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Article ; Online: Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.

Levy, Benjamin E / Oldenburg, Amy L

2022 Volume 67, Issue 15

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Acoustics ; Humans ; Phantoms, Imaging ; Spectrum Analysis ; Thrombosis ; Ultrasonography/methods
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac7ea5
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Article ; Online: All-fiber probes for endoscopic optical coherence tomography of the large airways.

Balakrishnan, Santosh / Oldenburg, Amy L

Applied optics

2021 Volume 60, Issue 22, Page(s) 6385–6392

Abstract: Endoscopic optical coherence tomography of large airways poses unique challenges. A hybrid lens is described that consists of a section of coreless fiber and graded index fiber (GIF), followed by a ball lens section. This design produces low numerical ... ...

Abstract	Endoscopic optical coherence tomography of large airways poses unique challenges. A hybrid lens is described that consists of a section of coreless fiber and graded index fiber (GIF), followed by a ball lens section. This design produces low numerical aperture beams better suited for large airway imaging. The performance of this lens is compared against conventional GIF and ball lens designs. Forward- and side-viewing probes were modeled, fabricated, and tested. The impact of a sheath on the beam profile was also investigated. Probes with working distances larger than 10 mm and depth-of-focus exceeding 12 mm are demonstrated with the proposed design.
MeSH term(s)	Airway Management/instrumentation ; Endoscopy/instrumentation ; Equipment Design ; Humans ; Lenses ; Normal Distribution ; Optical Fibers ; Refractometry ; Tomography, Optical Coherence/instrumentation
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.431010
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Article ; Online: Single Magnetic Particle Motion in Magnetomotive Ultrasound: An Analytical Model and Experimental Validation.

Levy, Benjamin E / Oldenburg, Amy L

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

2021 Volume 68, Issue 8, Page(s) 2635–2644

Abstract: Magnetomotive Ultrasound (MMUS) is an emerging imaging modality, in which magnetic nanoparticles (MNPs) are used as contrast agents. MNPs are driven by a time-varying magnetic force, and the resulting movement of the surrounding tissue is detected with a ...

Abstract	Magnetomotive Ultrasound (MMUS) is an emerging imaging modality, in which magnetic nanoparticles (MNPs) are used as contrast agents. MNPs are driven by a time-varying magnetic force, and the resulting movement of the surrounding tissue is detected with a signal processing algorithm. However, there is currently no analytical model to quantitatively predict this magnetically-induced displacement. Toward the goal of predicting motion due to forces on the distribution of MNPs, in this work, a model originally derived from the Navier-Stokes equation for the motion of a single magnetic particle subject to a magnetic gradient force is presented and validated. Displacement amplitudes for a spatially inhomogeneous and temporally sinusoidal force were measured as a function of force amplitude and Young's modulus, and the predicted linear and inverse relationships were confirmed in gelatin phantoms, respectively, with three out of four data sets exhibiting R
MeSH term(s)	Contrast Media ; Magnetic Phenomena ; Magnetite Nanoparticles ; Phantoms, Imaging ; Ultrasonography
Chemical Substances	Contrast Media ; Magnetite Nanoparticles
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1525-8955
ISSN (online)	1525-8955
DOI	10.1109/TUFFC.2021.3072867
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Article ; Online: In situ

Oeler, Kelsey J / Blackmon, Richard L / Kreda, Silvia M / Robinson, Taylor / Ghelardini, Melanie / Chapman, Brian S / Tracy, Joseph / Hill, David B / Oldenburg, Amy L

Journal of biomedical optics

2024 Volume 29, Issue 4, Page(s) 46004

Abstract: Significance: Assessing the nanostructure of polymer solutions and biofluids is broadly useful for understanding drug delivery and disease progression and for monitoring therapy.: Aim: Our objective is to quantify bronchial mucus solids concentration ...

Abstract	Significance: Assessing the nanostructure of polymer solutions and biofluids is broadly useful for understanding drug delivery and disease progression and for monitoring therapy. Aim: Our objective is to quantify bronchial mucus solids concentration (wt. %) during hypertonic saline (HTS) treatment Approach: Using PS-OCT, we quantified GNR translational ( Results: In polymer solutions and mucus, Conclusions: The extended dynamic range afforded by simultaneous measurement of
MeSH term(s)	Tomography, Optical Coherence/methods ; Humans ; Nanotubes/chemistry ; Gold/chemistry ; Mucus/chemistry ; Mucus/metabolism ; Diffusion ; Bronchi/diagnostic imaging ; Epithelial Cells/chemistry ; Epithelial Cells/metabolism ; Saline Solution, Hypertonic/pharmacology ; Saline Solution, Hypertonic/chemistry ; Cells, Cultured
Chemical Substances	Gold (7440-57-5) ; Saline Solution, Hypertonic
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1309154-2
ISSN	1560-2281 ; 1083-3668
ISSN (online)	1560-2281
ISSN	1083-3668
DOI	10.1117/1.JBO.29.4.046004
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Article ; Online: Magnetic Alignment for Plasmonic Control of Gold Nanorods Coated with Iron Oxide Nanoparticles.

