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Article ; Online: Beneficial Effect of Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation　- Results of the J-RHYTHM Registry 2.

Kodani, Eitaro / Atarashi, Hirotsugu / Inoue, Hiroshi / Okumura, Ken / Yamashita, Takeshi / Origasa, Hideki

Circulation journal : official journal of the Japanese Circulation Society

2016 Volume 80, Issue 4, Page(s) 843–851

Abstract: ... effects of non-vitamin K antagonist oral anticoagulants (NOACs) in Japanese patients ...

Abstract	Background: The J-RHYTHM Registry 2 was a multicenter, prospective observational study that extended the follow-up period of the J-RHYTHM Registry in order to investigate long-term outcomes and effects of non-vitamin K antagonist oral anticoagulants (NOACs) in Japanese patients with atrial fibrillation (AF). Methods and results: Among 6,616 patients with nonvalvular AF (NVAF) (men 71.0%, 69.7±9.9 years, CHADS2score 1.7±1.2), event rates were compared among patients receiving warfarin (n=3,964), NOACs (n=923), and no anticoagulation therapy (No-OAC, n=753) at the end of follow-up, except for 976 patients lacking anticoagulant data. During the 5-year follow-up period, thromboembolism occurred in 196 (4.9%), 19 (2.1%), and 45 (6.0%) patients, respectively; major hemorrhage in 233 (5.9%), 22 (2.4%), and 36 (4.8%); all-cause death in 230 (5.8%), 13 (1.4%), and 105 (13.9%), (P<0.001 for each). After adjusting for the components of the CHA2DS2-VASc score and antiplatelet drug use, the odds ratio (OR) in the Warfarin group was significantly lower for all-cause death compared with that in the No-OAC group (OR 0.30, 95% confidence interval [CI] 0.23-0.39, P<0.001), whereas ORs in the NOACs group were significantly lower for all events (OR 0.42, 95% CI 0.24-0.74, P=0.003 for thromboembolism; OR 0.53, 95% CI 0.31-0.93, P=0.027 for major hemorrhage; and OR 0.10, 95% CI 0.06-0.18, P<0.001 for all-cause death, respectively). Conclusions: NOACs could be beneficial for reducing event rates of all types in Japanese NVAF patients.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Asian Continental Ancestry Group ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Female ; Follow-Up Studies ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/adverse effects ; Prospective Studies ; Registries ; Thromboembolism/chemically induced ; Thromboembolism/epidemiology ; Vitamin K ; Warfarin/administration & dosage ; Warfarin/adverse effects
Chemical Substances	Anticoagulants ; Platelet Aggregation Inhibitors ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2016
Publishing country	Japan
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-16-0066
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Article ; Online: Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein.

Akasaka, Kazuyuki / Maeno, Akihiro / Murayama, Taichi / Tachibana, Hideki / Fujita, Yuzo / Yamanaka, Hitoki / Nishida, Noriyuki / Atarashi, Ryuichiro

Prion

2014 Volume 8, Issue 4, Page(s) 314–318

Abstract: ... heat and resistance against proteinase K digestion. A successful challenge to reverse the reaction ... the "proteinase K-resistant" fibrils (rHaPrP(res)) prepared from hamster prion protein (rHaPrP [23-231 ...

