LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 685780

Search options

  1. Article ; Online: X

    Zeng, Yan / Zhang, Xinsong / Li, Hang / Wang, Jiawei / Zhang, Jipeng / Zhou, Wangchunshu

    IEEE transactions on pattern analysis and machine intelligence

    2024  Volume 46, Issue 5, Page(s) 3156–3168

    Abstract: ... grained aligning and multi-grained localization simultaneously. Based on it, we present X ...

    Abstract Vision language pre-training aims to learn alignments between vision and language from a large amount of data. Most existing methods only learn image-text alignments. Some others utilize pre-trained object detectors to leverage vision language alignments at the object level. In this paper, we propose to learn multi-grained vision language alignments by a unified pre-training framework that learns multi-grained aligning and multi-grained localization simultaneously. Based on it, we present X
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2023.3339661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: The X

    Zheng, Zijie / Luo, Ganhua / Shi, Xinchong / Long, Yali / Shen, Wanqing / Li, Zhoulei / Zhang, Xiangsong

    Cellular oncology (Dordrecht)

    2019  Volume 43, Issue 1, Page(s) 95–106

    Abstract: Purpose: Traditional treatment regimens for advanced prostate cancer, especially castration-resistant prostate cancer, result in low survival times with severe side effects. Therefore, new treatment options are required. Vitamin C (VC) has been ... ...

    Abstract Purpose: Traditional treatment regimens for advanced prostate cancer, especially castration-resistant prostate cancer, result in low survival times with severe side effects. Therefore, new treatment options are required. Vitamin C (VC) has been identified as a promising anti-cancer agent of which the effects depend on the accumulation of H
    Methods: The anti-cancer effect of VC and/or SAS on prostate cancer cells was assessed using WST-8, colony formation and annexin V-FITC/PI FACS assays. Changes in cellular ROS and GSH levels were determined to verify our hypothesis. Finally, BALB/c nude mice bearing prostate cancer xenografts were used to assess the anti-cancer effects of single or combined VC and SAS therapies.
    Results: We found that SAS could potentiate the short- and long-term cytotoxicity of VC in prostate cancer cells. We also found that the synergistic effect of SAS and VC led to significant cellular GSH depletion, resulting in increased ROS accumulation. This synergistic effect could be reversed by the antioxidant N-acetyl-L-cysteine (NAC). The synergistic effect of SAS and VC was also noted in prostate cancer xenografts and correlated with immunohistochemistry results.
    Conclusions: Our results strongly indicate that SAS, a relatively non-toxic drug that targets cystine transporters, in combination with VC may be superior to their single applications in the treatment of prostate cancer.
    MeSH term(s) Acetylcysteine/pharmacology ; Amino Acid Transport System y+/antagonists & inhibitors ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Ascorbic Acid/metabolism ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Synergism ; Glutathione/metabolism ; Humans ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/metabolism ; Reactive Oxygen Species/metabolism ; Sulfasalazine/pharmacology ; Sulfasalazine/therapeutic use ; Transplantation, Heterologous
    Chemical Substances Amino Acid Transport System y+ ; Antioxidants ; Reactive Oxygen Species ; SLC7A11 protein, human ; Sulfasalazine (3XC8GUZ6CB) ; Glutathione (GAN16C9B8O) ; Ascorbic Acid (PQ6CK8PD0R) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2019-10-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2595109-9
    ISSN 2211-3436 ; 1875-8606 ; 2211-3428
    ISSN (online) 2211-3436
    ISSN 1875-8606 ; 2211-3428
    DOI 10.1007/s13402-019-00474-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6908: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Robust algorithm for precise X

    Zhang, Hongyuan / Han, Ge / Ma, Xin / Chen, Weibiao / Zhang, Xingying / Liu, Jiqiao / Gong, Wei

    Optics express

    2023  Volume 31, Issue 7, Page(s) 11846–11863

    Abstract: ... ...

    Abstract CO
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.482629
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Co-targeting BCL-X

    Khan, Sajid / Kellish, Patrick / Connis, Nick / Thummuri, Dinesh / Wiegand, Janet / Zhang, Peiyi / Zhang, Xuan / Budamagunta, Vivekananda / Hua, Nan / Yang, Yang / De, Umasankar / Jin, Lingtao / Zhang, Weizhou / Zheng, Guangrong / Hromas, Robert / Hann, Christine / Zajac-Kaye, Maria / Kaye, Frederic J / Zhou, Daohong

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 1

    Abstract: ... proteins, including BCL-X ...

