Article ; Online: Vasculitic neuropathy-related disability, pain, quality of life, and autonomic symptoms: A survey of 312 patients.
Rheumatology (Oxford, England)
2024
Abstract: Objectives: To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL), and autonomic dysfunction in patients with vasculitis.: Methods: Patients with vasculitis (with or without neuropathy) were invited ...
| Abstract | Objectives: To assess self-reported symptoms of neuropathy, disability, pain, health-related quality of life (HR-QOL), and autonomic dysfunction in patients with vasculitis. Methods: Patients with vasculitis (with or without neuropathy) were invited by Vasculitis UK to complete an anonymous online survey. Results: 312 patients (71% female) responded. Median age was 61-70 years. Median duration of vasculitis was 4 years (<2 months to > 15 years). Vasculitic types included granulomatosis with polyangiitis (34%), unspecified ANCA-associated vasculitis (13%), microscopic polyangiitis (11%), eosinophilic granulomatosis with polyangiitis (11%), giant cell arteritis (10%), non-systemic vasculitic neuropathy (2%), and other (19%). Many patients reported foot/hand symptoms suggestive of neuropathy, including numbness (64%), pain (54%), or weakness (40%). 242 patients (78%) met our definition of probable vasculitic neuropathy: diagnosis of neuropathy by vasculitis team OR numbness OR weakness in feet/hands. Only 52% had been formally diagnosed with neuropathy. Compared with 70 patients without neuropathy, neuropathy patients had greater disability measured by the inflammatory Rasch-built Overall Disability Scale (centile mean 63.1 (SD 17.3) vs 75.2 (16.7); p< 0.0001), Inflammatory Neuropathy Cause and Treatment scale (median 2 (IQR 1-4) vs 0.5 (0-2); p< 0.0001), and modified Rankin scale (median 2 (IQR 1-3) vs 2 (1-2); p= 0.0002); greater pain on an 11-point rating scale (mean 4.6 (SD 2.6) vs 3.5 (2.8); p= 0.0009); and poorer HR-QOL on the EQ5D-3L (summary index mean 0.58 (SD 0.29) vs 0.69 (0.28); p<0.0001). Two-thirds reported autonomic symptoms (not associated with neuropathy). Conclusion: Neuropathy is common and associated with significant disability, pain, and impaired HR-QOL in patients with systemic vasculitis. |
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| Language | English |
| Publishing date | 2024-01-30 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1464822-2 |
| ISSN | 1462-0332 ; 1462-0324 |
| ISSN (online) | 1462-0332 |
| ISSN | 1462-0324 |
| DOI | 10.1093/rheumatology/keae038 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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