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Article ; Online: Comment on: 'Blood does not buy goodwill: allowing culling increases poaching of a large carnivore'.

Pepin, Kim M / Kay, Shannon L / Davis, Amy J

2017 Volume 284, Issue 1851

MeSH term(s)	Animals ; Conservation of Natural Resources ; Endangered Species
Language	English
Publishing date	2017-03-22
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2016.1459
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Zs.A 1364: Show issues

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Article ; Online: Magnetic resonance elastography of the liver: everything you need to know to get started.

Pepin, Kay M / Welle, Christopher L / Guglielmo, Flavius F / Dillman, Jonathan R / Venkatesh, Sudhakar K

Abdominal radiology (New York)

2021 Volume 47, Issue 1, Page(s) 94–114

Abstract: Magnetic resonance elastography (MRE) of the liver has emerged as the non-invasive standard for the evaluation of liver fibrosis in chronic liver diseases (CLDs). The utility of MRE in the evaluation of different CLD in both adults and children has been ... ...

Abstract	Magnetic resonance elastography (MRE) of the liver has emerged as the non-invasive standard for the evaluation of liver fibrosis in chronic liver diseases (CLDs). The utility of MRE in the evaluation of different CLD in both adults and children has been demonstrated in several studies, and MRE has been recommended by several clinical societies. Consequently, the clinical indications for evaluation of CLD with MRE have increased, and MRE is currently used as an add-on test during routine liver MRI studies or as a standalone test. To meet the increasing clinical demand, MRE is being installed in many academic and private practice imaging centers. There is a need for a comprehensive practical guide to help these practices to deliver high-quality liver MRE studies as well as troubleshoot the common issues with MRE to ensure smooth running of the service. This comprehensive clinical practice review summarizes the indications and provides an overview on why to use MRE, technical requirements, system set-up, patient preparation, acquiring the data, and interpretation.
MeSH term(s)	Adult ; Child ; Elasticity Imaging Techniques/methods ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/pathology ; Liver Diseases/diagnostic imaging ; Liver Diseases/pathology ; Liver Function Tests ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-021-03324-0
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Zs.A 1262: Show issues

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Article ; Online: Quantifying Tumor Stiffness With Magnetic Resonance Elastography: The Role of Mechanical Properties for Detection, Characterization, and Treatment Stratification in Oncology.

Pepin, Kay M / McGee, Kiaran P

Topics in magnetic resonance imaging : TMRI

2018 Volume 27, Issue 5, Page(s) 353–362

Abstract: The viscoelastic properties of tissue are significantly altered with the development of tumors and these alterations can be assessed with magnetic resonance elastography (MRE). Accurate detection and characterization of malignant and benign lesions can ... ...

Abstract	The viscoelastic properties of tissue are significantly altered with the development of tumors and these alterations can be assessed with magnetic resonance elastography (MRE). Accurate detection and characterization of malignant and benign lesions can be obtained by quantifying tumor stiffness, improving the specificity and diagnostic accuracy of conventional magnetic resonance imaging. Furthermore, MRE can be used to stratify patients for treatment based on risk of normal tissue toxicity and surgical considerations including consistency and adherence of the tumor to surrounding structures. MRE is a reliable reproducible technique demonstrated in studies that include both patients with cancer and normal volunteers, and an average technical failure rate of <1%. The addition of MRE into a multiparametric magnetic resonance imaging assessment may improve the diagnosis and treatment of cancer.
MeSH term(s)	Elasticity ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Reproducibility of Results ; Sensitivity and Specificity ; Viscosity
Language	English
Publishing date	2018-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1112716-8
ISSN	1536-1004 ; 0899-3459
ISSN (online)	1536-1004
ISSN	0899-3459
DOI	10.1097/RMR.0000000000000181
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Article ; Online: Quantitative Musculoskeletal Tumor Imaging.

Howe, B Matthew / Broski, Stephen M / Littrell, Laurel A / Pepin, Kay M / Wenger, Doris E

Seminars in musculoskeletal radiology

2020 Volume 24, Issue 4, Page(s) 428–440

Abstract: The role of quantitative magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) techniques continues to grow and evolve in the evaluation of musculoskeletal tumors. In this review we discuss the MRI quantitative ... ...

Abstract	The role of quantitative magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) techniques continues to grow and evolve in the evaluation of musculoskeletal tumors. In this review we discuss the MRI quantitative techniques of volumetric measurement, chemical shift imaging, diffusion-weighted imaging, elastography, spectroscopy, and dynamic contrast enhancement. We also review quantitative PET techniques in the evaluation of musculoskeletal tumors, as well as virtual surgical planning and three-dimensional printing.
MeSH term(s)	Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/therapy ; Contrast Media ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Muscle Neoplasms/diagnostic imaging ; Muscle Neoplasms/therapy ; Positron-Emission Tomography/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1360919-1
ISSN	1098-898X ; 1089-7860
ISSN (online)	1098-898X
ISSN	1089-7860
DOI	10.1055/s-0040-1708825
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Zs.A 4887: Show issues

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Article ; Online: Association of breast cancer risk, density, and stiffness: global tissue stiffness on breast MR elastography (MRE).

