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Article ; Online: Benefits and challenges of reconstituting the actin cortex.

Waechtler, Brooke E / Jayasankar, Rajan / Morin, Emma P / Robinson, Douglas N

2024

Abstract: The cell's ability to change shape is a central feature in many cellular processes, including cytokinesis, motility, migration, and tissue formation. The cell constructs a network of contractile proteins underneath the cell membrane to form the cortex, ... ...

Abstract	The cell's ability to change shape is a central feature in many cellular processes, including cytokinesis, motility, migration, and tissue formation. The cell constructs a network of contractile proteins underneath the cell membrane to form the cortex, and the reorganization of these components directly contributes to cellular shape changes. The desire to mimic these cell shape changes to aid in the creation of a synthetic cell has been increasing. Therefore, membrane-based reconstitution experiments have flourished, furthering our understanding of the minimal components the cell uses throughout these processes. Although biochemical approaches increased our understanding of actin, myosin II, and actin-associated proteins, using membrane-based reconstituted systems has further expanded our understanding of actin structures and functions because membrane-cortex interactions can be analyzed. In this review, we highlight the recent developments in membrane-based reconstitution techniques. We examine the current findings on the minimal components needed to recapitulate distinct actin structures and functions and how they relate to the cortex's impact on cellular mechanical properties. We also explore how co-processing of computational models with wet-lab experiments enhances our understanding of these properties. Finally, we emphasize the benefits and challenges inherent to membrane-based, reconstitution assays, ranging from the advantage of precise control over the system to the difficulty of integrating these findings into the complex cellular environment.
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534372-5
ISSN	1949-3592 ; 1949-3584
ISSN (online)	1949-3592
ISSN	1949-3584
DOI	10.1002/cm.21855
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Article ; Online: Passion and performance anxiety: How it affects the incidence of musculoskeletal disorders in dancers.

Benoit-Piau, Justine / Gaudreault, Nathaly / Vallerand, Robert / Fortin, Sylvie / Guptill, Christine / Morin, Mélanie

Psychology of sport and exercise

2024 Volume 73, Page(s) 102632

Abstract: Objectives: This study aimed to examine the association between the incidence of musculoskeletal disorder episodes (MDEs) and obsessive and harmonious passion as well as performance anxiety throughout a dance season, which lasted 38 weeks.: Design: ... ...

Abstract	Objectives: This study aimed to examine the association between the incidence of musculoskeletal disorder episodes (MDEs) and obsessive and harmonious passion as well as performance anxiety throughout a dance season, which lasted 38 weeks. Design: Prospective cohort study. Methods: A total of 118 professional and preprofessional dancers were recruited and assessed at baseline, while 88 completed the follow-up. Their levels of passion and performance anxiety were assessed at the beginning of a dance season using the Passion Scale and the Kenny Music Performance Anxiety Inventory, respectively. To monitor the incidence of MDEs throughout a dance season, dancers were asked to complete a weekly electronic diary. Results: A higher level of obsessive passion was associated with a higher incidence of MDEs causing an interruption of dance activities (β = 0.264, p = 0.022). Harmonious passion and performance anxiety were not associated with MDEs throughout the season. Conclusions: Findings of this study support the role of obsessive passion in the development of MDEs in dancers.
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ISSN	1878-5476
ISSN (online)	1878-5476
DOI	10.1016/j.psychsport.2024.102632
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Article ; Online: Polygenic risk and hostile environments: Links to stable and dynamic antisocial behaviors across adolescence.

Acland, E L / Pocuca, N / Paquin, S / Boivin, M / Ouellet-Morin, I / Andlauer, T F M / Gouin, J P / Côté, S M / Tremblay, R E / Geoffroy, M / Castellanos-Ryan, N

Development and psychopathology

2024 , Page(s) 1–13

Abstract: Adverse environments are linked to elevated youth antisocial behavior. However, this relation is thought to depend, in part, on genetic susceptibility. The present study investigated whether polygenic risk for antisociality moderates relations between ... ...

