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  1. Article ; Online: From seconds to days: Neural plasticity viewed through a lipid lens.

    Vaughen, John P / Theisen, Emma / Clandinin, Thomas R

    Current opinion in neurobiology

    2023  Volume 80, Page(s) 102702

    Abstract: Many adult neurons are dynamically remodeled across timescales ranging from the rapid addition and removal of specific synaptic connections, to largescale structural plasticity events that reconfigure circuits over hours, days, and months. Membrane ... ...

    Abstract Many adult neurons are dynamically remodeled across timescales ranging from the rapid addition and removal of specific synaptic connections, to largescale structural plasticity events that reconfigure circuits over hours, days, and months. Membrane lipids, including brain-enriched sphingolipids, play crucial roles in these processes. In this review, we summarize progress at the intersection of neuronal activity, lipids, and structural remodeling. We highlight how brain activity modulates lipid metabolism to enable adaptive structural plasticity, and showcase glia as key players in membrane remodeling. These studies reveal that lipids act as critical signaling molecules that instruct the dynamic architecture of the brain.
    MeSH term(s) Neurons/physiology ; Neuronal Plasticity/physiology ; Neuroglia ; Signal Transduction ; Lipids ; Synapses/physiology
    Chemical Substances Lipids
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2023.102702
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    Zs.A 3260: Show issues Location:
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  2. Article ; Online: Visual processing in the fly, from photoreceptors to behavior.

    Currier, Timothy A / Pang, Michelle M / Clandinin, Thomas R

    Genetics

    2023  Volume 224, Issue 2

    Abstract: Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations of neuronal function, and detailed sensory physiology. A highlight of these ... ...

    Abstract Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations of neuronal function, and detailed sensory physiology. A highlight of these developments can be seen in the context of vision, where pioneering studies have uncovered fundamental and generalizable principles of sensory processing. Here we begin with an overview of vision-guided behaviors and common methods for probing visual circuits. We then outline the anatomy and physiology of brain regions involved in visual processing, beginning at the sensory periphery and ending with descending motor control. Areas of focus include contrast and motion detection in the optic lobe, circuits for visual feature selectivity, computations in support of spatial navigation, and contextual associative learning. Finally, we look to the future of fly visual neuroscience and discuss promising topics for further study.
    MeSH term(s) Animals ; Drosophila melanogaster/physiology ; Visual Perception/physiology ; Brain/physiology ; Behavior, Animal/physiology ; Eye
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyad064
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  3. Article ; Online: Neuroscience: Convergence of biological and artificial networks.

    Turner, Maxwell H / Clandinin, Thomas R

    Current biology : CB

    2021  Volume 31, Issue 18, Page(s) R1079–R1081

    Abstract: A new study shows that an artificial neural network trained to predict visual motion reproduces key properties of motion detecting circuits in the fruit fly. ...

    Abstract A new study shows that an artificial neural network trained to predict visual motion reproduces key properties of motion detecting circuits in the fruit fly.
    MeSH term(s) Animals ; Drosophila ; Neural Networks, Computer ; Neurosciences
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.07.051
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  4. Article ; Online: Mapping the neural dynamics of locomotion across the Drosophila brain.

    Brezovec, Bella E / Berger, Andrew B / Hao, Yukun A / Chen, Feng / Druckmann, Shaul / Clandinin, Thomas R

    Current biology : CB

    2024  Volume 34, Issue 4, Page(s) 710–726.e4

    Abstract: Locomotion engages widely distributed networks of neurons. However, our understanding of the spatial architecture and temporal dynamics of the networks that underpin walking remains incomplete. We use volumetric two-photon imaging to map neural activity ... ...

    Abstract Locomotion engages widely distributed networks of neurons. However, our understanding of the spatial architecture and temporal dynamics of the networks that underpin walking remains incomplete. We use volumetric two-photon imaging to map neural activity associated with walking across the entire brain of Drosophila. We define spatially clustered neural signals selectively associated with changes in either forward or angular velocity, demonstrating that neurons with similar behavioral selectivity are clustered. These signals reveal distinct topographic maps in diverse brain regions involved in navigation, memory, sensory processing, and motor control, as well as regions not previously linked to locomotion. We identify temporal trajectories of neural activity that sweep across these maps, including signals that anticipate future movement, representing the sequential engagement of clusters with different behavioral specificities. Finally, we register these maps to a connectome and identify neural networks that we propose underlie the observed signals, setting a foundation for subsequent circuit dissection. Overall, our work suggests a spatiotemporal framework for the emergence and execution of complex walking maneuvers and links this brain-wide neural activity to single neurons and local circuits.
    MeSH term(s) Animals ; Drosophila/physiology ; Brain/physiology ; Locomotion/physiology ; Neurons/physiology ; Brain Mapping/methods ; Connectome
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.12.063
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  5. Article ; Online: Visual and motor signatures of locomotion dynamically shape a population code for feature detection in

    Turner, Maxwell H / Krieger, Avery / Pang, Michelle M / Clandinin, Thomas R

    eLife

    2022  Volume 11

    Abstract: Natural vision is dynamic: as an animal moves, its visual input changes dramatically. How can the visual system reliably extract local features from an input dominated by self-generated signals? ... ...

