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  1. Book ; Online: Was hat der Landwirth in Preussen zu thun, um auch unter den heutigen Umständen zu bestehen und die Zinsen seiner Gläubiger zu berichtigen?

    Manitius, Karl Ludwig / Schultz, Daniel Friedrich

    Geschrieben im Octobermonat 1813

    (Digitale Sammlungen der ZB MED - Informationszentrum Lebenswissenschaften)

    2020  

    Title variant Was hat der Landwirt in Preußen zu tun, um auch unter den heutigen Umständen zu bestehen und die Zinsen seiner Gläubiger zu berichtigen?
    Series title Digitale Sammlungen der ZB MED - Informationszentrum Lebenswissenschaften
    Language German
    Size 1 Online-Ressource (43 Seiten)
    Publisher ZB MED - Informationszentrum Lebenswissenschaften
    Publishing place Köln
    Publishing country XA-DXDE
    Document type Book ; Online
    Note Name des Verfassers ermittelt
    HBZ-ID CT002017513
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Memantine Use and Cognitive Decline in Huntington's Disease: An Enroll-HD Study.

    Ogilvie, Amy C / Schultz, Jordan L

    Movement disorders clinical practice

    2023  Volume 10, Issue 7, Page(s) 1120–1125

    Abstract: Background: Memantine is an : Objective: To assess the effectiveness of memantine on the trajectory of cognitive decline in individuals with manifest HD.: Methods: Using participants from the Enroll-HD study, the primary analysis compared ... ...

    Abstract Background: Memantine is an
    Objective: To assess the effectiveness of memantine on the trajectory of cognitive decline in individuals with manifest HD.
    Methods: Using participants from the Enroll-HD study, the primary analysis compared trajectories in cognition over a 5-year period using linear mixed effect models of prevalent and incident memantine users who were propensity-score-matched with non-users on measures of disease progression and demographics.
    Results: In the primary analysis there were no significant differences in the trajectories between memantine users and non-users on any primary outcomes of interest.
    Conclusions: Memantine use was not associated with any clinical benefit for individuals with manifest HD. Further studies are warranted to assess the impact of memantine on clinical outcomes in HD.
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unravelling the role of huntingtin: from neurodevelopment to neurodegeneration.

    Schultz, Jordan L / Neema, Mohit / Nopoulos, Peg C

    Brain : a journal of neurology

    2023  Volume 146, Issue 11, Page(s) 4408–4410

    MeSH term(s) Humans ; Huntington Disease/genetics ; Neurons ; Nerve Tissue Proteins/genetics
    Chemical Substances Nerve Tissue Proteins
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.26: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A method for isolating contractile smooth muscle cells from cryopreserved tissue.

    Schultz, Matheus L C / Seth, Pranjal / Kachmar, Linda / Ijpma, Gijs / Lauzon, Anne-Marie

    American journal of physiology. Cell physiology

    2024  Volume 326, Issue 3, Page(s) C990–C998

    Abstract: Multiple techniques have been developed to isolate contractile smooth muscle cells (SMCs) from tissues with varying degrees of success. However, most of these approaches rely on obtaining fresh tissue, which poses logistical challenges. In the present ... ...

    Abstract Multiple techniques have been developed to isolate contractile smooth muscle cells (SMCs) from tissues with varying degrees of success. However, most of these approaches rely on obtaining fresh tissue, which poses logistical challenges. In the present study, we introduce a novel protocol for isolating contractile SMCs from cryopreserved smooth muscle (SM) tissue, thereby enhancing experimental efficiency. This protocol yields abundant viable, spindle-shaped, contractile SMCs that closely resemble those obtained from fresh samples. By analyzing the expression of contractile proteins, we demonstrate that both the isolated SMCs from cryopreserved tissue represent more accurately fresh SM tissue compared with cultured SMCs. Moreover, we demonstrate the importance of a brief incubation step of the tissue in culture medium before cell dissociation to achieve contractile SMCs. Finally, we provide a concise overview of our protocol optimization efforts, along with a summary of previously published methods, which could be valuable for the development of similar protocols for other species.
    MeSH term(s) Muscle Contraction ; Myocytes, Smooth Muscle/metabolism ; Muscle, Smooth/metabolism ; Phenotype ; Contractile Proteins/genetics ; Contractile Proteins/metabolism ; Cells, Cultured ; Cell Differentiation/genetics
    Chemical Substances Contractile Proteins
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00442.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Single DNA Point Mutation Leads to the Formation of a Cysteine-Tyrosine Crosslink in the Cysteine Dioxygenase from

