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  1. Article ; Online: To Use or Not Use Intraoperative Neuromonitoring: Utilization of Neuromonitoring During Spine Surgeries and Associated Conflicts of Interest, a Cross-Sectional Survey Study.

    Bible, Jesse E / Goss, Madison

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2022  Volume 6, Issue 3

    Abstract: ... importance when choosing to use IONM (7.4 ± 2.9; mean ± SD), followed by surgeon reassurance (6.2 ± 2.7; P ... < 0.0001 versus medicolegal) and belief it affects patient outcomes (5.2 ± 3.0; P = 0.004 versus ...

    Abstract Introduction: There are no universal guidelines that dictate the indications for the use of intraoperative neuromonitoring (IONM) in spine surgery resulting in its variable use. The choice to use IONM has been both cited in malpractice lawsuits and insurance claims, but no data exist regarding surgeons' rationale for making this choice. The goal of this study was to assess (1) the use of certain IONM modalities during common spine surgeries, (2) surgeons' rationale for use of IONM, and (3) IONM practices and potential conflicts of interest associated with its use.
    Methods: Respondents were asked to select each IONM modality they used during 20 different surgical scenarios within the spine followed by rating the importance of several reasons when selecting to use IONM. Finally, the occurrence of conflicts of interest, out-of-network billing, and cost were assessed.
    Results: Approximately one-half (47%) of respondents who perform anterior cervical diskectomy and fusion/total disk arthroplasty for radiculopathy use IONM, opposed to 76% for myelopathy. The presence of cord compression and/or neurologic symptoms increased IONM use by approximately 30% during trauma cases. Medicolegal was the reason of highest importance when choosing to use IONM (7.4 ± 2.9; mean ± SD), followed by surgeon reassurance (6.2 ± 2.7; P < 0.0001 versus medicolegal) and belief it affects patient outcomes (5.2 ± 3.0; P = 0.004 versus reassurance).
    Conclusions: Although there is increasing use of IONM, this has not translated to an absolute requirement for every spine surgery. Surgeons are faced with opposing influences of the medicolegal system and insurance payers. Future guidelines on using IONM should not be absolute, but rather should consider the risks of each procedure, along with how patients and surgeons value these risks, in addition to the costs. The findings of this study should help to serve as a guide to surgeons, payers, and courts as contemporary, common practices for the use of IONM during spinal surgical scenarios.
    MeSH term(s) Conflict of Interest ; Cross-Sectional Studies ; Humans ; Spine/surgery ; Surgeons ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI 10.5435/JAAOSGlobal-D-21-00273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of hyperbaric oxygen in osteoradionecrosis-a prophylactic insight.

    Dang, B / Gamage, S / Sethi, S / Jensen, E D / Sambrook, P / Goss, A

    Australian dental journal

    2023  Volume 68, Issue 3, Page(s) 171–178

    Abstract: ... with age (P = 0.006) and binary analysis showed alcohol consumption to be a significant predictor ...

    Abstract Background: Osteoradionecrosis (ORN) is an uncommon and debilitating consequence of head and neck radiotherapy and hyperbaric oxygen therapy (HBOT) has been advocated for prophylaxis prior to performing dentoalveolar procedures. The aim of this study was to evaluate a prophylactic HBOT protocol and describe the outcomes of susceptible individuals.
    Methods: A retrospective audit of adults who attended the Oral and Maxillofacial Surgery department at the Royal Adelaide Hospital (South Australia) who received dental extractions with a history of radiotherapy to the jaws from 2008 to 2020. Data including demographic information and outcomes of osteoradionecrosis and delayed healing was recorded.
    Results: A total of 121 individuals were eligible for case note review; 68.6% of individuals were male and 55.4% were aged over 67 years. Osteoradionecrosis occurred in 9.1% of individuals and delayed healing for 3.3%; fifteen individuals (12.4%) were unable to complete the HBOT protocol. The individuals who were diagnosed with ORN had a significant association with age (P = 0.006) and binary analysis showed alcohol consumption to be a significant predictor.
    Conclusions: Prophylactic HBOT protocol had a lower proportion of individuals diagnosed with ORN and those who were diagnosed were more likely to be younger males and have current alcohol consumption.
    MeSH term(s) Adult ; Humans ; Male ; Aged ; Female ; Osteoradionecrosis/prevention & control ; Hyperbaric Oxygenation/methods ; Retrospective Studies ; South Australia ; Head and Neck Neoplasms/radiotherapy
    Language English
    Publishing date 2023-06-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 603965-0
    ISSN 1834-7819 ; 0045-0421
    ISSN (online) 1834-7819
    ISSN 0045-0421
    DOI 10.1111/adj.12963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of an artificial intelligence-facilitated sperm detection tool in azoospermic samples for use in ICSI.

