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  1. Article ; Online: Polyarteritis Nodosa: Old Disease, New Etiologies.

    Wolff, Louis / Horisberger, Alice / Moi, Laura / Karampetsou, Maria P / Comte, Denis

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can also involve smaller vessels. The clinical ... ...

    Abstract Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can also involve smaller vessels. The clinical presentation is heterogeneous and characterized by a significant number of patients exhibiting general symptoms, including asthenia, fever, and unintended weight loss. Although PAN can involve virtually any organ, it preferentially affects the skin, nervous system, and the gastrointestinal tract. Orchitis is a rare but specific manifestation of PAN. The absence of granulomas, glomerulonephritis, and anti-neutrophil cytoplasmic antibodies serves to distinguish PAN from other types of vasculitis. Major complications consist of hemorrhagic and thrombotic events occurring in mesenteric, cardiac, cerebral, and renal systems. Historically, PAN was frequently linked to hepatitis B virus (HBV) infection, but this association has dramatically changed in recent years due to declining HBV prevalence. Current epidemiological research often identifies a connection between PAN and genetic syndromes as well as neoplasia. This article provides a comprehensive review of PAN, specifically focusing on the progression of its clinical manifestations over time.
    MeSH term(s) Male ; Humans ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/diagnosis ; Vasculitis ; Hepatitis B/complications ; Hepatitis B virus ; Gastrointestinal Tract
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Biologiques et lupus érythémateux systémique : nouveautés et perspectives.

    Clottu, Aurélie / Horisberger, Alice / Comte, Denis

    Revue medicale suisse

    2021  Volume 17, Issue 733, Page(s) 684–689

    Abstract: Systemic lupus erythematosus is a complex autoimmune disease that remains challenging to treat. Recent advances in the understanding of the pathogenesis of SLE pave the way for the evaluation of biologic medicine. The most promising therapeutic targets ... ...

    Title translation Biologics and systemic lupus erythematosous : new insights and perspectives.
    Abstract Systemic lupus erythematosus is a complex autoimmune disease that remains challenging to treat. Recent advances in the understanding of the pathogenesis of SLE pave the way for the evaluation of biologic medicine. The most promising therapeutic targets in SLE are those that interfere with B cells count or normal function, interferon inhibitors, JAK inhibitors and biologicals that alter the cytokines imbalance that characterizes SLE. Recent phase 3 clinical trials have evaluated the role of belimumab in lupus nephritis and the usefulness of anifrolumab in the treatment of moderate to severe SLE. Many more trials are currently underway and may improve the level of care of patients with SLE in the near future.
    MeSH term(s) B-Lymphocytes ; Biological Products ; Cytokines ; Humans ; Janus Kinase Inhibitors ; Lupus Erythematosus, Systemic/drug therapy
    Chemical Substances Biological Products ; Cytokines ; Janus Kinase Inhibitors
    Language French
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Successful Rapid Oral Desensitization to Ibrutinib in a Patient With Severe Immediate Hypersensitivity Reaction.

    Tsilimidos, Gerasimos / Horisberger, Alice / Ribi, Camillo / Cairoli, Anne / Stalder, Gregoire

    Clinical lymphoma, myeloma & leukemia

    2021  Volume 21, Issue 10, Page(s) e745–e747

    MeSH term(s) Adenine/analogs & derivatives ; Adenine/pharmacology ; Adenine/therapeutic use ; Administration, Oral ; Central Nervous System Neoplasms/drug therapy ; Female ; Humans ; Hypersensitivity, Immediate/drug therapy ; Middle Aged ; Piperidines/pharmacology ; Piperidines/therapeutic use
    Chemical Substances Piperidines ; ibrutinib (1X70OSD4VX) ; Adenine (JAC85A2161)
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Case Reports ; Editorial
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2021.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5903: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Impact of COVID-19 pandemic on SLE: beyond the risk of infection.

    Horisberger, Alice / Moi, Laura / Ribi, Camillo / Comte, Denis

    Lupus science & medicine

    2020  Volume 7, Issue 1

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Letter
    ZDB-ID 2779620-6
    ISSN 2053-8790
    ISSN 2053-8790
    DOI 10.1136/lupus-2020-000408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Polyarteritis Nodosa

    Louis Wolff / Alice Horisberger / Laura Moi / Maria P. Karampetsou / Denis Comte

    International Journal of Molecular Sciences, Vol 24, Iss 23, p

    Old Disease, New Etiologies

    2023  Volume 16668

    Abstract: Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can also involve smaller vessels. The clinical ... ...

    Abstract Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can also involve smaller vessels. The clinical presentation is heterogeneous and characterized by a significant number of patients exhibiting general symptoms, including asthenia, fever, and unintended weight loss. Although PAN can involve virtually any organ, it preferentially affects the skin, nervous system, and the gastrointestinal tract. Orchitis is a rare but specific manifestation of PAN. The absence of granulomas, glomerulonephritis, and anti-neutrophil cytoplasmic antibodies serves to distinguish PAN from other types of vasculitis. Major complications consist of hemorrhagic and thrombotic events occurring in mesenteric, cardiac, cerebral, and renal systems. Historically, PAN was frequently linked to hepatitis B virus (HBV) infection, but this association has dramatically changed in recent years due to declining HBV prevalence. Current epidemiological research often identifies a connection between PAN and genetic syndromes as well as neoplasia. This article provides a comprehensive review of PAN, specifically focusing on the progression of its clinical manifestations over time.
    Keywords PAN ; polyarteritis nodosa ; panarteritis nodosa ; monogenic ; VEXAS ; DADA2 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Maladies autoimmunes dans le contexte de la pandémie COVID-19.

