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  1. Article ; Online: Ventricular arrhythmias in severe cardiac failure - what is the role of radiotherapy?

    Lee, Justin

    Trends in cardiovascular medicine

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3419: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Proportional and non-proportional biaxial fatigue of Inconel 718/ by Justin Lee Koch

    Koch, Justin Lee

    (Report CSRD ; 121 ; UILU-ENG ; 85-3605)

    1985  

    Series title Report CSRD ; 121
    UILU-ENG ; 85-3605
    Publisher UMI
    Publishing place Ann Arbor
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Web Exclusive. Annals Graphic Medicine - More Than Skin Deep.

    Lee, Justin H

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) W62–W63

    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Webcast
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/G21-0059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Diagnostic and therapeutic potential of tonic gamma-aminobutyric acid from reactive astrocytes in brain diseases.

    Koh, Wuhyun / Lee, C Justin

    Clinical and translational medicine

    2024  Volume 14, Issue 4, Page(s) e1642

    MeSH term(s) Humans ; Astrocytes ; gamma-Aminobutyric Acid ; Brain Diseases/diagnosis ; Brain Diseases/drug therapy
    Chemical Substances gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles.

    Kang, Hyunji / Lee, C Justin

    Experimental & molecular medicine

    2024  Volume 56, Issue 4, Page(s) 850–860

    Abstract: A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of intracellular organelles. Recently, several TMEM proteins have been identified as functional ion channels. ...

    Abstract A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of intracellular organelles. Recently, several TMEM proteins have been identified as functional ion channels. The structures and functions of these proteins have been extensively studied over the last two decades, starting with TMEM16A (ANO1). In this review, we provide a summary of the electrophysiological properties of known TMEM proteins that function as ion channels, such as TMEM175 (K
    MeSH term(s) Humans ; Animals ; Ion Channels/metabolism ; Ion Channels/chemistry ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/chemistry ; Electrophysiological Phenomena
    Chemical Substances Ion Channels ; Membrane Proteins
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01206-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Atypical Presentation of Left Knee Swelling in a Recreational Rock-Climbing Athlete.

    Vijayaraghavan, Nevin / Lee, Justin

    Current sports medicine reports

    2023  Volume 22, Issue 4, Page(s) 115–116

    MeSH term(s) Humans ; Lower Extremity ; Sports ; Athletes ; Mountaineering
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2080040-X
    ISSN 1537-8918 ; 1537-890X
    ISSN (online) 1537-8918
    ISSN 1537-890X
    DOI 10.1249/JSR.0000000000001053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.

    Bhalla, Mridula / Lee, C Justin

    Molecular brain

    2024  Volume 17, Issue 1, Page(s) 3

    Abstract: Alzheimer's disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (Aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and reactive oxygen ... ...

    Abstract Alzheimer's disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (Aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and reactive oxygen species from astrocytes, and subsequent neurodegeneration. Recently, it was found that enzyme Ornithine Decarboxylase 1 (ODC1) acts as a bridge between the astrocytic urea cycle and the putrescine-to-GABA conversion pathway in the brain of AD mouse models as well as human patients. In this study, we show that the long-term knockdown of astrocytic Odc1 in APP/PS1 animals was sufficient to completely clear Aβ plaques in the hippocampus while simultaneously switching the astrocytes from a detrimental reactive state to a regenerative active state, characterized by proBDNF expression. Our experiments also reveal an effect of astrocytic ODC1 inhibition on the expression of genes involved in synapse pruning and organization, histone modification, apoptotic signaling and protein processing. These genes are previously known to be associated with astrocytic activation and together create a neuroregeneration-supportive environment in the brain. By inhibiting ODC1 for a long period of 3 months in AD mice, we demonstrate that the beneficial amyloid-clearing process of astrocytes can be completely segregated from the systemically harmful astrocytic response to insult. Our study reports an almost complete clearance of Aβ plaques by controlling an endogenous degradation process, which also modifies the astrocytic state to create a regeneration-supportive environment in the brain. These findings present the potential of modulating astrocytic clearance of Aβ as a powerful therapeutic strategy against AD.
    MeSH term(s) Animals ; Humans ; Mice ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Astrocytes/metabolism ; Brain/metabolism ; Disease Models, Animal ; gamma-Aminobutyric Acid/metabolism ; Mice, Transgenic ; Plaque, Amyloid/complications ; Ornithine Decarboxylase
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; gamma-Aminobutyric Acid (56-12-2) ; Ornithine Decarboxylase (EC 4.1.1.17)
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-024-01076-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Oceanobs'19: An Ocean of Opportunity. Volume I

    Lee, Tong / Speich, Sabrina / Lorenzoni, Laura / Chiba, Sanae / Muller-Karger, Frank E. / Dai, Minhan / Kabo-Bah, Amos T. / Siddorn, John / Manley, Justin / Snoussi, Maria / Chai, Fei / Manley, Justin

    2020  

    Keywords Science: general issues ; Neurosciences ; OceanObs'19 ; Ocean observing ; innovation ; information ; integration ; interoperability ; governance
    Size 1 electronic resource (783 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229900
    ISBN 9782889631186 ; 2889631184
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Book ; Online: Oceanobs'19: An Ocean of Opportunity. Volume II

    Lee, Tong / Speich, Sabrina / Lorenzoni, Laura / Chiba, Sanae / Muller-Karger, Frank E. / Dai, Minhan / Kabo-Bah, Amos T. / Siddorn, John / Manley, Justin / Snoussi, Maria / Chai, Fei / Manley, Justin

    2020  

    Keywords Science: general issues ; Oceanography (seas) ; OceanObs'19 ; Ocean observing ; innovation ; information ; integration ; interoperability ; governance
    Size 1 electronic resource (629 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230069
    ISBN 9782889631193 ; 2889631192
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Book ; Online: Oceanobs'19: An Ocean of Opportunity. Volume III

    Lee, Tong / Speich, Sabrina / Lorenzoni, Laura / Chiba, Sanae / Muller-Karger, Frank E. / Dai, Minhan / Kabo-Bah, Amos T. / Siddorn, John / Manley, Justin / Snoussi, Maria / Chai, Fei / Manley, Justin

    2020  

    Keywords Science: general issues ; Oceanography (seas) ; OceanObs'19 ; Ocean observing ; innovation ; information ; integration ; interoperability ; governance
    Size 1 electronic resource (867 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229898
    ISBN 9782889631209 ; 2889631206
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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