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Article: Role of acupuncture in critically ill patients: A systematic review.

Formenti, Paolo / Piuri, Gabriele / Bisatti, Roberto / Pinciroli, Riccardo / Umbrello, Michele

Journal of traditional and complementary medicine

2022 Volume 13, Issue 1, Page(s) 62–71

Abstract: Acupuncture is part of a complex medical approach used in China for about 2000 years, known as Traditional Chinese Medicine, whose central assumption is that health occurs when the patterned energy flow throughout the body is balanced. Within this ... ...

Abstract	Acupuncture is part of a complex medical approach used in China for about 2000 years, known as Traditional Chinese Medicine, whose central assumption is that health occurs when the patterned energy flow throughout the body is balanced. Within this paradigm, acute illness occurs when a major state of imbalance or disruption arises, and the use of acupuncture may help in correcting these imbalances. While the Chinese hospital system often offers the integration of traditional and western medicine, in Europe and the United States this combined approach is infrequently practiced. However, several investigations have consistently shown the effectiveness of acupuncture for different aspects of critical illness. The aim of this systematic review is to increase the clinician's awareness of the current evidence regarding the use of acupuncture for the management of critically ill patients, both alone or as a complement to western medicine. The effects of acupuncture on critical illness, with a particular focus on respiratory function, pain and delirium treatment and prevention, circulatory function, nutritional support, and recovery after acute illness are explored and summarized, and evidence is provided that acupuncture is an acceptable and feasible option for the management of several aspects of critical illness. In addition, we suggest a practical selection of potentially useful acupuncture points in the critical care setting, with indications for simple localization and the correct puncture method.
Language	English
Publishing date	2022-10-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2709698-1
ISSN	2225-4110
ISSN	2225-4110
DOI	10.1016/j.jtcme.2022.10.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity.

Bonizzi, Arianna / Piuri, Gabriele / Corsi, Fabio / Cazzola, Roberta / Mazzucchelli, Serena

Biomedicines

2021 Volume 9, Issue 7

Abstract: High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator ... ...

Abstract	High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Despite the evidence suggesting a clear inverse relationship between HDL cholesterol (HDL-c) concentration and the risk for cardiovascular disease, plasma HDL cholesterol levels do not predict the functionality and composition of HDLs. The importance of defining both the amount of cholesterol transported and lipoprotein functionality has recently been highlighted. Indeed, different clinical conditions such as obesity, diabetes mellitus type 2 (T2DM), and cardiovascular disease (CVD) can alter the HDL functionality, converting normal HDLs into dysfunctional ones, undergoing structural changes, and exhibiting proinflammatory, pro-oxidant, prothrombotic, and proapoptotic properties. The aim of the current review is to summarize the actual knowledge concerning the physical-chemical alteration of HDLs related to their functions, which have been found to be relevant in several pathological conditions associated with systemic inflammation and oxidative stress.
Language	English
Publishing date	2021-06-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9070729
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Article ; Online: Blind Analysis of Food-Related IgG Identifies Five Possible Nutritional Clusters for the Italian Population: Future Implications for Pregnancy and Lactation.

Piuri, Gabriele / Ferrazzi, Enrico / Speciani, Attilio Francesco

Nutrients

2019 Volume 11, Issue 5

Abstract: Background: The influence of diet in pregnant women on the immune tolerance process is intricate. Food-specific immunoglobulin G (IgG) was associated with exposure to particular food antigens. The IgG antibodies can cross the placental barrier and enter ...

