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  1. Article: Criteria for diagnosis of acute megakaryocytic leukemia.

    Strauchen, J A

    Blood

    2001  Volume 97, Issue 6, Page(s) 1898

    MeSH term(s) Bone Marrow/pathology ; Humans ; Leukemia, Megakaryoblastic, Acute/diagnosis ; Leukemia, Megakaryoblastic, Acute/pathology
    Language English
    Publishing date 2001-03-15
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.v97.6.1898
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  2. Article: Indolent T-lymphoblastic proliferation: report of a case with an 11-year history and association with myasthenia gravis.

    Strauchen, J A

    The American journal of surgical pathology

    2001  Volume 25, Issue 3, Page(s) 411–415

    Abstract: T-lymphoblastic lymphoma is a high-grade malignant lymphoma with frequent occurrence in young males, mediastinal involvement, and systemic dissemination. Indolent T-lymphoblastic proliferations have rarely been recognized. In the present case, we report ... ...

    Abstract T-lymphoblastic lymphoma is a high-grade malignant lymphoma with frequent occurrence in young males, mediastinal involvement, and systemic dissemination. Indolent T-lymphoblastic proliferations have rarely been recognized. In the present case, we report on an indolent T-lymphoblastic proliferation involving the oropharynx in a patient with myasthenia gravis with multiple local recurrences over an 11-year period without evidence of systemic dissemination. The T-lymphoblasts were consistently positive for terminal deoxynucleotidyl transferase (TdT), CD1, CD3, CD4, and CD8, corresponding to an intermediate thymocyte stage of differentiation. No cytokeratin-positive thymic epithelial cells were identified, ruling out an ectopic thymus or thymoma. T-receptor gene rearrangement studies by Southern blot revealed no monoclonal CT-beta rearrangement. Indolent T-lymphoblastic proliferations of undetermined clonality may rarely occur; predilection for involvement of oropharynx and possible association with myasthenia gravis are suggested.
    MeSH term(s) Adult ; Antigens, CD/metabolism ; Antigens, Neoplasm/metabolism ; DNA Nucleotidylexotransferase ; DNA, Neoplasm/analysis ; Humans ; Immunoenzyme Techniques ; Immunophenotyping ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Male ; Myasthenia Gravis/complications ; Myasthenia Gravis/metabolism ; Myasthenia Gravis/pathology ; Oropharynx/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
    Chemical Substances Antigens, CD ; Antigens, Neoplasm ; DNA, Neoplasm ; DNA Nucleotidylexotransferase (EC 2.7.7.31)
    Language English
    Publishing date 2001-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/00000478-200103000-00018
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  3. Article: Further "teleconsultation" called for.

    Strauchen, J A

    American journal of clinical pathology

    2000  Volume 113, Issue 4, Page(s) 595

    MeSH term(s) Adenocarcinoma/pathology ; Adenoma, Villous/pathology ; Colonic Neoplasms/pathology ; Humans ; Neoplasms, Multiple Primary/pathology ; Remote Consultation/methods ; Telepathology
    Language English
    Publishing date 2000-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
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  4. Article: MALT Lymphoma of the Bladder: A Case Report and Review of the Literature.

    Vempati, Prashant / Knoll, Miriam A / Alqatari, Mahfood / Strauchen, James / Malone, Adriana K / Bakst, Richard L

    Case reports in hematology

    2015  Volume 2015, Page(s) 934374

    Abstract: The presentation of a MALT lymphoma in the bladder is exceedingly rare. Furthermore, the optimal treatment of primary MALT confined to the bladder remains to be defined. Here, we report a case of a 65-year-old female with primary MALT lymphoma treated ... ...

    Abstract The presentation of a MALT lymphoma in the bladder is exceedingly rare. Furthermore, the optimal treatment of primary MALT confined to the bladder remains to be defined. Here, we report a case of a 65-year-old female with primary MALT lymphoma treated with definitive radiation therapy. The patient received a total dose of 30 Gy in 20 equal daily fractions to the bladder and tolerated the treatment well. In addition, we have extensively reviewed the relevant literature to better define the optimal management of this rare disease. In conclusion, primary MALT lymphoma of the bladder represents a rare malignancy with excellent prognosis if detected at an early stage. For early stage disease, definitive radiation represents an excellent treatment modality with a minimal side-effect profile.
    Language English
    Publishing date 2015-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627639-2
    ISSN 2090-6579 ; 2090-6560
    ISSN (online) 2090-6579
    ISSN 2090-6560
    DOI 10.1155/2015/934374
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  5. Article ; Online: Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency.

    Maglione, Paul J / Ko, Huaibin M / Beasley, Mary B / Strauchen, James A / Cunningham-Rundles, Charlotte

    The Journal of allergy and clinical immunology

    2013  Volume 133, Issue 2, Page(s) 535–542

    Abstract: Background: Despite reducing pneumonia and other infections, antibody replacement does not appear to treat pulmonary lymphoid hyperplasia (PLH) in patients with common variable immunodeficiency (CVID). The pathogenesis and optimal treatments remain to ... ...

