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  1. Article: Protective Effects of Lipoxin A

    Liu, Hsin-Hua / Cullen, Paul F / Sivak, Jeremy M / Gronert, Karsten / Flanagan, John G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the retinal nerve fiber layer (RNFL), resulting in a gradual decline of vision. A recent study by our groups indicated that the ... ...

    Abstract Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the retinal nerve fiber layer (RNFL), resulting in a gradual decline of vision. A recent study by our groups indicated that the levels of lipoxins A
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.575414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​.

    Karnam, Shruthi / Maurya, Shubham / Ng, Elainna / Choudhary, Amodini / Thobani, Arzin / Flanagan, John G / Gronert, Karsten

    Acta neuropathologica communications

    2024  Volume 12, Issue 1, Page(s) 58

    Abstract: Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin ... ...

    Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B
    MeSH term(s) Humans ; Animals ; Mice ; Lipoxins/pharmacology ; Astrocytes ; Cytokines ; Glaucoma ; Ocular Hypertension ; Retina ; Disease Models, Animal ; Primates
    Chemical Substances Lipoxins ; Cytokines
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-024-01767-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transvenous Access for Emergent Thoracic and Thoracoabdominal Aortic Aneurysm Repair in Patients Without Femoral Access.

    Grandi, Alessandro / Gronert, Catharina / Panuccio, Giuseppe / Rohlffs, Fiona / Yousef Al Sarhan, Daour / Kölbel, Tilo

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2023  , Page(s) 15266028231197972

    Abstract: Purpose: To describe the technique of transvenous access for emergent endovascular repair of thoracic and thoracoabdominal aneurysms exemplified with 2 cases.: Technique: Transvenous access to the aorta is described as an alternative access method to ...

    Abstract Purpose: To describe the technique of transvenous access for emergent endovascular repair of thoracic and thoracoabdominal aneurysms exemplified with 2 cases.
    Technique: Transvenous access to the aorta is described as an alternative access method to deliver aortic endografts in emergency situations. A 68-year-old female patient with severely compromised iliac and subclavian artery access was treated for a ruptured extent V thoraco-abdominal aortic aneurysm with a t-Branch (Cook Medical, Bjaeverskov, Denmark) delivered through a transcaval access. To avoid severe aortocaval shunting a balloon-expandable covered stent was deployed through a carotid access due to severe bilateral subclavian ostial stenosis. A 71-year-old man with an acute type B aortic dissection and bilateral narrow long-segment stenting of the iliac arteries was treated with a physician-modified thoracic endovascular aortic repair using an arteriovenous fenestration created at the level of the common iliac artery. We describe the access creation by fenestration using a transseptal needle.
    Conclusion: Transvenous access for thoracic and thoraco-abdominal aortic aneurysm repair is safe and feasible in selected emergent cases.
    Clinical impact: A transvenous approach may be helpful in selected patients when an endovascular repair needs to be performed but no arterial femoral access is available. This approach proved to be feasible even with large-bore introducer sheaths, taking its place in the armamentarium of the vascular surgeon for emergent complex endovascular aortic repairs.
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1177/15266028231197972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4547: Show issues Location:
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  4. Article: Regulation of Diseases-Associated Microglia in the Optic Nerve by Lipoxin B

    Maurya, Shubham / Lin, Maggie / Karnam, Shruthi / Singh, Tanirika / Kumar, Matangi / Ward, Emily / Flanagan, John G / Gronert, Karsten

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Background: The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B: Methods: Cellular targets and signaling of LXB: Results: Single- ... ...

    Abstract Background: The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B
    Methods: Cellular targets and signaling of LXB
    Results: Single-cell transcriptomics identified microglia as a primary target for LXB
    Conclusion: We identified early and dynamic changes in the microglia functional phenotype, reactivity, and induction of a unique CD74 microglia population in the distal optic nerve as key features of ocular hypertension-induced neurodegeneration. Our findings establish microglia regulation as a novel LXB
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.18.585452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Dysregulation of Neuroprotective Lipoxin Pathway in Astrocytes in Response to Cytokines and Ocular Hypertension.

    Karnam, Shruthi / Maurya, Shubham / Ng, Elainna / Choudhary, Amodini / Thobani, Arzin / Flanagan, John G / Gronert, Karsten

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin ... ...

    Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.22.546157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Erste Erfahrungen mit der W.-G.-Schultergelenks-Totalprothese

    Gronert, H J / Weigert, M

    Hefte zur Unfallheilkunde

    1975  , Issue 126, Page(s) 87–89

    Title translation First experiences with the total WG shoulder-joint prosthesis.
    MeSH term(s) Humans ; Humeral Fractures/surgery ; Joint Prosthesis/methods ; Shoulder Dislocation/surgery ; Shoulder Joint/surgery
    Language German
    Publishing date 1975-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 206514-9
    ISSN 0085-1469
    ISSN 0085-1469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Un I Zs.191: Show issues Location:
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  7. Article ; Online: Hypogastric Artery Stenting for Chronic Intermittent Spinal Cord Ischemia After Thoracic Endovascular Aortic Repair.

    Gronert, Catharina / Tsilimparis, Nikolaos / Panuccio, Giuseppe / Eleshra, Ahmed / Rohlffs, Fiona / Kölbel, Tilo

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2020  Volume 27, Issue 5, Page(s) 801–804

    Abstract: Purpose: To report a case of chronic intermittent spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) and its successful treatment using hypogastric artery stenting.: Case report: A 79-year-old patient presented in May 2013 ... ...

