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  1. Article ; Online: Hypermetabolic Broad Ligament Leiomyoma in Postmenopausal Women Mimicking Ovarian Tumors on 18 F-FDG PET/CT.

    Liu, Meixi / Wang, Peipei / Huo, Li / Cheng, Wuying

    Clinical nuclear medicine

    2023  Volume 48, Issue 4, Page(s) 376–377

    Abstract: Abstract: Extrauterine leiomyomas are rare and often occur in broad ligament or fallopian tube. Diagnosis of broad ligament leiomyoma is challenging for its solid nature and special location. Leiomyomas typically exhibit mild FDG uptake, especially in ... ...

    Abstract Abstract: Extrauterine leiomyomas are rare and often occur in broad ligament or fallopian tube. Diagnosis of broad ligament leiomyoma is challenging for its solid nature and special location. Leiomyomas typically exhibit mild FDG uptake, especially in postmenopausal woman. We here reported a 57-year-old postmenopausal woman with intense FDG-avid broad ligament leiomyoma on 18 F-FDG PET/CT, which might be misdiagnosed as ovarian tumor.
    MeSH term(s) Female ; Humans ; Middle Aged ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Uterine Neoplasms/pathology ; Broad Ligament/pathology ; Postmenopause ; Leiomyoma/pathology ; Ovarian Neoplasms
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment.

    Wu, Bo / Shi, Xiang / Jiang, Meixi / Liu, Hongxu

    Molecular cancer

    2023  Volume 22, Issue 1, Page(s) 38

    Abstract: Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor progression, recurrence and chemoresistance due to their typical ... ...

    Abstract Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor progression, recurrence and chemoresistance due to their typical stemness characteristics. CSCs are preferentially distributed in niches, and those niche sites exhibit characteristics typical of the tumor microenvironment (TME). The complex interactions between CSCs and TME illustrate these synergistic effects. The phenotypic heterogeneity within CSCs and the spatial interactions with the surrounding tumor microenvironment led to increased therapeutic challenges. CSCs interact with immune cells to protect themselves against immune clearance by exploiting the immunosuppressive function of multiple immune checkpoint molecules. CSCs also can protect themselves against immune surveillance by excreting extracellular vesicles (EVs), growth factors, metabolites and cytokines into the TME, thereby modulating the composition of the TME. Therefore, these interactions are also being considered for the therapeutic development of anti-tumor agents. We discuss here the immune molecular mechanisms of CSCs and comprehensively review the interplay between CSCs and the immune system. Thus, studies on this topic seem to provide novel ideas for reinvigorating therapeutic approaches to cancer.
    MeSH term(s) Humans ; Tumor Microenvironment ; Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Cytokines/metabolism ; Neoplastic Stem Cells/metabolism
    Chemical Substances Antineoplastic Agents ; Cytokines
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091373-4
    ISSN 1476-4598 ; 1476-4598
    ISSN (online) 1476-4598
    ISSN 1476-4598
    DOI 10.1186/s12943-023-01748-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased Uptake of Brown Tumor in 99m Tc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia.

    Zhang, Yuwei / Wang, Peipei / Liu, Meixi / Liu, Yu / Jing, Hongli

    Clinical nuclear medicine

    2023  Volume 48, Issue 11, Page(s) 978–979

    Abstract: Abstract: A 61-year-old man underwent a resection of tumor in the left tibia that caused osteomalacia 11 years ago. Postoperative bone pain and fatigue symptoms were briefly relieved but then recurred. To identify potential recurrent tumors, 99m Tc- ... ...

