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  1. Article: Biosimilars: To switch or not to switch - that is the question.

    Szekanecz, Zoltán

    Reumatologia

    2020  Volume 58, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2020-02-28
    Publishing country Poland
    Document type Editorial
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2020.93111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to: Comment on "effects of 1-year anti-TNF-α therapy on vascular function in rheumatoid arthritis and ankylosing spondylitis" by Cure et al.

    Szekanecz, Zoltán

    Rheumatology international

    2020  Volume 40, Issue 3, Page(s) 509

    MeSH term(s) Antirheumatic Agents ; Arthritis, Rheumatoid ; Humans ; Spondylitis, Ankylosing ; Tumor Necrosis Factor-alpha
    Chemical Substances Antirheumatic Agents ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2020-01-30
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04521-8
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  3. Article ; Online: Biosimilars

    Zoltán Szekanecz

    Rheumatology, Vol 58, Iss 1, Pp 1-

    To switch or not to switch – that is the question

    2020  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Editorial: Reviews in rheumatology.

    Henrotin, Yves / Szekanecz, Zoltan / Masuko, Kayo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1153419

    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1153419
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  5. Article: Corrigendum: Editorial: Reviews in rheumatology.

    Henrotin, Yves / Szekanecz, Zoltan / Masuko, Kayo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1187603

    Abstract: This corrects the article DOI: 10.3389/fmed.2023.1153419.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2023.1153419.].
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1187603
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  6. Article ; Online: Különböző védőeszközök hőkamerás vizsgálata és a kilélegzett levegő sebességének mérése teljes gégeeltávolításon átesett betegekben COVID–19-pandémia idején.

    Iszlai, Zoltán / Fodor, Béla / Szabó, Renáta / Szekanecz, Zoltán / Karosi, Tamás

    Orvosi hetilap

    2023  Volume 164, Issue 34, Page(s) 1327–1336

    Abstract: Introduction: In patients after total laryngectomies, the trachea and the lung can be easily infected by SARS-CoV-2 because the respiration happens through the tracheostoma.: Objective: The aim of our study was to examine whether patients with ... ...

    Title translation Thermal imaging and velocity measurements of the exhaled airflow in total laryngectomized patients during COVID-19 pandemic.
    Abstract Introduction: In patients after total laryngectomies, the trachea and the lung can be easily infected by SARS-CoV-2 because the respiration happens through the tracheostoma.
    Objective: The aim of our study was to examine whether patients with LaryTube™ can distribute aerosols to a greater extent than without LaryTube™, and to observe whether the surface of different protective instruments can be examined using the thermal camera in total laryngectomees. An important objective was also to confirm the assumption that the use of HME (heat and moisture exchanger) alone does not provide protection during COVID-19 pandemic. Finally, during our tests, we tried to get an answer to our assumption that the sample taken from the inner surface of the HME can be tested for SARS-CoV-2.
    Method: A total of 23 patients who underwent total laryngectomies were analyzed by velocity measurements and thermal imaging with and without HMEs and laryngeal tubes, using different types of PPEs. COVID-19 PCR testing was performed on patient tracheas and the inner surfaces of the HMEs.
    Results: Male patients with laryngeal tubes without HMEs demonstrated an increase in exhaled airflow velocity of more than 43% compared to male patients without laryngeal tubes; in female patients, the same value was more than 39%. Thermal imaging results confirmed that the lowest surface temperature was measured on FFP2 masks. The sent samples can be tested for SARS-CoV-2 using PCR, the presence of the virus was not detected.
    Conclusion: Laryngectomized patients without laryngeal tubes pose a lower risk for spreading viral aerosols due to the reduced velocity of the exhaled airflow caused by the absence of the tube as the narrowing factor. Patients with laryngeal tubes who undergo total laryngectomies during the COVID-19 pandemic should use HMEs with viral filter, if possible, also changing the laryngeal tubes to dermal adhesives for fitting their HMEs seems to be the best option. The surface of the used protective equipment can also be examined with thermal camera in the case of total laryngectomees. COVID-19 PCR testing of the tracheal secretion from the inner HME surfaces should become a routine in clinical practice if deemed necessary. Orv Hetil. 2023; 164(34): 1327-1336.
    MeSH term(s) Humans ; Female ; Male ; COVID-19/diagnosis ; Pandemics ; SARS-CoV-2 ; Ultrasonography ; Lung
    Language Hungarian
    Publishing date 2023-08-27
    Publishing country Hungary
    Document type English Abstract ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2023.32828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Atherosclerosis in autoimmune rheumatic diseases.

    Szekanecz, Zoltán / Kerekes, György / Shoenfeld, Yehuda

    European journal of internal medicine

    2023  Volume 115, Page(s) 46–47

    MeSH term(s) Humans ; Autoimmune Diseases/complications ; Arthritis, Rheumatoid ; Atherosclerosis/complications ; Rheumatic Diseases/complications ; Lupus Erythematosus, Systemic
    Language English
    Publishing date 2023-07-31
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.07.032
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    Zs.A 2608: Show issues Location:
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  8. Article ; Online: Effectiveness and waning of protection with the BNT162b2 vaccine against the SARS-CoV-2 Delta variant in immunocompromised individuals.

    Szekanecz, Zoltán / Vokó, Zoltán / Surján, Orsolya / Rákóczi, Éva / Szamosi, Szilvia / Szűcs, Gabriella / Szekanecz, Éva / Müller, Cecília / Kiss, Zoltán

    Frontiers in immunology

    2023  Volume 14, Page(s) 1247129

    Abstract: Introduction: In Hungary, the HUN-VE 3 study determined the comparative effectiveness of various primary and booster vaccination strategies during the Delta COVID-19 wave. That study included more than 8 million 18-100-year-old individuals from the ... ...