Abstract	Background: The influence of diet in pregnant women on the immune tolerance process is intricate. Food-specific immunoglobulin G (IgG) was associated with exposure to particular food antigens. The IgG antibodies can cross the placental barrier and enter into the colostrum, and maternal IgG is amply present in breast milk. This justifies studying the immunological connection between food-specific IgG antibodies and the mother-fetus relationship. This study was designed to analyze food-specific IgG concentrations and possible food-specific IgG concentration clusters in a large cohort of subjects with a common food culture. Methods: Food-specific IgG antibody concentrations were detected in 18,012 Caucasian or Southern European subjects over 18 years of age. We used an unsupervised hierarchical clustering algorithm to explore varying degrees of similarity among food-specific IgG antibodies. Results: We identified five food groups by the evaluation of food-specific IgG values: one includes foods with a high nickel content, the second cluster is associated with gluten, the third cluster includes dairy products, the fourth one is connected to fermented foods, and the last group is correlated with cooked oils. Discussion: The knowledge derived from studying a large sample allows us to determine food-specific IgG values from a single pregnant woman, compare it to an epidemic standard, and establish modifications required in her lifestyle to modulate her nutritional habits.
MeSH term(s)	Allergens ; Cluster Analysis ; Cohort Studies ; Female ; Food Hypersensitivity ; Humans ; Immunoglobulin G/blood ; Italy ; Lactation ; Milk, Human/chemistry ; Pregnancy
Chemical Substances	Allergens ; Immunoglobulin G
Language	English
Publishing date	2019-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11051096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Blind Analysis of Food-Related IgG Identifies Five Possible Nutritional Clusters for the Italian Population: Future Implications for Pregnancy and Lactation

Piuri, Gabriele / Ferrazzi, Enrico / Speciani, Attilio Francesco

Nutrients. 2019 May 17, v. 11, no. 5

2019

Abstract	Background: The influence of diet in pregnant women on the immune tolerance process is intricate. Food-specific immunoglobulin G (IgG) was associated with exposure to particular food antigens. The IgG antibodies can cross the placental barrier and enter into the colostrum, and maternal IgG is amply present in breast milk. This justifies studying the immunological connection between food-specific IgG antibodies and the mother–fetus relationship. This study was designed to analyze food-specific IgG concentrations and possible food-specific IgG concentration clusters in a large cohort of subjects with a common food culture. Methods: Food-specific IgG antibody concentrations were detected in 18,012 Caucasian or Southern European subjects over 18 years of age. We used an unsupervised hierarchical clustering algorithm to explore varying degrees of similarity among food-specific IgG antibodies. Results: We identified five food groups by the evaluation of food-specific IgG values: one includes foods with a high nickel content, the second cluster is associated with gluten, the third cluster includes dairy products, the fourth one is connected to fermented foods, and the last group is correlated with cooked oils. Discussion: The knowledge derived from studying a large sample allows us to determine food-specific IgG values from a single pregnant woman, compare it to an epidemic standard, and establish modifications required in her lifestyle to modulate her nutritional habits.
Keywords	algorithms ; antibodies ; antigens ; breast milk ; colostrum ; dairy products ; diet ; fermented foods ; food groups ; foodways ; gluten ; immunoglobulin G ; immunosuppression ; lactation ; lifestyle ; nickel ; oils ; pregnancy ; pregnant women
Language	English
Dates of publication	2019-0517
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11051096
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: HDL Dysfunctionality

Arianna Bonizzi / Gabriele Piuri / Fabio Corsi / Roberta Cazzola / Serena Mazzucchelli

Biomedicines, Vol 9, Iss 7, p

Clinical Relevance of Quality Rather Than Quantity

2021 Volume 729

Abstract	High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Despite the evidence suggesting a clear inverse relationship between HDL cholesterol (HDL-c) concentration and the risk for cardiovascular disease, plasma HDL cholesterol levels do not predict the functionality and composition of HDLs. The importance of defining both the amount of cholesterol transported and lipoprotein functionality has recently been highlighted. Indeed, different clinical conditions such as obesity, diabetes mellitus type 2 (T2DM), and cardiovascular disease (CVD) can alter the HDL functionality, converting normal HDLs into dysfunctional ones, undergoing structural changes, and exhibiting proinflammatory, pro-oxidant, prothrombotic, and proapoptotic properties. The aim of the current review is to summarize the actual knowledge concerning the physical–chemical alteration of HDLs related to their functions, which have been found to be relevant in several pathological conditions associated with systemic inflammation and oxidative stress.
Keywords	high-density lipoproteins ; HDL cholesterol ; dysfunctional HDL ; obesity ; diabetes mellitus type 2 ; cardiovascular disease ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Measuring Biomarkers for an Innovative Personal Food Profile.

Speciani, Attilio Francesco / Piuri, Gabriele

Journal of the American College of Nutrition

2015 Volume 34 Suppl 1, Page(s) 34–38

Abstract: Measuring the level of inflammation with an innovative approach (with blood analyses to evaluate the action of cytokines such as B-cell activating factor [BAFF], platelet activating factor [PAF], interleukin-6 [IL-6], sirtuin) allows you to better ... ...