    Abstract Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, including BCL-X
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01296-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book ; Online: X-Mesh

    Ma, Yiwei / Zhang, Xiaioqing / Sun, Xiaoshuai / Ji, Jiayi / Wang, Haowei / Jiang, Guannan / Zhuang, Weilin / Ji, Rongrong

    Towards Fast and Accurate Text-driven 3D Stylization via Dynamic Textual Guidance

    2023  

    Abstract: ... to unsatisfactory stylization and slow convergence. To address these limitations, we present X-Mesh, an innovative ... objective comparisons. Our extensive qualitative and quantitative experiments demonstrate that X-Mesh ...

    Abstract Text-driven 3D stylization is a complex and crucial task in the fields of computer vision (CV) and computer graphics (CG), aimed at transforming a bare mesh to fit a target text. Prior methods adopt text-independent multilayer perceptrons (MLPs) to predict the attributes of the target mesh with the supervision of CLIP loss. However, such text-independent architecture lacks textual guidance during predicting attributes, thus leading to unsatisfactory stylization and slow convergence. To address these limitations, we present X-Mesh, an innovative text-driven 3D stylization framework that incorporates a novel Text-guided Dynamic Attention Module (TDAM). The TDAM dynamically integrates the guidance of the target text by utilizing text-relevant spatial and channel-wise attentions during vertex feature extraction, resulting in more accurate attribute prediction and faster convergence speed. Furthermore, existing works lack standard benchmarks and automated metrics for evaluation, often relying on subjective and non-reproducible user studies to assess the quality of stylized 3D assets. To overcome this limitation, we introduce a new standard text-mesh benchmark, namely MIT-30, and two automated metrics, which will enable future research to achieve fair and objective comparisons. Our extensive qualitative and quantitative experiments demonstrate that X-Mesh outperforms previous state-of-the-art methods.

    Comment: Technical report
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 410
    Publishing date 2023-03-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book ; Online: X-Transfer

    Zhang, Lei / Chen, Hao / Hu, Shu / Zhu, Bin / Lin, Ching Sheng / Wu, Xi / Hu, Jinrong / Wang, Xin

    A Transfer Learning-Based Framework for GAN-Generated Fake Image Detection

    2023  

    Abstract: ... algorithm called X-Transfer, which enhances transfer learning by utilizing two neural networks that employ ...

    Abstract Generative adversarial networks (GANs) have remarkably advanced in diverse domains, especially image generation and editing. However, the misuse of GANs for generating deceptive images, such as face replacement, raises significant security concerns, which have gained widespread attention. Therefore, it is urgent to develop effective detection methods to distinguish between real and fake images. Current research centers around the application of transfer learning. Nevertheless, it encounters challenges such as knowledge forgetting from the original dataset and inadequate performance when dealing with imbalanced data during training. To alleviate this issue, this paper introduces a novel GAN-generated image detection algorithm called X-Transfer, which enhances transfer learning by utilizing two neural networks that employ interleaved parallel gradient transmission. In addition, we combine AUC loss and cross-entropy loss to improve the model's performance. We carry out comprehensive experiments on multiple facial image datasets. The results show that our model outperforms the general transferring approach, and the best metric achieves 99.04%, which is increased by approximately 10%. Furthermore, we demonstrate excellent performance on non-face datasets, validating its generality and broader application prospects.

    Comment: 9 pages, 3 figures, and 6 tables; references added
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2023-10-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book ; Online: SkillNet-X

    Feng, Zhangyin / Dai, Yong / Zhang, Fan / Tang, Duyu / Feng, Xiaocheng / Wu, Shuangzhi / Qin, Bing / Cao, Yunbo / Shi, Shuming

    A Multilingual Multitask Model with Sparsely Activated Skills

    2023  

    Abstract: ... multilingual multitask model, named SkillNet-X, which enables a single model to tackle many different tasks ... each of which corresponds to a skill module. SkillNet-X sparsely activates parts of the skill modules which are relevant ... We evaluate SkillNet-X on eleven natural language understanding datasets in four languages. Results show ...