Rizvi, Mehedi H / Wang, Ruosong / Schubert, Jonas / Crumpler, William D / Rossner, Christian / Oldenburg, Amy L / Fery, Andreas / Tracy, Joseph B

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 40, Page(s) e2203366

Abstract: Plasmonic nanoparticles that can be manipulated with magnetic fields are of interest for advanced optical applications, diagnostics, imaging, and therapy. Alignment of gold nanorods yields strong polarization-dependent extinction, and use of magnetic ... ...

Abstract	Plasmonic nanoparticles that can be manipulated with magnetic fields are of interest for advanced optical applications, diagnostics, imaging, and therapy. Alignment of gold nanorods yields strong polarization-dependent extinction, and use of magnetic fields is appealing because they act through space and can be quickly switched. In this work, cationic polyethyleneimine-functionalized superparamagnetic Fe
MeSH term(s)	Gold/chemistry ; Magnetic Fields ; Magnetic Iron Oxide Nanoparticles ; Nanotubes/chemistry ; Polyethyleneimine ; Serum Albumin, Bovine
Chemical Substances	Serum Albumin, Bovine (27432CM55Q) ; Gold (7440-57-5) ; Polyethyleneimine (9002-98-6)
Language	English
Publishing date	2022-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202203366
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Article ; Online: Diffusion tensor optical coherence tomography.

Marks, Daniel L / Blackmon, Richard L / Oldenburg, Amy L

Physics in medicine and biology

2018 Volume 63, Issue 2, Page(s) 25007

Abstract: In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is ... ...

Abstract	In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the sub-resolution motion of Brownian particles as they are constrained by tissue macromolecules, it has the potential to quantify nanoporous anisotropic tissue structure at micrometer resolution as relevant to extracellular matrices, neurons, and capillaries. Here we derive the principles of DT-OCT, relating the detected optical signal from a minimum of six probe beams with the six unique diffusion tensor and three flow vector components. The optimal geometry of the probe beams is determined given a finite numerical aperture, and a high-speed hardware implementation is proposed. Finally, Monte Carlo simulations are employed to assess the ability of the proposed DT-OCT system to quantify anisotropic diffusion of nanoparticles in a collagen matrix, an extracellular constituent that is known to become highly aligned during tumor development.
MeSH term(s)	Anisotropy ; Cells, Cultured ; Collagen/chemistry ; Diffusion Tensor Imaging/methods ; Extracellular Matrix/chemistry ; Fibroblasts/cytology ; Humans ; Monte Carlo Method
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2018-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/aa9cfe
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Article ; Online: Inversion of displacement fields to quantify the magnetic particle distribution in homogeneous elastic media from magnetomotive ultrasound.

Thapa, Diwash / Levy, Benjamin E / Marks, Daniel L / Oldenburg, Amy L

Physics in medicine and biology

2019 Volume 64, Issue 12, Page(s) 125019

Abstract: Magnetomotive ultrasound (MMUS) contrasts superparamagnetic iron-oxide nanoparticles (SPIOs) that undergo submicrometer-scale displacements in response to a magnetic gradient force applied to an imaging sample. Typically, MMUS signals are defined in a ... ...

Abstract	Magnetomotive ultrasound (MMUS) contrasts superparamagnetic iron-oxide nanoparticles (SPIOs) that undergo submicrometer-scale displacements in response to a magnetic gradient force applied to an imaging sample. Typically, MMUS signals are defined in a way that is proportional to the medium displacement, rendering an indirect measure of the density distribution of SPIOs embedded within. Displacement-based MMUS, however, suffers from 'halo effects' that extend into regions without SPIOs due to their inherent mechanical coupling with the medium. To reduce such effects and to provide a more accurate representation of the SPIO density distribution, we propose a model-based inversion of MMUS displacement fields by reconstructing the body force distribution. Displacement fields are modelled using the static Navier-Cauchy equation for linear, homogeneous, and isotropic media, and the body force fields are, in turn, reconstructed by minimizing a regularized least-squares error functional between the modelled and the measured displacement fields. This reconstruction, when performed on displacement fields of two tissue-mimicking phantoms with cuboidal SPIO-laden inclusions, improved the range of errors in measured heights and widths of the inclusions from 54%-282% pre-inversion to-15%-20%. Likewise, the post-inversion contrast to noise ratios (CNRs) of the images were significantly larger than displacement-derived CNRs alone (p = 0.0078, Wilcoxon signed rank test). Qualitatively, it was found that inversion ameliorates halo effects and increases overall detectability of the inclusion. These findings highlight the utility of model-based inversion as a tool for both signal processing and accurate characterization of the number density distribution of SPIOs in magnetomotive imaging.
MeSH term(s)	Contrast Media ; Dextrans/chemistry ; Elastic Modulus/physiology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Phenomena ; Magnetic Resonance Imaging/methods ; Magnetite Nanoparticles/chemistry ; Phantoms, Imaging ; Signal Processing, Computer-Assisted/instrumentation ; Ultrasonography/instrumentation ; Ultrasonography/methods
Chemical Substances	Contrast Media ; Dextrans ; Magnetite Nanoparticles ; ferumoxides (G6N3J05W84)
Language	English
Publishing date	2019-06-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab1f2b
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Article: Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility.

