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  1. Article: Multicyclic Norias: A First-Transition Approach to Extreme Values of the Currents.

    Polettini, Matteo / Neri, Izaak

    Journal of statistical physics

    2024  Volume 191, Issue 3, Page(s) 35

    Abstract: For continuous-time Markov chains we prove that, depending on the notion of effective ... ...

    Abstract For continuous-time Markov chains we prove that, depending on the notion of effective affinity
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017302-7
    ISSN 1572-9613 ; 0022-4715
    ISSN (online) 1572-9613
    ISSN 0022-4715
    DOI 10.1007/s10955-024-03236-5
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  2. Article ; Online: Second Law of Thermodynamics at Stopping Times.

    Neri, Izaak

    Physical review letters

    2020  Volume 124, Issue 4, Page(s) 40601

    Abstract: Events in mesoscopic systems often take place at first-passage times, as is for instance the case for a colloidal particle that escapes a metastable state. An interesting question is how much work an external agent has done on a particle when it escapes ... ...

    Abstract Events in mesoscopic systems often take place at first-passage times, as is for instance the case for a colloidal particle that escapes a metastable state. An interesting question is how much work an external agent has done on a particle when it escapes a metastable state. We develop a thermodynamic theory for processes in mesoscopic systems that terminate at stopping times, which generalize first-passage times. This theory implies a thermodynamic bound, reminiscent of the second law of thermodynamics, for the work exerted by an external protocol on a mesoscopic system at a stopping time. As an illustration, we use this law to bound the work required to stretch a polymer to a certain length or to let a particle escape from a metastable state.
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.124.040601
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  3. Article ; Online: Evidence-based mechanisms of synergy with IMiD agent-based combinations in multiple myeloma.

    Neri, Paola / Nijhof, Inger

    Critical reviews in oncology/hematology

    2023  Volume 188, Page(s) 104041

    Abstract: Treatment of multiple myeloma (MM) has seen great advances in recent years, and a key contributor to this change has been the effective use of combination therapies, which have improved both the depth and duration of patient responses. Immunomodulatory ... ...

    Abstract Treatment of multiple myeloma (MM) has seen great advances in recent years, and a key contributor to this change has been the effective use of combination therapies, which have improved both the depth and duration of patient responses. Immunomodulatory drug (IMiD) agents (lenalidomide and pomalidomide) have both tumoricidal and immunostimulatory functions, and due to their multiple mechanisms of action have become the backbone of numerous combination treatments in the newly diagnosed and relapsed/refractory settings. Although IMiD agent-based combination regimens provide improved clinical outcomes for patients with MM, the mechanisms underpinning these combinations are not well understood. In this review we describe the potential mechanisms of synergy leading to the enhanced activity observed when IMiD agents and other drug classes are used in combination through interrogation of the current knowledge surrounding their mechanism of actions.
    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Lenalidomide ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Immunomodulation
    Chemical Substances Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2023.104041
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1931: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Clustering coefficients for networks with higher order interactions.

    Ha, Gyeong-Gyun / Neri, Izaak / Annibale, Alessia

    Chaos (Woodbury, N.Y.)

    2024  Volume 34, Issue 4

    Abstract: We introduce a clustering coefficient for nondirected and directed hypergraphs, which we call the quad clustering coefficient. We determine the average quad clustering coefficient and its distribution in real-world hypergraphs and compare its value with ... ...

    Abstract We introduce a clustering coefficient for nondirected and directed hypergraphs, which we call the quad clustering coefficient. We determine the average quad clustering coefficient and its distribution in real-world hypergraphs and compare its value with those of random hypergraphs drawn from the configuration model. We find that real-world hypergraphs exhibit a nonnegligible fraction of nodes with a maximal value of the quad clustering coefficient, while we do not find such nodes in random hypergraphs. Interestingly, these highly clustered nodes can have large degrees and can be incident to hyperedges of large cardinality. Moreover, highly clustered nodes are not observed in an analysis based on the pairwise clustering coefficient of the associated projected graph that has binary interactions, and hence higher order interactions are required to identify nodes with a large quad clustering coefficient.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0188246
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  5. Article: The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study.

