsi, Eleni / Routsi, Christina / Kotanidou, Anastasia / Vaporidi, Katerina / Siempos, Ilias I

    Intensive care medicine

    2023  Volume 49, Issue 3, Page(s) 363–365

    MeSH term(s) Humans ; Respiratory Distress Syndrome ; Respiration, Artificial
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-06996-y
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    Zs.A 1089: Show issues Location:
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  9. Article ; Online: Postoperative acute respiratory distress syndrome in randomized controlled trials.

    Giannakoulis, Vassilis G / Papoutsi, Eleni / Kaldis, Vassileios / Tsirogianni, Athanasia / Kotanidou, Anastasia / Siempos, Ilias I

    Surgery

    2023  Volume 174, Issue 4, Page(s) 1050–1055

    Abstract: Background: Acute respiratory distress syndrome is a potentially fatal postoperative complication. We aimed to estimate temporal trends of the representation of patients with postoperative acute respiratory distress syndrome in clinical trials, ... ...

    Abstract Background: Acute respiratory distress syndrome is a potentially fatal postoperative complication. We aimed to estimate temporal trends of the representation of patients with postoperative acute respiratory distress syndrome in clinical trials, determine their distinct clinical features, and identify predictors of mortality.
    Methods: This is a secondary analysis of 7 randomized controlled clinical trials conducted by the Acute Respiratory Distress Syndrome Network and the Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury. Patients with acute respiratory distress syndrome were classified into a postoperative acute respiratory distress syndrome group (ie, patients who had undergone elective surgery in the immediate period before trial enrollment) and a non-postoperative acute respiratory distress syndrome group.
    Results: Out of 5,316 patients with acute respiratory distress syndrome, 256 (4.8%) had postoperative acute respiratory distress syndrome. Representation of postoperative acute respiratory distress syndrome in trials gradually declined from 2000 to 2011, but it remained stable afterward at 2.7%. Postoperative acute respiratory distress syndrome was associated with lower 90-day mortality (24.6% vs 30.9%, P = .032) than non-postoperative acute respiratory distress syndrome, even after adjusting for age, acute respiratory distress syndrome severity, usage of vasopressors at baseline, and the study publication year (hazard ratio 0.63, 95% confidence interval 0.49-0.82). Age (odds ratio 1.07, 95% confidence interval 1.04-1.09), immunosuppression (odds ratio 4.12, 95% confidence interval 1.43-11.86), and positive fluid balance (odds ratio 1.09, 95% confidence interval 1.04-1.14) were associated with 90-day mortality among patients with postoperative acute respiratory distress syndrome.
    Conclusion: Representation of postoperative acute respiratory distress syndrome in trials of the Acute Respiratory Distress Syndrome Network and the Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury gradually declined from 2000 to 2011 but remained stable afterward. Postoperative acute respiratory distress syndrome was associated with lower mortality than non-postoperative acute respiratory distress syndrome. These findings may put both temporal trends and the prognosis of postoperative acute respiratory distress syndrome in perspective. Also, positive fluid balance was associated with the mortality of patients with postoperative acute respiratory distress syndrome.
    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Acute Lung Injury/diagnosis ; Acute Lung Injury/etiology ; Elective Surgical Procedures/adverse effects ; Immunosuppression Therapy ; Respiratory Distress Syndrome/etiology
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.06.019
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    Uk I Zs.129: Show issues Location:
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  10. Article ; Online: Reclassification of Acute Respiratory Distress Syndrome: A Secondary Analysis of the ARDS Network Trials.

    Oromendia, Clara / Siempos, Ilias I

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 8, Page(s) 998–1001

    MeSH term(s) Adult ; Aged ; Cause of Death ; Female ; Humans ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Mortality ; Oxygen/metabolism ; Oxygen Inhalation Therapy ; Partial Pressure ; Randomized Controlled Trials as Topic ; Respiration, Artificial/statistics & numerical data ; Respiratory Distress Syndrome, Adult/classification ; Respiratory Distress Syndrome, Adult/metabolism ; Respiratory Distress Syndrome, Adult/therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2018-03-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201803-192RL
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