Article: Challenges in quantifying functional redundancy and selection in microbial communities.
bioRxiv : the preprint server for biology
2024
Abstract: Microbiomes can exhibit large variations in species abundances but high reproducibility in abundances of functional units, an observation often considered evidence for functional redundancy. Based on such reduction in functional variability, selection is ...
| Abstract | Microbiomes can exhibit large variations in species abundances but high reproducibility in abundances of functional units, an observation often considered evidence for functional redundancy. Based on such reduction in functional variability, selection is hypothesized to act on functional units in these ecosystems. However, the link between functional redundancy and selection remains unclear. Here, we show that reduction in functional variability does not always imply selection on functional profiles. We propose empirical null models to account for the confounding effects of statistical averaging and bias toward environment-independent beneficial functions. We apply our models to existing data sets, and find that the abundances of metabolic groups within microbial communities from bromeliad foliage do not exhibit any evidence of the previously hypothesized functional selection. By contrast, communities of soil bacteria or human gut commensals grown |
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| Language | English |
| Publishing date | 2024-03-29 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2024.03.26.586891 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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