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Article ; Online: Symmetric bis-benzimidazoles as DNA minor groove-binding agents with anti-tumour and antibacterial activity, and the evolution of the drug ridinilazole for the treatment of Clostridium difficile infections.

Baron, Anne / Sann, Christine Le / Mann, John

2022 Volume 58, Page(s) 116656

Abstract: We report the synthesis of a range of symmetrical bis-benzimidazoles (BBZ) which possess anticancer and antibacterial activities. One of these BBZs has specific activity against Clostridium difficile and is currently in a phase 3 clinical evaluation as ... ...

Abstract	We report the synthesis of a range of symmetrical bis-benzimidazoles (BBZ) which possess anticancer and antibacterial activities. One of these BBZs has specific activity against Clostridium difficile and is currently in a phase 3 clinical evaluation as the drug ridinilazole. X-ray and computer modelling studies showed that BBZs typically exhibit high specificity for oligonucleotide sequences that occur in the minor groove of DNA.
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Benzimidazoles/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clostridium Infections/drug therapy ; Crystallography, X-Ray ; DNA/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Pyridines/chemistry ; Pyridines/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antineoplastic Agents ; Benzimidazoles ; Pyridines ; ridinilazole (06DX01190R) ; bis-benzimidazole (16656-27-2) ; DNA (9007-49-2)
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2022.116656
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Article: Maleimide spacers as versatile linkers in the synthesis of bioconjugates of anthracyclines.

Le Sann, Christine

Natural product reports

2006 Volume 23, Issue 3, Page(s) 357–367

MeSH term(s)	Amino Acid Sequence ; Anthracyclines/chemical synthesis ; Anthracyclines/chemistry ; Anthracyclines/pharmacokinetics ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Ligands ; Maleimides/chemistry ; Molecular Sequence Data
Chemical Substances	Anthracyclines ; Antineoplastic Agents ; Ligands ; Maleimides ; maleimide (2519R1UGP8)
Language	English
Publishing date	2006-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b600666n
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Article: Inhibitors of types I and II dehydroquinase.

Le Sann, Christine / Gower, Mary A / Abell, Andrew D

Mini reviews in medicinal chemistry

2004 Volume 4, Issue 7, Page(s) 747–756

Abstract: Inhibitors of varying potency have been developed for types I and II 3-dehydroquinate dehydratase (dehydroquinase), enzymes from the shikimate and quinate pathways that catalyse the dehydration of dehydroquinate to dehydroshikimate. These inhibitors have ...

Abstract	Inhibitors of varying potency have been developed for types I and II 3-dehydroquinate dehydratase (dehydroquinase), enzymes from the shikimate and quinate pathways that catalyse the dehydration of dehydroquinate to dehydroshikimate. These inhibitors have resulted from enzyme mechanistic studies and from the direct search for enzyme inhibitors with herbicidal, fungicidal or antimicrobial potential. This review discusses the design of the various inhibitors that have been produced so far and some structure-activity relationships. The majority of these inhibitors are based on dehydroquinate analogues, although some work has also been carried out on dehydroshikimate and bissulfonamides. Some discussion is also presented on advances in the synthesis of these types of compounds.
MeSH term(s)	Aspergillus nidulans/enzymology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Hydro-Lyases/antagonists & inhibitors ; Hydro-Lyases/physiology ; Molecular Structure ; Mycobacterium tuberculosis/enzymology ; Salmonella typhimurium/enzymology ; Streptomyces coelicolor/enzymology ; Structure-Activity Relationship ; Substrate Specificity
Chemical Substances	Enzyme Inhibitors ; Hydro-Lyases (EC 4.2.1.-) ; 3-dehydroquinate dehydratase (EC 4.2.1.10)
Language	English
Publishing date	2004-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
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Article: Assembly intermediates in polyketide biosynthesis: enantioselective syntheses of beta-hydroxycarbonyl compounds.

