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  1. Book ; Thesis: Molekularbiologischer und mikrobiologischer Nachweis von pathogenen Mikroorganismen in legal und illegal importierten Lebensmitteln

    Schandock, Franziska

    2013  

    Author's details von Franziska Schandock
    Language German
    Size 47 S., Ill., Tab.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Beuth Hochschule f. Techn., Bachelorarb.--Berlin, 2013
    Database Federal Institute for Risk Assessment

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  2. Book ; Online: Arbeit und Qualifikation in der Green Economy

    Helmrich, Robert / Mohaupt, Franziska / Röttger, Christof / Schandock, Manuel / Zika, Gerd

    (Umwelt, Innovation, Beschäftigung / Umweltbundesamt ; 03/2014)

    2015  

    Author's details von Robert Helmrich, Manuel Schandock, Franziska Mohaupt, Christof Röttger, Gerd Zika
    Series title Umwelt, Innovation, Beschäftigung / Umweltbundesamt ; 03/2014
    Keywords Alternative Ökonomie ; Systemtransformation ; Arbeitswelt ; Anforderungsprofil ; Qualifikation ; Deutschland
    Language German
    Size Online-Ressource (19 S.), graph. Darst.
    Publisher Umweltbundesamt
    Publishing place Dessau-Roßlau
    Document type Book ; Online
    Note Zsfassung in engl. Sprache
    Database ECONomics Information System

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  3. Article ; Online: Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

    Schandock, Franziska / Riber, Camilla Frich / Röcker, Annika / Müller, Janis A / Harms, Mirja / Gajda, Paulina / Zuwala, Kaja / Andersen, Anna H F / Løvschall, Kaja Borup / Tolstrup, Martin / Kreppel, Florian / Münch, Jan / Zelikin, Alexander N

    Advanced healthcare materials

    2017  Volume 6, Issue 23

    Abstract: Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make ... ...

    Abstract Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Chlorocebus aethiops ; Ebolavirus/metabolism ; HEK293 Cells ; Humans ; Polymers/chemistry ; Polymers/pharmacology ; SARS Virus/metabolism ; Vero Cells ; Virus Diseases/drug therapy ; Virus Diseases/metabolism ; Virus Diseases/pathology ; Zika Virus/metabolism
    Chemical Substances Antiviral Agents ; Polymers
    Keywords covid19
    Language English
    Publishing date 2017-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201700748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  4. Article ; Online: miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality.

    Fischer, Simon / Paul, Albert Jesuran / Wagner, Andreas / Mathias, Sven / Geiss, Melanie / Schandock, Franziska / Domnowski, Martin / Zimmermann, Jörg / Handrick, René / Hesse, Friedemann / Otte, Kerstin

    Biotechnology and bioengineering

    2015  Volume 112, Issue 10, Page(s) 2142–2153

    Abstract: Histone deacetylase (HDAC) inhibitors have been exploited for years to improve recombinant protein expression in mammalian production cells. However, global HDAC inhibition is associated with negative effects on various cellular processes. microRNAs ( ... ...

    Abstract Histone deacetylase (HDAC) inhibitors have been exploited for years to improve recombinant protein expression in mammalian production cells. However, global HDAC inhibition is associated with negative effects on various cellular processes. microRNAs (miRNAs) have been shown to regulate gene expression in almost all eukaryotic cell types by controlling entire cellular pathways. Since miRNAs recently have gained much attention as next-generation cell engineering tool to improve Chinese hamster ovary (CHO) cell factories, we were interested if miRNAs are able to specifically repress HDAC expression in CHO cells to circumvent limitations of unspecific HDAC inhibition. We discovered a novel miRNA in CHO cells, miR-2861, which was shown to enhance productivity in various recombinant CHO cell lines. Furthermore, we demonstrate that miR-2861 might post-transcriptionally regulate HDAC5 in CHO cells. Intriguingly, siRNA-mediated HDAC5 suppression could be demonstrated to phenocopy pro-productive effects of miR-2861 in CHO cells. This supports the notion that miRNA-induced inhibition of HDAC5 may contribute to productivity enhancing effects of miR-2861. Furthermore, since product quality is fundamental to safety and functionality of biologics, we examined the effect of HDAC inhibition on critical product quality attributes. In contrast to unspecific HDAC inhibition using VPA, enforced expression of miR-2861 did not negatively influence antibody aggregation or N-glycosylation. Our findings highlight the superiority of miRNA-mediated inhibition of specific HDACs and present miR-2861 as novel cell engineering tool for improving CHO manufacturing cells.
    MeSH term(s) Animals ; Antibodies/genetics ; Antibodies/metabolism ; CHO Cells ; Cricetulus ; Gene Expression Regulation ; Histone Deacetylase Inhibitors/metabolism ; Metabolic Engineering ; MicroRNAs/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics
    Chemical Substances Antibodies ; Histone Deacetylase Inhibitors ; MicroRNAs ; Recombinant Proteins
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.25626
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 960: Show issues Location:
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