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  1. Article ; Online: The Importance of Nanocarriers' Intra- and Extracellular Degradation: What we Know and Should Know About it?

    Parodi, Alessandro / Voronina, Maya V / Zamyatnin, Andrey A

    Current medicinal chemistry

    2023  Volume 31, Issue 2, Page(s) 128–132

    Language English
    Publishing date 2023-03-17
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230315144546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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  2. Article ; Online: Therapeutic and diagnostic applications of carbon nanotubes in cancer: recent advances and challenges.

    Sharma, Muskan / Alessandro, Parodi / Cheriyamundath, Sanith / Lopus, Manu

    Journal of drug targeting

    2024  Volume 32, Issue 3, Page(s) 287–299

    Abstract: Carbon nanotubes (CNTs) are allotropes of carbon, composed of carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure facilitate their drug-carrying capacity. Therefore, CNTs ... ...

    Abstract Carbon nanotubes (CNTs) are allotropes of carbon, composed of carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure facilitate their drug-carrying capacity. Therefore, CNTs have been intensively explored for several biomedical applications, including as a potential treatment option for cancer. By incorporating smart fabrication strategies, CNTs can be designed to specifically target cancer cells. This targeted drug delivery approach not only maximizes the therapeutic utility of CNTs but also minimizes any potential side effects of free drug molecules. CNTs can also be utilised for photothermal therapy (PTT) which uses photosensitizers to generate reactive oxygen species (ROS) to kill cancer cells, and in immunotherapeutic applications. Regarding the latter, for example, CNT-based formulations can preferentially target intra-tumoural regulatory T-cells. CNTs also act as efficient antigen presenters. With their capabilities for photoacoustic, fluorescent and Raman imaging, CNTs are excellent diagnostic tools as well. Further, metallic nanoparticles, such as gold or silver nanoparticles, are combined with CNTs to create nanobiosensors to measure biological reactions. This review focuses on current knowledge about the theranostic potential of CNT, challenges associated with their large-scale production, their possible side effects and important parameters to consider when exploring their clinical usage.
    MeSH term(s) Humans ; Nanotubes, Carbon/chemistry ; Metal Nanoparticles/chemistry ; Silver ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Drug Delivery Systems
    Chemical Substances Nanotubes, Carbon ; Silver (3M4G523W1G)
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2024.2309575
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    Zs.A 4481: Show issues Location:
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  3. Article: New Advances in the Understanding of Proteases as Diagnostic and Pharmaceutical Targets in Homeostatic and Pathologic Conditions.

    Zamyatnin, Andrey A / Parodi, Alessandro

    Pharmaceutics

    2022  Volume 14, Issue 7

    Abstract: Protease biology represents a hot topic in biomedical research because of their pivotal role in regulating cell and tissue homeostasis, regeneration and pathogenesis [ ... ]. ...

    Abstract Protease biology represents a hot topic in biomedical research because of their pivotal role in regulating cell and tissue homeostasis, regeneration and pathogenesis [...].
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071516
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  4. Article ; Online: Linear streaks associated with retinitis pigmentosa.

    Battaglia Parodi, Maurizio / Arrigo, Alessandro / Aragona, Emanuela / Pina, Adelaide / Bandello, Francesco

    European journal of ophthalmology

    2024  , Page(s) 11206721241232450

    Abstract: Purpose: To describe a phenotypical manifestation characterized by the identification of peripheral linear streaks associated with retinitis pigmentosa (RP).: Methods: Study design is a prospective observational case series. All consecutive patients ... ...

    Abstract Purpose: To describe a phenotypical manifestation characterized by the identification of peripheral linear streaks associated with retinitis pigmentosa (RP).
    Methods: Study design is a prospective observational case series. All consecutive patients affected by RP underwent a complete ophthalmological examination. The diagnosis of peripheral linear streaks was based on the identification of curvilinear atrophic streaks in the periphery of the retina.
    Results: Overall, six out of 140 patients (4.2%) were affected by peripheral linear streaks associated with RP. A single patient showed also punched out chorioretinal lesions at the posterior pole, with macular neovascularization development over the follow-up, treated with ranibizumab injections.
    Conclusions: RP phenotypical manifestation characterized by peripheral linear streaks is infrequent and may provide additional evidence to support the contribution of inflammation in the pathogenesis of RP.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721241232450
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  5. Article ; Online: Ventriculitis and meningitis: by methicillin-resistant

    Sette, Claudia / Parodi, Alessandro / Barco, Sebastiano / Castagnola, Elio

    Journal of chemotherapy (Florence, Italy)

    2022  Volume 34, Issue 6, Page(s) 414–415

    Abstract: A case of HCAMV due to methicillin- ... ...