Le Sann, Christine / Munoz, Dulce M / Saunders, Natalie / Simpson, Thomas J / Smith, David I / Soulas, Florilène / Watts, Paul / Willis, Christine L

Organic & biomolecular chemistry

2005 Volume 3, Issue 9, Page(s) 1719–1728

Abstract: A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of ... ...

Abstract	A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted delta-lactones.
MeSH term(s)	Ketones/chemistry ; Macrolides/chemistry ; Macrolides/metabolism ; Magnetic Resonance Spectroscopy ; Spectrometry, Mass, Electrospray Ionization ; Stereoisomerism
Chemical Substances	Ketones ; Macrolides
Language	English
Publishing date	2005-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/b419492f
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Article: New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity.

Le Sann, Christine / Baron, Anne / Mann, John / van den Berg, Hendrik / Gunaratnam, Mekala / Neidle, Stephen

Organic & biomolecular chemistry

2006 Volume 4, Issue 7, Page(s) 1305–1312

Abstract: We describe new methodology for the synthesis of symmetric bis-benzimidazoles carrying 2-aryl moieties, including 2-[4-(3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)phenyl] substituents, together with the synthesis of novel hybrid molecules ... ...

Abstract	We describe new methodology for the synthesis of symmetric bis-benzimidazoles carrying 2-aryl moieties, including 2-[4-(3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)phenyl] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.
MeSH term(s)	Amides ; Base Pairing ; Base Sequence ; Benzaldehydes/chemistry ; Benzimidazoles/chemistry ; Benzimidazoles/toxicity ; Cell Division/drug effects ; Cell Line, Tumor ; Chlorambucil/pharmacology ; Crystallography, X-Ray ; DNA, Neoplasm/chemistry ; DNA, Neoplasm/drug effects ; Esters ; Humans ; Mechlorethamine/chemistry ; Mechlorethamine/toxicity ; Models, Molecular ; Molecular Conformation ; Oligodeoxyribonucleotides/chemistry ; Pyrrolidines/chemistry ; Rhodamines
Chemical Substances	Amides ; Benzaldehydes ; Benzimidazoles ; DNA, Neoplasm ; Esters ; Oligodeoxyribonucleotides ; Pyrrolidines ; Rhodamines ; Chlorambucil (18D0SL7309) ; Mechlorethamine (50D9XSG0VR) ; benzaldehyde (TA269SD04T)
Language	English
Publishing date	2006-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/b600567e
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Article ; Online: Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.

Huggins, Ashley A / Baird, C Lexi / Briggs, Melvin / Laskowitz, Sarah / Hussain, Ahmed / Fouda, Samar / Haswell, Courtney / Sun, Delin / Salminen, Lauren E / Jahanshad, Neda / Thomopoulos, Sophia I / Veltman, Dick J / Frijling, Jessie L / Olff, Miranda / van Zuiden, Mirjam / Koch, Saskia B J / Nawjin, Laura / Wang, Li / Zhu, Ye /

