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  1. Book: Transitioning from second-line to third-line therapy in metastatic colorectal cancer

    Marshall, John L. / Loupakis, Fotios / Bekaii-Saab, Tanios

    (Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 19, issue 1, supplement 3 (January 2021))

    2021  

    Author's details moderator John L. Marshall, MD; discussants Fotios Loupakis, MD, PhD, Tanios S. Bekaii-Saab, MD
    Series title Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 19, issue 1, supplement 3 (January 2021)
    Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Collection Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Language English
    Size 19 Seiten, Diagramme
    Publisher Millennium Medical Publishing
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020952867
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -19,Suppl.3- verfügbar in Königswinter Königswinter

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  2. Article: The importance of exposing patients with metastatic colorectal cancer to all treatment options.

    Loupakis, Fotios

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19 Suppl 3, Issue 1, Page(s) 3–5

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy ; Humans ; Neoplasm Metastasis
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Q&A: colorectal cancer in younger patients.

    Marshall, John L / Bekaii-Saab, Tanios S / Loupakis, Fotios

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19 Suppl 3, Issue 1, Page(s) 15–17

    MeSH term(s) Age Factors ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; Humans
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Hurrying up but not rushing, acting and not reacting, good sense and not common sense: Open thoughts and reasonable doubts on COVID-19 vaccination strategies in cancer patients.

    Loupakis, Fotios / Giusti, Raffaele / Di Maio, Massimo

    Critical reviews in oncology/hematology

    2021  Volume 167, Page(s) 103271

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Neoplasms/therapy ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-02-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2021.103271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Transitioning from second-line to third-line therapy in metastatic colorectal cancer.

    Marshall, John L / Loupakis, Fotios / Bekaii-Saab, Tanios S

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19 Suppl 3, Issue 1, Page(s) 1–20

    Abstract: In the setting of metastatic colorectal cancer, many gains in patient outcomes have been achieved throughout the last 2 decades. A primary driver of these gains is access to more lines of therapy. In the palliative metastatic setting, all patients ... ...

    Abstract In the setting of metastatic colorectal cancer, many gains in patient outcomes have been achieved throughout the last 2 decades. A primary driver of these gains is access to more lines of therapy. In the palliative metastatic setting, all patients ultimately progress and require continued treatment sequencing. The goal is to expose patients to all lines of available therapies. It is now possible to better select patients for each therapy. Treatment selection algorithms encompass disease factors and patient characteristics, such as overall condition and age. Appropriate molecular profiling assessments should be available early in the treatment course, to drive decision-making and allow use of alternative therapies when possible. The transition to third-line therapy can be prompted by changes in imaging scans or laboratory tests, as well as changes in the patient's symptom burden. It can be problematic to delay initiation of third-line therapy when it is clinically indicated. Many oncologists will consider rechallenging patients with the same chemotherapy that did not work earlier. Although this strategy is reasonable, it should not necessarily take precedence over use of agents with proven efficacy in later lines of therapy in randomized clinical trials, such as regorafenib and trifluridine/tipiracil. Clinicians now commonly adjust the dose of regorafenib. A delay in the initiation of these third-line agents can allow the patient's performance status to decrease, thus diminishing the opportunity for a successful outcome.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Clinical Decision-Making ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Disease Management ; Drug Combinations ; Humans ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/therapy ; Palliative Care ; Phenylurea Compounds/therapeutic use ; Pyridines/therapeutic use ; Pyrrolidines/therapeutic use ; Thymine/therapeutic use ; Trifluridine/therapeutic use
    Chemical Substances Drug Combinations ; Phenylurea Compounds ; Pyridines ; Pyrrolidines ; trifluridine tipiracil drug combination ; regorafenib (24T2A1DOYB) ; Thymine (QR26YLT7LT) ; Trifluridine (RMW9V5RW38)
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: New perspectives for TAS-102: TASK successful?