Abstract	The crucial step for the fatal neurodegenerative prion diseases involves the conversion of a normal cellular protein, PrP(C), into a fibrous pathogenic form, PrP(Sc), which has an unusual stability against heat and resistance against proteinase K digestion. A successful challenge to reverse the reaction from PrP(Sc) into PrP(C) is considered valuable, as it would give a key to dissolving the complex molecular events into thermodynamic and kinetic analyses and may also provide a means to prevent the formation of PrP(Sc) from PrP(C) eventually in vivo. Here we show that, by applying pressures at kbar range, the "proteinase K-resistant" fibrils (rHaPrP(res)) prepared from hamster prion protein (rHaPrP [23-231]) by seeding with brain homogenate of scrapie-infected hamster, becomes easily digestible. The result is consistent with the notion that rHaPrP(res) fibrils are dissociated into rHaPrP monomers under pressure and that the formation of PrP(Sc) from PrP(C) is thermodynamically controlled. Moreover, the efficient degradation of prion fibrils under pressure provides a novel means of eliminating infectious PrP(Sc) from various systems of pathogenic concern.
MeSH term(s)	Animals ; Brain/metabolism ; Brain/pathology ; Cricetinae/physiology ; Endopeptidase K/metabolism ; PrPC Proteins/analysis ; PrPC Proteins/metabolism ; PrPSc Proteins/analysis ; PrPSc Proteins/metabolism ; Pressure ; Protein Conformation ; Proteolysis ; Scrapie/metabolism ; Scrapie/pathology
Chemical Substances	PrPC Proteins ; PrPSc Proteins ; Endopeptidase K (EC 3.4.21.64)
Language	English
Publishing date	2014-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1933-690X
ISSN (online)	1933-690X
DOI	10.4161/pri.32081
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Article: [A Case of Ascending Colon Cancer Metastasis to Right External Iliac Lymph Nodes].

Yamamoto, Kota / Atarashi, Miyuki / Terashima, Takahiro / Kawamoto, Shunji / Kurogi, Norimitsu

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 49, Issue 11, Page(s) 1255–1257

Abstract: We report a rare case of postoperative ascending colon cancer metastasis to the right external iliac lymph nodes. A 57- year-old woman underwent a laparoscopic right colectomy and D3 lymph node dissection. Pathological findings indicated a Stage Ⅲb, ... ...

Abstract	We report a rare case of postoperative ascending colon cancer metastasis to the right external iliac lymph nodes. A 57- year-old woman underwent a laparoscopic right colectomy and D3 lymph node dissection. Pathological findings indicated a Stage Ⅲb, pT4aN1bM0 cancer. Because side effects were observed on adjuvant chemotherapy with FOLFOX, she was switched to S-1 administration every other week. Sixteen months postoperatively, right inguinal pain and elevated CEA values were noted. CT revealed two swollen right external iliac nodes with high FDG uptake on PET-CT. With the diagnosis of lymph node metastasis, an open celiotomy was performed to remove the lymph nodes. Pathological findings confirmed lymph node recurrence of ascending colon cancer. Postoperatively, her CEA values were normal and no recurrence was noted. This rare occurrence highlights the importance of examining adjacent lymph nodes for possible tumor recurrence. We report this case with the necessary literature review.
MeSH term(s)	Humans ; Female ; Middle Aged ; Colon, Ascending/surgery ; Positron Emission Tomography Computed Tomography ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Lymph Node Excision
Language	Japanese
Publishing date	2022-11-14
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Sparse random feature maps for the item-multiset kernel.

Atarashi, Kyohei / Oyama, Satoshi / Kurihara, Masahito

Neural networks : the official journal of the International Neural Network Society

2021 Volume 143, Page(s) 500–514

Abstract: Random feature maps are a promising tool for large-scale kernel methods. Since most random feature maps generate dense random features causing memory explosion, it is hard to apply them to very-large-scale sparse datasets. The factorization machines and ... ...