    Schultz, Rebecca L / Sabat, Grzegorz / Fox, Brian G / Brunold, Thomas C

    Biochemistry

    2023  Volume 62, Issue 12, Page(s) 1964–1975

    Abstract: Cysteine dioxygenase (CDO) is a non-heme iron-containing enzyme that catalyzes the oxidation of cysteine (Cys) to cysteine sulfinic acid (CSA). Crystal structures of eukaryotic CDOs revealed the presence of an unusual crosslink between the sulfur of a ... ...

    Abstract Cysteine dioxygenase (CDO) is a non-heme iron-containing enzyme that catalyzes the oxidation of cysteine (Cys) to cysteine sulfinic acid (CSA). Crystal structures of eukaryotic CDOs revealed the presence of an unusual crosslink between the sulfur of a cysteine residue (C93 in
    MeSH term(s) Animals ; Mice ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Cysteine/genetics ; Cysteine Dioxygenase/chemistry ; Cysteine Dioxygenase/genetics ; Kinetics ; Point Mutation ; Tyrosine/genetics
    Chemical Substances Cysteine (K848JZ4886) ; Cysteine Dioxygenase (EC 1.13.11.20) ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00083
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Statistical bounds on how induced seismicity stops.

    Schultz, Ryan / Ellsworth, William L / Beroza, Gregory C

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 1184

    Abstract: Earthquakes caused by human activities receive scrutiny due to the risks and hazards they pose. Seismicity that occurs after the causative anthropogenic operation stops has been particularly problematic-both because of high-profile cases of damage caused ...

    Abstract Earthquakes caused by human activities receive scrutiny due to the risks and hazards they pose. Seismicity that occurs after the causative anthropogenic operation stops has been particularly problematic-both because of high-profile cases of damage caused by this trailing seismicity and due to the loss of control for risk management. With this motivation, we undertake a statistical examination of how induced seismicity stops. We borrow the concept of Båth's law from tectonic aftershock sequences. Båth's law anticipates the difference between magnitudes in two subsets of seismicity as dependent on their population count ratio. We test this concept for its applicability to induced seismicity, including ~ 80 cases of earthquakes caused by hydraulic fracturing, enhanced geothermal systems, and other fluid-injections with clear operational end points. We find that induced seismicity obeys Båth's law: both in terms of the magnitude-count-ratio relationship and the power law distribution of residuals. Furthermore, the distribution of count ratios is skewed and heavy-tailed, with most earthquakes occurring during stimulation/injection. We discuss potential models to improve the characterization of these count ratios and propose a Seismogenic Fault Injection Test to measure their parameters in situ. We conclude that Båth's law quantifies the occurrence of earthquake magnitudes trailing anthropogenic operations.
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05216-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Autonomic Changes in Juvenile-Onset Huntington's Disease.

    Schultz, Jordan L / Nopoulos, Peg C

    Brain sciences

    2020  Volume 10, Issue 9

    Abstract: Patients with adult-onset Huntington's Disease (AOHD) have been found to have dysfunction of the autonomic nervous system that is thought to be secondary to neurodegeneration causing dysfunction of the brain-heart axis. However, this relationship has not ...

    Abstract Patients with adult-onset Huntington's Disease (AOHD) have been found to have dysfunction of the autonomic nervous system that is thought to be secondary to neurodegeneration causing dysfunction of the brain-heart axis. However, this relationship has not been investigated in patients with juvenile-onset HD (JOHD). The aim of this study was to compare simple physiologic measures between patients with JOHD (
    Language English
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci10090589
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  8. Article: Design and Development of a Traveling Wave Ferro-Microfluidic Device and System Rig for Potential Magnetophoretic Cell Separation and Sorting in a Water-Based Ferrofluid.

