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  1. Book ; Online ; Thesis: Fetuin-A-based theranostics in ectopic calcification

    Dzhanaev, Robert [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Mottaghy, Felix [Akademischer Betreuer]

    2023  

    Author's details Robert Dzhanaev ; Wilhelm Jahnen-Dechent, Felix Mottaghy
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Book ; Online ; Thesis: Reduzierte Sialylierung von Fetuin-A sowie Konzentrationen von Fetuin-A in Serum und Liquor cerebrospinalis sind assoziiert mit neuroinflammatorischen Erkrankungen im Kindes- und Jugendalter

    Ricken, Frederik [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Häusler, Martin Georg [Akademischer Betreuer]

    2023  

    Author's details Frederik Ricken ; Wilhelm Jahnen-Dechent, Martin Georg Häusler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Thesis: Zur Struktur, Lokalisation und biologischen Funktion von Alpha 2 -HS-Glycoprotein und den verwandten Fetuinen

    Jahnen-Dechent, Wilhelm

    1997  

    Author's details vorgelegt von Willi Jahnen-Dechent
    Language German
    Size V, 98 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Habil.-Schr., 1997
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT011144826
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 MB 1411 order for loan Magazin

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  4. Book ; Online ; Thesis: Fetuin-A protein distribution in mature inflamed and ischemic brain tissue

    Heinen, Miriam Christina [Verfasser] / Häusler, Martin Georg Akademischer Betreuer] / [Jahnen-Dechent, Wilhelm [Akademischer Betreuer]

    2023  

    Author's details Miriam Christina Heinen ; Martin Georg Häusler, Wilhelm Jahnen-Dechent
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  5. Article ; Online: Fibrin-Based Hydrogels with Reactive Amphiphilic Copolymers for Mechanical Adjustments Allow for Capillary Formation in 2D and 3D Environments.

    Wein, Svenja / Schemmer, Carina / Al Enezy-Ulbrich, Miriam Aischa / Jung, Shannon Anna / Rütten, Stephan / Kühnel, Mark / Jonigk, Danny / Jahnen-Dechent, Wilhelm / Pich, Andrij / Neuss, Sabine

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 3

    Abstract: This study focuses on enhancing controllable fibrin-based hydrogels for tissue engineering, addressing existing weaknesses. By integrating a novel copolymer, we improved the foundation for cell-based angiogenesis with adaptable structural features. ... ...

    Abstract This study focuses on enhancing controllable fibrin-based hydrogels for tissue engineering, addressing existing weaknesses. By integrating a novel copolymer, we improved the foundation for cell-based angiogenesis with adaptable structural features. Tissue engineering often faces challenges like waste disposal and nutrient supply beyond the 200 µm diffusion limit. Angiogenesis breaks through this limitation, allowing the construction of larger constructs. Our innovative scaffold combination significantly boosts angiogenesis, resulting in longer branches and more capillary network junctions. The copolymer attached to fibrin fibers enables precise adjustment of hydrogel mechanical dynamic properties for specific applications. Our material proves effective for angiogenesis, even under suppression factors like suramin. In our study, we prepared fibrin-based hydrogels with and without the copolymer PVP12400-co-GMA10mol%. Using a co-culture system of human umbilical vein endothelial cells (HUVEC) and mesenchymal stem cells (MSC), we analyzed angiogenetic behavior on and within the modified hydrogels. Capillary-like structures were reproducibly formed on different surfaces, demonstrating the general feasibility of three-dimensional endothelial cell networks in fibrin-based hydrogels. This highlights the biomaterial's suitability for in vitro pre-vascularization of biohybrid implants.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10030182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw.

    Malyaran, Hanna / Craveiro, Rogerio B / Mert, Sinan / Niederau, Christian / Maas, Sanne L / van der Vorst, Emiel P C / Hölzle, Frank / Jahnen-Dechent, Wilhelm / Wolf, Michael / Neuss, Sabine

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Periodontal defects' localization affects wound healing and bone remodeling, with faster healing in the upper jaw compared to the lower jaw. While differences in blood supply, innervation, and odontogenesis contribute, cell-intrinsic variances may exist. ...

    Abstract Periodontal defects' localization affects wound healing and bone remodeling, with faster healing in the upper jaw compared to the lower jaw. While differences in blood supply, innervation, and odontogenesis contribute, cell-intrinsic variances may exist. Few studies explored cell signaling in periodontal ligament stem cells (PDLSC), overlooking mandible-maxilla disparitiesUsing kinomics technology, we investigated molecular variances in PDLSC. Characterization involved stem cell surface markers, proliferation, and differentiation capacities. Kinase activity was analyzed via multiplex kinase profiling, mapping differential activity in known gene regulatory networks. Upstream kinase analysis identified stronger EphA receptor expression in the mandible, potentially inhibiting osteogenic differentiation. The PI3K-Akt pathway showed higher activity in lower-jaw PDLSC. PDLSC from the upper jaw exhibit superior proliferation and differentiation capabilities. Differential activation of gene regulatory pathways in upper vs. lower-jaw PDLSC suggests implications for regenerative therapies.
    MeSH term(s) Periodontal Ligament ; Osteogenesis/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Stem Cells/metabolism ; Cell Differentiation/physiology ; Mandible ; Cells, Cultured ; Cell Proliferation
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: The biological role of fetuin-B in inhibition of premature zona pellucida hardening during oocyte maturation

    Sadr, Seyedeh Zeynab [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Spehr, Marc [Akademischer Betreuer]

    2022  

    Author's details Seyedeh Zeynab Sadr ; Wilhelm Jahnen-Dechent, Marc Spehr
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
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  8. Book ; Online ; Thesis: Cellular response and clearance mechanisms triggered by protein-mineral complexes

    Koeppert, Sina [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Elling, Lothar [Akademischer Betreuer]

    2021  

    Author's details Sina Koeppert ; Wilhelm Jahnen-Dechent, Lothar Elling
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Online ; Thesis: Protein mineral particle-mediated cell and tissue calcification

    Gorgels, Andrea [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Blank, Lars Mathias [Akademischer Betreuer]

    2021  

    Author's details Andrea Gorgels ; Wilhelm Jahnen-Dechent, Lars M. Blank
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: Rational design and production of recombinant RANK ligand

    Dzhanaev, Robert [Verfasser] / Jahnen-Dechent, Wilhelm [Akademischer Betreuer] / Mottaghy, Felix [Akademischer Betreuer]

    2020  

    Author's details Robert Dzhanaev ; Wilhelm Jahnen-Dechent, Felix Mottaghy
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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