    Goss, Dale M / Vasilescu, Steven A / Vasilescu, Phillip A / Cooke, Simon / Kim, Shannon Hk / Sacks, Gavin P / Gardner, David K / Warkiani, Majid E

    Reproductive biomedicine online

    2024  Volume 49, Issue 1, Page(s) 103910

    Abstract: Research question: Can artificial intelligence (AI) improve the efficiency and efficacy of sperm searches in azoospermic samples?: Design: This two-phase proof-of-concept study began with a training phase using eight azoospermic patients (>10,000 ... ...

    Abstract Research question: Can artificial intelligence (AI) improve the efficiency and efficacy of sperm searches in azoospermic samples?
    Design: This two-phase proof-of-concept study began with a training phase using eight azoospermic patients (>10,000 sperm images) to provide a variety of surgically collected samples for sperm morphology and debris variation to train a convolutional neural network to identify spermatozoa. Second, side-by-side testing was undertaken on two cohorts of non-obstructive azoospermia patient samples: an embryologist versus the AI identifying all the spermatozoa in the still images (cohort 1, n = 4), and a side-by-side test with a simulated clinical deployment of the AI model with an intracytoplasmic sperm injection microscope and the embryologist performing a search with and without the aid of the AI (cohort 2, n = 4).
    Results: In cohort 1, the AI model showed an improvement in the time taken to identify all the spermatozoa per field of view (0.02 ± 0.30  ×  10
    Conclusions: AI-powered image analysis has the potential for seamless integration into laboratory workflows, to reduce the time to identify and isolate spermatozoa from surgical sperm samples from hours to minutes, thus increasing success rates from these treatments.
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2024.103910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antarctic Evacuation: A Retrospective Epidemiological Study of Medical Evacuations on US Military Aircraft in Antarctica.

    Brown, Samuel P / Mongold, Sarah M / Powell, Thomas L / Goss, Sarah E / Schauer, Steven G

    Medical journal (Fort Sam Houston, Tex.)

    2023  , Issue Per 23-1/2/3, Page(s) 41–46

    Abstract: Background: The international community has shown increasing interest in the Arctic and Antarctic due to the value polar regions have in terms of environmental research, natural resources, and national defense. The US Government maintains several ... ...

    Abstract Background: The international community has shown increasing interest in the Arctic and Antarctic due to the value polar regions have in terms of environmental research, natural resources, and national defense. The US Government maintains several permanent research and military facilities in polar regions. Medical evacuation (MEDEVAC) from these facilities can be limited for prolonged periods of time due to their extreme climates. Published data regarding MEDEVACs from these facilities is extremely limited.
    Methods: Evacuations on military aircraft registered in the Transportation Command Regulation and Command and Control Evacuation System (TRAC2ES) database in a previously de-identified dataset were queried for events from McMurdo, Antarctica. The data was analyzed to determine the number of evacuations, reasons for evacuation, and additional demographic data.
    Results: There were 31 evacuations from McMurdo Station and Scott Amundsen South Pole Station for 29 unique patients recorded in the available TRAC2ES dataset. Reasons for evacuation included traumatic brain/head injury, behavioral health concerns, extremity injuries, pregnancy, and various other medical/surgical concerns.
    Conclusions: MEDEVAC was typically required for advanced diagnostic/treatment modalities or if a patient could no longer fulfill his/her duties. Most evacuations were not directly related to environmental exposure. Given the climate in polar regions can preclude timely evacuation for large periods of time, the need for evacuation must be anticipated and mitigated whenever possible. Better data is needed to guide staffing and mission planning in this remote location.
    MeSH term(s) Humans ; Male ; Female ; Antarctic Regions ; Military Personnel ; Retrospective Studies ; Aircraft ; Transportation of Patients ; Brain Injuries, Traumatic
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ISSN 2694-3611
    ISSN (online) 2694-3611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Retrospective Analysis of the Impact of High- and Low-Quality Donor Livers for Patients with High-Acuity Illness.

    Varghese, Ron K / Handing, Greta E / Montgomery, Ashley E / Rana, Abbas A / Goss, John A

    Annals of transplantation

    2024  Volume 29, Page(s) e941931

    Abstract: ... impact on high-acuity patient mortality, compared with low-quality livers (OR=0.695 [0.549, 0.879], P=0 ... 002). High-quality livers also had significant impact on graft survival (OR=0.706 [0.558, 0.894], P=0 ...