Patel, Bhavika K / Pepin, Kay / Brandt, Kathy R / Mazza, Gina L / Pockaj, Barbara A / Chen, Jun / Zhou, Yuxiang / Northfelt, Donald W / Anderson, Karen / Kling, Juliana M / Vachon, Celine M / Swanson, Kristin R / Nikkhah, Mehdi / Ehman, Richard

Breast cancer research and treatment

2022 Volume 194, Issue 1, Page(s) 79–89

Abstract: Purpose: Quantify in vivo biomechanical tissue properties in various breast densities and in average risk and high-risk women using Magnetic Resonance Imaging (MRI)/MRE and examine the association between breast biomechanical properties and cancer risk ... ...

Abstract	Purpose: Quantify in vivo biomechanical tissue properties in various breast densities and in average risk and high-risk women using Magnetic Resonance Imaging (MRI)/MRE and examine the association between breast biomechanical properties and cancer risk based on patient demographics and clinical data. Methods: Patients with average risk or high-risk of breast cancer underwent 3.0 T breast MR imaging and elastography. Breast parenchymal enhancement (BPE), density (from most recent mammogram), stiffness, elasticity, and viscosity were recorded. Within each breast density group (non-dense versus dense), stiffness, elasticity, and viscosity were compared across risk groups (average versus high). Separately for stiffness, elasticity, and viscosity, a multivariable logistic regression model was used to evaluate whether the MRE parameter predicted risk status after controlling for clinical factors. Results: 50 average risk and 86 high-risk patients were included. Risk groups were similar in age, density, and menopausal status. Among patients with dense breasts, mean stiffness, elasticity, and viscosity were significantly higher in high-risk patients (N = 55) compared to average risk patients (N = 34; all p < 0.001). Stiffness remained a significant predictor of risk status (OR = 4.26, 95% CI [1.96, 9.25]) even after controlling for breast density, BPE, age, and menopausal status. Similar results were seen for elasticity and viscosity. Conclusion: A structurally based, quantitative biomarker of tissue stiffness obtained from MRE is associated with differences in breast cancer risk in dense breasts. Tissue stiffness could provide a novel prognostic marker to help identify high-risk women with dense breasts who would benefit from increased surveillance and/or risk reduction measures.
MeSH term(s)	Breast/diagnostic imaging ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/epidemiology ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-04-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06607-2
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Zs.A 1655: Show issues

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Article ; Online: Premarket Approval Through the 510(k) Process: Lessons from the Translation Process of Magnetic Resonance Elastography.

Aponte Ortiz, Jaime A / Konik, Ewa / Eckert, Elizabeth C / Pepin, Kay M / Greenberg-Worisek, Alexandra

Clinical and translational science

2018 Volume 11, Issue 5, Page(s) 447–449

MeSH term(s)	Device Approval ; Elasticity Imaging Techniques ; Humans ; Inventions ; Magnetic Resonance Imaging ; Translational Medical Research ; United States ; United States Food and Drug Administration
Language	English
Publishing date	2018-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.12581
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Article: Quantitative Musculoskeletal Tumor Imaging

Howe, B Matthew / Broski, Stephen M. / Littrell, Laurel A. / Pepin, Kay M. / Wenger, Doris E.

Seminars in Musculoskeletal Radiology

(Advanced Quantitative MSK Imaging)

2020 Volume 24, Issue 04, Page(s) 428–440

Series title	Advanced Quantitative MSK Imaging
Abstract	The role of quantitative magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) techniques continues to grow and evolve in the evaluation of musculoskeletal tumors. In this review we discuss the MRI quantitative techniques of volumetric measurement, chemical shift imaging, diffusion-weighted imaging, elastography, spectroscopy, and dynamic contrast enhancement. We also review quantitative PET techniques in the evaluation of musculoskeletal tumors, as well as virtual surgical planning and three-dimensional printing.
Keywords	sarcoma ; quantitative ; magnetic resonance imaging ; positron emission tomography/computed tomography
Language	English
Publishing date	2020-08-01
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1360919-1
ISSN	1098-898X ; 1089-7860
ISSN (online)	1098-898X
ISSN	1089-7860
DOI	10.1055/s-0040-1708825
Database	Thieme publisher's database

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Article: Evaluation of Pretreatment Magnetic Resonance Elastography for the Prediction of Radiation-Induced Liver Disease.

Mullikin, Trey C / Pepin, Kay M / Evans, Jaden E / Venkatesh, Sudhakar K / Ehman, Richard L / Merrell, Kenneth W / Haddock, Michael G / Harmsen, William S / Herman, Michael G / Hallemeier, Christopher L

Advances in radiation oncology

2021 Volume 6, Issue 6, Page(s) 100793

Abstract: Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients ... ...