    Abstract Background: Despite reducing pneumonia and other infections, antibody replacement does not appear to treat pulmonary lymphoid hyperplasia (PLH) in patients with common variable immunodeficiency (CVID). The pathogenesis and optimal treatments remain to be clarified.
    Objective: We aimed to better understand the pathology of CVID-associated lung disease. Tertiary lymphoneogenesis, although a component of interstitial lung disease associated with autoimmune diseases, has not previously been explored in patients with CVID.
    Methods: We examined the clinical characteristics and pathologic findings of 6 patients with CVID with nodular/infiltrative lung disease who had biopsy specimens demonstrating PLH.
    Results: In these subjects regions of PLH contained distinct B- and T-cell zones, with B-cell predominance in 1 patient and T-cell predominance in the others. Colocalization of Ki67, Bcl6, and CD23 within this ectopic lymphoid architecture demonstrated tertiary lymphoneogenesis with active centers of cellular proliferation. One patient received rituximab with improved pulmonary radiologic findings.
    Conclusion: Ectopic lymphoid tissue forming germinal centers suggest tertiary lymphoneogenesis in CVID-associated lung disease. B cell-targeted therapy might disrupt CVID-associated lymphoid hyperplasia.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antigens, CD/immunology ; B-Lymphocytes/immunology ; Biopsy ; Common Variable Immunodeficiency/drug therapy ; Common Variable Immunodeficiency/immunology ; Common Variable Immunodeficiency/pathology ; DNA-Binding Proteins/immunology ; Female ; Humans ; Hyperplasia/drug therapy ; Hyperplasia/immunology ; Hyperplasia/pathology ; Immunoglobulins/blood ; Immunologic Factors/therapeutic use ; Ki-67 Antigen/immunology ; Lung/pathology ; Lung Diseases/drug therapy ; Lung Diseases/immunology ; Lung Diseases/pathology ; Lymphoproliferative Disorders/drug therapy ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/pathology ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-6 ; Rituximab ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Antigens, CD ; BCL6 protein, human ; DNA-Binding Proteins ; Immunoglobulins ; Immunologic Factors ; Ki-67 Antigen ; Proto-Oncogene Proteins c-bcl-6 ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2013-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2013.08.022
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  6. Article: Sarcomatoid neoplasm of monocytic lineage.

    Strauchen, J A

    The American journal of surgical pathology

    1991  Volume 15, Issue 12, Page(s) 1206–1207

    MeSH term(s) Aged ; Humans ; Immunophenotyping ; Lymphatic Metastasis/pathology ; Male ; Monocytes ; Myelodysplastic Syndromes/complications ; Sarcoma/pathology ; Skin Neoplasms/pathology
    Language English
    Publishing date 1991-12
    Publishing country United States
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/00000478-199112000-00013
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  7. Article: Terminal deoxynucleotidyl transferase-positive cells in human tonsils.

    Strauchen, J A / Miller, L K

    American journal of clinical pathology

    2001  Volume 116, Issue 1, Page(s) 12–16

    Abstract: To study the possible cellular origin of recently recognized indolent terminal deoxynucleotidyl transferase (TdT)-positive T-lymphoblastic proliferations of the tonsils and oropharynx, we studied normal human tonsils for the presence of TdT-positive ... ...

    Abstract To study the possible cellular origin of recently recognized indolent terminal deoxynucleotidyl transferase (TdT)-positive T-lymphoblastic proliferations of the tonsils and oropharynx, we studied normal human tonsils for the presence of TdT-positive cells. TdT-positive cells were readily demonstrated in the tonsils from 15 children and adults by immunohistochemical staining. TdT-positive cells were distributed in discrete foci at the periphery of lobules of lymphoid tissue and adjacent to fibrous septa and had the morphologic features of small to medium-sized lymphocytes. Double-antibody staining indicated the TdT-positive cells had the phenotype of uncommitted early lymphoid precursors (CD3-, CD79a-, CD10-). Foci of TdT-positive cells were not identified in 6 reactive lymph nodes studied as controls. These studies indicate that tonsils, like bone marrow and thymus, are sites of lymphopoiesis. The presence of TdT-positive precursor cells in human tonsils may be a factor in the pathogenesis of recently described indolent T-lymphoblastic proliferations involving the tonsils and oropharynx. The presence of TdT-positive cells in human tonsils should not be misinterpreted as evidence of lymphoblastic lymphoma or leukemia.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; DNA Nucleotidyltransferases/metabolism ; Humans ; Hyperplasia ; Immunohistochemistry ; Infant ; Lymph Nodes/enzymology ; Lymph Nodes/pathology ; Middle Aged ; Palatine Tonsil/enzymology ; Palatine Tonsil/pathology
    Chemical Substances DNA Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2001-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/M8V2-DWPB-DVX1-UBPC
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  8. Article: Leucocyte common antigen in the differential diagnosis of Hodgkin's disease.