    Abstract Purpose: To report a case of chronic intermittent spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) and its successful treatment using hypogastric artery stenting.
    Case report: A 79-year-old patient presented in May 2013 with a thoracic aortic aneurysm (TAA) and a contained rupture. He urgently underwent TEVAR that covered 274 mm of descending thoracic aorta without immediate postoperative signs of acute SCI. At 3-month follow-up, he reported repeating incidents of sudden lower extremity weakness leading to a fall with a humerus fracture. A neurological consultation revealed the tentative diagnosis of intermittent SCI caused by TEVAR and initially recommended a conservative approach. During the following year there was no clinical improvement of the symptoms. Computed tomography angiography showed a high-grade stenosis of the right hypogastric artery, which was stented in November 2014 to improve the collateral network of spinal cord perfusion. Following treatment, the patient had no further neurological symptoms; at 32 months after the reintervention, the imaging follow-up documented a patent stent and continued exclusion of the TAA.
    Conclusion: Intermittent neurological symptoms after TEVAR should be suspected as chronic intermittent SCI. The improvement of collateral networks of the spinal cord by revascularization of the hypogastric artery is a viable treatment option.
    MeSH term(s) Aged ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/physiopathology ; Aortic Aneurysm, Thoracic/surgery ; Aortic Rupture/diagnostic imaging ; Aortic Rupture/physiopathology ; Aortic Rupture/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Chronic Disease ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Humans ; Male ; Regional Blood Flow ; Spinal Cord/blood supply ; Spinal Cord Ischemia/diagnostic imaging ; Spinal Cord Ischemia/etiology ; Spinal Cord Ischemia/physiopathology ; Spinal Cord Ischemia/therapy ; Stents ; Treatment Outcome ; Vascular Patency
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1177/1526602820925445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4547: Show issues Location:
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  8. Article ; Online: Feasibility and Preliminary Patency of Prophylactic Hypogastric Artery Stenting for Prevention of Spinal Cord Ischemia in Complex Endovascular Aortic Repair.

    Gronert, Catharina / Panuccio, Giuseppe / Eleshra, Ahmed / Rohlffs, Fiona / Debus, Eike Sebastian / Tsilimparis, Nikolaos / Kölbel, Tilo

    Annals of vascular surgery

    2021  Volume 80, Page(s) 241–249

    Abstract: Background: To report early results of feasibility and patency of prophylactic hypogastric artery (HA) stenting during complex endovascular aortic repair.: Methods: This is a single centre retrospective non comparative cohort study of all consecutive ...

    Abstract Background: To report early results of feasibility and patency of prophylactic hypogastric artery (HA) stenting during complex endovascular aortic repair.
    Methods: This is a single centre retrospective non comparative cohort study of all consecutive patients undergoing prophylactic HA stenting during fenestrated and/or branched EVAR (F/B EVAR) in order to prevent spinal cord ischemia (SCI). Endpoints included technical success and early outcomes in terms of morbidity, mortality and patency of the implanted stents.
    Results: Between May 2014 and June 2019 prophylactic HA stenting was performed in 36 consecutive patients with significant HA stenosis during F/B EVAR to prevent SCI. 69.4% of patients presented with asymptomatic, 25% with symptomatic and 5.6% with ruptured aortic aneurysms. 55.6% were treated for thoracoabdominal aortic aneurysms, 44.4% for pararenal abdominal aortic aneurysms. In 13.9% aortic coverage was limited to the abdominal aorta. In 86.1% the aortic coverage was in the thoracoabdominal aortic segment. Unilateral HA stenting was performed in 91.7%, whereas 8.3% underwent bilateral stenting. Technical success was 100%. The primary patency of the implanted stents after a median follow-up time of 9.5 months was 97.5%. One intraprocedural bleeding from an HA branch occurred and was successfully treated by coil embolization. No further procedure-related complications occurred. 11.1% of the patients developed SCI.
    Conclusions: HA stenting is feasible and safe with high rates of technical success and short-term patency.
    MeSH term(s) Aged ; Aged, 80 and over ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/surgery ; Aortic Rupture/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/methods ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Feasibility Studies ; Female ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Spinal Cord/blood supply ; Spinal Cord Ischemia/etiology ; Spinal Cord Ischemia/prevention & control ; Stents ; Vascular Patency
    Language English
    Publishing date 2021-10-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2021.07.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2882: Show issues Location:
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  9. Article: Intra-atrial ECG guidance for positioning central vein catheters.

    Gronert, G A

    British journal of anaesthesia

    2004  Volume 92, Issue 4, Page(s) 599; author reply 600–1

    MeSH term(s) Catheterization, Central Venous/methods ; Echocardiography/methods ; Humans ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2004-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
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  10. Article ; Online: Endovascular Repair Using a 7-Branch Stent-Graft for a Thoracoabdominal Aortic Aneurysm With Variant Renovisceral Artery Anatomy.

    Eleshra, Ahmed / Spanos, Konstantinos / Panuccio, Giuseppe / Gronert, Catharina / Rohlffs, Fiona / Kölbel, Tilo

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2019  Volume 27, Issue 2, Page(s) 231–236

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Aged ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/physiopathology ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/instrumentation ; Endovascular Procedures/instrumentation ; Hepatic Artery/abnormalities ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/physiopathology ; Hepatic Artery/surgery ; Humans ; Male ; Prosthesis Design ; Regional Blood Flow ; Renal Artery/abnormalities ; Renal Artery/diagnostic imaging ; Renal Artery/physiopathology ; Renal Artery/surgery ; Splenic Artery/abnormalities ; Splenic Artery/diagnostic imaging ; Splenic Artery/physiopathology ; Splenic Artery/surgery ; Stents ; Treatment Outcome ; Vascular Patency
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1177/1526602819892557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4547: Show issues Location:
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