Yang, Lin / Yu, Xiao / Fuller, Ashley M / Troester, Melissa A / Oldenburg, Amy L

Quantitative imaging in medicine and surgery

2020 Volume 10, Issue 1, Page(s) 76–85

Abstract: Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label- ...

Abstract	Background: An understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models. Methods: OCT-SFS is sensitive to relatively high speed (~0.16-8 µm/min) motions of subcellular light scattering components occurring over short (~2-114 s) time scales, termed "intracellular motility." In this study, OCT speckle fluctuation spectra are quantified by two metrics: the intracellular motility amplitude, Results: In this work, we observed a significant decrease in both Conclusions: OCT-SFS revealed cell line-specific response patterns, in terms of intracellular motility, to different motility suppression mechanisms. This provides a foundation for future OCT-SFS studies of longitudinal responses of the mammary gland in toxicology and drug research.
Language	English
Publishing date	2020-01-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims.2019.08.15
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Article ; Online: Epithelial p53 Status Modifies Stromal-Epithelial Interactions During Basal-Like Breast Carcinogenesis.

Fuller, Ashley M / Yang, Lin / Hamilton, Alina M / Pirone, Jason R / Oldenburg, Amy L / Troester, Melissa A

Journal of mammary gland biology and neoplasia

2021 Volume 26, Issue 2, Page(s) 89–99

Abstract: Basal-like breast cancers (BBC) exhibit subtype-specific phenotypic and transcriptional responses to stroma, but little research has addressed how stromal-epithelial interactions evolve during early BBC carcinogenesis. It is also unclear how common ... ...

Abstract	Basal-like breast cancers (BBC) exhibit subtype-specific phenotypic and transcriptional responses to stroma, but little research has addressed how stromal-epithelial interactions evolve during early BBC carcinogenesis. It is also unclear how common genetic defects, such as p53 mutations, modify these stromal-epithelial interactions. To address these knowledge gaps, we leveraged the MCF10 progression series of breast cell lines (MCF10A, MCF10AT1, and MCF10DCIS) to develop a longitudinal, tissue-contextualized model of p53-deficient, pre-malignant breast. Acinus asphericity, a morphogenetic correlate of cell invasive potential, was quantified with optical coherence tomography imaging, and gene expression microarrays were performed to identify transcriptional changes associated with p53 depletion and stromal context. Co-culture with stromal fibroblasts significantly increased the asphericity of acini derived from all three p53-deficient, but not p53-sufficient, cell lines, and was associated with the upregulation of 38 genes. When considered as a multigene score, these genes were upregulated in co-culture models of invasive BBC with increasing stromal content, as well as in basal-like relative to luminal breast cancers in two large human datasets. Taken together, stromal-epithelial interactions during early BBC carcinogenesis are dependent upon epithelial p53 status, and may play important roles in the acquisition of an invasive morphologic phenotype.
MeSH term(s)	Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Transformation, Neoplastic/pathology ; Coculture Techniques ; Epithelial Cells/pathology ; Female ; Fibroblasts ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Neoplasm Invasiveness/pathology ; Stromal Cells/pathology ; Tumor Suppressor Protein p53/deficiency ; Tumor Suppressor Protein p53/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1327345-0
ISSN	1573-7039 ; 1083-3021
ISSN (online)	1573-7039
ISSN	1083-3021
DOI	10.1007/s10911-020-09477-w
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Article ; Online: Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.

Bu, Ruofei / Balakrishnan, Santosh / Iftimia, Nicusor / Price, Hillel / Zdanski, Carlton / Mitran, Sorin / Oldenburg, Amy L

IEEE transactions on bio-medical engineering

2021 Volume 68, Issue 8, Page(s) 2360–2367

Abstract: Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. ... ...

Abstract	Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.
MeSH term(s)	Animals ; Burns ; Elasticity Imaging Techniques ; Lung Diseases ; Swine ; Tomography, Optical Coherence ; Trachea
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2020.3037288
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