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  1. Article: Anti-Inflammatory Activity of APPA (Apocynin and Paeonol) in Human Articular Chondrocytes.

    Fernández-Moreno, Mercedes / Hermida-Gómez, Tamara / Larkins, Nicholas / Reynolds, Alan / Blanco, Francisco J

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 1

    Abstract: Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the joint space which results in pain. The current pharmacological treatment of OA is inadequate and pharmacological interventions focus on symptom management. APPA, ...

    Abstract Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the joint space which results in pain. The current pharmacological treatment of OA is inadequate and pharmacological interventions focus on symptom management. APPA, a combination of apocynin (AP) and paeonol (PA), is a potential drug for treating OA. The aim of this study was to analyze the effects of APPA on the modulation of the inflammatory response in chondrocytes. Samples were incubated with IL-1β and APPA, and their responses to proinflammatory cytokines, catabolic mediators and redox responses were then measured. The effect of APPA on mitogenesis was also evaluated. Results show that APPA attenuated the expression of IL-8, TNF-α, MMP-3, MMP-13, SOD-2 and iNOS, resulting in the protection of human articular cartilage. APPA decreased PGC-1α gene expression induced by IL-1β. APPA did not modulate the gene expression of Mfn2, Sirt-1 or Sirt-3. The overall findings indicate that APPA may be an effective treatment for OA by targeting several of the pathways involved in OA pathogenesis.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010118
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  2. Article ; Online: Controversy and Agreement Among Guidelines Defining Ambulatory Hypertension in Children.

    Venettacci, Oliver / Larkins, Nicholas G

    Kidney international reports

    2020  Volume 5, Issue 5, Page(s) 569–571

    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.02.1032
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  3. Article ; Online: Belatacept in the treatment of acute T-cell mediated rejection and maintenance immunosuppression in a paediatric kidney transplant recipient.

    Soraru, Jacqueline / Sheriff, Dawn / Rajakaruna, Ramela / Larkins, Nicholas

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 7, Page(s) 641–642

    MeSH term(s) Abatacept/adverse effects ; Child ; Graft Rejection/drug therapy ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; T-Lymphocytes
    Chemical Substances Immunosuppressive Agents ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2022-03-14
    Publishing country Australia
    Document type Letter
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14036
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    Zs.A 4822: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Oral agents for acute severe hypertension in children with minimal or no symptoms.

    Hijazzi, Sally / Moon, Kwi / Larkins, Nicholas G

    Journal of paediatrics and child health

    2022  Volume 58, Issue 11, Page(s) 1935–1941

    Abstract: Acute hypertension is common among children admitted to hospital, and large or rapid increases in blood pressure place children at risk of complications such as posterior reversible encephalopathy syndrome. Guidelines in the United States and Europe now ... ...

    Abstract Acute hypertension is common among children admitted to hospital, and large or rapid increases in blood pressure place children at risk of complications such as posterior reversible encephalopathy syndrome. Guidelines in the United States and Europe now include definitions guiding the identification of acute severe hypertension (otherwise known as hypertensive crisis) and its management. This review discusses these recommendations and the appropriate use of oral antihypertensive agents for children with minimal or no symptoms. We focus on the role of oral calcium channel blockers, including isradipine (a second-generation dihydropyridine), given recent changes to regulatory approvals in Australia. The differing pharmacokinetic and pharmacodynamic properties of agents are compared, with the aim of facilitating directed drug selection and dosing.
    MeSH term(s) Child ; Humans ; Posterior Leukoencephalopathy Syndrome/drug therapy ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Calcium Channel Blockers/therapeutic use ; Blood Pressure ; Administration, Oral
    Chemical Substances Antihypertensive Agents ; Calcium Channel Blockers
    Language English
    Publishing date 2022-09-21
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16210
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    Zs.A 227: Show issues Location:
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  5. Article ; Online: Time's Up! Start Dialysis Later in Children.

    Larkins, Nicholas G / Craig, Jonathan C

    Journal of the American Society of Nephrology : JASN

    2019  Volume 30, Issue 8, Page(s) 1344–1345

    MeSH term(s) Child ; ErbB Receptors ; Glomerular Filtration Rate ; Humans ; Nephrology ; Renal Dialysis
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2019040429
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    Zs.A 3344: Show issues Location:
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  6. Article ; Online: Successful Kidney Transplantation for Children Within 3 Weeks of COVID-19 Infection.

    Donald, Julia S / Yeoh, Daniel / McCarthy, Hugh J / Larkins, Nicholas G

    Transplantation

    2022  Volume 106, Issue 12, Page(s) e515–e516

    MeSH term(s) Child ; Humans ; COVID-19 ; Kidney Transplantation/adverse effects ; SARS-CoV-2
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Letter
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004346
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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  7. Article ; Online: Timing of Kidney Replacement Therapy among Children and Young Adults.

