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Article: An Inflammatory Reaction to Stored Fascia Lata 37 Years Postimplantation.

Esmail, Kaisra / Jordan, David Ronald / Brownstein, Seymour / Tang, Tina / Burns, Bruce

2021 Volume 7, Issue 3, Page(s) 194–198

Abstract: We report a rare case of a suspected inflammatory reaction to stored fascia lata 37 years post-placement. Clinical, imaging, histopathological, and immunohistochemical findings are presented, with a literature review on reactions to stored fascia lata. A ...

Abstract	We report a rare case of a suspected inflammatory reaction to stored fascia lata 37 years post-placement. Clinical, imaging, histopathological, and immunohistochemical findings are presented, with a literature review on reactions to stored fascia lata. A 39-year-old woman had upper eyelid congenital ptosis repaired successfully at 2 years with bilateral frontalis suspension procedures using stored fascia lata. Thirty-seven years later, the patient presented with swelling of her eyelids and forehead, which was tender to the touch, in the same pattern as the fascia lata slings placed earlier. Histopathological examination disclosed a non-necrotizing granulomatous inflammatory infiltrate with numerous asteroid bodies. Initially, it was responsive to oral prednisone, but with recurrent inflammation, long-term methotrexate was required to control the inflammation. To our knowledge, this type of delayed inflammatory reaction has not been previously reported. It raises a concern about the use of allogeneic donor tissue and accepted sterilization techniques that may not be 100% effective in deactivating all components of the donor graft, including potential infectious pathogens, leading to a subsequent latent reaction.
Language	English
Publishing date	2021-02-09
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2806965-1
ISSN	2296-4657 ; 2296-4681
ISSN (online)	2296-4657
ISSN	2296-4681
DOI	10.1159/000510205
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Article ; Online: Posterior Embryotoxon Revisited: An Immunohistologic Study.

Alwadani, Saeed / Alward, Wallace L M / Syed, Nasreen A / Bouhenni, Rachida A / Brownstein, Seymour / Edward, Deepak P

Ophthalmology. Glaucoma

2022 Volume 5, Issue 4, Page(s) 396–401

Abstract: Purpose: This series describes the immunopathologic features of posterior embryotoxon (PE) and demonstrates that it is not an anterior displaced Schwalbe's line as commonly described, but a peripheral corneal stromal nub variable in location with ... ...

Abstract	Purpose: This series describes the immunopathologic features of posterior embryotoxon (PE) and demonstrates that it is not an anterior displaced Schwalbe's line as commonly described, but a peripheral corneal stromal nub variable in location with abnormal extracellular matrix. Design: Case series. Participants: Archived specimens from patients with PE. Methods: Sections from archived formalin-fixed, paraffin-embedded specimens (n = 9; 7 autopsy and 2 trabeculectomy specimens) were examined by light microscopy. Immunohistochemistry was performed on 5 specimens to characterize the extracellular matrix composition of PE. Results: Posterior embryotoxon appeared as nubs of whorled collagen extending from the corneal stroma, lined in some instances, by Descemet membrane. These nubs were located anterior to Schwalbe's line (n = 4), posteriorly (n = 1), partially embedded in the trabecular meshwork (n = 1), or at Schwalbe's line (n = 2). Qualitatively, collagen I labeling of the PE stroma was similar or weaker than the corneal stroma, whereas collagen III staining was focal and slightly more intense compared with the corneal stroma. Lumican and keratan sulfate staining was similar or less intense in PE compared with the corneal stroma. Main outcome measures: Identify location of PE and its immunohistochemical features. Conclusions: In contrast to the widely accepted definition of PE as a prominent, anteriorly displaced Schwalbe line, histologic evidence suggests that it is a direct extension of the corneal stroma with variable locations that may displace the attenuated Descemet membrane when located anterior to or at Schwalbe's line. Immunohistochemical examination revealed that the composition of PE's extracellular matrix was similar to corneal stroma but with some variability in staining intensity.
MeSH term(s)	Collagen ; Corneal Stroma ; Eye Abnormalities ; Humans ; Keratan Sulfate ; Sclera
Chemical Substances	Collagen (9007-34-5) ; Keratan Sulfate (9056-36-4)
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2589-4196
ISSN (online)	2589-4196
DOI	10.1016/j.ogla.2022.01.003
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Article ; Online: Fibrous Histiocytoma of the Conjunctiva.

