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Article ; Online: Magnesium therapeutic potential against Covid-19: Could it be an "All-in-one" therapy?

Errasfa, Mourad

2021 Volume 34, Issue 1, Page(s) 32–34

MeSH term(s)	Blood Coagulation ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/virology ; Humans ; Magnesium/blood ; Magnesium/therapeutic use ; SARS-CoV-2/physiology
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1036384-1
ISSN	1952-4021 ; 0953-1424
ISSN (online)	1952-4021
ISSN	0953-1424
DOI	10.1684/mrh.2020.0474
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Article ; Online: Milk Oligosaccharides and Lectins as Candidates for Clinical Trials Against Covid-19

Errasfa, Mourad

Current Nutrition & Food Science

2020 Volume 16

Abstract: Background: Covid-19 pandemia is causing a very high death toll around the world and a serious fall in the global economy. Many clinical trials are currently underway to check the effectiveness of some known drugs. The physiopathology associated with the ...

Abstract	Background: Covid-19 pandemia is causing a very high death toll around the world and a serious fall in the global economy. Many clinical trials are currently underway to check the effectiveness of some known drugs. The physiopathology associated with the virus infection is currently better understood and good prophylactic drug therapies are implemented, such as antibiotics and blood thinners, though, no specific drugs against SARS-Cov-2 were developed yet. Objective: In the present research work, it is aimed to carry out a bibliographic investigation on some active molecular species that could be used against Covid-19, based on their chemical properties to bind to glycoproteins. In the case of SARS-Cov-2, the targeted glycoprotein is the surface virus spike S glycoprotein, that the virus uses to attach to and invade human cells. It is of high pharmacological value to investigate possible active natural substances endowed with a property to bind glycoproteins. In this line of research, oligosaccharides and lectins are two molecular species that have glycoprotein binding properties. Methods: A bibliographic research was carried out on oligosaccharides and lectins in various sources of scientific publications. Relevant chemical and pharmacological properties of oligosaccharides and lectins were searched and their main natural sources were identified. Results: In the present paper, I summarize some scientific evidence to support the therapeutic potential of camel milk as a source of oligosaccharides and its possible use as a functional diet in parallel to drug therapies of Covid-19. On the other hand, sugar- and glycoprotein binding properties of some lectins of plant and seaweed origin are reported, and their pharmaceutical use is underlined. Conclusion: In the present study, scientific evidence was documented that encouraged further clinical investigations on camel milk oligosaccharides and lectins of plant and seaweed origin in the management of Covid-19 physiopathology.
Keywords	Food Science ; Nutrition and Dietetics ; Public Health, Environmental and Occupational Health ; covid19
Language	English
Publisher	Bentham Science Publishers Ltd.
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2182729-1
ISSN	2212-3881 ; 1573-4013
ISSN (online)	2212-3881
ISSN	1573-4013
DOI	10.2174/1573401316999200819125355
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of Argan Oil Consumption on Knee Osteoarthritis Symptoms: A Randomized Controlled Clinical Trial.

Essouiri, Jamila / Harzy, Taoufik / Benaicha, Nadia / Errasfa, Mourad / Abourazzak, Fatima Ezzahra

Current rheumatology reviews

2017 Volume 13, Issue 3, Page(s) 231–235

Abstract: Background: Knee osteoarthritis (KOA) is a common chronic degenerative disorder. It causes joint pain, walking difficulties and a decline in general physical function. Many pain drugs and treatment modalities can be prescribed for KOA. Among traditional ...

Abstract	Background: Knee osteoarthritis (KOA) is a common chronic degenerative disorder. It causes joint pain, walking difficulties and a decline in general physical function. Many pain drugs and treatment modalities can be prescribed for KOA. Among traditional medicines in Morocco, Argan oil has been used in the treatment of knee osteoarthritis to reduce pain and improve physical activity, though there have been no medical-based evidence for such treatment. Argan oil is known to have anti-oxidant and lipid modulatory properties due to its content of many substances, such as tocopherols, phytosterols, saturated and unsaturated fatty acids. Objectives: This study was undertaken in order to investigate the effect of daily consumption of culinary argan oil on KOA symptoms. Patients and methods: We conducted a randomized controlled clinical trial on patients with KOA according to the American College of Rheumatology (ACR) criteria. Patients were divided into 2 groups: argan oil group who received argan oil to be consumed every morning (30 ml per day) for 8 weeks and control group with no treatment. Clinical assessment before and after 8 weeks study was performed by several tests such as the Visual Analogue Scale (VAS) for pain, walking perimeter, the Western Ontario and McMaster Universities osteoarthritis index (WOMAC), and the Lequesne index. Results: The study included 100 patients. 51 patients were randomly assigned to argan oilgroup while 49 patients were randomly assigned to control group with no treatment. Mean age of our patients was 58.24 ± 7.2 years, with a majority of women (93%). Following 8 weeks of argan oil consumption, argan oil group had a very significant decrease of VAS for pain (p< 0.0001), with a significant decrease in WOMAC pain index (p < 0.0001), and improvement of WOMAC function index (p < 0.0001). Lequesne index (p < 0.0001) as well as walking distance (p =0,002) significantly improved. When data of argan oil group were compared to those of control group, we found statistically significant differences in all the above measured parameters: VAS of pain (P=0,02), WOMAC pain (p<0,0001), WOMAC function (p<0,0001), walking distance (p=0,001) and lequesne index (p<0,0001). Conclusion: Patient's consumption of argan oil seems to be safe and efficacious in improving clinical symptoms of KOA.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/drug therapy ; Pain/etiology ; Plant Oils/therapeutic use
Chemical Substances	Plant Oils ; argan oil (4V59G5UW9X)
Language	English
Publishing date	2017
Publishing country	United Arab Emirates
Document type	Journal Article ; Randomized Controlled Trial
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397113666170710123031
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Article ; Online: Consumption of Argan Oil Improves Anti-Oxidant and Lipid Status in Hemodialysis Patients.