Abstract	Measuring the level of inflammation with an innovative approach (with blood analyses to evaluate the action of cytokines such as B-cell activating factor [BAFF], platelet activating factor [PAF], interleukin-6 [IL-6], sirtuin) allows you to better understand the body's language. The body recognizes foods and food antigens through a mapping performed by means of immunoglobulin G (IgG). Recent studies have shown that high levels of IgG in a nutrient express the personal excess of that food in the daily nutrition. Food is the most important source of hidden inflammation but is also the main tool for regaining wellness. Europeans have reactions to milk, yeast, and gluten, whereas the Japanese have reactions to rice and soybeans. Scientific knowledge of inflammatory mediators allows the discovery of new drugs, new supplements, and new plant compounds (Resveratrol, Maqui, oil of Perilla) that are able to reduce inflammation and support well-being. The interaction between the environment, nutrition, and knowledge of inflammation is an evolution and at the same time a revolution to gain and maintain health.
MeSH term(s)	B-Cell Activating Factor/blood ; Biomarkers/analysis ; Diet/methods ; Food Analysis ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/immunology ; Inflammation/diet therapy ; Inflammation/pathology ; Inflammation Mediators/analysis ; Inflammation Mediators/immunology ; Interleukin-6/blood ; Platelet Activating Factor/analysis ; Precision Medicine/methods ; Sirtuins/blood
Chemical Substances	B-Cell Activating Factor ; Biomarkers ; Immunoglobulin G ; Inflammation Mediators ; Interleukin-6 ; Platelet Activating Factor ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
DOI	10.1080/07315724.2015.1080109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maternal AA/EPA Ratio and Triglycerides as Potential Biomarkers of Patients at Major Risk for Pharmacological Therapy in Gestational Diabetes.

Soldavini, Chiara Maria / Piuri, Gabriele / Rossi, Gabriele / Corsetto, Paola Antonia / Benzoni, Linda / Maggi, Valeria / Privitera, Giulia / Spadafranca, Angela / Rizzo, Angela Maria / Ferrazzi, Enrico

Nutrients

2022 Volume 14, Issue 12

Abstract: Gestational diabetes mellitus (GD) is characterized by glycemic and lipid metabolism alterations in an environment of low-grade inflammation. Our trial aimed to assess the effect of nutraceutical supplements (omega-3 fatty acids, anthocyanins, and alpha- ... ...

Abstract	Gestational diabetes mellitus (GD) is characterized by glycemic and lipid metabolism alterations in an environment of low-grade inflammation. Our trial aimed to assess the effect of nutraceutical supplements (omega-3 fatty acids, anthocyanins, and alpha-cyclodextrins) in GD patients and evaluate the role of anthropometric, metabolic, and inflammatory parameters as biomarkers to identify subjects who require pharmacological hypoglycemic treatment during gestation. Pregnant women with GD at 24-28 weeks of gestation were enrolled in a double-blind trial and randomized to receive either nutraceutical supplements or a placebo for 12 weeks. No statistically significant differences were observed between the two groups in blood and urine measurements of metabolic, inflammatory, and antioxidant parameters. In the whole cohort, pre-pregnancy BMI and anthropometric measurements were significantly different in patients who required pharmacological intervention. These patients showed higher triglycerides, CRP, and insulin levels and gave birth to newborns with significantly higher weights. Subjects with a greater AA/EPA ratio had higher PAF levels and gave birth four days earlier. In conclusion, one-to-one nutritional coaching and poor compliance with nutraceutical supplementation might have outweighed the impact of this intervention. However, triglyceride concentration and the AA/EPA ratio seems to be a biomarker for higher inflammatory levels and GD candidates for pharmacological treatment. An adequate assumption of omega-3 in women with GD, either by a controlled diet or by nutraceutical supplementation, reduces the need for pharmacological therapy.
MeSH term(s)	Anthocyanins/therapeutic use ; Biomarkers ; Diabetes, Gestational/drug therapy ; Dietary Supplements ; Double-Blind Method ; Fatty Acids, Omega-3/therapeutic use ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Triglycerides
Chemical Substances	Anthocyanins ; Biomarkers ; Fatty Acids, Omega-3 ; Triglycerides
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122502
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes.