    Abstract Abstract: A 61-year-old man underwent a resection of tumor in the left tibia that caused osteomalacia 11 years ago. Postoperative bone pain and fatigue symptoms were briefly relieved but then recurred. To identify potential recurrent tumors, 99m Tc-HYNIC-TOC scintigraphy was performed. Images revealed an osteolytic lesion in the right tibia with increased uptake. The lesion was subsequently resected, which pathologically proved a brown tumor. Symptoms of bone pain and weakness caused by osteomalacia did not relieve 4 months after the operation. Here, we present a rare case of brown tumor with high activity on 99m Tc-HYNIC-TOC SPECT/CT, mimicking a culprit tumor of osteomalacia.
    MeSH term(s) Male ; Humans ; Middle Aged ; Osteomalacia/diagnostic imaging ; Osteomalacia/etiology ; Octreotide ; Organotechnetium Compounds ; Neoplasms/diagnostic imaging ; Radionuclide Imaging ; Pain/complications
    Chemical Substances Octreotide (RWM8CCW8GP) ; Organotechnetium Compounds
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  4. Article ; Online: Mesenteric Castleman Disease Misdiagnosed as Lymph Node Metastasis of Rectal Cancer on 18 F-FDG PET/CT.

    Liu, Meixi / Zhou, Jiaolin / Zhu, Wenjia / Huo, Li / Cheng, Wuying

    Clinical nuclear medicine

    2023  Volume 48, Issue 11, Page(s) 985–986

    Abstract: Abstract: Two years ago, a 64-year-old man underwent an 18 F-FDG PET/CT for staging rectal cancer. Besides the hypermetabolic rectal lesion, the image revealed a mesenteric lymph node with intense activity and multiple lung nodules with slight FDG ... ...

    Abstract Abstract: Two years ago, a 64-year-old man underwent an 18 F-FDG PET/CT for staging rectal cancer. Besides the hypermetabolic rectal lesion, the image revealed a mesenteric lymph node with intense activity and multiple lung nodules with slight FDG uptake, which were highly suspected of metastases. After surgery and multiple cycles of chemotherapy, the follow-up 18 F-FDG PET/CT showed remission of all lesions except for the enlarged mesenteric lymph node with higher metabolic activity. Serum CEA remained normal during the follow-up. Postoperative pathology of the mesenteric lymph node confirmed Castleman disease.
    MeSH term(s) Male ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Radiopharmaceuticals ; Castleman Disease/diagnostic imaging ; Castleman Disease/pathology ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/pathology ; Diagnostic Errors
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Letter to the Editor: Comment on "HepatoScore-14: Measures of Biological Heterogeneity Significantly Improve Prediction of Hepatocellular Carcinoma Risk".

    Sun, Lejia / Guan, Ai / Liu, Meixi / Mao, Yilei

    Hepatology (Baltimore, Md.)

    2021  Volume 73, Issue 6, Page(s) 2613–2614

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms
    Language English
    Publishing date 2021-05-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  6. Article ; Online: Letter to the editor: prediction of survival in colorectal cancer using artificial intelligence.

    Guan, Ai / Sun, Lejia / Liu, Meixi / Mao, Yilei

    Gut

    2020  Volume 70, Issue 9, Page(s) 1804–1805

    MeSH term(s) Artificial Intelligence ; Colorectal Neoplasms/diagnosis ; Humans
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2020-323382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  7. Article ; Online: Gallium-68 labeled somatostatin receptor antagonist PET/CT in over 500 patients with neuroendocrine neoplasms: experience from a single center in China.

    Liu, Meixi / Cheng, Yuejuan / Bai, Chunmei / Zhao, Hong / Jia, Ru / Chen, Jingci / Zhu, Wenjia / Huo, Li

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Purpose: Somatostatin receptor antagonists have shown promising performance for imaging neuroendocrine neoplasms. However, there is a lack of studies exploring the diagnostic performance of SSTR antagonists or comparing them with agonists in a large ... ...