Eljaoudi, Rachid / Elkabbaj, Driss / Bahadi, Abdelali / Ibrahimi, Azeddine / Benyahia, Mohammed / Errasfa, Mourad

Phytotherapy research : PTR

2015 Volume 29, Issue 10, Page(s) 1595–1599

Abstract: Objective: Virgin Argan oil (VAO) is of interest in oxidative stress and lipid profile because of its fat composition and antioxidant compounds. We investigated the effect of VAO consumption on lipid profile and antioxidant status in hemodialysis ... ...

Abstract	Objective: Virgin Argan oil (VAO) is of interest in oxidative stress and lipid profile because of its fat composition and antioxidant compounds. We investigated the effect of VAO consumption on lipid profile and antioxidant status in hemodialysis patients after a 4-week period of consumption. Methods: In a crossover, controlled trial, 37 patients (18 men, 19 women) with end-stage renal disease on maintenance hemodialysis, were randomly assigned to a 4-week VAO diet. Fasting plasma lipids, vitamin E and oxidized LDL (ox-LDL) were analyzed. Malondialdehyde (MDA) was determined before and after hemodialysis session. Results: There was no significant change in serum total cholesterol and ox-LDL. However, VAO consumption decreased the levels of triglyceride (p = 0.03), total cholesterol (p = 0.02) and low-density lipoprotein (p = 0.03) and increased the levels of high-density lipoprotein (p = 0.01). Plasma vitamin E contents significantly increased from baseline only in VAO-group (p < 0.001). Hemodialysis session increased MDA levels, but the increase in VAO group was less than in control group. Conclusion: VAO consumption improved lipid profile and oxidative stress status in hemodialysis patients.
MeSH term(s)	Adult ; Aged ; Antioxidants/administration & dosage ; Cholesterol/blood ; Diet ; Female ; Humans ; Lipids/blood ; Lipoproteins, HDL/blood ; Lipoproteins, LDL ; Male ; Malondialdehyde/blood ; Middle Aged ; Oxidants ; Oxidative Stress/drug effects ; Plant Oils/administration & dosage ; Renal Dialysis ; Sapotaceae ; Triglycerides/blood ; Vitamin E/pharmacology
Chemical Substances	Antioxidants ; Lipids ; Lipoproteins, HDL ; Lipoproteins, LDL ; Oxidants ; Plant Oils ; Triglycerides ; oxidized low density lipoprotein ; Vitamin E (1406-18-4) ; argan oil (4V59G5UW9X) ; Malondialdehyde (4Y8F71G49Q) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.5405
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Article: Impact of improving quality of dialysis fluid on oxidative stress and lipid profile in hemodialysis patients.

Elkabbaj, Driss / Bahadi, Abdelali / Cherrah, Yahia / Errasfa, Mourad / Eljaoudi, Rachid

ISRN nephrology

2012 Volume 2013, Page(s) 717849

Abstract: The aim of this study was to evaluate the levels of malondialdehyde as an oxidative stress marker in the same hemodialysis patients after changing the quality of dialysate with ultrapure dialysis fluid. Methods. This prospective study concerns ... ...