Abstract	Random feature maps are a promising tool for large-scale kernel methods. Since most random feature maps generate dense random features causing memory explosion, it is hard to apply them to very-large-scale sparse datasets. The factorization machines and related models, which use feature combinations efficiently, scale well for large-scale sparse datasets and have been used in many applications. However, their optimization problems are typically non-convex. Therefore, although they are optimized by using gradient-based iterative methods, such methods cannot find global optimum solutions in general and require a large number of iterations for convergence. In this paper, we define the item-multiset kernel, which is a generalization of the itemset kernel and dot product kernels. Unfortunately, random feature maps for the itemset kernel and dot product kernels cannot approximate the item-multiset kernel. We thus develop a method that converts an item-multiset kernel into an itemset kernel, enabling the item-multiset kernel to be approximated by using a random feature map for the itemset kernel. We propose two random feature maps for the itemset kernel, which run faster and are more memory efficient than the existing feature map for the itemset kernel. They also generate sparse random features when the original (input) feature vector is sparse and thus linear models using proposed methods . Experiments using real-world datasets demonstrated the effectiveness of the proposed methodology: linear models using the proposed random feature maps ran from 10 to 100 times faster than ones based on existing methods.
MeSH term(s)	Algorithms
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	740542-x
ISSN	1879-2782 ; 0893-6080
ISSN (online)	1879-2782
ISSN	0893-6080
DOI	10.1016/j.neunet.2021.06.024
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Article: Predictive ability of visit-to-visit blood pressure indices for adverse events in patients with non-valvular atrial fibrillation: Subanalysis of the J-RHYTHM Registry.

Kodani, Eitaro / Inoue, Hiroshi / Atarashi, Hirotsugu / Okumura, Ken / Suzuki, Shinya / Yamashita, Takeshi / Origasa, Hideki

International journal of cardiology. Heart & vasculature

2023 Volume 46, Page(s) 101216

Abstract: Background: We previously reported that standard deviation (SD) of systolic blood pressure (SBP), an index of BP variability, and SBP-time in target range (TTR), an index of BP consistency, were significantly associated with adverse events in patients ... ...

Abstract	Background: We previously reported that standard deviation (SD) of systolic blood pressure (SBP), an index of BP variability, and SBP-time in target range (TTR), an index of BP consistency, were significantly associated with adverse events in patients with non-valvular atrial fibrillation (NVAF). Thus, this study aimed to compare predictive ability for adverse events among visit-to-visit BP variability/consistency indices using data from the J-RHYTHM Registry. Methods: Of 7406 outpatients with NVAF, 7226 (age, 69.7 ± 9.9 years; men, 70.7%), in whom BP was measured 4 times or more (14.6 ± 5.0 times) during the 2-year follow-up period or until occurrence of an event, were included. As BP consistency for target SBP between 110 and 130 mmHg, SBP-TTR by the Rosendaal method and SBP-frequency in range (FIR) were calculated. Predictive ability was expressed by the area under receiver-operating-characteristic curve (AUC). AUCs of SBP-TTR and SBP-FIR for adverse events were compared with those of SBP-SD by the DeLong's test. Results: SBP-SD, SBP-TTR, and SBP-FIR were 11.0 ± 4.2 mmHg, 49.5 ± 28.3%, and 52.3 ± 23.0%, respectively. AUCs of these indices for thromboembolism, major hemorrhage, and all-cause death were 0.62, 0.64, and 0.63 for SBP-SD; 0.56, 0.55, and 0.56 for SBP-TTR; and 0.55, 0.56, and 0.58 for SBP-FIR; respectively. AUCs of SBP-SD were significantly larger than those of SBP-TTR for major hemorrhage (P = 0.010) and all-cause death (P = 0.014), and SBP-FIR for major hemorrhage (P = 0.016). Conclusion: Among visit-to-visit BP variability/consistency indices, predictive ability of SBP-SD for major hemorrhage and all-cause death was superior to that of SBP-TTR and SBP-FIR in patients with NVAF.
Language	English
Publishing date	2023-05-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2023.101216
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Article: [Two Cases of Transfusion-Free Hepatectomy Following Chemotherapy for H3 Grade of Simultaneous Liver Metastases].

Ogawa, Tatsuya / Kawamoto, Shunji / Yamamoto, Kota / Atarashi, Miyuki / Terashima, Takahiro / Kurogi, Norimitsu

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 50, Issue 2, Page(s) 236–238

Abstract: We report 2 cases of transfusion-free treatment for H3 grade of simultaneous liver metastases of the colon which were treated with the chemotherapy followed by R0 liver resection. Case 1 was a 67-year-old woman bearing ascending colon cancer and a ... ...