    Hewlin, Rodward L / Edwards, Maegan / Schultz, Christopher

    Micromachines

    2023  Volume 14, Issue 4

    Abstract: The timely detection and diagnosis of diseases and accurate monitoring of specific genetic conditions require rapid and accurate separation, sorting, and direction of target cell types toward a sensor device surface. In that regard, cellular manipulation, ...

    Abstract The timely detection and diagnosis of diseases and accurate monitoring of specific genetic conditions require rapid and accurate separation, sorting, and direction of target cell types toward a sensor device surface. In that regard, cellular manipulation, separation, and sorting are progressively finding application potential within various bioassay applications such as medical disease diagnosis, pathogen detection, and medical testing. The aim of this paper is to present the design and development of a simple traveling wave ferro-microfluidic device and system rig purposed for the potential manipulation and magnetophoretic separation of cells in water-based ferrofluids. This paper details in full: (1) a method for tailoring cobalt ferrite nanoparticles for specific diameter size ranges (10-20 nm), (2) the development of a ferro-microfluidic device for potentially separating cells and magnetic nanoparticles, (3) the development of a water-based ferrofluid with magnetic nanoparticles and non-magnetic microparticles, and (4) the design and development of a system rig for producing the electric field within the ferro-microfluidic channel device for magnetizing and manipulating nonmagnetic particles in the ferro-microfluidic channel. The results reported in this work demonstrate a proof of concept for magnetophoretic manipulation and separation of magnetic and non-magnetic particles in a simple ferro-microfluidic device. This work is a design and proof-of-concept study. The design reported in this model is an improvement over existing magnetic excitation microfluidic system designs in that heat is efficiently removed from the circuit board to allow a range of input currents and frequencies to manipulate non-magnetic particles. Although this work did not analyze the separation of cells from magnetic particles, the results demonstrate that non-magnetic (
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14040889
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  9. Article ; Online: Out-of-hospital intravenous catheter insertion: Now is not the time to sit idle.

    Schultz, Brendan / Bertenshaw, Claire / Parker, Lachlan

    American journal of infection control

    2023  

    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Letter
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.08.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Quantifying the Onset of Unintended Weight Loss in Huntington's Disease: A Retrospective Analysis of Enroll-HD.

    Ogilvie, Amy C / Nopoulos, Peg C / Schultz, Jordan L

    Journal of Huntington's disease

    2021  Volume 10, Issue 4, Page(s) 485–492

    Abstract: Background: Unintended weight loss and decreased body mass indexes (BMIs) are common symptoms of individuals with manifest HD. It is unknown at what point during disease progression weight loss starts to accelerate relative to a healthy individual's ... ...

    Abstract Background: Unintended weight loss and decreased body mass indexes (BMIs) are common symptoms of individuals with manifest HD. It is unknown at what point during disease progression weight loss starts to accelerate relative to a healthy individual's weight and when recommended interventions should be initiated to have the strongest impact on patient care.
    Objective: The objective of this study was to identify a point in time relative to age at motor onset when the decline in weight in HD starts to accelerate relative to a non-HD population. The relationship between initiation of weight loss interventions and changes in weight loss was also explored.
    Methods: Participants from the fifth version of the Enroll-HD study were identified for this research. Linear mixed-effects piecewise regression models were used to estimate the point in time relative to the reported age of motor onset in which BMI started to decline in participants with HD compared to healthy non-HD controls. A post-hoc descriptive analysis was performed to look at when nutritional supplements and swallow therapy were initiated in participants with HD relative to motor onset.
    Results: BMI decline in the HD group began to accelerate compared to controls approximately 5.7 years after the reported age of motor onset (95% CI: 4.7-6.9). The average initiation times of swallow therapy and nutritional supplements were 7.7 years (SD = 5.5 years) and 6.7 years (SD = 6.5 years) after motor onset, respectively.
    Conclusion: Our findings suggest a potential point for intervention of nutrition programs or therapies used to prevent future weight loss.
    MeSH term(s) Cognition ; Disease Progression ; Humans ; Huntington Disease/therapy ; Retrospective Studies ; Weight Loss
    Language English
    Publishing date 2021-10-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2673033-9
    ISSN 1879-6400 ; 1879-6397
    ISSN (online) 1879-6400
    ISSN 1879-6397
    DOI 10.3233/JHD-210488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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