Abstract	The aim of this study was to evaluate the levels of malondialdehyde as an oxidative stress marker in the same hemodialysis patients after changing the quality of dialysate with ultrapure dialysis fluid. Methods. This prospective study concerns hemodialysis patients; all patients were in the first step treated with conventional dialysate, and in the second step (three months later) the same patients were treated with online produced ultrapure dialysis fluid. The malondialdehyde, C-reactive protein, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, fibrinogen, and albumin were quantified before the two steps. Results. Thirty-seven patients completed the study. Ultrapure dialysis fluid reduced but not significantly the malondialdehyde concentrations. Both dialysis fluids were associated with improvement in the malondialdehyde level before and after the hemodialysis session. In lipid parameters, there was a significant decrease with conventional dialysis fluid versus ultrapure dialysis fluid of triglycerides, total cholesterol, and high-density lipoprotein in patients' blood. Instead, the level of low-density lipoprotein, fibrinogen, albumin, and C-reactive protein does not change significantly. Conclusion. The lipid parameters were improved for triglycerides and total cholesterol. Malondialdehyde increases following the hemodialysis session, and the conventional dialysate increased malondialdehyde levels more than the ultrapure dialysis but the differences were not statistically significant.
Language	English
Publishing date	2012-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2688501-3
ISSN	2314-405X
ISSN	2314-405X
DOI	10.5402/2013/717849
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Article ; Online: Efficacy of Argane Oil on Metabolic Syndrome in a Moroccan Knee Osteoarthritis Population.

Essouiri, Jamila / Abourazzak, Fatima Ezzahra / Lazrak, Faiza / Najdi, Adil / Benaicha, Nadia / Harzy, Taoufik / Errasfa, Mourad

Current rheumatology reviews

2016 Volume 14, Issue 1, Page(s) 84–88

Abstract: Five medical conditions which characterize metabolic syndrome are abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low highdensity lipoproteins cholesterol. When a patient has any three of the ... ...

Abstract	Five medical conditions which characterize metabolic syndrome are abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low highdensity lipoproteins cholesterol. When a patient has any three of the five above conditions, he is known to have metabolic syndrome, and these conditions represent a key element in cardiovascular diseases. On the other hand, knee osteoarthritis is a degenerative disease which was shown to be affected by some of the parameters of metabolic syndrome. Edible Argane oil is used in Moroccan folk medicine against several health conditions, such as knee osteoarthritis, though, evidence-based medical data about the above health benefit from Argane oil treatment are lacking. In the present clinical controlled study, we have found that consumption of Argane oil by 38 patients who have knee osteoarthritis and metabolic syndrome can improve several of their metabolic syndrome parameters and decrease their blood lipid atherogenic ratios. The present clinical study, to the best of our knowledge, is the first one to show that Argane oil consumption could be a therapeutic preventive tool against key cardiovascular risk factors of metabolic syndrome in knee osteoarthritis patients.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/drug therapy ; Middle Aged ; Morocco ; Osteoarthritis, Knee/complications ; Plant Oils/therapeutic use
Chemical Substances	Plant Oils ; argan oil (4V59G5UW9X)
Language	English
Publishing date	2016-12-02
Publishing country	United Arab Emirates
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397112666161205103009
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Article ; Online: Copper, zinc and selenium imbalance in Moroccan haemodialysis patients and its correlation to lipid peroxidation

Rachid Eljaoudi / Mourad Errasfa / Mohammed Benyahia / Abdelali Bahadi / Yahia Cherrah / Azeddine Ibrahimi / Driss Elkabbaj

International Journal of Research in Medical Sciences, Vol 3, Iss 8, Pp 2079-

2015 Volume 2085

Abstract: Background: Haemodialysis patients are at risk of developing trace elements imbalance and lipid peroxidation. The present study was aimed to assess plasma levels of copper (Cu), zinc (Zn), selenium (Se) and malondialdehyde (MDA) of haemodialysis patients ...

Abstract	Background: Haemodialysis patients are at risk of developing trace elements imbalance and lipid peroxidation. The present study was aimed to assess plasma levels of copper (Cu), zinc (Zn), selenium (Se) and malondialdehyde (MDA) of haemodialysis patients and to investigate the possible effect of haemodialysis on these trace elements and MDA imbalance. Methods: Blood samples of fifty hemodialysis patients and forty healthy controls subjects were analyzed for determination of hemoglobin, albumin, creatinine, urea and high-sensitivity C-reactive protein (hs-CRP). Cu, Zn and Se were determined in plasma (before and after hemodialysis) and erythrocytes and MDA in plasma before and after hemodialysis. Results: The study showed that, plasma Zn and Se concentrations were lower in haemodialysis patients compared to that of healthy controls, while plasma Cu, MDA and Cu/Zn ratio were higher. Plasma Cu/Zn ratios were positively correlated to MDA and weakly correlated to hs-CRP levels whereas plasma Se concentrations were inversely correlated to MDA. In addition, MDA levels increased after haemodialysis session. Conclusions: Based on the results of the present study regarding the imbalance of trace elements in haemodialysis patients, it seems reasonable to periodically assess the trace elements status and consider possible correctional therapy in case of deficiency. [Int J Res Med Sci 2015; 3(8.000): 2079-2085]
Keywords	Trace element ; Oxidative stress ; Haemodialysis ; Lipid peroxidation ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	Medip Academy
Document type	Article ; Online
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Article: Consumption of Argan Oil Improves Anti‐Oxidant and Lipid Status in Hemodialysis Patients