Abstract	We report 2 cases of transfusion-free treatment for H3 grade of simultaneous liver metastases of the colon which were treated with the chemotherapy followed by R0 liver resection. Case 1 was a 67-year-old woman bearing ascending colon cancer and a metastatic mass occupying the left lobe of the liver with 160 mm in diameter. Laparoscopic ileocecal resection and 30-day left hepatectomy were performed after the 7 courses of FOLFOX plus bevacizumab(BEV). Case 2 was a 72- year-old woman bearing transverse colon cancer with more than 10 foci of liver metastases ranging from 21 mm to 100 mm in diameter. After the transverse colon resection and 12 months of chemotherapy from FOLFOX plus BEV to FOLFIRI plus panitumumab, partial liver resection was performed for each of size-reduced foci. In both patients who declined blood transfusion, optimization of red cells and autologous transfusion with hemodilution contributed to the safe liver resection with no postoperative complications.
MeSH term(s)	Female ; Humans ; Aged ; Hepatectomy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fluorouracil ; Colonic Neoplasms/surgery ; Liver Neoplasms/secondary ; Leucovorin ; Colorectal Neoplasms/surgery
Chemical Substances	Fluorouracil (U3P01618RT) ; Leucovorin (Q573I9DVLP)
Language	Japanese
Publishing date	2023-02-20
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Characteristics and outcomes in elderly patients with non-valvular atrial fibrillation and high bleeding risk: subanalysis of the J-RHYTHM Registry.

Kodani, Eitaro / Inoue, Hiroshi / Atarashi, Hirotsugu / Okumura, Ken / Yamashita, Takeshi / Origasa, Hideki

Heart and vessels

2023 Volume 39, Issue 4, Page(s) 330–339

Abstract: Recently, a once-daily dose of edoxaban (15-mg) has been approved for stroke prevention in non-valvular atrial fibrillation (NVAF) patients aged ≥ 80 years, in whom standard oral anticoagulants are not recommended because of high bleeding risk (HBR), ... ...

Abstract	Recently, a once-daily dose of edoxaban (15-mg) has been approved for stroke prevention in non-valvular atrial fibrillation (NVAF) patients aged ≥ 80 years, in whom standard oral anticoagulants are not recommended because of high bleeding risk (HBR), based on the ELDERCARE-AF trial. However, information regarding the characteristics and clinical outcomes among such patients is limited. Thus, this study aimed to clarify the characteristics and event rates in elderly patients with NVAF and HBR defined by the ELDERCARE-AF criteria. Of the 7406 NVAF outpatients included in the J-RHYTHM Registry, 60 patients with creatinine clearance (CrCl) < 15 mL/min were excluded. The remaining 7346 patients (age, 69.7 ± 9.9 years; men, 70.9%; warfarin use, 78.7%) were divided into three groups: Group 1, aged < 80 years (n = 6165); Group 2, aged ≥ 80 years without HBR (n = 584); and Group 3, aged ≥ 80 years with HBR (at least one of the followings; CrCl, 15-30 mL/min, history of bleeding, body weight ≤ 45 kg, and antiplatelet use) (n = 597, eligible for 15-mg edoxaban). Patients in Group 3 had a higher prevalence of comorbidities, and therefore, both higher thromboembolic and bleeding risk scores than in the other groups. During the 2-year follow-up period, the incidence rates (per 100 person-years) of thromboembolism in Groups 1, 2, and 3 were 0.7, 1.5, and 2.1 (P < 0.001), major hemorrhage, 0.8, 1.2, and 2.0 (P < 0.001), and all-cause death, 0.8, 2.6, and 4.6 (P < 0.001), respectively. Adjusted hazard ratios of Group 3 were 1.64 (95% confidence interval 0.89-3.04, P = 0.116) for thromboembolism, 1.53 (0.85-2.72, P = 0.154) for major hemorrhage, and 1.84 (1.19-2.85, P = 0.006) for all-cause death compared with Group 1. The NVAF Patients aged ≥ 80 years with HBR defined by the ELDERCARE-AF criteria were certainly at a higher adverse event risk, especially for all-cause death. Clinical trial registration: The J-RHYTHM Registry is registered in the University Hospital Medicine Information Network (UMIN) Clinical Trials Registry (unique identifier: UMIN000001569) http://www.umin.ac.jp/ctr/ .
MeSH term(s)	Male ; Aged ; Humans ; Middle Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Anticoagulants/adverse effects ; Thromboembolism/epidemiology ; Registries ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Pyridines ; Thiazoles
Chemical Substances	edoxaban (NDU3J18APO) ; Anticoagulants ; Pyridines ; Thiazoles
Language	English
Publishing date	2023-12-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-023-02343-9
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Article: [Laparoscopic Total Gastrectomy for Jehovah's Witness Gastric Cancer Patient after Preoperative Blood Augmentation].