Soon, Alexander K / Brownstein, Seymour / O'Connor, Michael / Iordanous, Yiannis

Ophthalmic plastic and reconstructive surgery

2017 Volume 33, Issue 5, Page(s) e133

Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000000785
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Zs.A 2159: Show issues

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Article ; Online: Diffuse siliconoma of the eyelid.

Soon, Alexander K / Brownstein, Seymour / Gilberg, Steven M / Tang, Tina

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2018 Volume 54, Issue 3, Page(s) e111–e113

MeSH term(s)	Biopsy ; Diagnosis, Differential ; Endotamponade/adverse effects ; Eyelid Diseases/diagnosis ; Eyelid Diseases/etiology ; Eyelids/pathology ; Granuloma, Foreign-Body/diagnosis ; Humans ; Laser Coagulation/methods ; Male ; Middle Aged ; Ophthalmoscopy ; Retinal Detachment/surgery ; Silicone Oils/adverse effects
Chemical Substances	Silicone Oils
Language	English
Publishing date	2018-10-19
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2018.08.003
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Article ; Online: Ophthalmia nodosa secondary to caterpillar-hair-induced conjunctivitis in a child.

Saleh, Solin / Brownstein, Seymour / Kapasi, Mustafa / O'Connor, Michael / Blanco, Paula

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2019 Volume 55, Issue 2, Page(s) e56–e59

MeSH term(s)	Animals ; Child ; Conjunctivitis/etiology ; Conjunctivitis/pathology ; Conjunctivitis/surgery ; Endophthalmitis/etiology ; Endophthalmitis/pathology ; Endophthalmitis/surgery ; Eye Foreign Bodies/etiology ; Eye Foreign Bodies/pathology ; Eye Foreign Bodies/surgery ; Eyelids/pathology ; Foreign-Body Reaction/etiology ; Foreign-Body Reaction/pathology ; Foreign-Body Reaction/surgery ; Humans ; Larva ; Male ; Moths ; Ophthalmologic Surgical Procedures ; Sensilla ; Visual Acuity/physiology
Language	English
Publishing date	2019-12-23
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2019.10.001
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Zs.A 588: Show issues

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Article ; Online: Malignant melanoma of the conjunctiva.

Brownstein, Seymour

Cancer control : journal of the Moffitt Cancer Center

2004 Volume 11, Issue 5, Page(s) 310–316

Abstract: Background: Conjunctival melanoma is a relatively rare ocular malignancy with substantial associated morbidity and mortality.: Methods: More than 100 articles on conjunctival melanoma were reviewed, including most of the relevant recent publications ... ...

Abstract	Background: Conjunctival melanoma is a relatively rare ocular malignancy with substantial associated morbidity and mortality. Methods: More than 100 articles on conjunctival melanoma were reviewed, including most of the relevant recent publications cited in a current MEDLINE search. The author's experience with conjunctival melanomas is also incorporated in this review. Results: Recognition of their precursor lesions at an early stage is important. Staging of the disease by sentinel lymph node biopsy is now advocated in some centers. Surgical excision with adjuvant cryotherapy and alcohol corneal epithelialectomy is usually effective in eradicating most of these lesions. Extensive cases of flat primary acquired melanosis with atypia may be managed with mitomycin C. Multifocal and advanced melanoma, especially in cases showing intraocular or orbital invasion, may require exenteration and/or radiotherapy to adequately extirpate the neoplasm locally. However, systemic metastases already may have occurred in these patients with advanced disease. Conclusions: Conjunctival melanoma is a condition of concern because of its rarity and lethal potential. Advances in the understanding and management of this neoplasm have markedly reduced the mortality and possibly the morbidity associated with this malignancy.
MeSH term(s)	Brachytherapy/methods ; Conjunctival Neoplasms/diagnosis ; Conjunctival Neoplasms/therapy ; Cryotherapy/methods ; Diagnosis, Differential ; Humans ; Melanoma/diagnosis ; Melanoma/therapy ; Melanosis/diagnosis ; Nevus/diagnosis ; Ophthalmologic Surgical Procedures/methods ; Prognosis ; Sentinel Lymph Node Biopsy/methods ; Treatment Outcome
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
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Zs.A 4467: Show issues

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Article: Benign Solitary Fibrous Histiocytoma of Xanthomatous Subtype of the Perilimbal Conjunctiva and Adjacent Sclera in a Youth.

