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Article ; Online: A mitosis-specific AMPK trimer?

Carmena, Mar

2012 Volume 11, Issue 7, Page(s) 1269

MeSH term(s)	AMP-Activated Protein Kinases/analysis ; Humans
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2012-04-01
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.19902
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Article ; Online: Flies stretch their cells to avoid a chromatin trap.

Carmena, Mar

The Journal of cell biology

2012 Volume 199, Issue 5, Page(s) 719–721

Abstract: Before the final step of cytokinesis, termed abscission, dividing cells need to ensure that the cleavage plane is clear of chromatin. In this issue, Kotadia et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201208041) show that in Drosophila melanogaster, ...

Abstract	Before the final step of cytokinesis, termed abscission, dividing cells need to ensure that the cleavage plane is clear of chromatin. In this issue, Kotadia et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201208041) show that in Drosophila melanogaster, larval neuroblasts elongate to allow segregation of extra-long chromatids and clearance of the midzone, thereby avoiding cytokinesis failure and aneuploidy.
MeSH term(s)	Adaptation, Physiological ; Animals ; Cell Shape/physiology ; Chromatids/metabolism ; Chromosome Segregation ; Cytokinesis ; Drosophila melanogaster/cytology ; Neural Stem Cells/cytology
Language	English
Publishing date	2012-11-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201210135
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Article ; Online: Abscission checkpoint control: stuck in the middle with Aurora B.

Carmena, Mar

Open biology

2012 Volume 2, Issue 7, Page(s) 120095

Abstract: At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal ... ...

Abstract	At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.
MeSH term(s)	Aurora Kinase B ; Aurora Kinases ; Cell Cycle Checkpoints/physiology ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; HeLa Cells ; Humans ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism
Chemical Substances	Chromatin ; AURKB protein, human (EC 2.7.11.1) ; Aurora Kinase B (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2012-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2630944-0
ISSN	2046-2441 ; 2046-2441
ISSN (online)	2046-2441
ISSN	2046-2441
DOI	10.1098/rsob.120095
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Article ; Online: Abscission checkpoint control

Mar Carmena

Open Biology, Vol 2, Iss

stuck in the middle with Aurora B

2012 Volume 7

Abstract: At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal ... ...

Abstract	At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.
Keywords	aurora b kinase ; chromosomal passenger complex ; endosomal sorting complex required for transport-iii ; cytokinesis ; abscission ; checkpoint ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	The Royal Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: AMPK: Sensing energy to travel in mitosis.

Carmena, Mar

Cell cycle (Georgetown, Tex.)

2009 Volume 8, Issue 17, Page(s) 2682–2683

MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Cell Polarity ; Energy Metabolism ; Mitosis ; Myosin Light Chains/metabolism ; Phosphorylation
Chemical Substances	Myosin Light Chains ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2009-09-01
Publishing country	United States
Document type	News ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
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Article: Cytokinesis: the final stop for the chromosomal passengers.

Carmena, Mar

Biochemical Society transactions

2008 Volume 36, Issue Pt 3, Page(s) 367–370

Abstract: The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation ... ...

Abstract	The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned since then about the role of the CPC in the late stages of mitosis and cytokinesis.
MeSH term(s)	Actomyosin/metabolism ; Animals ; Chromosomes/metabolism ; Cytokinesis ; Cytoskeletal Proteins/metabolism ; Humans ; Intermediate Filaments/metabolism ; Spindle Apparatus/metabolism
Chemical Substances	Cytoskeletal Proteins ; Actomyosin (9013-26-7)
Language	English
Publishing date	2008-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/BST0360367
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Zs.A 944: Show issues

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Article ; Online: Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.

Siles-Lucas, Mar / Casulli, Adriano / Cirilli, Roberto / Carmena, David

PLoS neglected tropical diseases

2018 Volume 12, Issue 4, Page(s) e0006422

Abstract: Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and ... ...

Abstract	Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans. To compensate this therapeutic shortfall, new treatment alternatives are urgently needed, including the identification, development, and assessment of novel compound classes and drug targets. Here is presented a thorough overview of the range of compounds that have been tested against E. granulosus and E. multilocularis in recent years, including in vitro and in vivo data on their mode of action, dosage, administration regimen, therapeutic outcomes, and associated clinical symptoms. Drugs covered included albendazole, mebendazole, and other members of the benzimidazole family and their derivatives, including improved formulations and combined therapies with other biocidal agents. Chemically synthetized molecules previously known to be effective against other infectious and non-infectious conditions such as anti-virals, antibiotics, anti-parasites, anti-mycotics, and anti-neoplastics are addressed. In view of their increasing relevance, natural occurring compounds derived from plant and fungal extracts are also discussed. Special attention has been paid to the recent application of genomic science on drug discovery and clinical medicine, particularly through the identification of small inhibitor molecules tackling key metabolic enzymes or signalling pathways.
MeSH term(s)	Albendazole/pharmacology ; Animals ; Anthelmintics/pharmacology ; Benzimidazoles/pharmacology ; Echinococcosis/drug therapy ; Echinococcosis/parasitology ; Echinococcus multilocularis/drug effects ; Humans ; Larva/drug effects ; Mebendazole/pharmacology ; Mice
Chemical Substances	Anthelmintics ; Benzimidazoles ; Mebendazole (81G6I5V05I) ; benzimidazole (E24GX49LD8) ; Albendazole (F4216019LN)
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0006422
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Progress in the pharmacological treatment of human cystic and alveolar echinococcosis

Mar Siles-Lucas / Adriano Casulli / Roberto Cirilli / David Carmena

PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e

Compounds and therapeutic targets.