    Abstract Traditional multitask learning methods basically can only exploit common knowledge in task- or language-wise, which lose either cross-language or cross-task knowledge. This paper proposes a general multilingual multitask model, named SkillNet-X, which enables a single model to tackle many different tasks from different languages. To this end, we define several language-specific skills and task-specific skills, each of which corresponds to a skill module. SkillNet-X sparsely activates parts of the skill modules which are relevant either to the target task or the target language. Acting as knowledge transit hubs, skill modules are capable of absorbing task-related knowledge and language-related knowledge consecutively. Based on Transformer, we modify the multi-head attention layer and the feed forward network layer to accommodate skill modules. We evaluate SkillNet-X on eleven natural language understanding datasets in four languages. Results show that SkillNet-X performs better than task-specific baselines and two multitask learning baselines (i.e., dense joint model and Mixture-of-Experts model). Furthermore, skill pre-training further improves the performance of SkillNet-X on almost all datasets. To investigate the generalization of our model, we conduct experiments on two new tasks and find that SkillNet-X significantly outperforms baselines.
    Keywords Computer Science - Computation and Language
    Subject code 004
    Publishing date 2023-06-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: [A case of X-linked Alport syndrome with esophageal leiomyomatosis].

    Tang, Z L / Yao, J / Zhang, P / He, X / Jia, L L / Shi, K L / Xia, Z K / Gao, C L

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2024  Volume 62, Issue 3, Page(s) 275–277

    MeSH term(s) Humans ; Leiomyomatosis/genetics ; Nephritis, Hereditary/complications ; Nephritis, Hereditary/genetics
    Language Chinese
    Publishing date 2024-02-20
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20231014-00287
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Enhancing X-Ray Sensitization with Multifunctional Nanoparticles.

    Liu, Jiayi / Wu, JunYong / Chen, Taili / Yang, Bin / Liu, XiangPing / Xi, Jing / Zhang, Ziyang / Gao, Yawen / Li, ZhiHong

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2400954

    Abstract: In the progression of X-ray-based radiotherapy for the treatment of cancer, the incorporation ...

    Abstract In the progression of X-ray-based radiotherapy for the treatment of cancer, the incorporation of nanoparticles (NPs) has a transformative impact. This study investigates the potential of NPs, particularly those comprised of high atomic number elements, as radiosensitizers. This aims to optimize localized radiation doses within tumors, thereby maximizing therapeutic efficacy while preserving surrounding tissues. The multifaceted applications of NPs in radiotherapy encompass collaborative interactions with chemotherapeutic, immunotherapeutic, and targeted pharmaceuticals, along with contributions to photodynamic/photothermal therapy, imaging enhancement, and the integration of artificial intelligence technology. Despite promising preclinical outcomes, the paper acknowledges challenges in the clinical translation of these findings. The conclusion maintains an optimistic stance, emphasizing ongoing trials and technological advancements that bolster personalized treatment approaches. The paper advocates for continuous research and clinical validation, envisioning the integration of NPs as a revolutionary paradigm in cancer therapy, ultimately enhancing patient outcomes.
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202400954
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online: Advanced X-by-Wire Technologies in Design, Control and Measurement for Vehicular Electrified Chassis

    Li, Yong / Xu, Xing / Zhang, Lin / Qin, Yechen / Lu, Yang

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; energy consumption optimization ; torque distribution ; energy efficiency ; motor efficiency ; four in-wheel motor drive electric vehicle ; nonlinear model predictive control ; four-wheel drive ; acceleration slip regulation ; intervention and exit mechanisms ; autonomous driving ; planning algorithm ; variable Gaussian safety field ; reinforcement learning ; policy gradient ; x-by-wire vehicle ; trajectory tracking control ; model predictive control ; hierarchical control ; distributed drive electric vehicles ; additional roll moment ; decoupling control ; load transfer rate ; electronically controlled air suspension ; solenoid valve ; extended Kalman filter bank ; fault diagnosis ; fault-tolerant control ; distributed driving electric vehicles ; polynomial path planning ; torque allocation ; obstacle avoidance path tracking ; fuzzy neural network ; particle swarm algorithm ; PID control ; active suspension ; MATLAB/Simulink simulation ; suspension ; mechatronic inerter ; bridge network ; high-order impedance ; real vehicle test ; autonomous vehicle ; path tracking control ; non-singular fast terminal sliding mode control ; model reference control ; vehicle ; fractional-order electrical network ; structure-immittance approach ; optimal design ; multi-agent coordinated control system ; active collision avoidance ; blackboard model ; real-time ; electric vehicles ; regenerative braking ; energy recovery ; genetic algorithm ; braking stability ; seat suspension ; inerter ; mechatronic system ; permanent magnet synchronous machine (PMSM) ; position sensorless compound control ; high frequency (HF) signal injection method ; I/F control ; model-based techniques ; n/a
    Language English
    Size 1 electronic resource (268 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030381937
    ISBN 9783036580579 ; 3036580573
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top