    Loupakis, Fotios / Lonardi, Sara

    The Lancet. Oncology

    2017  Volume 18, Issue 9, Page(s) 1139–1141

    MeSH term(s) Drug Combinations ; Trifluridine ; Uracil/analogs & derivatives
    Chemical Substances Drug Combinations ; TAS 102 ; Uracil (56HH86ZVCT) ; Trifluridine (RMW9V5RW38)
    Language English
    Publishing date 2017-07-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30574-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  7. Article: The relationship among posttraumatic stress disorder, posttraumatic growth, and suicidal ideation among Italian healthcare workers during the first wave of COVID-19 pandemic.

    Gesi, Camilla / Cafaro, Rita / Achilli, Francesco / Boscacci, Maria / Cerioli, Matteo / Cirnigliaro, Giovanna / Loupakis, Fotios / Di Maio, Massimo / Dell'Osso, Bernardo

    CNS spectrums

    2023  Volume 29, Issue 1, Page(s) 60–64

    Abstract: Objective: The COVID-19 pandemic impacted mental health across different groups, including healthcare workers (HWs). To date, few studies focused on potential positive aspects that may follow the exposure to the pandemic. We investigated the prevalence ... ...

    Abstract Objective: The COVID-19 pandemic impacted mental health across different groups, including healthcare workers (HWs). To date, few studies focused on potential positive aspects that may follow the exposure to the pandemic. We investigated the prevalence of posttraumatic stress disorder (PTSD) in Italian HWs and whether posttraumatic growth (PTG) dimensions affected the risk of suicidal ideation (SI) during the first COVID-19 wave.
    Methods: An online self-report survey was conducted between April and May 2020. Sociodemographic data, information about COVID-19-related stressful events, Impact of the Event Scale-revised, and Post-Traumatic Growth Inventory-Short Form (PTGI-SF) scores were collected and compared between participants. Patient Health Questionnaire-9 scores were also collected to assess SI through item 9. Multivariate logistic regression was used to assess the relationship between PTGI and SI.
    Results: Among 948 HWs, 257 (27.0%) reported a provisional PTSD diagnosis. The median PTGI-SF score was 24. Participants reporting PTSD symptoms had higher scores in the
    Conclusions: COVID-19 pandemic has been indicated as a risk factor for SI, also among HWs. PTG may have a protective role on suicide risk. Improvements in
    MeSH term(s) Humans ; Posttraumatic Growth, Psychological ; Suicidal Ideation ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Pandemics ; COVID-19/epidemiology ; Italy/epidemiology
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852923002493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5171: Show issues Location:
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    Zs.MO 340: Show issues

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  8. Article ; Online: Cancer Immunotherapy and Identification of Prognostic and Predictive Biomarkers.

    Criscitiello, Carmen / Santangelo, Michele / Loupakis, Fotios

    BioMed research international

    2018  Volume 2018, Page(s) 5184075

    MeSH term(s) Biomarkers, Tumor/immunology ; Humans ; Immunotherapy/methods ; Neoplasms/diagnosis ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2018-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/5184075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Systematic review of randomised clinical trials and observational studies for patients with RAS wild-type or BRAF

    García-Alfonso, Pilar / Lièvre, Astrid / Loupakis, Fotios / Tadmouri, Abir / Khan, Sadya / Barcena, Leticia / Stintzing, Sebastian

    Critical reviews in oncology/hematology

    2022  Volume 173, Page(s) 103646

    Abstract: Approximately 8-10% of metastatic colorectal cancer (mCRC) tumours harbour ... ...

    Abstract Approximately 8-10% of metastatic colorectal cancer (mCRC) tumours harbour BRAF
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cetuximab/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Humans ; Mutation ; Observational Studies as Topic ; Progression-Free Survival ; Proto-Oncogene Proteins B-raf/genetics ; Randomized Controlled Trials as Topic
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2022-03-25
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2022.103646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Cancer Immunotherapy and Identification of Prognostic and Predictive Biomarkers

    Carmen Criscitiello / Michele Santangelo / Fotios Loupakis

    BioMed Research International, Vol

    2018  Volume 2018

    Keywords Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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