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  1. Book: Mastocytosis

    Castells, Mariana C.

    (Immunology and allergy clinics of North America ; volume 38, number 3 (August 2018))

    2018  

    Author's details editor Mariana C. Castells
    Series title Immunology and allergy clinics of North America ; volume 38, number 3 (August 2018)
    Collection
    Language English
    Size xvii Seiten, Seite 342-543, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019808887
    ISBN 978-0-323-61392-7 ; 0-323-61392-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 710 -38,3- verfügbar in Königswinter Königswinter

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  2. Book: Drug hypersensitivity and desensitizations

    Castells, Mariana C.

    (Immunology and allergy clinics of North America ; volume 37, number 4 (November 2017))

    2017  

    Author's details editor Mariana C. Castells
    Series title Immunology and allergy clinics of North America ; volume 37, number 4 (November 2017)
    Collection
    Language English
    Size xviii Seiten, Seite 630-815, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019530326
    ISBN 978-0-323-54883-0 ; 0-323-54883-0
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Anaphylaxis and hypersensitivity reactions

    Castells, Mariana C.

    2011  

    Author's details Mariana C. Castells, ed
    Language English
    Size XIII, 361 S. : Ill.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016652372
    ISBN 978-1-6032-7950-5 ; 978-1-60327-950-5 ; 1-60327-950-4 ; 1-6032-7950-4 ; 9781603279512 ; 1603279512
    Database Catalogue ZB MED Medicine, Health

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    2011 A 128 order for loan Magazin

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  4. Article ; Online: Mast cell disorders: A framework of allergy and hematology symptoms leading to personalized treatments.

    Castells, Mariana C

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2021  Volume 127, Issue 4, Page(s) 403–404

    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/pathology ; Humans ; Hypersensitivity/immunology ; Mast Cells/immunology ; Mast Cells/metabolism ; Mastocytosis/diagnosis ; Mastocytosis/drug therapy ; Mastocytosis/genetics ; Mastocytosis/pathology ; Precision Medicine/methods ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-kit/genetics ; Social Media ; Tryptases/genetics
    Chemical Substances Protein Kinase Inhibitors ; KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2021.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anaphylaxis: watch out, it is everywhere now!

    Castells, Mariana C

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 124, Issue 2, Page(s) 116–117

    MeSH term(s) Allergens ; Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Humans ; Immunoglobulin E/immunology ; Severity of Illness Index
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2019.12.013
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  6. Article ; Online: Drug allergy labeling and delabeling in the coronavirus disease 2019 era: What is important and what do we need to know.

    Castells, Mariana C

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 124, Issue 6, Page(s) 523–525

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Drug Hypersensitivity ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Who, What, Where, When, Why, and How of Drug Desensitization.

    Yang, Barbara C / Castells, Mariana C

    Immunology and allergy clinics of North America

    2022  Volume 42, Issue 2, Page(s) 403–420

    Abstract: Hypersensitivity reactions to drugs have increased in the past 25 years due to increased exposures and availability of efficient, targeted, and personalized medications. Rapid drug desensitization is a clinical procedure that allows for the safe ... ...

    Abstract Hypersensitivity reactions to drugs have increased in the past 25 years due to increased exposures and availability of efficient, targeted, and personalized medications. Rapid drug desensitization is a clinical procedure that allows for the safe administration of a drug in patients with a history of such hypersensitivity reactions. Desensitization allows the continued use of first-line therapies, leading to higher efficacy of treatment, fewer side effects, cost-effectiveness, and increased quality of life and life expectancy of patients when compared with the use of second-line therapy. In this review, we discuss the who, what, where, when, why, and how of drug desensitization.
    MeSH term(s) Anaphylaxis/etiology ; Desensitization, Immunologic/methods ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy ; Humans ; Quality of Life
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2021.12.004
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  8. Article ; Online: Utilizing Biologics in Drug Desensitization.

    Yang, Barbara C / Castells, Mariana C

    Current allergy and asthma reports

    2022  Volume 23, Issue 1, Page(s) 1–11

    Abstract: Purpose of review: The purpose of this literature review was to review the latest advancements with biologics in rapid drug desensitization. Our methodology was to highlight both desensitization to biologics themselves and the use of biologics in ... ...

    Abstract Purpose of review: The purpose of this literature review was to review the latest advancements with biologics in rapid drug desensitization. Our methodology was to highlight both desensitization to biologics themselves and the use of biologics in desensitization to both biologic and nonbiologic drugs.
    Recent findings: Biologics are a vast category of drugs that include monoclonal antibodies, nanobodies, modern vaccinations, and even hormones. Desensitization to biologics can be safely performed through standardized procedure. Biomarkers are used both in vitro and in vivo to help identify and classify hypersensitivity reactions. Hypersensitivity reactions to the mRNA vaccinations against SARS-CoV-2 present their own unique challenges to management. There are specific excipients in monoclonal antibodies that are thought to be responsible for many of their hypersensitivity reactions. Certain biologics can even be used to assist in desensitization to other drugs. Rapid drug desensitization is a standardized procedure that may be able to help many patients who have experienced hypersensitivity reactions to biologics and would best be treated with them to continue to receive them. Biologic drugs have opened a new era in medicine for the prevention and treatment of infectious diseases, cancer, and inflammatory diseases. Hypersensitivity reactions to biologics are quite common. This literature review presents the latest advancements in our understanding of hypersensitivity reactions to biologics, how rapid drug desensitization can be used to continue therapy despite history of hypersensitivity, and how biologics themselves can be used to aid in desensitization itself.
    MeSH term(s) Humans ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy ; COVID-19 ; SARS-CoV-2 ; Antibodies, Monoclonal/therapeutic use ; Desensitization, Immunologic/methods ; Anaphylaxis/etiology ; Biological Products/adverse effects
    Chemical Substances Antibodies, Monoclonal ; Biological Products
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-022-01052-z
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  9. Article ; Online: Maintaining Safety with SARS-CoV-2 Vaccines. Reply.

    Castells, Mariana C / Phillips, Elizabeth J

    The New England journal of medicine

    2021  Volume 384, Issue 10, Page(s) e37

    MeSH term(s) Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2100766
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  10. Article ; Online: Capturing Drug-Induced Anaphylaxis Through Electronic Health Records: A Step Forward.

    Castells, Mariana C

    The journal of allergy and clinical immunology. In practice

    2018  Volume 7, Issue 1, Page(s) 112–113

    MeSH term(s) Anaphylaxis ; Drug Hypersensitivity ; Electronic Health Records ; Humans
    Language English
    Publishing date 2018-12-31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2018.10.045
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