Miyaishi, Keita / Kawamoto, Shunji / Yamamoto, Kota / Atarashi, Miyuki / Terashima, Takahiro / Kurogi, Norimitsu

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 48, Issue 13, Page(s) 1910–1912

Abstract: An 80-year-old female of Jehovah's Witness with anemia was diagnosed with advanced gastric cancer(cT4aN2M0, stage ⅢA). The first value of Hb at the clinic was 7.5 g/dL that made it difficult to perform total gastrectomy in safe. The treatment of blood ... ...

Abstract	An 80-year-old female of Jehovah's Witness with anemia was diagnosed with advanced gastric cancer(cT4aN2M0, stage ⅢA). The first value of Hb at the clinic was 7.5 g/dL that made it difficult to perform total gastrectomy in safe. The treatment of blood augmentation included the administration of intravenous iron and oral intake of vitamins in the earlier period. The number of hemoglobin was not optimized sufficiently in the first 10 days, that necessitated administration of erythropoietin( ESPO® INJECTION: 24,000 unit×2 times). Hb value increased in 11.6 g/dL 34 days after the treatment, that enabled laparoscopic total gastrectomy to be performed. The tumor infiltrated left crus of diaphragm. The patient was discharged in 16th postoperative day with Hb value of 10.1 g/dL without any complications. Pathological findings showed pT4b(crus) N2M0, stage ⅢB. Preoperative blood augmentation benefited the patients with anemia who decline allogenic blood transfusion. Anemia with malignant tumors is associated with not only iron deficiency due to the chronic bleeding but also functional deficiency or iron sequestration due to malignant itself, inflammation and infection. Erythropoiesis along with infusion of iron contributed to the optimization of Hb value that ensure performing total gastrectomy in safe.
MeSH term(s)	Aged, 80 and over ; Female ; Gastrectomy ; Humans ; Iron Deficiencies ; Jehovah's Witnesses ; Laparoscopy ; Stomach Neoplasms/surgery
Language	Japanese
Publishing date	2022-01-16
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Impact of heart rate on adverse events in patients with non-valvular atrial fibrillation: Subanalysis of the J-RHYTHM Registry.

Kodani, Eitaro / Inoue, Hiroshi / Atarashi, Hirotsugu / Okumura, Ken / Yamashita, Takeshi / Origasa, Hideki

International journal of cardiology. Heart & vasculature

2022 Volume 43, Page(s) 101148

Abstract: Background: Although heart rate (HR) is reportedly associated with major cardiovascular outcomes in the general population, its impact on adverse events in patients with non-valvular atrial fibrillation (NVAF) remains controversial. Thus, we performed !# ...

