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  1. Book: Cellular adhesion in development and disease

    Yap, Alpha S.

    (Current topics in developmental biology ; 112)

    2015  

    Author's details ed. by Alpha S. Yap
    Series title Current topics in developmental biology ; 112
    Collection
    Language English
    Size XVII, 517, [22] S. : Ill.
    Edition 1. ed.
    Publisher Elsevier Academic Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018613387
    ISBN 978-0-12-407758-4 ; 0-12-407758-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 175 -112- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Talking with force at cell-cell adhesions.

    Mann, Zoya / Yap, Alpha S

    Nature cell biology

    2024  Volume 26, Issue 1, Page(s) 26–28

    MeSH term(s) Cell Adhesion ; Focal Adhesions ; Actins ; Extracellular Matrix
    Chemical Substances Actins
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01263-0
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  3. Article ; Online: The importance of character development in scientific research.

    Schwartz, Martin A / Yap, Alpha S

    Journal of cell science

    2023  Volume 136, Issue 13

    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.261405
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  4. Article ; Online: Editorial introduction.

    Yap, Alpha S

    Molecular biology of the cell

    2020  Volume 31, Issue 16, Page(s) 1651–1653

    Abstract: Welcome to this Fourth Special Issue ... ...

    Abstract Welcome to this Fourth Special Issue of
    MeSH term(s) Actins ; Biophysics ; Molecular Biology ; Nuclear Pore ; Stress, Mechanical
    Chemical Substances Actins
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E20-06-0414
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  5. Article ; Online: Paradigms Lost Perspectives: revisiting well-worn models and concepts.

    Yap, Alpha S / Wallingford, John B / Bement, William M

    Molecular biology of the cell

    2023  Volume 34, Issue 5, Page(s) ed1

    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E23-01-0001
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  6. Article ; Online: Cadherins and the cortex: A matter of time?

    Noordstra, Ivar / Morris, Richard G / Yap, Alpha S

    Current opinion in cell biology

    2023  Volume 80, Page(s) 102154

    Abstract: Cell adhesion systems commonly operate in close partnership with the cytoskeleton. Adhesion receptors bind to the cortex and regulate its dynamics, organization and mechanics; conversely, the cytoskeleton influences aspects of adhesion, including ... ...

    Abstract Cell adhesion systems commonly operate in close partnership with the cytoskeleton. Adhesion receptors bind to the cortex and regulate its dynamics, organization and mechanics; conversely, the cytoskeleton influences aspects of adhesion, including strength, stability and ductility. In this review we consider recent advances in elucidating such cooperation, focusing on interactions between classical cadherins and actomyosin. The evidence presents an apparent paradox. Molecular mechanisms of mechanosensation by the cadherin-actin apparatus imply that adhesion strengthens under tension. However, this does not always translate to the broader setting of confluent tissues, where increases in fluctuations of tension can promote intercalation due to the shrinkage of adherens junctions. Emerging evidence suggests that understanding of timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales.
    MeSH term(s) Cadherins/metabolism ; Cell Adhesion/physiology ; Cytoskeleton/metabolism ; Actins/metabolism ; Microtubules/metabolism ; Adherens Junctions/metabolism
    Chemical Substances Cadherins ; Actins
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102154
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  7. Article ; Online: Adherens junctions as molecular regulators of emergent tissue mechanics.

    Campàs, Otger / Noordstra, Ivar / Yap, Alpha S

    Nature reviews. Molecular cell biology

    2023  Volume 25, Issue 4, Page(s) 252–269

    Abstract: Tissue and organ development during embryogenesis relies on the collective and coordinated action of many cells. Recent studies have revealed that tissue material properties, including transitions between fluid and solid tissue states, are controlled in ... ...