Abstract	Adverse environments are linked to elevated youth antisocial behavior. However, this relation is thought to depend, in part, on genetic susceptibility. The present study investigated whether polygenic risk for antisociality moderates relations between hostile environments and stable as well as dynamic antisocial behaviors across adolescence. We derived two antisocial-linked polygenic risk scores (PRS) (
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036173-x
ISSN	1469-2198 ; 0954-5794
ISSN (online)	1469-2198
ISSN	0954-5794
DOI	10.1017/S095457942400004X
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Article: Estimating pregnancy rate from blubber progesterone levels of a blindly biopsied beluga population poses methodological, analytical and statistical challenges.

Renaud, L-A / Bordeleau, X / Kellar, N M / Pigeon, G / Michaud, R / Morin, Y / Lair, S / Therien, A / Lesage, V

Conservation physiology

2023 Volume 11, Issue 1, Page(s) coad075

Abstract: Beluga ( ...

Abstract	Beluga (
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2721508-8
ISSN	2051-1434
ISSN	2051-1434
DOI	10.1093/conphys/coad075
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Article: Use of Oenological Tannins to Protect the Colour of Rosé Wine in a Bioprotection Strategy with

Puyo, Maëlys / Simonin, Scott / Klein, Géraldine / David-Vaizant, Vanessa / Quijada-Morín, Natalia / Alexandre, Hervé / Tourdot-Maréchal, Raphaëlle

Foods (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: Although bioprotection is now recognised as an alternative to ... ...

Abstract	Although bioprotection is now recognised as an alternative to SO
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12040735
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Article ; Online: Projection of snowfall extremes in the French Alps as a function of elevation and global warming level

E. Le Roux / G. Evin / R. Samacoïts / N. Eckert / J. Blanchet / S. Morin

The Cryosphere, Vol 17, Pp 4691-

2023 Volume 4704

Abstract: Following the projected increase in extreme precipitation, an increase in extreme snowfall may be expected in cold regions, e.g., for high latitudes or at high elevations. By contrast, in low- to medium-elevation areas, the probability of experiencing ... ...

Abstract	Following the projected increase in extreme precipitation, an increase in extreme snowfall may be expected in cold regions, e.g., for high latitudes or at high elevations. By contrast, in low- to medium-elevation areas, the probability of experiencing rainfall instead of snowfall is generally projected to increase due to warming conditions. Yet, in mountainous areas, despite the likely existence of these contrasted trends according to elevation, changes in extreme snowfall with warming remain poorly quantified. This paper assesses projected changes in heavy and extreme snowfall, i.e., in mean annual maxima and 100-year return levels, in the French Alps as a function of elevation and global warming level. We apply a recent methodology, based on the analysis of annual maxima with non-stationary extreme value models, to an ensemble of 20 adjusted general circulation model–regional climate model (GCM–RCM) pairs from the EURO-CORDEX experiment under the Representative Concentration Pathway 8.5 (RCP8.5) scenario. For each of the 23 massifs of the French Alps, maxima in the hydrological sense (1 August to 31 July) are provided from 1951 to 2100 and every 300 m of elevations between 900 and 3600 m. Results rely on relative or absolute changes computed with respect to current climate conditions (corresponding here to +1 ∘ C global warming level) at the massif scale and averaged over all massifs. Overall, daily mean annual maxima of snowfall are projected to decrease below 3000 m and increase above 3600 m, while 100-year return levels are projected to decrease below 2400 m and increase above 3300 m. At elevations in between, values are on average projected to increase until +3 ∘ C of global warming and then decrease. At +4 ∘ C, average relative changes in mean annual maxima and 100-year return levels, respectively, vary from −26 % and −15 % at 900 m to +3 % and +8 % at 3600 m. Finally, for each global warming level between +1.5 and +4 ∘ C, we compute the elevation threshold that separates contrasted trends, i.e., where ...
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	333 ; 511
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article ; Online: Biological sex-related differences in the postprandial triglyceride response to intermittent hypoxaemia in young adults: a randomized crossover trial.

Goulet, Nicholas / Marcoux, Caroline / Bourgon, Vincent / Morin, Renée / Mauger, Jean-François / Amaratunga, Ruwan / Imbeault, Pascal

The Journal of physiology

2024

Abstract: Obstructive sleep apnoea is characterized by chronic intermittent hypoxaemia and is independently associated with an increased risk of metabolic comorbidities (e.g. type II diabetes and ischaemic heart disease). These comorbidities could be attributable ... ...