    Abstract Purpose: Somatostatin receptor antagonists have shown promising performance for imaging neuroendocrine neoplasms. However, there is a lack of studies exploring the diagnostic performance of SSTR antagonists or comparing them with agonists in a large cohort of patients with NENs. This study aimed to retrospectively review all SSTR antagonist PET/CT scans conducted at Peking Union Medical College Hospital since November 2018 in patients with confirmed or suspected NENs.
    Methods: Four types of SSTR antagonists were utilized, including [
    Results: A total of 622 antagonist scans from 549 patients were included in the analysis. The patient-level sensitivity, specificity, and accuracy of antagonist imaging (all tracers combined) were 91.0% (443/487), 91.9% (57/62), and 91.1% (500/549), respectively. In 181 patients with a comparative [
    Conclusion: Gallium-68 labeled SSTR antagonists could serve as alternatives to SSTR agonists for imaging of NENs. Among various antagonists, [
    Language English
    Publishing date 2024-02-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06639-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1227: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Retraction Note: Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis.

    Peng, Meixi / Yang, Dan / Hou, Yixuan / Liu, Shuiqing / Zhao, Maojia / Qin, Yilu / Chen, Rui / Teng, Yong / Liu, Manran

    Cell death & disease

    2023  Volume 14, Issue 9, Page(s) 640

    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06174-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The status of nuclear medicine in China: the first official national survey.

    Zhang, Haiqiong / Zheng, Jin / Hu, Nan / Liu, Yu / Yang, Guangjie / Liu, Meixi / Jing, Hongli / Huo, Li

    European journal of nuclear medicine and molecular imaging

    2024  

    Abstract: Aim/introduction: The National Nuclear Medicine Quality Control Center of China conducted the first official survey to investigate the nationwide situation of nuclear medicine in 2020. The survey aimed to unveil the current nuclear medicine situation ... ...

    Abstract Aim/introduction: The National Nuclear Medicine Quality Control Center of China conducted the first official survey to investigate the nationwide situation of nuclear medicine in 2020. The survey aimed to unveil the current nuclear medicine situation and its quality control in China.
    Materials and methods: The web-based survey was conducted and the data was collected via the National Clinical Improvement System (NCIS) of China from 1st April to 31st May 2021.
    Results: A total of 808 institutes across 30 provinces responded to the national survey. For human resources, there are 4460 physicians, 3077 technologists, 339 physicists, and 309 radiochemists. There are 887 single-photon imaging instruments, including 823 SPECT or SPECT/CT, and 365 PET instruments including 314 PET/CT. Six hundred twenty-four institutes perform SPECT examinations and 319 institutes perform PET examinations. 60% of SPECT scans are bone scintigraphy. A total of 97% of PET scans use an [
    Conclusion: These results of the first official survey towards current status of nuclear medicine in China are the foundation for the establishment of the quality control management system.
    Language English
    Publishing date 2024-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06687-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis.

    Huang, Yongxiu / Peng, Meixi / Qin, Huanhuan / Li, Yan / Pei, Li / Liu, Xindong / Zhao, Xueya

    Cellular signalling

    2023  Volume 106, Page(s) 110623

    Abstract: Acute myeloid leukemia (AML) is a heterogeneous disorder with high morbidity and mortality under the existing treatment strategy. Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high ... ...

    Abstract Acute myeloid leukemia (AML) is a heterogeneous disorder with high morbidity and mortality under the existing treatment strategy. Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high LAPTM4B was associated with poor outcome. Moreover, LAPTM4B promoted leukemia progression in vitro and in vivo. Mechanically, LAPTM4B interacted with RPS9, and positively regulated RPS9 protein stability, which enhanced leukemia cell progression via activating STAT3. Our findings indicate for the first time that LAPTM4B contributes to leukemia progression in a RPS9/STAT3-dependent manner, suggesting that LAPTM4B may serve as a promising target for treatment of AML.
    MeSH term(s) Humans ; Oncogene Proteins/metabolism ; Leukemia, Myeloid, Acute ; Membrane Proteins/metabolism ; STAT3 Transcription Factor/metabolism
    Chemical Substances Oncogene Proteins ; LAPTM4B protein, human ; Membrane Proteins ; STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2023.110623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2579: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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