    Porcaro, Giuseppina / Laganà, Antonio Simone / Neri, Isabella / Aragona, Cesare

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background-We evaluated whether the oral intake of high-molecular-weight hyaluronic acid (HMWHA) in association with alpha lipoic acid (ALA), magnesium, vitamin B6, and vitamin D can improve the resorption of subchorionic hematoma in cases of threatened ... ...

    Abstract Background-We evaluated whether the oral intake of high-molecular-weight hyaluronic acid (HMWHA) in association with alpha lipoic acid (ALA), magnesium, vitamin B6, and vitamin D can improve the resorption of subchorionic hematoma in cases of threatened miscarriage. Methods-In this study, we enrolled 56 pregnant women with threatened miscarriage (i.e., subchorionic hematomas, pelvic pain/uterine contractions, and/or vaginal bleeding) between the 6th and the 13th week of gestation. They were treated with vaginal progesterone (200 mg/twice a day) (control group;
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030706
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  6. Article ; Online: Role of fluctuations in epidemic resurgence after a lockdown.

    Neri, I / Gammaitoni, L

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 6452

    Abstract: Most popular statistical models in epidemic evolution focus on the dynamics of average relevant quantities and overlooks the role of small fluctuations on the model parameters. Models for Covid-19 are no exception. In this paper we show that the role of ... ...

    Abstract Most popular statistical models in epidemic evolution focus on the dynamics of average relevant quantities and overlooks the role of small fluctuations on the model parameters. Models for Covid-19 are no exception. In this paper we show that the role of time-correlated fluctuations, far from being negligible, can in fact determine the spreading of an epidemic and, most importantly, the resurgence of the exponential diffusion in the presence of time-limited episodes in promiscuity behaviours. The results found in this work are not only relevant and specific for the Covid-19 epidemic but are more general and can be applied to other epidemics.
    MeSH term(s) Algorithms ; COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control ; Humans ; Models, Statistical ; SARS-CoV-2/isolation & purification ; Time Factors
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85808-z
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  7. Article: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review.

    Manieri, Elisa / Dondi, Arianna / Neri, Iria / Lanari, Marcello

    Frontiers in medicine

    2023  Volume 10, Page(s) 1108345

    Abstract: Despite being rare, the Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a serious, possibly fatal condition that may affect both adults and children who may be also burdened by delayed sequelae. It is an adverse drug reaction ... ...

    Abstract Despite being rare, the Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a serious, possibly fatal condition that may affect both adults and children who may be also burdened by delayed sequelae. It is an adverse drug reaction characterized by widespread skin involvement, fever, lymphadenopathy, visceral involvement, and laboratory abnormalities (eosinophilia, mononucleosis-like atypical lymphocytes). It is more frequently triggered by anticonvulsants, sulphonamides, or antibiotics, the latter being responsible for up to 30% of pediatric cases. The disease typically develops 2-8 weeks after exposure to the culprit medication, with fever and widespread skin eruption; mild viral prodromes are possible. Unfortunately, diagnosis is challenging due to the absence of a reliable test; however, a score by the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) allows to classify suspect patients into no, possible, probable, or definite DRESS cases. Moreover, rapid-onset DRESS syndrome has been described in recent years. It affects children more often than adults and differs from the most common form because it appears ≤15 days vs. >15 days after starting the drug, it is usually triggered by antibiotics or iodinated contrast media rather than by anticonvulsants and has a higher presence of lymphadenopathy. Differential diagnosis between rapid-onset antibiotic-driven DRESS syndrome, viral exanthems, or other drug eruptions may be challenging, but it is mandatory to define it as early as possible to start adequate treatment and monitor possible complications. The present review reports the latest evidence about the diagnosis and treatment of pediatric DRESS syndrome.
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1108345
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  8. Article ; Online: Pyopericardium presenting as pericardial tamponade in a patient with common variable immunodeficiency disorder.

    Windels, An / Neri, Inês / Conceição, Catarina / Osório, Joana

    BMJ case reports

    2023  Volume 16, Issue 10

    Abstract: A male patient in his 20s with a medical history of common variable immunodeficiency disorder, non-compliant with therapy, presented to the emergency department with respiratory distress and severe hypoxaemia. Chest radiography demonstrated extensive ... ...