Ali-Ridha, Andre / Brownstein, Seymour / O'Connor, Michael / Milman, Tatyana / Tang, Tina

Ocular oncology and pathology

2018 Volume 4, Issue 6, Page(s) 341–344

Abstract: Aims: To report the clinical and pathological features of a benign fibrous histiocytoma of the xanthomatous subtype in the perilimbal conjunctiva and adjacent sclera in a youth.: Methods: An 11-year-old Caucasian boy presented with a yellowish dome- ... ...

Abstract	Aims: To report the clinical and pathological features of a benign fibrous histiocytoma of the xanthomatous subtype in the perilimbal conjunctiva and adjacent sclera in a youth. Methods: An 11-year-old Caucasian boy presented with a yellowish dome-shaped conjunctival mass abutting the inferotemporal limbus of the left eye. The tumor measured 4 mm in its maximum diameter. The lesion was excised and was noted to extend into the sclera. Three years postoperatively, there was no evidence of recurrence. Results: Histopathological examination disclosed a highly cellular lesion composed predominantly of benign-appearing foamy histiocytes without multinucleated giant cells. The tumor contained sparse fibrous septa without a storiform configuration. Immunohistochemical analysis showed diffuse cytoplasmic positive staining with adipophilin, CD34, and CD163. Conclusion: A lesion comprised of numerous homogeneous foamy histiocytes without multinucleated giant cells in the perilimbal conjunctiva and adjacent sclera of a youth is presented as a unique case of a rare variant of fibrous histiocytoma of the xanthomatous subtype.
Language	English
Publishing date	2018-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806965-1
ISSN	2296-4657 ; 2296-4681
ISSN (online)	2296-4657
ISSN	2296-4681
DOI	10.1159/000486421
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Article: Langerhans cell histiocytosis in an 18-month-old child presenting as periorbital cellulitis.

Ali-Ridha, Andre / Brownstein, Seymour / O'Connor, Michael / Gilberg, Steve / Tang, Tina

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

2018 Volume 32, Issue 1, Page(s) 52–55

Abstract: Langerhans cell histiocytosis (LCH) is a rare multi-system disease. It presents infrequently as a childhood orbital tumor, and can mimic more common inflammatory orbital disease processes. We report the clinical, histopathological, and electron ... ...

Abstract	Langerhans cell histiocytosis (LCH) is a rare multi-system disease. It presents infrequently as a childhood orbital tumor, and can mimic more common inflammatory orbital disease processes. We report the clinical, histopathological, and electron microscopic findings of orbital LCH in an 18-month-old child, along with a review of the recent literature regarding molecular pathogenetic analysis of LCH. The child presented with a two-week history of progressive left periorbital edema and redness. He was initially diagnosed and treated empirically for bacterial periorbital cellulitis, but subsequently underwent ophthalmological consultation after he failed to improve. Histopathological examination of an orbital biopsy specimen revealed numerous Langerhans-type cells, which stain positive for CD1A and CD207 (langerin). Electron microscopic examination demonstrated characteristic Birbeck granules within the Langerhans-type cells. Three year follow-up did not demonstrate recurrence or disease progression.
Language	English
Publishing date	2018-02-16
Publishing country	Saudi Arabia
Document type	Journal Article
ISSN	1319-4534
ISSN	1319-4534
DOI	10.1016/j.sjopt.2018.02.006
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Article ; Online: Advanced glycation end products and diabetic retinopathy.

Milne, Ross / Brownstein, Seymour

Amino acids

2011 Volume 44, Issue 6, Page(s) 1397–1407

Abstract: Retinopathy is a serious microvascular complication of diabetes and a major cause of blindness in young adults, worldwide. Early diabetic retinopathy is characterized by a loss of pericytes from retinal capillaries, the appearance of acellular ... ...