Abstract	Obstructive sleep apnoea is characterized by chronic intermittent hypoxaemia and is independently associated with an increased risk of metabolic comorbidities (e.g. type II diabetes and ischaemic heart disease). These comorbidities could be attributable to hypoxaemia-induced alterations in blood lipid profiles. However, it remains unclear whether intermittent hypoxaemia alters triglyceridaemia differently between biological sexes. Therefore, we used a randomized crossover design to examine whether 6 h of moderate intermittent hypoxaemia (15 hypoxaemic cycles/h, 85% oxyhaemoglobin saturation) alters plasma triglyceride levels differently between men and women after a high-fat meal. Relative to men, women displayed lower levels of total triglycerides, in addition to denser triglyceride-rich lipoprotein triglycerides (TRL-TG; mainly very low-density lipoprotein triglycerides and chylomicron remnant triglycerides) and buoyant TRL-TG (mainly chylomicron triglycerides) during normoxia (ambient air) and intermittent hypoxaemia (sex × time: all P ≤ 0.008). Intermittent hypoxaemia led to higher triglyceride levels (condition: all P ≤ 0.016); however, this effect was observed only in men (sex × condition: all P ≤ 0.002). Compared with normoxia, glucose levels were higher in men and lower in women during intermittent hypoxaemia (sex × condition: P < 0.001). The different postprandial responses between biological sexes occurred despite similar reductions in mean oxyhaemoglobin saturation and similar elevations in insulin levels, non-esterified fatty acid levels and mean heart rate (sex × condition: all P ≥ 0.185). These results support growing evidence showing that intermittent hypoxaemia impacts men and women differently, and they might help to explain biological sex-related discrepancies in the rate of certain comorbidities associated with intermittent hypoxaemia. KEY POINTS: Intermittent hypoxaemia is a key characteristic of obstructive sleep apnoea and alters lipid metabolism in multiple tissues, resulting in increased circulating triglyceride levels, an important risk factor for cardiometabolic diseases. Circulating triglyceride levels are regulated differently between biological sexes, with women typically displaying much lower fasting and postprandial triglyceride levels than men, partly explaining why women of all ages experience lower mortality rates from cardiometabolic diseases. In this study, healthy young men and women consumed a high-fat meal and were then exposed to 6 h of intermittent hypoxaemia or ambient air. We show that postprandial triglyceride levels are significantly lower in women compared with men and that intermittent hypoxaemia leads to higher postprandial triglyceride levels in men only. These results might help us to understand better why women living with obstructive sleep apnoea experience lower rates of cardiometabolic diseases (e.g. type II diabetes and ischaemic heart disease) than men living with obstructive sleep apnoea.
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP285430
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Article ; Online: Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.

Morin, Sophie / Tremblay, Andréa / Dumais, Elizabeth / Julien, Pierre / Flamand, Nicolas / Pouliot, Roxane

Biomolecules

2023 Volume 13, Issue 9

Abstract: ... of the inflammatory cascade derived from n-6 polyunsaturated fatty acids (n-6 PUFAs). Bioactive lipid mediators ... whereas n-3 PUFAs' derivatives are anti-inflammatory metabolites. Here, we sought to evaluate the influence ... increased epidermal and dermal linolenic acid (LA) and AA levels. N-6 PUFA lipid mediators were strongly ...

Abstract	Psoriasis is a skin disease characterized by epidermal hyperplasia and an inappropriate activation of the adaptive immunity. A dysregulation of the skin's lipid mediators is reported in the disease with a predominance of the inflammatory cascade derived from n-6 polyunsaturated fatty acids (n-6 PUFAs). Bioactive lipid mediators derived from arachidonic acid (AA) are involved in the inflammatory functions of T cells in psoriasis, whereas n-3 PUFAs' derivatives are anti-inflammatory metabolites. Here, we sought to evaluate the influence of a supplementation of the culture media with eicosapentaenoic acid (EPA) on the lipid profile of a psoriatic skin model produced with polarized T cells. Healthy and psoriatic skin substitutes were produced following the auto-assembly technique. Psoriatic skin substitutes produced with or without T cells presented increased epidermal and dermal linolenic acid (LA) and AA levels. N-6 PUFA lipid mediators were strongly measured in psoriatic substitutes, namely, 13-hydroxyoctadecadienoic acid (13-HODE), prostaglandin E
MeSH term(s)	Humans ; Eicosapentaenoic Acid/pharmacology ; Eicosapentaenoic Acid/metabolism ; T-Lymphocytes/metabolism ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Eicosanoids ; Arachidonic Acid/metabolism ; Skin Diseases ; Psoriasis ; Dinoprostone
Chemical Substances	Eicosapentaenoic Acid (AAN7QOV9EA) ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Eicosanoids ; Arachidonic Acid (27YG812J1I) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13091413
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Article ; Online: N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model.