    Strauchen, J A

    Hematological oncology

    1989  Volume 7, Issue 2, Page(s) 149–153

    Abstract: The utility of immunohistochemical staining for leukocyte common antigen (LCA) in the differential diagnosis of Hodgkin's disease was studied in a series of 42 cases of Hodgkin's and non-Hodgkin's lymphoma and compared with Leu M-1, a proposed marker for ...

    Abstract The utility of immunohistochemical staining for leukocyte common antigen (LCA) in the differential diagnosis of Hodgkin's disease was studied in a series of 42 cases of Hodgkin's and non-Hodgkin's lymphoma and compared with Leu M-1, a proposed marker for Reed-Sternberg cells. LCA staining of neoplastic cells was absent in 23 of 24 cases of Hodgkin's disease but present in 16 of 18 cases of non-Hodgkin's lymphoma including eight of 10 cases with pleomorphic Reed-Sternberg-like cells. Leu M-1, in contrast was present in 14 of 24 cases of Hodgkin's disease, but also in five of 18 cases of non-Hodgkin's lymphoma including five of 10 cases with pleomorphic Reed-Sternberg-like cells. Immunohistochemical staining for LCA appears useful in the differential diagnosis of Hodgkin's disease and appears to be a better discriminant than Leu M-1.
    MeSH term(s) Antigens, Differentiation/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Diagnosis, Differential ; Histocompatibility Antigens/analysis ; Hodgkin Disease/diagnosis ; Hodgkin Disease/immunology ; Hodgkin Disease/pathology ; Humans ; Immunohistochemistry ; Leukocyte Common Antigens ; Lewis X Antigen
    Chemical Substances Antigens, Differentiation ; Antigens, Differentiation, Myelomonocytic ; Histocompatibility Antigens ; Lewis X Antigen ; Leukocyte Common Antigens (EC 3.1.3.48)
    Language English
    Publishing date 1989-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2900070206
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  9. Article: Interleukin receptors in lymphoid lesions. Relevance to diagnosis, biology, and therapy.

    Strauchen, J A

    Pathology annual

    1989  Volume 24 Pt 2, Page(s) 149–165

    Abstract: Interleukin 2 and its receptor have emerged as a central control system in the regulation of the immune response and the proliferation of T cells, B cells, and macrophage. IL-2 receptor expression is strongly associated with several forms of human ... ...

    Abstract Interleukin 2 and its receptor have emerged as a central control system in the regulation of the immune response and the proliferation of T cells, B cells, and macrophage. IL-2 receptor expression is strongly associated with several forms of human lymphoproliferative disease including adult T-cell leukemia-lymphoma, hairy cell leukemia, Hodgkin's disease, and peripheral T-cell lymphoma in which it may play a pathogenetic role. IL-2 receptor expression may also play a role in some B-cell non-Hodgkin's lymphomas and histiocytic proliferations. Recent discoveries in immunology and advances in biotechnology have opened therapeutic possibilities for IL-2 including the use of anti-Tac monoclonal antibodies and immunoconjugates for the therapy of Tac-positive lymphoproliferative disease, the use of anti-Tac monoclonal antibodies as novel immunosuppressants, and the use of genetically engineered recombinant IL-2 and activated autologous lymphocytes in the adoptive immunotherapy of cancer. Therapeutic and diagnostic applications of IL-2 continue to be defined.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Diagnosis, Differential ; Humans ; Immunotherapy ; Leukemia/diagnosis ; Leukemia/immunology ; Leukemia/pathology ; Leukemia/therapy ; Lymphoma/diagnosis ; Lymphoma/immunology ; Lymphoma/pathology ; Lymphoma/therapy ; Receptors, Interleukin-2/immunology ; Receptors, Interleukin-2/metabolism
    Chemical Substances Antibodies, Monoclonal ; Receptors, Interleukin-2
    Language English
    Publishing date 1989
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207654-8
    ISSN 0079-0184
    ISSN 0079-0184
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  10. Article: Haemangioblastic transformation of myeloproliferative disease?

    Strauchen, James A / Cuttner, Janet / Holland, James F

    British journal of haematology

    2007  Volume 138, Issue 6, Page(s) 819–821

    MeSH term(s) Bone Marrow Examination ; Brain Neoplasms/pathology ; Hemangioblastoma/pathology ; Humans ; Male ; Middle Aged ; Neoplasms, Multiple Primary/pathology ; Skull Neoplasms/pathology ; Thrombocytosis/pathology
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/j.1365-2141.2007.06726.x
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