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  1. Article ; Online: Resolved: EMT Produces Fibroblasts in the Kidney.

    Duffield, Jeremy S

    Journal of the American Society of Nephrology : JASN

    2023  Volume 21, Issue 8, Page(s) 1247–1253

    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/01.asn.0000926920.55714.a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The glomerular filtration barrier: a structural target for novel kidney therapies.

    Daehn, Ilse S / Duffield, Jeremy S

    Nature reviews. Drug discovery

    2021  Volume 20, Issue 10, Page(s) 770–788

    Abstract: Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently treated with immunosuppressive agents, antihypertensives and diuretics with partial but limited success. Most ...

    Abstract Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently treated with immunosuppressive agents, antihypertensives and diuretics with partial but limited success. Most kidney disease is characterized by breakdown of the glomerular filtration barrier (GFB). Specialized podocyte cells maintain the GFB, and structure-function experiments and studies of intercellular communication between the podocytes and other GFB cells, combined with advances from genetics and genomics, have laid the groundwork for a new generation of therapies that directly intervene at the GFB. These include inhibitors of apolipoprotein L1 (APOL1), short transient receptor potential channels (TRPCs), soluble fms-like tyrosine kinase 1 (sFLT1; also known as soluble vascular endothelial growth factor receptor 1), roundabout homologue 2 (ROBO2), endothelin receptor A, soluble urokinase plasminogen activator surface receptor (suPAR) and substrate intermediates for coenzyme Q10 (CoQ
    MeSH term(s) Animals ; Glomerular Filtration Barrier/drug effects ; Glomerular Filtration Barrier/physiology ; Glomerular Filtration Barrier/physiopathology ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-021-00242-0
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  3. Article ; Online: Beyond EMT: Epithelial STAT3 as a Central Regulator of Fibrogenesis.

    Duffield, Jeremy S

    Journal of the American Society of Nephrology : JASN

    2016  Volume 27, Issue 12, Page(s) 3502–3504

    MeSH term(s) Epithelial Cells ; Epithelial-Mesenchymal Transition ; Fibrosis ; STAT3 Transcription Factor
    Chemical Substances STAT3 Transcription Factor
    Language English
    Publishing date 2016-07-01
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2016060603
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  4. Article ; Online: Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.

    Lemos, Dario R / Duffield, Jeremy S

    Science translational medicine

    2018  Volume 10, Issue 426

    Abstract: Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique ... ...

    Abstract Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.
    MeSH term(s) Animals ; Fibrosis/therapy ; Humans ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/physiology
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aan5174
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  5. Article ; Online: Cellular and molecular mechanisms in kidney fibrosis.

    Duffield, Jeremy S

    The Journal of clinical investigation

    2014  Volume 124, Issue 6, Page(s) 2299–2306

    Abstract: Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of pathological matrix in the interstitial space and within the walls of glomerular capillaries as well as the cellular processes resulting in this deposition are ... ...

    Abstract Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of pathological matrix in the interstitial space and within the walls of glomerular capillaries as well as the cellular processes resulting in this deposition are increasingly recognized as important factors amplifying kidney injury and accelerating nephron demise. Recent insights into the cellular and molecular mechanisms of fibrogenesis herald the promise of new therapies to slow kidney disease progression. This review focuses on new findings that enhance understanding of cellular and molecular mechanisms of fibrosis, the characteristics of myofibroblasts, their progenitors, and molecular pathways regulating both fibrogenesis and its resolution.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Epigenesis, Genetic ; Fibrosis ; Forkhead Transcription Factors/metabolism ; Humans ; Kidney/metabolism ; Kidney/pathology ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Pericytes/metabolism ; Pericytes/pathology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology
    Chemical Substances FOXD1 protein, human ; Forkhead Transcription Factors
    Language English
    Publishing date 2014-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI72267
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  6. Article ; Online: The elusive source of myofibroblasts: problem solved?

    Duffield, Jeremy S

    Nature medicine

    2012  Volume 18, Issue 8, Page(s) 1178–1180

    MeSH term(s) Animals ; Fibrosis ; Mice ; Muscle, Skeletal/pathology ; Muscular Diseases/pathology ; Myofibroblasts/cytology ; Pericytes/cytology ; Skin Diseases/pathology
    Language English
    Publishing date 2012-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.2867
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  7. Article ; Online: What can target kidney fibrosis?

    Leaf, Irina A / Duffield, Jeremy S

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2017  Volume 32, Issue suppl_1, Page(s) i89–i97

    Abstract: Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an independent predictor of disease progression. Deposition of pathological matrix in the walls of glomerular capillaries, the interstitial space and around arterioles ... ...

    Abstract Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an independent predictor of disease progression. Deposition of pathological matrix in the walls of glomerular capillaries, the interstitial space and around arterioles both predicts and contributes to functional demise of the nephron and its surrounding vasculature. Recent identification of the major cell populations of fibroblast precursors in the kidney interstitium as pericytes and tissue-resident mesenchymal stem cells, and in the glomerulus as podocytes, parietal epithelial and mesangial cells, has enabled the study of the fibrogenic process in much greater depth directly in the fibroblast precursors. These cells are not only matrix-producing cells, but are also important innate immune surveillance cells that regulate the inflammatory process, exacerbate tissue damage by release of radicals and cytokines, and contribute to parenchymal and microvascular dysfunction by aberrant wound-healing responses. Innate immune signaling in fibroblasts and their precursors is intimately intertwined with the process of fibrogenesis. In addition, genomic and genetic studies also point to defective responses in loci close to genes involved in solute transport, metabolism, autophagy, protein handling and vascular homeostasis, principally in the epithelium and endothelium, as upstream drivers of the fibrotic process, indicating that cellular crosstalk is vital for development of fibrosis. As we move beyond TGFβ inhibition as a central target for fibrosis, targeting innate immune signaling and metabolic dysfunction appear increasingly tenable alternative targets for novel therapies.
    MeSH term(s) Animals ; Fibrosis/pathology ; Fibrosis/prevention & control ; Humans ; Kidney/pathology
    Language English
    Publishing date 2017-01-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfw388
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  8. Article ; Online: Dendritic cells take on more tasks in the liver?

    Duffield, Jeremy S

    Hepatology (Baltimore, Md.)

    2011  Volume 55, Issue 1, Page(s) 16–19

    MeSH term(s) Animals ; Dendritic Cells/immunology ; Hepatitis/immunology ; Humans ; Liver/cytology ; Liver/immunology ; Phagocytosis/immunology
    Language English
    Publishing date 2011-11-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.25498
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  9. Article ; Online: Macrophages in kidney repair and regeneration.

    Duffield, Jeremy S

    Journal of the American Society of Nephrology : JASN

    2011  Volume 22, Issue 2, Page(s) 199–201

    MeSH term(s) Cell Proliferation ; Humans ; Kidney/blood supply ; Kidney/physiology ; Macrophages/physiology ; Phenotype ; Regeneration ; Reperfusion Injury/physiopathology
    Language English
    Publishing date 2011-02-02
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2010121301
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  10. Article ; Online: Epithelial to mesenchymal transition in injury of solid organs: fact or artifact?

    Duffield, Jeremy S

    Gastroenterology

    2010  Volume 139, Issue 4, Page(s) 1081–3, 1083.e1–5

    MeSH term(s) Cell Differentiation ; Epithelial Cells/pathology ; Fibroblasts/pathology ; Fibrosis ; Humans ; Kidney/pathology ; Liver/pathology ; Mesoderm/pathology ; Pancreas/pathology
    Language English
    Publishing date 2010-10
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2010.08.017
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