Abstract	Purpose: Magnetic resonance (MR) elastography (E) is a noninvasive technique for quantifying liver stiffness (LS) for fibrosis. This study evaluates whether LS is associated with risk of developing radiation-induced liver disease (RILD) in patients receiving liver-directed radiation therapy (RT). Methods and materials: Based on prior studies, LS ≤3 kPa was considered normal and LS >3.0 kPa as representing fibrosis. RILD was defined as an increase in Child-Pugh (CP) score of ≥2 from baseline within 1 year of RT. Univariate and multivariate Cox models were used to assess correlation. Results: One hundred two patients, 51 with primary liver tumors and 51 with liver metastases, were identified with sufficient follow-up. In univariate models, pre-RT LS >3.0 kPa (hazard ratio [HR] 4.9; 95% confidence interval [CI], 1.6-14; Conclusions: Elevated pre-RT LS is associated with an increased risk of RILD in patients receiving liver-directed RT.
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2021.100793
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Article ; Online: Magnetic resonance elastography (MRE) in cancer: Technique, analysis, and applications.

Pepin, Kay M / Ehman, Richard L / McGee, Kiaran P

Progress in nuclear magnetic resonance spectroscopy

2015 Volume 90-91, Page(s) 32–48

Abstract: Tissue mechanical properties are significantly altered with the development of cancer. Magnetic resonance elastography (MRE) is a noninvasive technique capable of quantifying tissue mechanical properties in vivo. This review describes the basic ... ...

Abstract	Tissue mechanical properties are significantly altered with the development of cancer. Magnetic resonance elastography (MRE) is a noninvasive technique capable of quantifying tissue mechanical properties in vivo. This review describes the basic principles of MRE and introduces some of the many promising MRE methods that have been developed for the detection and characterization of cancer, evaluation of response to therapy, and investigation of the underlying mechanical mechanisms associated with malignancy.
MeSH term(s)	Animals ; Elasticity Imaging Techniques/methods ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Neoplasms/physiopathology
Language	English
Publishing date	2015-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	209325-x
ISSN	1873-3301 ; 0079-6565
ISSN (online)	1873-3301
ISSN	0079-6565
DOI	10.1016/j.pnmrs.2015.06.001
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Zs.A 2654: Show issues

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Article ; Online: Evaluating wildlife-cattle contact rates to improve the understanding of dynamics of bovine tuberculosis transmission in Michigan, USA.

Lavelle, Michael J / Kay, Shannon L / Pepin, Kim M / Grear, Daniel A / Campa, Henry / VerCauteren, Kurt C

Preventive veterinary medicine

2016 Volume 135, Page(s) 28–36

Abstract: Direct and indirect contacts among individuals drive transmission of infectious disease. When multiple interacting species are susceptible to the same pathogen, risk assessment must include all potential host species. Bovine tuberculosis (bTB) is an ... ...

Abstract	Direct and indirect contacts among individuals drive transmission of infectious disease. When multiple interacting species are susceptible to the same pathogen, risk assessment must include all potential host species. Bovine tuberculosis (bTB) is an example of a disease that can be transmitted among several wildlife species and to cattle, although the potential role of several wildlife species in spillback to cattle remains unclear. To better understand the complex network of contacts and factors driving disease transmission, we fitted proximity logger collars to beef and dairy cattle (n=37), white-tailed deer (Odocoileus virginianus; n=29), raccoon (Procyon lotor; n=53), and Virginia opossum (Didelphis virginiana; n=79) for 16 months in Michigan's Lower Peninsula, USA. We determined inter- and intra-species direct and indirect contact rates. Data on indirect contact was calculated when collared animals visited stationary proximity loggers placed at cattle feed and water resources. Most contact between wildlife species and cattle was indirect, with the highest contact rates occurring between raccoons and cattle during summer and fall. Nearly all visits (>99%) to cattle feed and water sources were by cattle, whereas visitation to stored cattle feed was dominated by deer and raccoon (46% and 38%, respectively). Our results suggest that indirect contact resulting from wildlife species visiting cattle-related resources could pose a risk of disease transmission to cattle and deserves continued attention with active mitigation.
MeSH term(s)	Animal Distribution ; Animals ; Animals, Wild ; Cattle ; Deer ; Didelphis ; Disease Reservoirs/veterinary ; Michigan ; Mycobacterium bovis/physiology ; Raccoons ; Tuberculosis, Bovine/microbiology ; Tuberculosis, Bovine/transmission
Language	English
Publishing date	2016-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	43399-8
ISSN	1873-1716 ; 0167-5877
ISSN (online)	1873-1716
ISSN	0167-5877
DOI	10.1016/j.prevetmed.2016.10.009
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