Li, Gen / Stein, Dan J / Ipser, Jonathan / Seedat, Soraya / du Plessis, Stefan / van den Heuvel, Leigh L / Suarez-Jimenez, Benjamin / Zhu, Xi / Kim, Yoojean / He, Xiaofu / Zilcha-Mano, Sigal / Lazarov, Amit / Neria, Yuval / Stevens, Jennifer S / Ressler, Kerry J / Jovanovic, Tanja / van Rooij, Sanne J H / Fani, Negar / Hudson, Anna R / Mueller, Sven C / Sierk, Anika / Manthey, Antje / Walter, Henrik / Daniels, Judith K / Schmahl, Christian / Herzog, Julia I / Říha, Pavel / Rektor, Ivan / Lebois, Lauren A M / Kaufman, Milissa L / Olson, Elizabeth A / Baker, Justin T / Rosso, Isabelle M / King, Anthony P / Liberzon, Isreal / Angstadt, Mike / Davenport, Nicholas D / Sponheim, Scott R / Disner, Seth G / Straube, Thomas / Hofmann, David / Qi, Rongfeng / Lu, Guang Ming / Baugh, Lee A / Forster, Gina L / Simons, Raluca M / Simons, Jeffrey S / Magnotta, Vincent A / Fercho, Kelene A / Maron-Katz, Adi / Etkin, Amit / Cotton, Andrew S / O'Leary, Erin N / Xie, Hong / Wang, Xin / Quidé, Yann / El-Hage, Wissam / Lissek, Shmuel / Berg, Hannah / Bruce, Steven / Cisler, Josh / Ross, Marisa / Herringa, Ryan J / Grupe, Daniel W / Nitschke, Jack B / Davidson, Richard J / Larson, Christine L / deRoon-Cassini, Terri A / Tomas, Carissa W / Fitzgerald, Jacklynn M / Blackford, Jennifer Urbano / Olatunji, Bunmi O / Kremen, William S / Lyons, Michael J / Franz, Carol E / Gordon, Evan M / May, Geoffrey / Nelson, Steven M / Abdallah, Chadi G / Levy, Ifat / Harpaz-Rotem, Ilan / Krystal, John H / Dennis, Emily L / Tate, David F / Cifu, David X / Walker, William C / Wilde, Elizabeth A / Harding, Ian H / Kerestes, Rebecca / Thompson, Paul M / Morey, Rajendra

Molecular psychiatry

2024

Abstract: Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map ...

Abstract	Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02352-0
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Zs.A 4812: Show issues

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Article ; Online: Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.

Campos, Adrian I / Van Velzen, Laura S / Veltman, Dick J / Pozzi, Elena / Ambrogi, Sonia / Ballard, Elizabeth D / Banaj, Nerisa / Başgöze, Zeynep / Bellow, Sophie / Benedetti, Francesco / Bollettini, Irene / Brosch, Katharina / Canales-Rodríguez, Erick J / Clarke-Rubright, Emily K / Colic, Lejla / Connolly, Colm G / Courtet, Philippe / Cullen, Kathryn R / Dannlowski, Udo /

Dauvermann, Maria R / Davey, Christopher G / Deverdun, Jeremy / Dohm, Katharina / Erwin-Grabner, Tracy / Goya-Maldonado, Roberto / Fani, Negar / Fortea, Lydia / Fuentes-Claramonte, Paola / Gonul, Ali Saffet / Gotlib, Ian H / Grotegerd, Dominik / Harris, Mathew A / Harrison, Ben J / Haswell, Courtney C / Hawkins, Emma L / Hill, Dawson / Hirano, Yoshiyuki / Ho, Tiffany C / Jollant, Fabrice / Jovanovic, Tanja / Kircher, Tilo / Klimes-Dougan, Bonnie / le Bars, Emmanuelle / Lochner, Christine / McIntosh, Andrew M / Meinert, Susanne / Mekawi, Yara / Melloni, Elisa / Mitchell, Philip / Morey, Rajendra A / Nakagawa, Akiko / Nenadić, Igor / Olié, Emilie / Pereira, Fabricio / Phillips, Rachel D / Piras, Fabrizio / Poletti, Sara / Pomarol-Clotet, Edith / Radua, Joaquim / Ressler, Kerry J / Roberts, Gloria / Rodriguez-Cano, Elena / Sacchet, Matthew D / Salvador, Raymond / Sandu, Anca-Larisa / Shimizu, Eiji / Singh, Aditya / Spalletta, Gianfranco / Steele, J Douglas / Stein, Dan J / Stein, Frederike / Stevens, Jennifer S / Teresi, Giana I / Uyar-Demir, Aslihan / van der Wee, Nic J / van der Werff, Steven J / van Rooij, Sanne J H / Vecchio, Daniela / Verdolini, Norma / Vieta, Eduard / Waiter, Gordon D / Whalley, Heather / Whittle, Sarah L / Yang, Tony T / Zarate, Carlos A / Thompson, Paul M / Jahanshad, Neda / van Harmelen, Anne-Laura / Blumberg, Hilary P / Schmaal, Lianne / Rentería, Miguel E

Neuropsychology

2023 Volume 37, Issue 3, Page(s) 315–329

Abstract: Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling ... ...

Abstract	Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data in international consortia. Method: Here, we examine this issue through two approaches: (a) an extensive literature search on the reliability and concurrent validity of the most commonly used instruments and (b) by pooling data (N ∼ 6,000 participants) from cohorts from the Enhancing NeuroImaging Genetics Through Meta-Analysis (ENIGMA) Major Depressive Disorder and ENIGMA-Suicidal Thoughts and Behaviour working groups, to assess the concurrent validity of instruments currently used for assessing suicidal thoughts or behavior. Results: We observed moderate-to-high correlations between measures, consistent with the wide range (κ range: 0.15-0.97; r range: 0.21-0.94) reported in the literature. Two common multi-item instruments, the Columbia Suicide Severity Rating Scale and the Beck Scale for Suicidal Ideation were highly correlated with each other (r = 0.83). Sensitivity analyses identified sources of heterogeneity such as the time frame of the instrument and whether it relies on self-report or a clinical interview. Finally, construct-specific analyses suggest that suicide ideation items from common psychiatric questionnaires are most concordant with the suicide ideation construct of multi-item instruments. Conclusions: Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations including distinct instruments should be feasible provided they harmonize across instruments or focus on specific constructs of suicidality. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnosis ; Reproducibility of Results ; Retrospective Studies ; Suicidal Ideation ; Risk Assessment
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000850
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Zs.A 3002: Show issues

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Article ; Online: Recognition of microbial viability via TLR8 drives T

Ugolini, Matteo / Gerhard, Jenny / Burkert, Sanne / Jensen, Kristoffer Jarlov / Georg, Philipp / Ebner, Friederike / Volkers, Sarah M / Thada, Shruthi / Dietert, Kristina / Bauer, Laura / Schäfer, Alexander / Helbig, Elisa T / Opitz, Bastian / Kurth, Florian / Sur, Saubashya / Dittrich, Nickel / Gaddam, Sumanlatha / Conrad, Melanie L / Benn, Christine S /

Blohm, Ulrike / Gruber, Achim D / Hutloff, Andreas / Hartmann, Susanne / Boekschoten, Mark V / Müller, Michael / Jungersen, Gregers / Schumann, Ralf R / Suttorp, Norbert / Sander, Leif E

Nature immunology

2018 Volume 19, Issue 4, Page(s) 386–396

Abstract: Live attenuated vaccines are generally highly efficacious and often superior to inactivated vaccines, yet the underlying mechanisms of this remain largely unclear. Here we identify recognition of microbial viability as a potent stimulus for follicular ... ...

Abstract	Live attenuated vaccines are generally highly efficacious and often superior to inactivated vaccines, yet the underlying mechanisms of this remain largely unclear. Here we identify recognition of microbial viability as a potent stimulus for follicular helper T cell (T
MeSH term(s)	Adult ; Animals ; Antibody Formation/immunology ; Cell Differentiation/immunology ; Female ; Humans ; Lymphocyte Activation/immunology ; Male ; Microbial Viability/immunology ; Swine ; T-Lymphocytes, Helper-Inducer/immunology ; Toll-Like Receptor 8/immunology ; Vaccines, Attenuated/immunology
Chemical Substances	TLR8 protein, human ; Toll-Like Receptor 8 ; Vaccines, Attenuated
Language	English
Publishing date	2018-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-018-0068-4
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: Consistent patterns of common species across tropical tree communities.

Cooper, Declan L M / Lewis, Simon L / Sullivan, Martin J P / Prado, Paulo I / Ter Steege, Hans / Barbier, Nicolas / Slik, Ferry / Sonké, Bonaventure / Ewango, Corneille E N / Adu-Bredu, Stephen / Affum-Baffoe, Kofi / de Aguiar, Daniel P P / Ahuite Reategui, Manuel Augusto / Aiba, Shin-Ichiro / Albuquerque, Bianca Weiss / de Almeida Matos, Francisca Dionízia / Alonso, Alfonso / Amani, Christian A / do Amaral, Dário Dantas /

do Amaral, Iêda Leão / Andrade, Ana / de Andrade Miranda, Ires Paula / Angoboy, Ilondea B / Araujo-Murakami, Alejandro / Arboleda, Nicolás Castaño / Arroyo, Luzmila / Ashton, Peter / Aymard C, Gerardo A / Baider, Cláudia / Baker, Timothy R / Balinga, Michael Philippe Bessike / Balslev, Henrik / Banin, Lindsay F / Bánki, Olaf S / Baraloto, Chris / Barbosa, Edelcilio Marques / Barbosa, Flávia Rodrigues / Barlow, Jos / Bastin, Jean-Francois / Beeckman, Hans / Begne, Serge / Bengone, Natacha Nssi / Berenguer, Erika / Berry, Nicholas / Bitariho, Robert / Boeckx, Pascal / Bogaert, Jan / Bonyoma, Bernard / Boundja, Patrick / Bourland, Nils / Boyemba Bosela, Faustin / Brambach, Fabian / Brienen, Roel / Burslem, David F R P / Camargo, José Luís / Campelo, Wegliane / Cano, Angela / Cárdenas, Sasha / Cárdenas López, Dairon / de Sá Carpanedo, Rainiellen / Carrero Márquez, Yrma Andreina / Carvalho, Fernanda Antunes / Casas, Luisa Fernanda / Castellanos, Hernán / Castilho, Carolina V / Cerón, Carlos / Chapman, Colin A / Chave, Jerome / Chhang, Phourin / Chutipong, Wanlop / Chuyong, George B / Cintra, Bruno Barçante Ladvocat / Clark, Connie J / Coelho de Souza, Fernanda / Comiskey, James A / Coomes, David A / Cornejo Valverde, Fernando / Correa, Diego F / Costa, Flávia R C / Costa, Janaina Barbosa Pedrosa / Couteron, Pierre / Culmsee, Heike / Cuni-Sanchez, Aida / Dallmeier, Francisco / Damasco, Gabriel / Dauby, Gilles / Dávila, Nállarett / Dávila Doza, Hilda Paulette / De Alban, Jose Don T / de Assis, Rafael L / De Canniere, Charles / De Haulleville, Thales / de Jesus Veiga Carim, Marcelo / Demarchi, Layon O / Dexter, Kyle G / Di Fiore, Anthony / Din, Hazimah Haji Mohammad / Disney, Mathias I / Djiofack, Brice Yannick / Djuikouo, Marie-Noël K / Do, Tran Van / Doucet, Jean-Louis / Draper, Freddie C / Droissart, Vincent / Duivenvoorden, Joost F / Engel, Julien / Estienne, Vittoria / Farfan-Rios, William / Fauset, Sophie / Feeley, Kenneth J / Feitosa, Yuri Oliveira / Feldpausch, Ted R / Ferreira, Cid / Ferreira, Joice / Ferreira, Leandro Valle / Fletcher, Christine D / Flores, Bernardo Monteiro / Fofanah, Alusine / Foli, Ernest G / Fonty, Émile / Fredriksson, Gabriella M / Fuentes, Alfredo / Galbraith, David / Gallardo Gonzales, George Pepe / Garcia-Cabrera, Karina / García-Villacorta, Roosevelt / Gomes, Vitor H F / Gómez, Ricardo Zárate / Gonzales, Therany / Gribel, Rogerio / Guedes, Marcelino Carneiro / Guevara, Juan Ernesto / Hakeem, Khalid Rehman / Hall, Jefferson S / Hamer, Keith C / Hamilton, Alan C / Harris, David J / Harrison, Rhett D / Hart, Terese B / Hector, Andy / Henkel, Terry W / Herbohn, John / Hockemba, Mireille B N / Hoffman, Bruce / Holmgren, Milena / Honorio Coronado, Euridice N / Huamantupa-Chuquimaco, Isau / Hubau, Wannes / Imai, Nobuo / Irume, Mariana Victória / Jansen, Patrick A / Jeffery, Kathryn J / Jimenez, Eliana M / Jucker, Tommaso / Junqueira, André Braga / Kalamandeen, Michelle / Kamdem, Narcisse G / Kartawinata, Kuswata / Kasongo Yakusu, Emmanuel / Katembo, John M / Kearsley, Elizabeth / Kenfack, David / Kessler, Michael / Khaing, Thiri Toe / Killeen, Timothy J / Kitayama, Kanehiro / Klitgaard, Bente / Labrière, Nicolas / Laumonier, Yves / Laurance, Susan G W / Laurance, William F / Laurent, Félix / Le, Tinh Cong / Le, Trai Trong / Leal, Miguel E / Leão de Moraes Novo, Evlyn Márcia / Levesley, Aurora / Libalah, Moses B / Licona, Juan Carlos / Lima Filho, Diógenes de Andrade / Lindsell, Jeremy A / Lopes, Aline / Lopes, Maria Aparecida / Lovett, Jon C / Lowe, Richard / Lozada, José Rafael / Lu, Xinghui / Luambua, Nestor K / Luize, Bruno Garcia / Maas, Paul / Magalhães, José Leonardo Lima / Magnusson, William E / Mahayani, Ni Putu Diana / Makana, Jean-Remy / Malhi, Yadvinder / Maniguaje Rincón, Lorena / Mansor, Asyraf / Manzatto, Angelo Gilberto / Marimon, Beatriz S / Marimon-Junior, Ben Hur / Marshall, Andrew R / Martins, Maria Pires / Mbayu, Faustin M / de Medeiros, Marcelo Brilhante / Mesones, Italo / Metali, Faizah / Mihindou, Vianet / Millet, Jerome / Milliken, William / Mogollón, Hugo F / Molino, Jean-François / Mohd Said, Mohd Nizam / Monteagudo Mendoza, Abel / Montero, Juan Carlos / Moore, Sam / Mostacedo, Bonifacio / Mozombite Pinto, Linder Felipe / Mukul, Sharif Ahmed / Munishi, Pantaleo K T / Nagamasu, Hidetoshi / Nascimento, Henrique Eduardo Mendonça / Nascimento, Marcelo Trindade / Neill, David / Nilus, Reuben / Noronha, Janaína Costa / Nsenga, Laurent / Núñez Vargas, Percy / Ojo, Lucas / Oliveira, Alexandre A / de Oliveira, Edmar Almeida / Ondo, Fidèle Evouna / Palacios Cuenca, Walter / Pansini, Susamar / Pansonato, Marcelo Petratti / Paredes, Marcos Ríos / Paudel, Ekananda / Pauletto, Daniela / Pearson, Richard G / Pena, José Luis Marcelo / Pennington, R Toby / Peres, Carlos A / Permana, Andrea / Petronelli, Pascal / Peñuela Mora, Maria Cristina / Phillips, Juan Fernando / Phillips, Oliver L / Pickavance, Georgia / Piedade, Maria Teresa Fernandez / Pitman, Nigel C A / Ploton, Pierre / Popelier, Andreas / Poulsen, John R / Prieto, Adriana / Primack, Richard B / Priyadi, Hari / Qie, Lan / Quaresma, Adriano Costa / de Queiroz, Helder Lima / Ramirez-Angulo, Hirma / Ramos, José Ferreira / Reis, Neidiane Farias Costa / Reitsma, Jan / Revilla, Juan David Cardenas / Riutta, Terhi / Rivas-Torres, Gonzalo / Robiansyah, Iyan / Rocha, Maira / Rodrigues, Domingos de Jesus / Rodriguez-Ronderos, M Elizabeth / Rovero, Francesco / Rozak, Andes H / Rudas, Agustín / Rutishauser, Ervan / Sabatier, Daniel / Sagang, Le Bienfaiteur / Sampaio, Adeilza Felipe / Samsoedin, Ismayadi / Satdichanh, Manichanh / Schietti, Juliana / Schöngart, Jochen / Scudeller, Veridiana Vizoni / Seuaturien, Naret / Sheil, Douglas / Sierra, Rodrigo / Silman, Miles R / Silva, Thiago Sanna Freire / da Silva Guimarães, José Renan / Simo-Droissart, Murielle / Simon, Marcelo Fragomeni / Sist, Plinio / Sousa, Thaiane R / de Sousa Farias, Emanuelle / de Souza Coelho, Luiz / Spracklen, Dominick V / Stas, Suzanne M / Steinmetz, Robert / Stevenson, Pablo R / Stropp, Juliana / Sukri, Rahayu S / Sunderland, Terry C H / Suzuki, Eizi / Swaine, Michael D / Tang, Jianwei / Taplin, James / Taylor, David M / Tello, J Sebastián / Terborgh, John / Texier, Nicolas / Theilade, Ida / Thomas, Duncan W / Thomas, Raquel / Thomas, Sean C / Tirado, Milton / Toirambe, Benjamin / de Toledo, José Julio / Tomlinson, Kyle W / Torres-Lezama, Armando / Tran, Hieu Dang / Tshibamba Mukendi, John / Tumaneng, Roven D / Umaña, Maria Natalia / Umunay, Peter M / Urrego Giraldo, Ligia Estela / Valderrama Sandoval, Elvis H / Valenzuela Gamarra, Luis / Van Andel, Tinde R / van de Bult, Martin / van de Pol, Jaqueline / van der Heijden, Geertje / Vasquez, Rodolfo / Vela, César I A / Venticinque, Eduardo Martins / Verbeeck, Hans / Veridiano, Rizza Karen A / Vicentini, Alberto / Vieira, Ima Célia Guimarães / Vilanova Torre, Emilio / Villarroel, Daniel / Villa Zegarra, Boris Eduardo / Vleminckx, Jason / von Hildebrand, Patricio / Vos, Vincent Antoine / Vriesendorp, Corine / Webb, Edward L / White, Lee J T / Wich, Serge / Wittmann, Florian / Zagt, Roderick / Zang, Runguo / Zartman, Charles Eugene / Zemagho, Lise / Zent, Egleé L / Zent, Stanford

Nature

2024 Volume 625, Issue 7996, Page(s) 728–734

Abstract: Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most ... ...

Abstract	Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations
MeSH term(s)	Biodiversity ; Forests ; Trees/anatomy & histology ; Trees/classification ; Trees/growth & development ; Tropical Climate ; Africa ; Asia, Southeastern
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06820-z
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Article ; Online: Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.

Zhu, Xi / Kim, Yoojean / Ravid, Orren / He, Xiaofu / Suarez-Jimenez, Benjamin / Zilcha-Mano, Sigal / Lazarov, Amit / Lee, Seonjoo / Abdallah, Chadi G / Angstadt, Michael / Averill, Christopher L / Baird, C Lexi / Baugh, Lee A / Blackford, Jennifer U / Bomyea, Jessica / Bruce, Steven E / Bryant, Richard A / Cao, Zhihong / Choi, Kyle /

Cisler, Josh / Cotton, Andrew S / Daniels, Judith K / Davenport, Nicholas D / Davidson, Richard J / DeBellis, Michael D / Dennis, Emily L / Densmore, Maria / deRoon-Cassini, Terri / Disner, Seth G / Hage, Wissam El / Etkin, Amit / Fani, Negar / Fercho, Kelene A / Fitzgerald, Jacklynn / Forster, Gina L / Frijling, Jessie L / Geuze, Elbert / Gonenc, Atilla / Gordon, Evan M / Gruber, Staci / Grupe, Daniel W / Guenette, Jeffrey P / Haswell, Courtney C / Herringa, Ryan J / Herzog, Julia / Hofmann, David Bernd / Hosseini, Bobak / Hudson, Anna R / Huggins, Ashley A / Ipser, Jonathan C / Jahanshad, Neda / Jia-Richards, Meilin / Jovanovic, Tanja / Kaufman, Milissa L / Kennis, Mitzy / King, Anthony / Kinzel, Philipp / Koch, Saskia B J / Koerte, Inga K / Koopowitz, Sheri M / Korgaonkar, Mayuresh S / Krystal, John H / Lanius, Ruth / Larson, Christine L / Lebois, Lauren A M / Li, Gen / Liberzon, Israel / Lu, Guang Ming / Luo, Yifeng / Magnotta, Vincent A / Manthey, Antje / Maron-Katz, Adi / May, Geoffery / McLaughlin, Katie / Mueller, Sven C / Nawijn, Laura / Nelson, Steven M / Neufeld, Richard W J / Nitschke, Jack B / O'Leary, Erin M / Olatunji, Bunmi O / Olff, Miranda / Peverill, Matthew / Phan, K Luan / Qi, Rongfeng / Quidé, Yann / Rektor, Ivan / Ressler, Kerry / Riha, Pavel / Ross, Marisa / Rosso, Isabelle M / Salminen, Lauren E / Sambrook, Kelly / Schmahl, Christian / Shenton, Martha E / Sheridan, Margaret / Shih, Chiahao / Sicorello, Maurizio / Sierk, Anika / Simmons, Alan N / Simons, Raluca M / Simons, Jeffrey S / Sponheim, Scott R / Stein, Murray B / Stein, Dan J / Stevens, Jennifer S / Straube, Thomas / Sun, Delin / Théberge, Jean / Thompson, Paul M / Thomopoulos, Sophia I / van der Wee, Nic J A / van der Werff, Steven J A / van Erp, Theo G M / van Rooij, Sanne J H / van Zuiden, Mirjam / Varkevisser, Tim / Veltman, Dick J / Vermeiren, Robert R J M / Walter, Henrik / Wang, Li / Wang, Xin / Weis, Carissa / Winternitz, Sherry / Xie, Hong / Zhu, Ye / Wall, Melanie / Neria, Yuval / Morey, Rajendra A

NeuroImage

2023 Volume 283, Page(s) 120412

Abstract: Background: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different ... ...

Abstract	Background: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group. Methods: We analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls using traditional machine learning methods. Second, we assessed the utility of the denoising variational autoencoder (DVAE) and evaluated its classification performance. Third, we assessed the generalizability and reproducibility of both models using leave-one-site-out cross-validation procedure for each modality. Results: We found lower performance in classifying PTSD vs. controls with data from over 20 sites (60 % test AUC for s-MRI, 59 % for rs-fMRI and 56 % for d-MRI), as compared to other studies run on single-site data. The performance increased when classifying PTSD from HC without trauma history in each modality (75 % AUC). The classification performance remained intact when applying the DVAE framework, which reduced the number of features. Finally, we found that the DVAE framework achieved better generalization to unseen datasets compared with the traditional machine learning frameworks, albeit performance was slightly above chance. Conclusion: These results have the potential to provide a baseline classification performance for PTSD when using large scale neuroimaging datasets. Our findings show that the control group used can heavily affect classification performance. The DVAE framework provided better generalizability for the multi-site data. This may be more significant in clinical practice since the neuroimaging-based diagnostic DVAE classification models are much less site-specific, rendering them more generalizable.
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Reproducibility of Results ; Big Data ; Neuroimaging ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120412
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