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Article ; Online: A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes.

Coudy-Gandilhon, Cécile / Gueugneau, Marine / Chambon, Christophe / Taillandier, Daniel / Combaret, Lydie / Polge, Cécile / Millet, Guillaume Y / Féasson, Léonard / Béchet, Daniel

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master ...

Abstract	Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR).
MeSH term(s)	Aging/physiology ; Athletes ; Exercise/physiology ; Humans ; Middle Aged ; Muscle, Skeletal/physiology ; Physical Endurance/physiology
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073713
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Temporal regulation of transgene expression controlled by amino acid availability in human T cells.

Dougé, Aurore / Vituret, Cyrielle / Carraro, Valérie / Parry, Laurent / Coudy-Gandilhon, Cécile / Lemal, Richard / Combaret, Lydie / Maurin, Anne-Catherine / Averous, Julien / Jousse, Céline / Bay, Jacques-Olivier / Verrelle, Pierre / Fafournoux, Pierre / Bruhat, Alain / Rouzaire, Paul

HLA

2023 Volume 103, Issue 1, Page(s) e15252

Abstract: T cell therapy strategies, from allogeneic stem cell transplantation toward genetically-modified T cells infusion, develop powerful anti-tumor effects but are often accompanied by side effects and their efficacy remains sometimes to be improved. It ... ...

Abstract	T cell therapy strategies, from allogeneic stem cell transplantation toward genetically-modified T cells infusion, develop powerful anti-tumor effects but are often accompanied by side effects and their efficacy remains sometimes to be improved. It therefore appears important to provide a flexible and easily reversible gene expression regulation system to control T cells activity. We developed a gene expression regulation technology that exploits the physiological GCN2-ATF4 pathway's ability to induce gene expression in T cells in response to one essential amino acid deficiency. We first demonstrated the functionality of NUTRIREG in human T cells by transient expression of reporter genes. We then validated that NUTRIREG can be used in human T cells to transiently express a therapeutic gene such as IL-10. Overall, our results represent a solid basis for the promising use of NUTRIREG to regulate transgene expression in human T cells in a reversible way, and more generally for numerous preventive or curative therapeutic possibilities in cellular immunotherapy strategies.
MeSH term(s)	Humans ; Graft vs Host Disease/prevention & control ; Transplantation, Homologous ; Amino Acids ; Alleles ; Hematopoietic Stem Cell Transplantation/adverse effects ; T-Lymphocytes ; Transgenes
Chemical Substances	Amino Acids
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15252
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Article ; Online: A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes

Cécile Coudy-Gandilhon / Marine Gueugneau / Christophe Chambon / Daniel Taillandier / Lydie Combaret / Cécile Polge / Guillaume Y. Millet / Léonard Féasson / Daniel Béchet

International Journal of Molecular Sciences, Vol 23, Iss 3713, p

2022 Volume 3713

Abstract	Middle-aged and master endurance athletes exhibit similar physical performance and long-term muscle adaptation to aerobic exercise. Nevertheless, we hypothesized that the short-term plasticity of the skeletal muscle might be distinctly altered for master athletes when they are challenged by a single bout of prolonged moderate-intensity exercise. Six middle-aged (37Y) and five older (50Y) master highly-trained athletes performed a 24-h treadmill run (24TR). Vastus lateralis muscle biopsies were collected before and after the run and assessed for proteomics, fiber morphometry, intramyocellular lipid droplets (LD), mitochondrial oxidative activity, extracellular matrix (ECM), and micro-vascularisation. Before 24TR, muscle fiber type morphometry, intramyocellular LD, oxidative activity, ECM and micro-vascularisation were similar between master and middle-aged runners. For 37Y runners, 24TR was associated with ECM thickening, increased capillary-to-fiber interface, and an 89% depletion of LD in type-I fibers. In contrast, for 50Y runners, 24TR did not alter ECM and capillarization and poorly depleted LDs. Moreover, an impaired succinate dehydrogenase activity and functional class scoring of proteomes suggested reduced oxidative phosphorylation post-24TR exclusively in 50Y muscle. Collectively, our data support that middle-aged and master endurance athletes exhibit distinct transient plasticity in response to a single bout of ultra-endurance exercise, which may constitute early signs of muscle aging for master athletes.
Keywords	aging ; exercise ; skeletal muscle ; capillaries ; lipid droplets ; extracellular matrix ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization.