Simard, Mélissa / Tremblay, Andréa / Morin, Sophie / Rioux, Geneviève / Flamand, Nicolas / Pouliot, Roxane

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12113

Abstract: ... abnormal epidermal differentiation and dysregulated lipid metabolism. Some lipid mediators of the N ... study was to characterize the endocannabinoid system and evaluate the effects of n-3-derived NAEs ... namely N-eicosapentaenoyl-ethanolamine (EPEA), in psoriatic keratinocytes using a psoriatic skin model ...

Abstract	Psoriasis is an inflammatory skin disease that is characterized by keratinocyte hyperproliferation, abnormal epidermal differentiation and dysregulated lipid metabolism. Some lipid mediators of the N-acylethanolamines (NAEs) and monoacylglycerols (MAGs) can bind to cannabinoid (CB) receptors and are referred to as part of the endocannabinoidome. Their implication in psoriasis remains unknown. The aim of the present study was to characterize the endocannabinoid system and evaluate the effects of n-3-derived NAEs, namely N-eicosapentaenoyl-ethanolamine (EPEA), in psoriatic keratinocytes using a psoriatic skin model produced by tissue engineering, following the self-assembly method. Psoriatic skin substitutes had lower FAAH2 expression and higher MAGL, ABHD6 and ABHD12 expression compared with healthy skin substitutes. Treatments with alpha-linolenic acid (ALA) increased the levels of EPEA and 1/2-docosapentaenoyl-glycerol, showing that levels of n-3 polyunsaturated fatty acids modulate related NAE and MAG levels. Treatments of the psoriatic substitutes with 10 μM of EPEA for 7 days resulted in decreased epidermal thickness and number of Ki67 positive keratinocytes, both indicating decreased proliferation of psoriatic keratinocytes. EPEA effects on keratinocyte proliferation were inhibited by the CB
MeSH term(s)	Humans ; Ethanolamine/metabolism ; Skin/metabolism ; Keratinocytes/metabolism ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Cell Proliferation ; Ethanolamines/pharmacology ; Ethanolamines/metabolism ; Monoacylglycerol Lipases/metabolism
Chemical Substances	Ethanolamine (5KV86114PT) ; N-acylethanolamines ; Ethanolamines ; ABHD12 protein, human (EC 3.1.1.23) ; Monoacylglycerol Lipases (EC 3.1.1.23)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39185-4
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Article ; Online: Is health-related quality of life trajectory associated with dialysis modality choice in advanced chronic kidney disease?

Morin, Catherine / Pichette, Maude / Elftouh, Naoual / Imbeault, Benoit / Laurin, Louis-Philippe / Lafrance, Jean-Philippe / Goupil, Rémi / Nadeau-Fredette, Annie-Claire

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2024 , Page(s) 8968608231217807

Abstract: Background: Patients with advanced chronic kidney disease have lower health-related quality of life (HRQOL) than the general population. There is uncertainty regarding patterns of HRQOL changes before dialysis initiation. This study aimed to ... ...

Abstract	Background: Patients with advanced chronic kidney disease have lower health-related quality of life (HRQOL) than the general population. There is uncertainty regarding patterns of HRQOL changes before dialysis initiation. This study aimed to characterise HRQOL trajectory and assess its potential association with intended dialysis modality. Methods: This prospective single-centre cohort study followed adults with an estimated glomerular filtration rate ≤15 mL/min/1.73 m Results: One hundred and nine patients were included. At baseline, crude physical composite summary (PCS) (45 ± 10 vs. 39 ± 8) was higher in patients choosing home dialysis ( Conclusions: Patients choosing home dialysis had improved MCS over time compared to those not selecting home dialysis. More work is needed to determine how differences in processes of care and/or unmeasured patient characteristics modulate this association.
Language	English
Publishing date	2024-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.1177/08968608231217807
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