Piuri, Gabriele / Zocchi, Monica / Della Porta, Matteo / Ficara, Valentina / Manoni, Michele / Zuccotti, Gian Vincenzo / Pinotti, Luciano / Maier, Jeanette A / Cazzola, Roberta

Nutrients

2021 Volume 13, Issue 2

Abstract: Magnesium ( ... ...

Abstract	Magnesium (Mg
MeSH term(s)	Adult ; Child ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Dietary Supplements ; Gastrointestinal Microbiome ; Humans ; Magnesium/administration & dosage ; Magnesium Deficiency/drug therapy ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/metabolism ; Obesity/metabolism ; Proteomics ; Thiamine/metabolism ; Vitamin D/metabolism
Chemical Substances	Vitamin D (1406-16-2) ; Magnesium (I38ZP9992A) ; Thiamine (X66NSO3N35)
Language	English
Publishing date	2021-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13020320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Maternal AA/EPA Ratio and Triglycerides as Potential Biomarkers of Patients at Major Risk for Pharmacological Therapy in Gestational Diabetes

Nutrients. 2022 June 16, v. 14, no. 12

2022

Abstract	Gestational diabetes mellitus (GD) is characterized by glycemic and lipid metabolism alterations in an environment of low-grade inflammation. Our trial aimed to assess the effect of nutraceutical supplements (omega-3 fatty acids, anthocyanins, and alpha-cyclodextrins) in GD patients and evaluate the role of anthropometric, metabolic, and inflammatory parameters as biomarkers to identify subjects who require pharmacological hypoglycemic treatment during gestation. Pregnant women with GD at 24–28 weeks of gestation were enrolled in a double-blind trial and randomized to receive either nutraceutical supplements or a placebo for 12 weeks. No statistically significant differences were observed between the two groups in blood and urine measurements of metabolic, inflammatory, and antioxidant parameters. In the whole cohort, pre-pregnancy BMI and anthropometric measurements were significantly different in patients who required pharmacological intervention. These patients showed higher triglycerides, CRP, and insulin levels and gave birth to newborns with significantly higher weights. Subjects with a greater AA/EPA ratio had higher PAF levels and gave birth four days earlier. In conclusion, one-to-one nutritional coaching and poor compliance with nutraceutical supplementation might have outweighed the impact of this intervention. However, triglyceride concentration and the AA/EPA ratio seems to be a biomarker for higher inflammatory levels and GD candidates for pharmacological treatment. An adequate assumption of omega-3 in women with GD, either by a controlled diet or by nutraceutical supplementation, reduces the need for pharmacological therapy.
Keywords	alpha-cyclodextrin ; anthocyanins ; antioxidants ; biomarkers ; blood ; compliance ; dietary supplements ; gestational diabetes ; inflammation ; insulin ; lipid metabolism ; placebos ; pregnancy ; risk ; therapeutics ; triacylglycerols ; urine
Language	English
Dates of publication	2022-0616
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122502
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes.

Piuri, Gabriele / Basello, Katia / Rossi, Gabriele / Soldavini, Chiara Maria / Duiella, Silvia / Privitera, Giulia / Spadafranca, Angela / Costanzi, Andrea / Tognon, Emiliana / Cappelletti, Mattia / Corsetto, Paola Antonia / Rizzo, Angela Maria / Speciani, Attilio Francesco / Ferrazzi, Enrico

Nutrients

2020 Volume 12, Issue 2

Abstract: Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell ... ...

Abstract	Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM. Methods: We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism. Results: In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4-47.5) ng/mL to 40.1 (30.5-80.5) ng/mL ( Conclusion: These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.
MeSH term(s)	Adult ; Anthropometry ; Biomarkers/blood ; Body Constitution ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/metabolism ; Female ; Humans ; Infant, Newborn ; Inflammation ; Platelet Activating Factor ; Pregnancy ; Pyruvaldehyde/blood ; Serum Albumin ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Biomarkers ; Platelet Activating Factor ; Serum Albumin ; Tumor Necrosis Factor-alpha ; glycated serum albumin ; Pyruvaldehyde (722KLD7415)
Language	English
Publishing date	2020-02-14
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12020479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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