    Abstract BACKGROUND Patients with high-acuity liver failure have increased access to marginal and split liver options, owing to historically high waitlist mortality rates. While most research states that donor liver quality has no impact on patients with high-acuity illness, there have been inconsistencies in recent research on how liver quality impacts post-transplant outcomes for these patients. We aimed to quantify donor liver quality with various post-transplantation patient outcomes for patients with high-acuity illness. MATERIAL AND METHODS Using the liver donor risk index (LDRI), model for end stage liver disease (MELD), and clinically relevant recipient factors, we used multivariate logistic regression to analyze how donor liver quality affects varying measures of patient outcomes for 9923 high-acuity patients from June 18, 2013, to June 18, 2022. RESULTS Using LDRI, high-quality livers had a significant protective impact on high-acuity patient mortality, compared with low-quality livers (OR=0.695 [0.549, 0.879], P=0.002). High-quality livers also had significant impact on graft survival (OR=0.706 [0.558, 0.894], P=0.004). Two sensitivity patient mortality analyses, excluding patients with status 1A and hepatocellular carcinoma, showed significant protective findings for high-quality livers. High-quality livers had insignificant outcomes on long-term survivor mortality, length of hospitalization, and primary non-function outcomes, compared with low-quality donor livers. CONCLUSIONS While our findings suggest donor quality has an impact on high-acuity patient outcomes, these findings indicate further research is needed in intent-to-treat analysis on clinical offer data to provide a clearer finding of how donor quality affects patients with high-acuity illness.
    MeSH term(s) Humans ; End Stage Liver Disease/surgery ; Liver Transplantation ; Living Donors ; Retrospective Studies ; Severity of Illness Index ; Liver Neoplasms
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.941931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Bacterial Mutation During Seasonal Epidemics.

    Sharma, Anuj / Timilsina, Sujan / Abrahamian, Peter / Minsavage, Gerald V / Jones, Jeffrey B / Vallad, Gary E / Goss, Erica M

    Molecular plant-microbe interactions : MPMI

    2024  Volume 37, Issue 2, Page(s) 93–97

    Abstract: Rapidly evolving bacterial pathogens pose a unique challenge for long-term plant disease management. In this study, we investigated the types and rate of mutations in bacterial populations during seasonal disease epidemics. Two phylogenetically distinct ... ...

    Abstract Rapidly evolving bacterial pathogens pose a unique challenge for long-term plant disease management. In this study, we investigated the types and rate of mutations in bacterial populations during seasonal disease epidemics. Two phylogenetically distinct strains of the bacterial spot pathogen,
    MeSH term(s) Seasons ; Plant Diseases/microbiology ; Bacteria/genetics ; Genome, Bacterial/genetics ; Mutation ; Xanthomonas/genetics
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 743331-1
    ISSN 1943-7706 ; 0894-0282
    ISSN (online) 1943-7706
    ISSN 0894-0282
    DOI 10.1094/MPMI-10-23-0164-SC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What is the Risk of Developing Osteonecrosis Following Dental Extractions for Patients on Denosumab for Osteoporosis?

    Colella, Anthony / Yu, Elaine / Sambrook, Paul / Hughes, Toby / Goss, Alastair

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2022  Volume 81, Issue 2, Page(s) 232–237

    Abstract: Purpose: Osteonecrosis of the jaws (ONJ) occurs in patients on antiresorptive drugs for osteoporosis with the risk with oral bisphosphonates being known to be of the order of 0.1 to 0.3% while the risk for patients on denosumab for osteoporosis is not ... ...

    Abstract Purpose: Osteonecrosis of the jaws (ONJ) occurs in patients on antiresorptive drugs for osteoporosis with the risk with oral bisphosphonates being known to be of the order of 0.1 to 0.3% while the risk for patients on denosumab for osteoporosis is not known. The aim of this study was to determine the risk of developing ONJ in a consecutive series of patients on denosumab for osteoporosis having dental extractions.
    Material and methods: A prospective cohort study of patients on denosumab for osteoporosis having dental extractions in the period January 1, 2017 and June 30, 2021 were compared to a control group not on antiresorptives. Detailed demographic records including length of time on antiresorptives and CTX values were obtained. Comparison to further define risk factors was made between those patients developing ONJ to those who didn't.
    Results: The treatment group included 427 patients who were on denosumab for osteoporosis; they collectively underwent 561 episodes of dental treatment involving extractions for a total of 1081 extractions, with 10 developing ONJ (risk 2.3%). The control group consisted of 299 patients who were not taking denosumab; they collectively underwent 315 episodes of dental treatment for a total of 669 extractions, and none of them developed ONJ. There were significant differences in age and sex, but not medical comorbidities between the treatment and control groups. Within the treatment group, there were no significant differences in any of these characteristics between those who did, and those who didn't, develop ONJ. Within the treatment group, the number of extractions modified the risk of developing ONJ (odds ratio, 1.35; confidence interval, 1.1-1.7). Of the 76 patients who had extractions between 6 and 7 months after the last denosumab injection, none developed ONJ.
    Conclusions: The risk of ONJ in patients on denosumab for osteoporosis is a magnitude greater than for patients on the oral bisphosphonates 2.3% v 0 - 0.3%, which is 7.7 times more likely. Number of extractions and early resumption of the next dose of denosumab increases the risk of ONJ.
    MeSH term(s) Humans ; Denosumab/adverse effects ; Prospective Studies ; Osteoporosis/drug therapy ; Bone Density Conservation Agents/adverse effects ; Osteonecrosis/chemically induced ; Diphosphonates/adverse effects ; Tooth Extraction/adverse effects ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/therapy
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2022.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evidence for transporter-mediated uptake of environmental L-glutamate in a freshwater sponge, Ephydatia muelleri.