    Larkins, Nicholas G / Lim, Wai / Goh, Carrie / Francis, Anna / McCarthy, Hugh / Kim, Siah / Wong, Germaine / Craig, Jonathan C

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 8, Page(s) 1041–1050

    Abstract: Background: No randomized trials exist to guide the timing of the initiation of KRT in children. We sought to define trends and predictors of the eGFR at initiation of KRT, center-related clinical practice variation, and any association with patient ... ...

    Abstract Background: No randomized trials exist to guide the timing of the initiation of KRT in children. We sought to define trends and predictors of the eGFR at initiation of KRT, center-related clinical practice variation, and any association with patient survival.
    Methods: Children and young adults (1-25 years) commencing KRT (dialysis or kidney transplantation) between 1995 and 2018 were included using data from the Australia and New Zealand Dialysis and Transplant Registry. The associations between eGFR on commencing KRT and covariates were estimated using quantile regression. Cox regression was used to estimate the association between eGFR and patient survival. Logistic regression, categorizing eGFR about a value of 10 ml/min per 1.73 m 2 , was used in conjunction with a random effect by center to quantify clinical practice variation.
    Results: Overall, 2274 participants were included. The median eGFR at KRT initiation increased from 7 to 9 ml/min per 1.73 m 2 over the study period and the 90th centile from 11 to 17 ml/min per 1.73 m 2 . The effect of era on median eGFR was modified by modality, with a greater increase among those receiving a preemptive kidney transplant (1.0 ml/min per 1.73 m 2 per 5 years; 95% confidence interval [CI], 0.6 to 1.5) or peritoneal dialysis (0.7 ml/min per 1.73 m 2 per 5 years; 95% CI, 0.4 to 0.9) compared with hemodialysis (0.1 ml/min per 1.73 m 2 per 5 years; 95% CI, -0.1 to 0.3). There were 252 deaths (median follow-up 8.5 years, interquartile range 3.7-14.2) and no association between eGFR and survival (hazard ratio, 1.01 per ml/min per 1.73 m 2

    95% CI, 0.98 to 1.04). Center variation explained 6% of the total variance in the odds of initiating KRT earlier. This rose to over 10% when comparing pediatric centers alone.
    Conclusions: Children and young adults progressively commenced KRT earlier. This change was more pronounced for children starting peritoneal dialysis or receiving a preemptive kidney transplant. Earlier initiation of KRT was not associated with any difference in patient survival. A substantial proportion of clinical practice variation was due to center variation alone.
    Podcast: This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_08_08_CJN0000000000000204.mp3.
    MeSH term(s) Humans ; Child ; Young Adult ; Renal Replacement Therapy ; Renal Dialysis ; Kidney Transplantation ; Peritoneal Dialysis ; Registries
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000204
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    Zs.A 6584: Show issues Location:
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  8. Article ; Online: Identifying leadership for clinical governance in rural and remote primary health care services.

    Kwedza, Ru K / Zwar, Nicholas / Johnson, Julie K / Larkins, Sarah

    The Australian journal of rural health

    2020  Volume 28, Issue 4, Page(s) 414–416

    MeSH term(s) Australia ; Clinical Governance ; Humans ; Leadership ; Primary Health Care/organization & administration ; Rural Health Services/organization & administration
    Language English
    Publishing date 2020-07-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2069573-1
    ISSN 1440-1584 ; 1038-5282
    ISSN (online) 1440-1584
    ISSN 1038-5282
    DOI 10.1111/ajr.12653
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  9. Article ; Online: A Call for Australian Clinical Practice Guidelines for Paediatric Hypertension.

    Mynard, Jonathan P / Chaturvedi, Swasti / Cheung, Michael M H / Clark, Malcolm / Gabb, Genevieve / Jeffries-Stokes, Christine / Jennings, Garry L / McNab, Sarah / Medley, Tanya / Mihailidou, Anastasia S / Schlaich, Markus / Larkins, Nicholas G / Quinlan, Catherine

    Heart, lung & circulation

    2023  Volume 32, Issue 9, Page(s) 1032–1034

    MeSH term(s) Child ; Humans ; Australia/epidemiology ; Hypertension/diagnosis ; Hypertension/therapy ; Blood Pressure
    Language English
    Publishing date 2023-07-24
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.06.726
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    Zs.A 4988: Show issues Location:
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  10. Article ; Online: Childhood IgA Nephropathy Successfully Treated with Targeted-Release Budesonide: A Case Report.

    Venettacci, Oliver / Larkins, Nicholas / Willis, Francis

    Journal of paediatrics and child health

    2018  Volume 54, Issue 12, Page(s) 1403

    MeSH term(s) Budesonide/administration & dosage ; Child ; Drug Delivery Systems ; Glomerulonephritis, IGA/drug therapy ; Glucocorticoids/administration & dosage ; Humans ; Male ; Treatment Outcome
    Chemical Substances Glucocorticoids ; Budesonide (51333-22-3)
    Language English
    Publishing date 2018-11-28
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14259
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