Deval, Christiane / Calonne, Julie / Coudy-Gandilhon, Cécile / Vazeille, Emilie / Bechet, Daniel / Polge, Cécile / Taillandier, Daniel / Attaix, Didier / Combaret, Lydie

International journal of molecular sciences

2020 Volume 21, Issue 10

Abstract: Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality ... ...

Abstract	Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy and recovery kinetics. We studied mitochondrial biogenesis, dynamic, movement along microtubules, and addressing to autophagy. Our data indicated that mitochondria quality control adapted differently to immobilization and remobilization in GA and TA muscles. Data showed i) a disruption of mitochondria dynamic that occurred earlier in the immobilized TA, ii) an overriding role of mitophagy that involved Parkin-dependent and/or independent processes during immobilization in the GA and during remobilization in the TA, and iii) increased mitochondria biogenesis during remobilization in both muscles. This strongly emphasized the need to consider several muscle groups to study the mechanisms involved in muscle atrophy and their ability to recover, in order to provide broad and/or specific clues for the development of strategies to maintain muscle mass and improve the health and quality of life of patients.
MeSH term(s)	Animals ; Male ; Mitochondria, Muscle/metabolism ; Mitophagy ; Motor Activity ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/metabolism ; Rats ; Rats, Wistar ; Restraint, Physical/adverse effects
Language	English
Publishing date	2020-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21103691
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Article ; Online: Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine.

Carraro, Valérie / Combaret, Lydie / Coudy-Gandilhon, Cécile / Parry, Laurent / Averous, Julien / Maurin, Anne-Catherine / Jousse, Céline / Voyard, Guillaume / Fafournoux, Pierre / Papet, Isabelle / Bruhat, Alain

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Chronic treatment with acetaminophen (APAP) induces cysteine (Cys) and glutathione (GSH) deficiency which leads to adverse metabolic effects including muscle atrophy. Mammalian cells respond to essential amino acid deprivation through the phosphorylation ...

Abstract	Chronic treatment with acetaminophen (APAP) induces cysteine (Cys) and glutathione (GSH) deficiency which leads to adverse metabolic effects including muscle atrophy. Mammalian cells respond to essential amino acid deprivation through the phosphorylation of the eukaryotic translation initiation factor 2α (eIF2α). Phosphorylated eIF2α leads to the recruitment of activating transcription factor 4 (ATF4) to specific CCAAT/enhancer-binding protein-ATF response element (CARE) located in the promoters of target genes. Our purpose was to study the activation of the eIF2α-ATF4 pathway in response to APAP-induced Cys deficiency, as well as the potential contribution of the eIF2α kinase GCN2 and the effect of dietary supplementation with Cys. Our results showed that chronic treatment with APAP activated both GCN2 and PERK eIF2α kinases and downstream target genes in the liver. Activation of the eIF2α-ATF4 pathway in skeletal muscle was accompanied by muscle atrophy even in the absence of GCN2. The dietary supplementation with cysteine reversed APAP-induced decreases in plasma-free Cys, liver GSH, muscle mass, and muscle GSH. Our new findings demonstrate that dietary Cys supplementation also reversed the APAP-induced activation of GCN2 and PERK and downstream ATF4-target genes in the liver.
MeSH term(s)	Acetaminophen/adverse effects ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Animals ; Cysteine/metabolism ; Dietary Supplements ; Eukaryotic Initiation Factor-2/metabolism ; Glutathione/metabolism ; Mammals/metabolism ; Muscular Atrophy/chemically induced ; Phosphorylation ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
Chemical Substances	Eukaryotic Initiation Factor-2 ; Activating Transcription Factor 4 (145891-90-3) ; Acetaminophen (362O9ITL9D) ; eIF-2 Kinase (EC 2.7.11.1) ; Glutathione (GAN16C9B8O) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2022-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137196
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Article ; Online: UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin.