Abstract	Retinopathy is a serious microvascular complication of diabetes and a major cause of blindness in young adults, worldwide. Early diabetic retinopathy is characterized by a loss of pericytes from retinal capillaries, the appearance of acellular capillaries and microaneurysms, and a breakdown of the blood-retinal barrier. In later stages, this can evolve into the proliferative phase in which there is neovascularization of the retina, which greatly increases the probability of vision loss. Advanced glycation end products (AGEs) which accumulate under hyperglycemic conditions are thought to play an important role in the pathogenesis of diabetic retinopathy. AGEs arise primarily by the modification of amine groups of proteins by reactive dicarbonyls such as methylglyoxal. Intracellular proteins including anti-oxidant enzymes, transcription factors and mitochondrial proteins are targets of dicarbonyl modification and this can modify their functional properties and thus compromise cellular physiology. Likewise, modification of extracellular proteins by dicarbonyls can impair cell adhesion and can generate ligands that can potentially bind to cell surface AGE receptors that activate pro-inflammatory signaling pathways. AGE inhibitors have been shown to provide protection in animal models of diabetic retinopathy and currently are being evaluated in clinical trials.
MeSH term(s)	Animals ; Blood-Retinal Barrier/metabolism ; Blood-Retinal Barrier/physiopathology ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/physiopathology ; Diabetic Retinopathy/prevention & control ; Glycation End Products, Advanced/antagonists & inhibitors ; Glycation End Products, Advanced/metabolism ; Molecular Targeted Therapy/methods ; Neovascularization, Pathologic/metabolism ; Pericytes/pathology ; Pyridoxamine/pharmacology ; Pyruvaldehyde/metabolism ; Retina/physiopathology ; Signal Transduction/drug effects
Chemical Substances	Glycation End Products, Advanced ; Pyridoxamine (6466NM3W93) ; Pyruvaldehyde (722KLD7415)
Language	English
Publishing date	2011-09-11
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-011-1071-3
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Zs.A 3490: Show issues

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Article ; Online: Pilomatrixoma of the ocular adnexa: report of 3 cases with variations in the histopathological findings.

Chen, Henry C / Brownstein, Seymour / Tang, Tina / Grynspan, David / Belliveau, Michel J / El Demellawy, Dina / O'Connor, Michael

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2019 Volume 54, Issue 4, Page(s) 413–416

Abstract: Objective: To report the clinical and variations in the histopathological features of pilomatrixoma of the ocular adnexa in 3 young individuals.: Design: A retrospective case series was performed with clinical, histological, and immunohistochemical ... ...

Abstract	Objective: To report the clinical and variations in the histopathological features of pilomatrixoma of the ocular adnexa in 3 young individuals. Design: A retrospective case series was performed with clinical, histological, and immunohistochemical analysis. Participants: Case 1 is an 18-year-old male who presented with a reddish-blue swelling under the left eyebrow. The lesion measured 2 × 1 cm. Case 2 is a 2-year-old female who presented with a reddish-blue nodule inferior to the right eyebrow with telangiectatic vessels. The lesion measured 6 × 4 × 4 mm. Case 3 is a 14-year-old female who presented with a subcutaneous lesion under the right upper eyebrow with fluctuating inflammation. The lesion measured 12 × 3 × 2 mm. Histopathological examination of case 1 disclosed peripheral basaloid cells and central shadow cells containing calcific foci, separated by a transition zone. In case 2, histopathological analysis revealed central calcific foci in islands of shadow cells with more peripheral basaloid cells. In case 3, we observed numerous clusters of shadow cells with focal calcifications, as well as basaloid cells in a disorganized configuration. Conclusion: Pilomatrixoma is an uncommon benign skin neoplasm originating from the matrix of the hair root. We describe a spectrum of histopathological findings in pilomatrixoma of the ocular adnexal in 3 young individuals.
MeSH term(s)	Adolescent ; Biopsy ; Child, Preschool ; Diagnosis, Differential ; Eyebrows/pathology ; Eyelid Neoplasms/diagnosis ; Female ; Hair Diseases/diagnosis ; Humans ; Male ; Pilomatrixoma/diagnosis ; Skin Neoplasms/diagnosis
Language	English
Publishing date	2019-01-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2018.10.015
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