    Abstract Natural vision is dynamic: as an animal moves, its visual input changes dramatically. How can the visual system reliably extract local features from an input dominated by self-generated signals? In
    MeSH term(s) Animals ; Drosophila/physiology ; Locomotion/physiology ; Vision, Ocular ; Neurons/physiology ; Interneurons ; Motion Perception/physiology
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82587
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  6. Article ; Online: The connectome predicts resting-state functional connectivity across the Drosophila brain.

    Turner, Maxwell H / Mann, Kevin / Clandinin, Thomas R

    Current biology : CB

    2021  Volume 31, Issue 11, Page(s) 2386–2394.e3

    Abstract: Anatomical connectivity can constrain both a neural circuit's function and its underlying computation. This principle has been demonstrated for many small, defined neural circuits. For example, connectome reconstructions have informed models for ... ...

    Abstract Anatomical connectivity can constrain both a neural circuit's function and its underlying computation. This principle has been demonstrated for many small, defined neural circuits. For example, connectome reconstructions have informed models for direction selectivity in the vertebrate retina
    MeSH term(s) Animals ; Brain ; Cerebral Cortex ; Connectome ; Drosophila ; Humans ; Magnetic Resonance Imaging ; Nerve Net
    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.03.004
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  7. Article ; Online: Drosophila Vision: An Eye for Change.

    Wienecke, Carl F-R / Clandinin, Thomas R

    Current biology : CB

    2020  Volume 30, Issue 2, Page(s) R66–R68

    Abstract: Two new studies show that neuronal adaptation to changes in visual contrast is widespread in the early Drosophila visual system, improving velocity estimation in downstream motion detectors. ...

    Abstract Two new studies show that neuronal adaptation to changes in visual contrast is widespread in the early Drosophila visual system, improving velocity estimation in downstream motion detectors.
    MeSH term(s) Adaptation, Physiological ; Animals ; Drosophila ; Motion ; Motion Perception ; Vision, Ocular
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.11.069
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  8. Article ; Online: Developmental Biology: Neurons That Divide Together Wire Together.

    Pang, Michelle M / Clandinin, Thomas R

    Current biology : CB

    2018  Volume 28, Issue 12, Page(s) R715–R717

    Abstract: Retinotopic maps represent a fundamental organizing principle of visual system wiring. A recent study illustrates how careful coordination of developmental strategies can simultaneously create a diverse array of cell types and establish a complex wiring ... ...

    Abstract Retinotopic maps represent a fundamental organizing principle of visual system wiring. A recent study illustrates how careful coordination of developmental strategies can simultaneously create a diverse array of cell types and establish a complex wiring diagram.
    MeSH term(s) Developmental Biology ; Neurons ; Visual Pathways
    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2018.05.007
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  9. Article ; Online: Elementary Motion Detection in Drosophila: Algorithms and Mechanisms.

    Yang, Helen H / Clandinin, Thomas R

    Annual review of vision science

    2018  Volume 4, Page(s) 143–163

    Abstract: Motion in the visual world provides critical information to guide the behavior of sighted animals. Furthermore, as visual motion estimation requires comparisons of signals across inputs and over time, it represents a paradigmatic and generalizable neural ...

    Abstract Motion in the visual world provides critical information to guide the behavior of sighted animals. Furthermore, as visual motion estimation requires comparisons of signals across inputs and over time, it represents a paradigmatic and generalizable neural computation. Focusing on the Drosophila visual system, where an explosion of technological advances has recently accelerated experimental progress, we review our understanding of how, algorithmically and mechanistically, motion signals are first computed.
    MeSH term(s) Algorithms ; Animals ; Cues ; Drosophila/physiology ; Models, Theoretical ; Motion Perception/physiology ; Photoreceptor Cells, Invertebrate/physiology ; Signal Transduction/physiology ; Visual Pathways/physiology
    Language English
    Publishing date 2018-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2805730-2
    ISSN 2374-4650 ; 2374-4642
    ISSN (online) 2374-4650
    ISSN 2374-4642
    DOI 10.1146/annurev-vision-091517-034153
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  10. Article ; Online: Coupling of activity, metabolism and behaviour across the Drosophila brain.

    Mann, Kevin / Deny, Stephane / Ganguli, Surya / Clandinin, Thomas R

    Nature

    2021  Volume 593, Issue 7858, Page(s) 244–248

    Abstract: Coordinated activity across networks of neurons is a hallmark of both resting and active behavioural states in many ... ...

    Abstract Coordinated activity across networks of neurons is a hallmark of both resting and active behavioural states in many species
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Behavior, Animal ; Brain/cytology ; Brain/metabolism ; Brain/physiology ; Drosophila melanogaster/cytology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology ; Energy Metabolism ; Female ; Male ; Metabolic Networks and Pathways ; Neural Pathways ; Neurons/metabolism ; Optogenetics ; Rest
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03497-0
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