    Abstract A male patient in his 20s with a medical history of common variable immunodeficiency disorder, non-compliant with therapy, presented to the emergency department with respiratory distress and severe hypoxaemia. Chest radiography demonstrated extensive bilateral infiltrates and an increased cardiothoracic ratio.
    MeSH term(s) Male ; Humans ; Pericardial Effusion/diagnosis ; Cardiac Tamponade/diagnosis ; Cardiac Tamponade/etiology ; Cardiac Tamponade/surgery ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/diagnosis ; Pericarditis/complications ; Pericardiocentesis/adverse effects
    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255362
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  9. Article ; Online: L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcomes.

    Menichini, Daniela / Feliciello, Lia / Neri, Isabella / Facchinetti, Fabio

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2023  Volume 36, Issue 1, Page(s) 2217465

    Abstract: Background/aim of the study: L-Arginine (L-Arg)/Nitric Oxide (NO) system is involved in the pathophysiology of relevant Obstetric conditions. This review aims at summarizing the effects of L-Arg supplementation in pregnancy looking at safety and ... ...

    Abstract Background/aim of the study: L-Arginine (L-Arg)/Nitric Oxide (NO) system is involved in the pathophysiology of relevant Obstetric conditions. This review aims at summarizing the effects of L-Arg supplementation in pregnancy looking at safety and efficacy.
    Methods: We conducted a systematic review of the literature utilizing PubMed for studies published from inception to September 2022. The search included human and animal studies where L-Arg was supplemented pre-conceptionally or during pregnancy, by either oral or intravenous route. The main perinatal outcomes were focused.
    Results: Among 1028 publications, 51 studies were eligible for inclusion, 25 were performed in women, and the remnant in animals. Compared to controls/placebo, the supplementation with L-Arg reduced the development of pre-eclampsia (four studies), decreased blood pressure, and reduced the need for antihypertensive drugs in women with Hypertensive Disorders of Pregnancy (HDP, eight studies). In women carrying growth retarded fetuses, L-Arg improved fetoplacental circulation, birth weight and neonatal outcomes (five studies), while in the case of threatened preterm birth, L-Arg reduced uterine contractions (two studies). In several animal species, L-Arg supplementation in pregnancy improved reproductive performance by increasing the litter number and size. Moreover, in pre-eclamptic and metabolic syndrome experimental models, maternal hypertension and fetal growth were improved.
    Conclusion: L-Arg displays biological activities in pregnancies complicated by HDP and growth restriction, both in women and animal models. L-Arg administration is safe and could be a candidate as an intervention beneficial to maternal and fetal outcomes, at least in moderate clinical disorders.
    MeSH term(s) Pregnancy ; Animals ; Infant, Newborn ; Female ; Humans ; Premature Birth/prevention & control ; Dietary Supplements ; Pre-Eclampsia/prevention & control ; Fetus ; Arginine
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2023.2217465
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3510: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Localization and Universality of Eigenvectors in Directed Random Graphs.

    Metz, Fernando Lucas / Neri, Izaak

    Physical review letters

    2021  Volume 126, Issue 4, Page(s) 40604

    Abstract: Although the spectral properties of random graphs have been a long-standing focus of network theory, the properties of right eigenvectors of directed graphs have so far eluded an exact analytic treatment. We present a general theory for the statistics of ...

    Abstract Although the spectral properties of random graphs have been a long-standing focus of network theory, the properties of right eigenvectors of directed graphs have so far eluded an exact analytic treatment. We present a general theory for the statistics of the right eigenvector components in directed random graphs with a prescribed degree distribution and with randomly weighted links. We obtain exact analytic expressions for the inverse participation ratio and show that right eigenvectors of directed random graphs with a small average degree are localized. Remarkably, if the fourth moment of the degree distribution is finite, then the critical mean degree of the localization transition is independent of the degree fluctuations, which is different from localization in undirected graphs that is governed by degree fluctuations. We also show that in the high connectivity limit the distribution of the right eigenvector components is solely determined by the degree distribution. For delocalized eigenvectors, we recover in this limit the universal results from standard random matrix theory that are independent of the degree distribution, while for localized eigenvectors the eigenvector distribution depends on the degree distribution.
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.126.040604
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