    Horisberger, Alice / Moi, Laura / Ribi, Camillo / Comte, Denis

    Revue medicale suisse

    2020  Volume 16, Issue N° 691-2, Page(s) 827–830

    Abstract: Patient suffering from autoimmune diseases (AID) typically have an increased risk of infection, which is attributed to the disease itself, but also to immunosuppressive drugs (IS) and comorbidities. During the current COVID-19 outbreak, the way to manage ...

    Title translation Autoimmune diseases in the context of pandemic COVID-19.
    Abstract Patient suffering from autoimmune diseases (AID) typically have an increased risk of infection, which is attributed to the disease itself, but also to immunosuppressive drugs (IS) and comorbidities. During the current COVID-19 outbreak, the way to manage these diseases remains elusive. Limited data is currently available on AID and IS in the context of this new coronavirus infection. To date, there is no evidence to support an increase in complications of COVID-19 in these patients. In addition, certain drugs that are commonly used to treat AID could be part of the therapeutic arsenal used in COVID-19. The purpose of this article is to review the unique aspects of patients with AID during the COVID-19 outbreak.
    MeSH term(s) Autoimmune Diseases/complications ; Autoimmune Diseases/therapy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language French
    Publishing date 2020-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Prise en charge du syndrome des ­anticorps antiphospholipides chez l’adulte.

    Doms, Jacqueline / Horisberger, Alice / Ribi, Camillo

    Revue medicale suisse

    2020  Volume 16, Issue 689, Page(s) 670–674

    Abstract: The antiphospholipid syndrome (APS) is a complex autoimmune -disease characterized by the expression of antiphospholipid -antibodies (APL) and a variety of clinical presentation. The latest classification defines APS by the occurrence of vascular ... ...

    Title translation Management of the antiphospholipid syndrome in adults.
    Abstract The antiphospholipid syndrome (APS) is a complex autoimmune -disease characterized by the expression of antiphospholipid -antibodies (APL) and a variety of clinical presentation. The latest classification defines APS by the occurrence of vascular thrombosis and/or typical obstetrical morbidity together with persistently -detectable APL at least 12 weeks apart. The latest recommendation proposes a risk profile based on the type and titer of APL detected, in order to guide the intensity of prophylactic measures. Based on current knowledge, novel oral anticoagulants should not be used in APS, particularly in patients with a high-risk APL profile or arterial thrombosis. Beyond the mere aspect of anticoagulant treatment, immunomodulatory approaches to the APS such as hydroxychloroquine are under investigation.
    MeSH term(s) Adult ; Antibodies, Antiphospholipid/blood ; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/drug therapy ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Knowledge ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/drug therapy ; Risk Factors ; Thrombosis/blood ; Thrombosis/drug therapy ; Thrombosis/etiology
    Chemical Substances Antibodies, Antiphospholipid ; Anticoagulants ; Hydroxychloroquine (4QWG6N8QKH)
    Language French
    Publishing date 2020-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Measurement of circulating CD21

    Horisberger, Alice / Humbel, Morgane / Fluder, Natalia / Bellanger, Florence / Fenwick, Craig / Ribi, Camillo / Comte, Denis

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9189

    Abstract: Determining disease activity in systemic lupus erythematosus (SLE) patients is challenging and limited by the lack of reliable biomarkers. Abnormally activated B cells play a key role in the pathogenesis of SLE, but their measure in clinical practice is ... ...

    Abstract Determining disease activity in systemic lupus erythematosus (SLE) patients is challenging and limited by the lack of reliable biomarkers. Abnormally activated B cells play a key role in the pathogenesis of SLE, but their measure in clinical practice is currently not recommended. Here, we studied peripheral B cells to identify a valid biomarker. We analyzed peripheral B cells in a discovery cohort of 30 SLE patients compared to 30 healthy controls (HC) using mass cytometry and unsupervised clustering analysis. The relevant B cell populations were subsequently studied by flow cytometry in a validation cohort of 63 SLE patients, 28 autoimmune diseases controls and 39 HC. Our data show an increased frequency of B cell populations with activated phenotype in SLE compared to healthy and autoimmune diseases controls. These cells uniformly lacked the expression of CD21 and CD27. Measurement of CD21
    MeSH term(s) Autoimmune Diseases ; B-Lymphocytes ; Biomarkers ; Complement System Proteins ; Humans ; Lupus Erythematosus, Systemic ; Lymphocyte Count
    Chemical Substances Biomarkers ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-12775-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of COVID-19 pandemic on SLE

    Camillo Ribi / Alice Horisberger / Laura Moi / Denis Comte

    Lupus Science and Medicine , Vol 7, Iss

    beyond the risk of infection

    2020  Volume 1

    Keywords Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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