    Abstract Introduction: In Hungary, the HUN-VE 3 study determined the comparative effectiveness of various primary and booster vaccination strategies during the Delta COVID-19 wave. That study included more than 8 million 18-100-year-old individuals from the beginning of the pandemic. Immunocompromised (IC) individuals have increased risk for COVID-19 and disease course might be more severe in them. In this study, we wished to estimate the risk of SARS-CoV-2 infection and COVID-19 related death in IC individuals compared to healthy ones and the effectiveness of the BNT162b2 vaccine by reassessing HUN-VE 3 data.
    Patients and methods: Among the 8,087,988 individuals undergoing follow-up from the onset of the pandemic in the HUN-VE 3 cohort, we selected all the 263,116 patients with a diagnosis corresponding with IC and 6,128,518 controls from the second wave, before vaccinations started. The IC state was defined as two occurrences of corresponding ICD-10 codes in outpatient or inpatient claims data since 1 January, 2013. The control group included patients without chronic diseases. The data about vaccination, SARS-CoV-2 infection and COVID-19 related death were obtained from the National Public Health Center (NPHC) during the Delta wave. Cases of SARS-CoV-2 infection were reported on a daily basis using a centralized system via the National Public Health Center (NPHC).
    Results: Out of the 263,116 IC patients 12,055 patients (4.58%) and out of the 6,128,518 healthy controls 202,163 (3.30%) acquired SARS-CoV-2 infection. Altogether 436 IC patients and 2141 healthy controls died in relation to COVID-19. The crude incidence rate ratio (IRR) of SARS-CoV-2 infection was 1.40 (95%CI: 1.37-1.42) comparing IC patients to healthy controls. The crude mortality rate ratio was 4.75 (95%CI: 4.28-5.27). With respect to SARS-CoV-2 infection, interestingly, the BNT162b2 vaccine was more effective in IC patients compared to controls. Primary vaccine effectiveness (VE) was higher in IC patients compared to controls and the booster restored VE after waning. VE regarding COVID-19 related death was less in IC patients compared to healthy individuals. Booster vaccination increased VE against COVID-19-related death in both IC patients and healthy controls.
    Conclusion: There is increased risk of SARS-CoV-2 infection and COVID-19 related mortality in IC patient. Moreover, booster vaccination using BNT162b2 might restore impaired VE in these individuals.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; BNT162 Vaccine ; Vaccines
    Chemical Substances BNT162 Vaccine ; Vaccines
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1247129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Post-acute COVID-19 syndrome

    Szekanecz, Zoltán / Vályi-Nagy, István

    Orvosi hetilap

    2021  Volume 162, Issue 27, Page(s) 1067–1078

    Abstract: Összefoglaló. A posztakut COVID-19 szindróma (PACS) az akut betegséget követő 4-12 hét szubakut, tünetes szakasznak, valamint az ezt követő krónikus poszt-COVID-időszaknak az együttesét jelenti. A PACS különböző általános tünetekkel és szervi (pulmonalis, ...

    Title translation Posztakut COVID-19 szindróma.
    Abstract Összefoglaló. A posztakut COVID-19 szindróma (PACS) az akut betegséget követő 4-12 hét szubakut, tünetes szakasznak, valamint az ezt követő krónikus poszt-COVID-időszaknak az együttesét jelenti. A PACS különböző általános tünetekkel és szervi (pulmonalis, cardiovascularis, neuropszichiátriai, endokrin, mozgásszervi, bőrgyógyászati, renalis) manifesztációkkal jár. Ebben az összefoglalóban áttekintjük a PACS kialakulásához vezető patogenetikai és rizikótényezőket. Bemutatjuk a klinikumot és a diagnosztikát. A PACS ellátása alapvetően háziorvosi feladat, mely a szervi tünetek gyógyszeres és nem gyógyszeres kezeléséből, multidiszciplináris rehabilitációból és gondozásból áll. Kitérünk a háziorvos feladataira, a szakellátásba történő beutalás indokaira és a poszt-COVID-hálózat létrehozásának és működtetésének szükségességére is. Orv Hetil. 2021; 162(27): 1067-1078. Summary. Post-acute COVID-19 syndrome (PACS) includes the subacute, symptomatic phase 4-12 weeks after acute COVID-19 as well as the subsequent chronic post-COVID-19 period. PACS is associated with various general symptoms and organ (pulmonary, cardiovascular, neuropsychiatric, endocrine, musculoskeletal, dermatological, renal) manifestations. In this summary, we review the pathogenetic and risk factors leading to the development of PACS. We present the clinical picture and diagnostics. PACS should usually be managed by the general practitioner. The management of PACS includes pharmacological and non-pharmacological treatment, multidisciplinary rehabilitation and regular follow-ups. Here we also discuss the tasks of the general practitioner, the reasons for referral to specialists and the need to set up and operate a post-COVID-19 network. Orv Hetil. 2021; 162(27): 1067-1078.
    MeSH term(s) COVID-19 ; General Practitioners ; Humans ; Risk Factors ; SARS-CoV-2 ; Syndrome
    Language Hungarian
    Publishing date 2021-07-04
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2021.32282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Corrigendum

    Yves Henrotin / Zoltan Szekanecz / Kayo Masuko

    Frontiers in Medicine, Vol

    Editorial: Reviews in rheumatology

    2023  Volume 10

    Keywords rheumatoid arthritis ; systemic lupus erythematosus (SLE) ; frozen shoulder ; cytokines ; biomarkers ; mitochondria ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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