    Abstract A case of HCAMV due to methicillin-resistant
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cerebral Ventriculitis/drug therapy ; Humans ; Linezolid ; Meningitis ; Methicillin Resistance ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Staphylococcus epidermidis ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Linezolid (ISQ9I6J12J)
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2022.2066782
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    Zs.MO 387: Show issues

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  6. Article ; Online: Smartphone Eye Examination: Artificial Intelligence and Telemedicine.

    Vilela, Manuel Augusto Pereira / Arrigo, Alessandro / Parodi, Maurizio Battaglia / da Silva Mengue, Carolina

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2023  Volume 30, Issue 2, Page(s) 341–353

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Artificial Intelligence ; Smartphone ; Reproducibility of Results ; Diabetic Retinopathy/diagnosis ; Telemedicine/methods ; Blindness
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2023.0041
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    Zs.A 4576: Show issues Location:
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  7. Article ; Online: Multimodal imaging in Best Vitelliform Macular Dystrophy: Literature review and novel insights.

    Bianco, Lorenzo / Arrigo, Alessandro / Antropoli, Alessio / Berni, Alessandro / Saladino, Andrea / Vilela, Manuel Ap / Mansour, Ahmad M / Bandello, Francesco / Battaglia Parodi, Maurizio

    European journal of ophthalmology

    2023  Volume 34, Issue 1, Page(s) 39–51

    Abstract: Best Vitelliform Macular Dystrophy (BVMD) is a dominantly inherited retinal disease caused by dominant variants in ... ...

    Abstract Best Vitelliform Macular Dystrophy (BVMD) is a dominantly inherited retinal disease caused by dominant variants in the
    MeSH term(s) Humans ; Vitelliform Macular Dystrophy/diagnostic imaging ; Vitelliform Macular Dystrophy/genetics ; Retina/pathology ; Retinal Pigment Epithelium/pathology ; Macula Lutea/pathology ; Tomography, Optical Coherence/methods ; Fluorescein Angiography/methods ; Multimodal Imaging ; Bestrophins/genetics
    Chemical Substances Bestrophins ; BEST1 protein, human
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721231166434
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    Zs.A 3342: Show issues Location:
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  8. Article ; Online: Free flap monitoring of tissue oxygen saturation: A new device in oral reconstruction.

    Zingaretti, Nicola / Di Filippo, Jacopo / Robiony, Massimo / Tel, Alessandro / De Francesco, Francesco / Riccio, Michele / Parodi, Pier Camillo

    Oral oncology

    2024  Volume 149, Page(s) 106693

    MeSH term(s) Humans ; Free Tissue Flaps ; Oxygen Saturation ; Spectroscopy, Near-Infrared
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106693
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    Zs.A 456: Show issues Location:
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  9. Article ; Online: Letter to the Editor: Could ChatGPT Improve Knowledge in Surgery?

    Tel, Alessandro / Parodi, Pier Camillo / Robiony, Massimo / Zanotti, Bruno / Zingaretti, Nicola

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 3942–3943

    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Letter
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13518-z
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  10. Article ; Online: Inner retinal thickness in Stargardt disease.

    Battaglia Parodi, Maurizio / Arrigo, Alessandro / Bianco, Lorenzo / Antropoli, Alessio / Saladino, Andrea / Pili, Lorenzo / Pina, Adelaide / Battista, Marco / Bandello, Francesco

    European journal of ophthalmology

    2024  , Page(s) 11206721241229473

    Abstract: Purpose: To analyze the alterations at the level of the inner retina in patients affected by Stargardt disease (STGD1).: Methods: Cross-sectional investigation involving STGD1 patients with genetically confirmed diagnosis, who underwent optical ... ...

    Abstract Purpose: To analyze the alterations at the level of the inner retina in patients affected by Stargardt disease (STGD1).
    Methods: Cross-sectional investigation involving STGD1 patients with genetically confirmed diagnosis, who underwent optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), and microperimetry.
    Results: Overall, 31 patients (62 eyes) with genetically confirmed STGD1 were included in the study. Mean inner retinal thickness, vessel density of plexa, and retinal sensitivity resulted significantly reduced in STGD patients, compared with healthy controls (
    Conclusions: Inner retina is irregularly altered in STGD1, showing variable quantitative alterations as detected on OCT. Inner retinal status might represent a useful biomarker to better characterize STGD1 and to ascertain the effects of new treatment approaches.
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721241229473
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