Eljaoudi, Rachid / Elkabbaj, Driss / Bahadi, Abdelali / Ibrahimi, Azeddine / Benyahia, Mohammed / Errasfa, Mourad

Phytotherapy research. 2015 Oct., v. 29, no. 10

2015

Abstract	Objective: Virgin Argan oil (VAO) is of interest in oxidative stress and lipid profile because of its fat composition and antioxidant compounds. We investigated the effect of VAO consumption on lipid profile and antioxidant status in hemodialysis patients after a 4‐week period of consumption. Methods: In a crossover, controlled trial, 37 patients (18 men, 19 women) with end‐stage renal disease on maintenance hemodialysis, were randomly assigned to a 4‐week VAO diet. Fasting plasma lipids, vitamin E and oxidized LDL (ox‐LDL) were analyzed. Malondialdehyde (MDA) was determined before and after hemodialysis session. Results: There was no significant change in serum total cholesterol and ox‐LDL. However, VAO consumption decreased the levels of triglyceride (p = 0.03), total cholesterol (p = 0.02) and low‐density lipoprotein (p = 0.03) and increased the levels of high‐density lipoprotein (p = 0.01). Plasma vitamin E contents significantly increased from baseline only in VAO‐group (p < 0.001). Hemodialysis session increased MDA levels, but the increase in VAO group was less than in control group. Conclusion: VAO consumption improved lipid profile and oxidative stress status in hemodialysis patients. Copyright © 2015 John Wiley & Sons, Ltd.
Keywords	antioxidants ; blood lipids ; blood serum ; cholesterol ; diet ; fasting ; hemodialysis ; high density lipoprotein ; kidney diseases ; low density lipoprotein ; malondialdehyde ; men ; oils ; oxidative stress ; patients ; triacylglycerols ; vitamin E ; women
Language	English
Dates of publication	2015-10
Size	p. 1595-1599.
Publishing place	Heyden & Son
Document type	Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.5405
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Does Metabolic Syndrome or its Individual Components Affect Pain and Function in Knee Osteoarthritis Women?

Abourazzak, Fatima E / Talbi, Sofia / Lazrak, Faiza / Azzouzi, Hamida / Aradoini, Nassia / Keita, Salia / Errasfa, Mourad / Harzy, Taoufik

Current rheumatology reviews

2015 Volume 11, Issue 1, Page(s) 8–14

Abstract: Background: Current studies and research support the role of metabolic syndrome (MetS) in knee osteoarthritis (OA). However, few studies have focused on its impact on knee OA parameters. The aim of this study was to investigate if metabolic syndrome or ... ...

Abstract	Background: Current studies and research support the role of metabolic syndrome (MetS) in knee osteoarthritis (OA). However, few studies have focused on its impact on knee OA parameters. The aim of this study was to investigate if metabolic syndrome or its individual components affect the intensity of pain, functional disability, and radiographic severity in knee osteoarthritis women. Materials and methods: We conducted a cross sectional study including confirmed radiographic knee osteoarthritis according to Kellgren and Lawrence scale, with and without metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The two groups were compared for pain Visual Analogue Scale (VAS), Lequesne index, Womac function, and radiological grade after adjusting for significant covariates. Multiple regression analysis was used to identify the independent effects of each specific component for metabolic syndrome on knee osteoarthritis parameters. Results: One hundred thirty women were included. The mean age was 56.68 ±8.07 [34-75] years, and the mean BMI was 32.54±2.92 [23-37] kg/m2. The prevalence of metabolic syndrome was 48.5%. Women with and without metabolic syndrome had similar knee osteoarthritis parameters. However, accumulation of MetS components was associated with higher level of pain (OR = 3.7, CI = [1.5-5.9], p=0.001), independently of age and BMI. Multiple regression analyses showed, after adjusting for all covariates, that hyperglycemia had a positive impact on pain (p=0.009), waist circumference was positively associated with Lequesne index (p=0.04), high triglycerides level was significantly associated with increased pain (p=0.04) and higher Lequesne score (p=0.05), and Systolic blood pressure was positively correlated with Lequesne index (p=0.01). Conclusion: In addition to weight reduction, appropriate treatment of metabolic syndrome needs to become an important management strategy for knee pain and functional impairment.
Language	English
Publishing date	2015
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397111666150522093337
Database	MEDical Literature Analysis and Retrieval System OnLINE

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