    Weinrauch, Alyssa M / Dumar, Zachary J / Overduin, Sienna L / Goss, Greg G / Leys, Sally P / Blewett, Tamzin A

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

    2024  

    Abstract: ... known how L-glutamate is obtained by E. muelleri in sufficient quantities (i.e., 70 µM) to mediate ... from the environment across the body surface of E. muelleri. We demonstrate carrier mediated uptake of two distinct ...

    Abstract The freshwater sponge, Ephydatia muelleri, lacks a nervous or endocrine system and yet it exhibits a coordinated whole-body action known as a "sneeze" that can be triggered by exposure to L-glutamate. It is not known how L-glutamate is obtained by E. muelleri in sufficient quantities (i.e., 70 µM) to mediate this response endogenously. The present study tested the hypothesis that L-glutamate can be directly acquired from the environment across the body surface of E. muelleri. We demonstrate carrier mediated uptake of two distinct saturable systems with maximal transport rates (J
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 231245-1
    ISSN 1432-136X ; 0174-1578
    ISSN (online) 1432-136X
    ISSN 0174-1578
    DOI 10.1007/s00360-024-01544-6
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  9. Article ; Online: The Long and the Short of It in Cystic Fibrosis Clinical Research Outcomes.

    West, Natalie E / Goss, Christopher H / Nichols, David P

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 4, Page(s) 430–431

    MeSH term(s) Child ; Cystic Fibrosis ; Humans ; Ibuprofen ; Respiratory Physiological Phenomena
    Chemical Substances Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201801-056ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Physical Therapists Are Routinely Performing the Requisite Skills to Directly Refer for Musculoskeletal Imaging: An Observational Study.

    Mabry, Lance M / Severin, Richard / Gisselman, Angela S / Ross, Michael D / Davenport, Todd E / Young, Brian A / Keil, Aaron P / Goss, Don L

    The Journal of manual & manipulative therapy

    2022  Volume 30, Issue 5, Page(s) 261–272

    Abstract: ... 0.06) compared to their masters- (6.44 ± 0.19) and bachelors-trained (5.95 ± 0.21) counterparts (p ... imaging skills (7.60 ± 0.11 vs. 6.79 ± 0.07, p < 0.001). Imaging skill performance was greater among board ... certified physical therapists (7.39 ± 0.09 vs. 6.71 ± 0.08, p < 0.001) and APTA members (7.06 ± 0.07 vs. 6 ...

    Abstract Objectives: To explore if physical therapists are practicing skills necessary to refer patients for musculoskeletal imaging.
    Methods: An expert panel established a list of nine requisite skills to refer for musculoskeletal imaging. A blinded expert panel validated the list using a 5-point Likert scale. The skills list was examined via an electronic survey distributed to United States physical therapists.
    Results: 4,796 respondents were included. Each of the nine skills were routinely performed by a majority of the respondents (range: 54.52-94.72%). Respondents routinely performed 6.95 (± 0.06) skills, with 67.41% routinely performing seven or more skills. Doctors of physical therapy routinely performed more imaging skills (7.15 ± 0.06) compared to their masters- (6.44 ± 0.19) and bachelors-trained (5.95 ± 0.21) counterparts (p < 0.001). Residency/fellowship-trained physical therapists were more likely to routinely perform more imaging skills (7.60 ± 0.11 vs. 6.79 ± 0.07, p < 0.001). Imaging skill performance was greater among board-certified physical therapists (7.39 ± 0.09 vs. 6.71 ± 0.08, p < 0.001) and APTA members (7.06 ± 0.07 vs. 6.65 ± 0.12, p < 0.001).
    Conclusion: Physical therapists are routinely practicing the requisite imaging skills to directly refer to a radiologist for musculoskeletal imaging.
    MeSH term(s) Fellowships and Scholarships ; Humans ; Internship and Residency ; Physical Therapists ; Physical Therapy Modalities ; Surveys and Questionnaires ; United States
    Language English
    Publishing date 2022-08-13
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 920432-5
    ISSN 2042-6186 ; 1066-9817
    ISSN (online) 2042-6186
    ISSN 1066-9817
    DOI 10.1080/10669817.2022.2106729
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