Abstract	Background: Although heart rate (HR) is reportedly associated with major cardiovascular outcomes in the general population, its impact on adverse events in patients with non-valvular atrial fibrillation (NVAF) remains controversial. Thus, we performed Results: Of 7406 outpatients with NVAF from 158 institutions, 6886 (age, 69.8 ± 9.9 years; men, 70.8%), in whom both baseline HR and HR-end (at the time closest to an event or at the last visit of follow-up) were measured during the two-year follow-up period or until the occurrence of an event, constituted the study group. The baseline HR and HR-end values were 72.5 ± 13.3 bpm and 73.3 ± 13.3 bpm, respectively. Thromboembolism, major hemorrhage, all-cause death, and cardiovascular death occurred in 117 (1.7%), 130 (1.9%), 157 (2.3%), and 58 (0.8%) patients, respectively. Baseline HR was not associated with any adverse event, whereas HR-end (per 1-bpm increase) was significantly associated with an increased incidence of all adverse events. Furthermore, the highest quartile of HR-end (≥80 bpm) was independently associated with the incidence of major hemorrhage (adjusted odds ratio [OR], 2.90; 95% confidence interval [CI], 1.69-4.96; P < 0.001), all-cause death (OR, 3.42; 95% CI, 1.99-5.88; P < 0.001), and cardiovascular death (OR, 5.07; 95% CI, 1.49-17.22; P = 0.009) compared with the second quartile (64-71 bpm), even after adjusting for known confounding factors, HR-controlling drug use, and systolic blood pressure-end. Conclusions: In patients with NVAF, HR-end was significantly associated with adverse events independent of systolic blood pressure-end, whereas baseline HR was not.
Language	English
Publishing date	2022-11-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2022.101148
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Article ; Online: Impact of Systolic Blood Pressure Time in Target Range on Adverse Events in Patients With Nonvalvular Atrial Fibrillation (from the J-RHYTHM Registry).

Kodani, Eitaro / Inoue, Hiroshi / Atarashi, Hirotsugu / Okumura, Ken / Suzuki, Shinya / Yamashita, Takeshi / Origasa, Hideki

The American journal of cardiology

2022 Volume 180, Page(s) 52–58

Abstract: Although time in target range (TTR) of systolic blood pressure (BP), an index of consistency of BP control, is reportedly associated with major cardiovascular outcomes, the impact of BP-TTR on adverse events in patients with nonvalvular atrial ... ...

Abstract	Although time in target range (TTR) of systolic blood pressure (BP), an index of consistency of BP control, is reportedly associated with major cardiovascular outcomes, the impact of BP-TTR on adverse events in patients with nonvalvular atrial fibrillation (NVAF) has not been thoroughly investigated. Thus, we performed a post hoc analysis to clarify it in patients with NVAF using data of the J-RHYTHM registry. Of 7,406 outpatients with NVAF, 7,226 (age, 70 ± 10 years; men, 71%), in whom BP was measured 4 times or more (15 ± 5 times) during the 2-year follow-up period or until occurrence of an event, constituted the study group. Systolic BP-TTR, with a target range of 110 to 130 mm Hg, was calculated by Rosendaal linear interpolation method. Overall systolic BP-TTR was 50 ± 28%. Thromboembolism, major hemorrhage, all-cause death, and cardiovascular death occurred in 110 (1.5%), 121 (1.7%), 168 (2.3%), and 60 patients (0.8%), respectively. Each 1% increase in systolic BP-TTR was significantly associated with a decreased incidence of all adverse events in the unadjusted model; whereas, significant association was observed only for cardiovascular death (adjusted hazard ratio 0.983, 95% confidence interval 0.971 to 0.995, p = 0.006) after adjusting for known confounders and systolic BP at the time closest to an event. In contrast, each 1% increase in systolic BP time in subtarget range of <110 mm Hg was significantly associated with an increased risk of thromboembolism (hazard ratio 1.014, 95% confidence interval 1.005 to 1.024, p = 0.002). In conclusion, systolic BP-TTR and BP time in subtarget range would be useful for risk evaluation of cardiovascular death and thromboembolism, respectively, in patients with NVAF.
MeSH term(s)	Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Blood Pressure ; Humans ; Male ; Middle Aged ; Registries ; Thromboembolism/epidemiology ; Thromboembolism/etiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.06.045
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In stock of ZB MED Cologne/Königswinter

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Order via subito

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In stock of ZB MED Cologne/Königswinter

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Full text online

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

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Kategorien

Order via subito

Full text online

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito