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Book: Myelodysplastic syndromes

Deeg, Hans Joachim

(Hematologic malignancies)

2013

Author's details	H. Joachim Deeg
Series title	Hematologic malignancies
Keywords	Myelodysplastisches Syndrom
Subject	MDS ; Präleukämie ; Präleukose ; Präleukämisches Syndrom ; Hämatopoetische Dysplasie
Language	English
Size	VIII, 245 S. : Ill., graph. Darst., 260 mm x 193 mm
Edition	2. ed.
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT017729638
ISBN	978-3-642-36228-6 ; 3-642-36228-1 ; 9783642362293 ; 364236229X
Database	Catalogue ZB MED Medicine, Health

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2013 A 2075	available for loan (reading room)	Lesesaal EG

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Book: Hematologic malignancies: myelodysplastic syndromes

Deeg, Hans Joachim

with 25 tables

(Hematologic malignancies)

2006

Title variant	Myelodysplastic syndromes
Author's details	H. J. Deeg
Series title	Hematologic malignancies
Keywords	Myelodysplastisches Syndrom
Subject	MDS ; Präleukämie ; Präleukose ; Präleukämisches Syndrom ; Hämatopoetische Dysplasie
Language	English
Size	XII, 139 S. : Ill., graph. Darst., 25 cm
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT014580610
ISBN	978-3-540-26188-9 ; 3-540-26188-5
Database	Catalogue ZB MED Medicine, Health

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2005 A 5805	order for loan	Magazin

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Book ; Online: Aplastische Anämie

Schrezenmeier, Hubert / Brümmendorf, Tim Henrik / Deeg, Hans Joachim / Höchsmann, Britta Elisabeth Hedwig / Machherndl-Spandl, Sigrid / Panse, Jens Peter / Passweg, Jakob R. / Röth, Alexander / Schubert, Jörg / Wörmann, Bernhard

Leitlinie : ICD-10: D61 : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

(Onkopedia Leitlinien)

2018

Abstract: Die Aplastische Anämie (AA) (Synonyma: Panmyelopathie, Panmyelophthise) umfasst eine heterogene Gruppe seltener Erkrankungen, die zu Knochenmarkinsuffizienz führen. Abzugrenzen sind die häufigeren erworbenen Aplastischen Anämien von den "Inherited Bone ... ...

Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie Schweizerische Gesellschaft für Medizinische Onkologie Schweizerische Gesellschaft für Hämatologie
Author's details	DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Hubert Schrezenmeier, Tim Henrik Brümmendorf, Hans Joachim Deeg, Britta Höchsmann, Sigrid Machherndl-Spandl, Jens Panse, Jakob Passweg, Alexander Röth, Jörg Schubert, Bernhard Wörmann
Series title	Onkopedia Leitlinien
Abstract	Die Aplastische Anämie (AA) (Synonyma: Panmyelopathie, Panmyelophthise) umfasst eine heterogene Gruppe seltener Erkrankungen, die zu Knochenmarkinsuffizienz führen. Abzugrenzen sind die häufigeren erworbenen Aplastischen Anämien von den "Inherited Bone Marrow Failure Syndromes". Klinisch dominieren bei der Aplastischen Anämie die Symptome der Bi- oder Trizytopenie mit Anämie, Granulozytopenie, Thrombozytopenie in unterschiedlichen Kombinationen und in variablem Ausmaß. Die Therapie orientiert sich an der Ätiologie und vor allem an der klinischen Ausprägung. Bei mäßig schwerer Aplastischer Anämie wird abwartendes Verhalten empfohlen oder, bei Therapieindikation, eine immunsuppressive Therapie. Bei schwerer oder sehr schwerer Aplastischer Anämie ist die allogene Stammzelltransplantation kurativ. Wenn nicht durchführbar, ist auch bei diesen Patienten die immunsuppressive Therapie mit Anti-Thymozyten-Globulin vom Pferd plus Cyclosporin A der Goldstandard in der Primärtherapie. Neue Arzneimittel erweitern die Therapieoptionen im Rezidiv und bei Refraktärität, insbesondere Eltrombopag.
Subject code	610
Language	German
Size	1 Online-Ressource (31 Seiten), Diagramme
Edition	Stand: August 2018
Publisher	DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
Note	Vorherige Autoren: Werner Linkesch ; Open Access
HBZ-ID	HT020190566
DOI	10.4126/FRL01-006416259
Database	Repository for Life Sciences

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Article: New thinking about health expectancy: introduction to the special section.

Solé-Auró, Aïda / Deeg, Dorly J H

European journal of ageing

2021 Volume 18, Issue 4, Page(s) 439–441

Language	English
Publishing date	2021-05-28
Publishing country	Germany
Document type	Editorial
ZDB-ID	2190233-1
ISSN	1613-9372
ISSN	1613-9372
DOI	10.1007/s10433-021-00630-w
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Article ; Online: Intraneural vascularity of the median, ulnar and common peroneal nerve: Microvascular ultrasound and pathophysiological implications.

Deeg, Johannes / Mündel, Felix / Loizides, Alexander / Gruber, Leonhard / Gruber, Hannes

Australasian journal of ultrasound in medicine

2023 Volume 26, Issue 3, Page(s) 175–183

Abstract: Objectives: Changes in the microvascular environment are considered crucial in the pathogenesis of compression neuropathies. Several studies have demonstrated elevated intraneural vascularity in severe neuropathy compared with healthy subjects, where ... ...

Abstract	Objectives: Changes in the microvascular environment are considered crucial in the pathogenesis of compression neuropathies. Several studies have demonstrated elevated intraneural vascularity in severe neuropathy compared with healthy subjects, where intraneural vascularity is considered predominantly undetectable. The aim of this study was to assess and quantify intraneural vasculature by superb microvascular imaging (SMI) in healthy volunteers in the median, ulnar and common peroneal nerve. Methods: Intraneural vascularity was quantified in 26 healthy volunteers (312 segments overall) by SMI sonography using a 22-MHz linear transducer. Individual nerve segment vascularity was compared with the mean vascularity using one-way ANOVA and Kruskal-Wallis tests, respectively. Vendor-provided quantification and manual vessel count were compared by linear regression analysis. Results: Intraneural vascularity was detectable in all nerve segments (100.0%). Vessel density was highest in the median nerve at the wrist (1.54 ± 0.44/mm Conclusion: Superb microvascular imaging can facilitate the visualisation of nerve vascularity and even detect local variations in vessel density. The pathophysiological implications for peripheral neuropathies, especially compression neuropathies, warrant further investigation, but the absence of visible intraneural vasculature as a negative finding in the diagnostic of compression neuropathies should be interpreted with caution, as the intraneural vascularity may lie beyond the 18 MHz resolution power of a transducer.
Language	English
Publishing date	2023-02-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2843953-3
ISSN	2205-0140 ; 1836-6864
ISSN (online)	2205-0140
ISSN	1836-6864
DOI	10.1002/ajum.12334
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Article ; Online: Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels.

van Schoor, Natasja M / de Jongh, Renate T / Lips, Paul / Deeg, Dorly J H / Kok, Almar A L

Aging clinical and experimental research

2024 Volume 36, Issue 1, Page(s) 93

Abstract: Background: Peak expiratory flow rate (PEFR) predicts mortality and other negative health outcomes. However, little evidence exists on how PEFR changes with ageing and how trajectories of change differ among older people.: Aims: To identify ... ...

Abstract	Background: Peak expiratory flow rate (PEFR) predicts mortality and other negative health outcomes. However, little evidence exists on how PEFR changes with ageing and how trajectories of change differ among older people. Aims: To identify trajectories of PEFR in older men and women, and to study characteristics associated with these trajectories. Methods: Data from the Longitudinal Aging Study Amsterdam were used, an ongoing cohort study in a representative sample of Dutch older men and women. PEFR was assessed using the Mini-Wright peak flow meter across a 13-year follow-up in 991 men and 1107 women. Trajectories were analyzed using Latent Class Growth Analysis. Results: Mean age was 72.5 (SD 8.4) in men and 72.4 (SD 8.4) in women. In men, three declining trajectories were identified, i.e. high, intermediate and low, with prevalences of 30%, 46% and 24%, respectively. In women, two declining trajectories were identified, i.e. high and low, with prevalences of 62 and 38%. All trajectories showed linear decline and differed mostly with regard to their intercept. Significant differences between trajectories with regard to baseline demographic, health and lifestyle characteristics were observed, e.g., men and women in the low PEFR trajectory were older, had more chronic diseases, and were more often smoker. Discussion and conclusions: Trajectories in both men and women differ mainly in baseline level of PEFR and not in rate of decline over time. Therefore, one PEFR measurement might be sufficient to give an indication of the trajectory that an older adult is likely to follow.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Cohort Studies ; Peak Expiratory Flow Rate ; Longitudinal Studies ; Aging
Language	English
Publishing date	2024-04-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-024-02735-5
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Zs.A 3343: Show issues

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Article ; Online: Enjoyment of Sexuality and Longevity in Late Midlife and Older Adults: The Longitudinal Ageing Study Amsterdam.

Beerepoot, Shanice / Luesken, Suzanne W M / Huisman, Martijn / Deeg, Dorly J H

Journal of applied gerontology : the official journal of the Southern Gerontological Society

2022 Volume 41, Issue 6, Page(s) 1615–1624

Abstract: Sexual well-being refers to the evaluation of one's sexuality. We examined the association of enjoyment of sexuality with longevity and the moderating role of perceived importance of sexuality in this association. In the population-based Longitudinal ... ...

Abstract	Sexual well-being refers to the evaluation of one's sexuality. We examined the association of enjoyment of sexuality with longevity and the moderating role of perceived importance of sexuality in this association. In the population-based Longitudinal Ageing Study Amsterdam, the survival of initially 55-84-year-olds was followed during 27 years. Complete data were available for 1042 participants (45.3%). Analyses were adjusted for health-related and psychosocial covariates. 60% of the participants experienced their sexuality as enjoyable and 44% as important. Enjoyment of sexuality was weakly, positively associated with longevity (B[CI] = 0.29[-0.004;0.58]). Perceived importance modified this association: only in those who perceived sexuality as important, the association between enjoyment and longevity was statistically significant (B[CI] = 0.78[0.29;1.27]). Positive affect, functional limitations, emotional loneliness, self-rated health, sense of mastery and alcohol consumption accounted for 35% of the latter association. Interventions may target older adults who perceive sexuality as important but not enjoyable.
MeSH term(s)	Aged ; Aging/psychology ; Humans ; Longevity ; Pleasure ; Sexual Behavior/psychology ; Sexuality/psychology
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	155897-3
ISSN	1552-4523 ; 0733-4648
ISSN (online)	1552-4523
ISSN	0733-4648
DOI	10.1177/07334648221078852
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Article: Employment trends at older ages: policy impact or secular change?

Deeg, Dorly J H / Blekesaune, Morten / de Wind, Astrid

European journal of ageing

2021 Volume 19, Issue 3, Page(s) 689–698

Abstract: Observed increases in retirement age are generally attributed to policies to extend working lives (PEW). In a quasi-experimental design, we examine to what extent increases in employment of older workers can be attributed to secular changes in individual ...

Abstract	Observed increases in retirement age are generally attributed to policies to extend working lives (PEW). In a quasi-experimental design, we examine to what extent increases in employment of older workers can be attributed to secular changes in individual characteristics as opposed to PEW. We compare two countries: one with clear PEW (the Netherlands) and one without PEW (Norway). Data come from the Dutch Longitudinal Aging Study Amsterdam and the NORwegian Longitudinal study on Aging and Generations. From each study, two same-age (55-64 years) samples are selected, one recruited in 2002-03, and one recruited after five (Norway) and ten years (Netherlands). In pooled regression analysis, paid work is the outcome variable, and time of measurement, the main independent variable. Individual characteristics include age, sex, educational level, self-perceived health, functional limitations, sense of mastery, and work status of partner. Employment rose in both countries, faster in the Netherlands than in Norway. Of the rise in employment, individual characteristics explained less in the Netherlands than in Norway. Accounting for these, the interaction countrytime was significant, indicating an extra rise in employment of 5.2 and 7.5% points for Dutch men and women, net of individual characteristics and unobserved factors that are assumed to be similar in both countries. The extra rise in the Netherlands represents 57% of the total rise for both sexes. Thus, secular change in individual characteristics explains part of the rise in employment in both countries. In the Netherlands, other factors such as PEW may additionally explain the rise in employment. Supplementary information:* The online version contains supplementary material available at 10.1007/s10433-021-00664-0.
Language	English
Publishing date	2021-12-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2190233-1
ISSN	1613-9372
ISSN	1613-9372
DOI	10.1007/s10433-021-00664-0
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Article ; Online: Treatment ethics, quality of life and health economics in the management of hematopoietic malignancies in older patients.

Deeg, H J

Bone marrow transplantation

2015 Volume 50, Issue 9, Page(s) 1145–1149

Abstract: The prevalence of diseases such as AML or myelodysplastic syndromes increases with the aging of the population. Only intensive chemotherapy or hematopoietic cell transplantation have curative potential. However, comorbid conditions may interfere with ... ...

Abstract	The prevalence of diseases such as AML or myelodysplastic syndromes increases with the aging of the population. Only intensive chemotherapy or hematopoietic cell transplantation have curative potential. However, comorbid conditions may interfere with effective therapy. Although transplantation following low-intensity conditioning is being carried out in patients even in their 70s, these are highly selected patients, and the data cannot be extrapolated to the population at large. Further, such a therapy in older individuals may be associated with considerable morbidity and the need for prolonged hospitalization and rehabilitation, stressing the system and draining family resources. As the focus of many older individuals is on quality of life, it is important to emphasize that, for various advanced malignancies, emerging data indicate that quality of life may be better and survival may be longer with palliative care. A re-assessment of treatment decisions in older patients is in order. We tend to 'oversell', and particularly older patients do not have a full understanding of the impact of the proposed therapy on their lives. Our conversations with these patients must include a discussion of supportive/palliative care and must address end-of-life issues. Talking about death may mean talking about life.
MeSH term(s)	Aged ; Aged, 80 and over ; Bioethical Issues ; Female ; Health Services for the Aged/economics ; Health Services for the Aged/ethics ; Hematologic Neoplasms/economics ; Hematologic Neoplasms/therapy ; Humans ; Male ; Quality of Life
Language	English
Publishing date	2015-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2015.130
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Book: A guide to blood and marrow transplantation

Deeg, Hans Joachim

with 32 tables

1999

Title variant	Blood and marrow transplantation
Author's details	H. J. Deeg
Keywords	Bone Marrow Transplantation ; Hematopoietic Stem Cell Transplantation ; Graft vs Host Disease / prevention & control ; Knochenmarktransplantation ; Periphere Stammzellentransplantation
Subject	Periphere Blutstammzellentransplantation ; Periphere Stammzellentransfusion ; Periphere Blutstammzellentransfusion ; PBST ; Hämatopoetische Stammzelltransplantation ; Peripheral stem cell transplantation ; Hematopoietic stem cell transplantation ; Peripheral stem cell transfusion ; PBSCT ; Peripheral blood progenitor cell transplantation ; Knochenmark
Language	English
Size	XII, 230 S. : Ill., graph. Darst.
Edition	3. completely rev. ed.
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book
Old title	2. Aufl. u.d.T. A guide to bone marrow transplantation
HBZ-ID	HT009238228
ISBN	3-540-62540-2 ; 978-3-540-62540-7
Database	Catalogue ZB MED Medicine, Health

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1998 A 8745	order for loan	Magazin

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