Peris-Moreno, Dulce / Malige, Mélodie / Claustre, Agnès / Armani, Andrea / Coudy-Gandilhon, Cécile / Deval, Christiane / Béchet, Daniel / Fafournoux, Pierre / Sandri, Marco / Combaret, Lydie / Taillandier, Daniel / Polge, Cécile

Cells

2021 Volume 10, Issue 8

Abstract: The ubiquitin proteasome system (UPS) is the main player of skeletal muscle wasting, a common characteristic of many diseases (cancer, etc.) that negatively impacts treatment and life prognosis. Within the UPS, the E3 ligase MuRF1/TRIM63 targets for ... ...

Abstract	The ubiquitin proteasome system (UPS) is the main player of skeletal muscle wasting, a common characteristic of many diseases (cancer, etc.) that negatively impacts treatment and life prognosis. Within the UPS, the E3 ligase MuRF1/TRIM63 targets for degradation several myofibrillar proteins, including the main contractile proteins alpha-actin and myosin heavy chain (MHC). We previously identified five E2 ubiquitin-conjugating enzymes interacting with MuRF1, including UBE2L3/UbcH7, that exhibited a high affinity for MuRF1 (K
MeSH term(s)	Actins/metabolism ; Animals ; Cell Line ; Dexamethasone/pharmacology ; Histocompatibility Antigens Class II/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle Proteins/metabolism ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Protein Binding ; RNA Interference ; RNA, Small Interfering/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Conjugating Enzymes/antagonists & inhibitors ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Actins ; Histocompatibility Antigens Class II ; Muscle Proteins ; RNA, Small Interfering ; Tripartite Motif Proteins ; Dexamethasone (7S5I7G3JQL) ; Ube2l3 protein, mouse (EC 2.3.2.23) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Trim63 protein, mouse (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10081974
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men.

Gueugneau, Marine / Coudy-Gandilhon, Cécile / Chambon, Christophe / Verney, Julien / Taillandier, Daniel / Combaret, Lydie / Polge, Cécile / Walrand, Stéphane / Roche, Frédéric / Barthélémy, Jean-Claude / Féasson, Léonard / Béchet, Daniel

International journal of molecular sciences

2021 Volume 22, Issue 8

Abstract: 1) Background: Aging is associated with a progressive decline in muscle mass and function. Aging is also a primary risk factor for metabolic syndrome, which further alters muscle metabolism. However, the molecular mechanisms involved remain to be ... ...

Abstract	(1) Background: Aging is associated with a progressive decline in muscle mass and function. Aging is also a primary risk factor for metabolic syndrome, which further alters muscle metabolism. However, the molecular mechanisms involved remain to be clarified. Herein we performed omic profiling to decipher in muscle which dominating processes are associated with healthy aging and metabolic syndrome in old men. (2) Methods: This study included 15 healthy young, 15 healthy old, and 9 old men with metabolic syndrome. Old men were selected from a well-characterized cohort, and each vastus lateralis biopsy was used to combine global transcriptomic and proteomic analyses. (3) Results: Over-representation analysis of differentially expressed genes (ORA) and functional class scoring of pathways (FCS) indicated that healthy aging was mainly associated with upregulations of apoptosis and immune function and downregulations of glycolysis and protein catabolism. ORA and FCS indicated that with metabolic syndrome the dominating biological processes were upregulation of proteolysis and downregulation of oxidative phosphorylation. Proteomic profiling matched 586 muscle proteins between individuals. The proteome of healthy aging revealed modifications consistent with a fast-to-slow transition and downregulation of glycolysis. These transitions were reduced with metabolic syndrome, which was more associated with alterations in NADH/NAD
MeSH term(s)	Animals ; Glycolysis/genetics ; Glycolysis/physiology ; Humans ; Metabolic Syndrome/genetics ; Metabolic Syndrome/metabolism ; Muscle, Skeletal/metabolism ; Proteomics/methods ; Sarcopenia/genetics ; Sarcopenia/metabolism ; Transcriptome/genetics
Language	English
Publishing date	2021-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22084205
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Article ; Online: Mitophagy and Mitochondria Biogenesis Are Differentially Induced in Rat Skeletal Muscles during Immobilization and/or Remobilization

Christiane Deval / Julie Calonne / Cécile Coudy-Gandilhon / Emilie Vazeille / Daniel Bechet / Cécile Polge / Daniel Taillandier / Didier Attaix / Lydie Combaret