2018 Volume 0006422

Abstract	Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans. To compensate this therapeutic shortfall, new treatment alternatives are urgently needed, including the identification, development, and assessment of novel compound classes and drug targets. Here is presented a thorough overview of the range of compounds that have been tested against E. granulosus and E. multilocularis in recent years, including in vitro and in vivo data on their mode of action, dosage, administration regimen, therapeutic outcomes, and associated clinical symptoms. Drugs covered included albendazole, mebendazole, and other members of the benzimidazole family and their derivatives, including improved formulations and combined therapies with other biocidal agents. Chemically synthetized molecules previously known to be effective against other infectious and non-infectious conditions such as anti-virals, antibiotics, anti-parasites, anti-mycotics, and anti-neoplastics are addressed. In view of their increasing relevance, natural occurring compounds derived from plant and fungal extracts are also discussed. Special attention has been paid to the recent application of genomic science on drug discovery and clinical medicine, particularly through the identification of small inhibitor molecules tackling key metabolic enzymes or signalling pathways.
Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Subject code	572
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?

Archambault, Vincent / Carmena, Mar

Cell cycle (Georgetown, Tex.)

2012 Volume 11, Issue 8, Page(s) 1490–1495

Abstract: The events of cell division are regulated by a complex interplay between kinases and phosphatases. Cyclin-dependent kinases (Cdks), polo-like kinases (Plks) and Aurora kinases play central roles in this process. Polo kinase (Plk1 in humans) regulates a ... ...

Abstract	The events of cell division are regulated by a complex interplay between kinases and phosphatases. Cyclin-dependent kinases (Cdks), polo-like kinases (Plks) and Aurora kinases play central roles in this process. Polo kinase (Plk1 in humans) regulates a wide range of events in mitosis and cytokinesis. To ensure the accuracy of these processes, polo activity itself is subject to complex regulation. Phosphorylation of polo in its T loop (or activation loop) increases its kinase activity several-fold. It has been shown that Aurora A kinase, with its co-factor Bora, activates Plk1 in G(2), and that this is essential for recovery from cell cycle arrest induced by DNA damage. In a recent article published in PLoS Biology, we report that Drosophila polo is activated by Aurora B kinase at centromeres, and that this is crucial for polo function in regulating chromosome dynamics in prometaphase. Our results suggest that this regulatory pathway is conserved in humans. Here, we propose a model for the collaboration between Aurora B and polo in the regulation of kinetochore attachment to microtubules in early mitosis. Moreover, we suggest that Aurora B could also function to activate Polo/Plk1 in cytokinesis. Finally, we discuss recent findings and open questions regarding the activation of polo and polo-like kinases by different kinases in mitosis, cytokinesis and other processes.
MeSH term(s)	Aurora Kinase B ; Aurora Kinases ; Cell Cycle Checkpoints ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Cytokinesis ; DNA Damage ; Humans ; Kinetochores/metabolism ; Microtubules/metabolism ; Mitosis ; Phosphorylation ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Protein Structure, Tertiary ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/metabolism ; Polo-Like Kinase 1
Chemical Substances	Cell Cycle Proteins ; Proto-Oncogene Proteins ; bora protein, human ; AURKB protein, human (EC 2.7.11.1) ; Aurora Kinase B (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2012-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.19724
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Article: The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic.

Carmena, Mar / Earnshaw, William C / Glover, David M

Frontiers in cell and developmental biology

2015 Volume 3, Page(s) 73

Abstract: Aurora kinases comprise a family of highly conserved serine-threonine protein kinases that play a pivotal role in the regulation of cell cycle. Aurora kinases are not only involved in the control of multiple processes during cell division but also ... ...

Abstract	Aurora kinases comprise a family of highly conserved serine-threonine protein kinases that play a pivotal role in the regulation of cell cycle. Aurora kinases are not only involved in the control of multiple processes during cell division but also coordinate chromosomal and cytoskeletal events, contributing to the regulation of checkpoints and ensuring the smooth progression of the cell cycle. Because of their fundamental contribution to cell cycle regulation, Aurora kinases were originally identified in independent genetic screens designed to find genes involved in the regulation of cell division. The first aurora mutant was part of a collection of mutants isolated in C. Nusslein-Volhard's laboratory. This collection was screened in D. M. Glover's laboratory in search for mutations disrupting the centrosome cycle in embryos derived from homozygous mutant mothers. The mutants identified were given names related to the "polar regions," and included not only aurora but also the equally famous polo. Ipl1, the only Aurora in yeast, was identified in a genetic screen looking for mutations that caused chromosome segregation defects. The discovery of a second Aurora-like kinase in mammals opened a new chapter in the research of Aurora kinases. The rat kinase AIM was found to be highly homologous to the fly and yeast proteins, but localized at the midzone and midbody and was proposed to have a role in cytokinesis. Homologs of the equatorial Aurora (Aurora B) were identified in metazoans ranging from flies to humans. Xenopus Aurora B was found to be in a complex with the chromosomal passenger INCENP, and both proteins were shown to be essential in flies for chromosome structure, segregation, central spindle formation and cytokinesis. Fifteen years on, Aurora kinase research is an active field of research. After the successful introduction of the first anti-mitotic agents in cancer therapy, both Auroras have become the focus of attention as targets for the development of new anti-cancer drugs. In this review we will aim to give a historical overview of the research on Aurora kinases, highlighting the most relevant milestones in the advance of the field.
Language	English
Publishing date	2015-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2015.00073
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