    Abstract Tissue and organ development during embryogenesis relies on the collective and coordinated action of many cells. Recent studies have revealed that tissue material properties, including transitions between fluid and solid tissue states, are controlled in space and time to shape embryonic structures and regulate cell behaviours. Although the collective cellular flows that sculpt tissues are guided by tissue-level physical changes, these ultimately emerge from cellular-level and subcellular-level molecular mechanisms. Adherens junctions are key subcellular structures, built from clusters of classical cadherin receptors. They mediate physical interactions between cells and connect biochemical signalling to the physical characteristics of cell contacts, hence playing a fundamental role in tissue morphogenesis. In this Review, we take advantage of the results of recent, quantitative measurements of tissue mechanics to relate the molecular and cellular characteristics of adherens junctions, including adhesion strength, tension and dynamics, to the emergent physical state of embryonic tissues. We focus on systems in which cell-cell interactions are the primary contributor to morphogenesis, without significant contribution from cell-matrix interactions. We suggest that emergent tissue mechanics is an important direction for future research, bridging cell biology, developmental biology and mechanobiology to provide a holistic understanding of morphogenesis in health and disease.
    MeSH term(s) Adherens Junctions/metabolism ; Cadherins/metabolism ; Cell Communication ; Morphogenesis ; Embryonic Development ; Cell Adhesion/physiology
    Chemical Substances Cadherins
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-023-00688-7
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  8. Article ; Online: Chiral crown conformation of Rh(2)(S-PTTL)(4): enantioselective cyclopropanation with alpha-alkyl-alpha-diazoesters.

    DeAngelis, Andrew / Dmitrenko, Olga / Yap, Glenn P A / Fox, Joseph M

    Journal of the American Chemical Society

    2009  Volume 131, Issue 21, Page(s) 7230–7231

    Abstract: ... for intermolecular Rh(2)(S-PTTL)(4)-catalyzed cyclopropanation using alpha-alkyl-alpha-diazoesters. Intermolecular ... Herein, we provide crystallographic and computational evidence that Hashimoto's Rh(2)(S-PTTL)(4 ... In Rh(2)(S-PTTL)(4), all four tert-butyl groups are aligned on the same face of the catalyst, and each C ...

    Abstract Herein, we provide crystallographic and computational evidence that Hashimoto's Rh(2)(S-PTTL)(4) catalyst adopts a "chiral crown" conformation with a reactive chiral face and an unreactive achiral face. In Rh(2)(S-PTTL)(4), all four tert-butyl groups are aligned on the same face of the catalyst, and each C-(t-Bu) bond is roughly parallel to the central Rh-Rh bond. This orients the four phthalimido groups on the opposite face of the catalyst. Also described is an enantioselective and diastereoselective protocol for intermolecular Rh(2)(S-PTTL)(4)-catalyzed cyclopropanation using alpha-alkyl-alpha-diazoesters. Intermolecular cyclopropanation is selective over two competing intramolecular pathways: C-H insertion and beta-hydride elimination. On the basis of density functional theory calculations and the Davies-Singleton model for cyclopropanation, a model for asymmetric induction is proposed.
    MeSH term(s) Catalysis ; Cyclopropanes/chemistry ; Diazonium Compounds/chemistry ; Esters/chemistry ; Models, Molecular ; Molecular Conformation ; Organometallic Compounds/chemistry ; Rhodium/chemistry ; Stereoisomerism
    Chemical Substances Cyclopropanes ; Diazonium Compounds ; Esters ; Organometallic Compounds ; Rhodium (DMK383DSAC)
    Language English
    Publishing date 2009-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/ja9026852
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  9. Article ; Online: How adherens junctions move cells during collective migration.

    Gupta, Shafali / Yap, Alpha S

    Faculty reviews

    2021  Volume 10, Page(s) 56

    Abstract: In this review, we consider how the association between adherens junctions and the actomyosin cytoskeleton influences collective cell movement. We focus on recent findings which reveal different ways for adherens junctions to promote the locomotion of ... ...

    Abstract In this review, we consider how the association between adherens junctions and the actomyosin cytoskeleton influences collective cell movement. We focus on recent findings which reveal different ways for adherens junctions to promote the locomotion of cells within tissues: through lamellipodia and junctional contraction. These contributions reflect how classic cadherins establish sites of cortical actin assembly and how adherens junctions couple to contractile actomyosin, respectively. The diverse interplay between cadherin adhesion and the cytoskeleton thus provides different ways for adherens junctions to support epithelial locomotion.
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/10-56
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  10. Article ; Online: For whom the cell tolls.

    Noordstra, Ivar / Yap, Alpha S

    Developmental cell

    2021  Volume 56, Issue 11, Page(s) 1555–1557

    Abstract: Toll receptors are key determinants of planar polarity during Drosophila gastrulation. Two papers in the current issue of Developmental Cell now identify key features of their downstream signaling that allow cell symmetry to be broken by apparently non- ... ...

    Abstract Toll receptors are key determinants of planar polarity during Drosophila gastrulation. Two papers in the current issue of Developmental Cell now identify key features of their downstream signaling that allow cell symmetry to be broken by apparently non-polarized Toll receptors.
    MeSH term(s) Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Gastrulation ; Signal Transduction
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.05.013
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