International Journal of Molecular Sciences, Vol 21, Iss 3691, p

2020 Volume 3691

Abstract	Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy and recovery kinetics. We studied mitochondrial biogenesis, dynamic, movement along microtubules, and addressing to autophagy. Our data indicated that mitochondria quality control adapted differently to immobilization and remobilization in GA and TA muscles. Data showed i) a disruption of mitochondria dynamic that occurred earlier in the immobilized TA, ii) an overriding role of mitophagy that involved Parkin-dependent and/or independent processes during immobilization in the GA and during remobilization in the TA, and iii) increased mitochondria biogenesis during remobilization in both muscles. This strongly emphasized the need to consider several muscle groups to study the mechanisms involved in muscle atrophy and their ability to recover, in order to provide broad and/or specific clues for the development of strategies to maintain muscle mass and improve the health and quality of life of patients.
Keywords	immobilization ; recovery ; mitophagy ; microtubules ; physical inactivity ; skeletal muscle ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice.

Bayle, Dominique / Coudy-Gandilhon, Cécile / Gueugneau, Marine / Castiglioni, Sara / Zocchi, Monica / Maj-Zurawska, Magdalena / Palinska-Saadi, Adriana / Mazur, André / Béchet, Daniel / Maier, Jeanette A

Nutrients

2021 Volume 13, Issue 7

Abstract: ... Chronic ... ...

Abstract	Chronic Mg
MeSH term(s)	Animals ; Cation Transport Proteins/metabolism ; Disease Models, Animal ; Energy Metabolism/genetics ; Homeostasis/genetics ; Magnesium/metabolism ; Magnesium Deficiency/genetics ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Signal Transduction/genetics
Chemical Substances	Cation Transport Proteins ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072169
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Article ; Online: Association Between Physical Activity, Quadriceps Muscle Performance, and Biological Characteristics of Very Old Men and Women.

Varesco, Giorgio / Coudy-Gandilhon, Cécile / Lapole, Thomas / Decourt, Alice / Gueugneau, Marine / Barthélémy, Jean-Claude / Roche, Frédéric / Bechet, Daniel / Féasson, Léonard / Rozand, Vianney

The journals of gerontology. Series A, Biological sciences and medical sciences

2021 Volume 77, Issue 1, Page(s) 47–54

Abstract: The aim of the study was to evaluate the association between physical activity, knee extensors (KE) performance (ie, isometric strength and fatigability), and biological parameters (ie, muscle structural, microvascular, and metabolic properties) in ... ...

Abstract	The aim of the study was to evaluate the association between physical activity, knee extensors (KE) performance (ie, isometric strength and fatigability), and biological parameters (ie, muscle structural, microvascular, and metabolic properties) in healthy very old men and women. Thirty very old adults (82 ± 1 years, 15 women) performed an isometric Quadriceps Intermittent Fatigue (QIF) test for the assessment of KE maximal force, total work (index of absolute performance), and fatigability. Muscle biopsies from the vastus lateralis muscle were collected to assess muscle fibers type and morphology, microvasculature, and enzymes activity. Correlation analyses were used to investigate the relationships between physical activity (steps/day, actimetry), KE performance, and biological data for each sex separately. Men, compared to women, showed greater total work at the QIF test (44 497 ± 8 629 Ns vs 26 946 ± 4 707 Ns; p < .001). Steps per day were correlated with total work only for women (r = 0.73, p = .011). In men, steps per day were correlated with the percentage (r = 0.57, p = .033), shape factor (r = 0.75, p = .002), and capillary tortuosity of type IIX fibers (r = 0.59, p = .035). No other relevant correlations were observed for men or women between steps per day and biological parameters. Physical activity level was positively associated with the capacity of very old women to perform a fatiguing test, but not maximal force production capacity of the KE. Physical activity of very old men was not correlated with muscle performance. We suggest that very old women could be at higher risk of autonomy loss and increasing the steps per day count could provide a sufficient stimulus for adaptations in less active women.
MeSH term(s)	Exercise/physiology ; Female ; Humans ; Isometric Contraction/physiology ; Knee/physiology ; Male ; Muscle Fatigue/physiology ; Muscle, Skeletal/physiology ; Quadriceps Muscle/physiology
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glab239
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