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  1. Article: Toward optimal health: the experts respond to skin cancer. Interview by Jodi Godfrey Meisler, M.S., R.D..

    Rigel, D / Skouge, J

    Journal of women's health & gender-based medicine

    1999  Volume 8, Issue 5, Page(s) 593–596

    MeSH term(s) Female ; Humans ; Incidence ; Male ; Melanoma/epidemiology ; Melanoma/prevention & control ; Melanoma/surgery ; Mohs Surgery ; Skin Neoplasms/epidemiology ; Skin Neoplasms/prevention & control ; Skin Neoplasms/surgery ; Sunburn ; Sunscreening Agents ; United States/epidemiology
    Chemical Substances Sunscreening Agents
    Language English
    Publishing date 1999-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1494558-7
    ISSN 1524-6094
    ISSN 1524-6094
    DOI 10.1089/jwh.1.1999.8.593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3584: Show issues Location:
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  2. Article ; Online: Response to Marchetti et al.

    Rigel, Darrell S / Whitaker, John W / Skelsey, Maral K / Peck, Gary / Howell, Michael D / Jansen, Burkhard

    The Journal of investigative dermatology

    2021  Volume 142, Issue 1, Page(s) 232–234

    MeSH term(s) Humans ; Postoperative Complications
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.06.024
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  3. Article ; Online: Electrical impedance spectroscopy significantly enhances correct biopsy choice for pigmented skin lesions beyond clinical evaluation and dermoscopy.

    Zakria, Danny / Brownstone, Nicholas / Han, Joseph / Owji, Shayan / Dirr, McKenzie / Rigel, Darrell

    Melanoma research

    2022  Volume 33, Issue 1, Page(s) 80–83

    Abstract: The purpose of this study was to investigate whether EIS technology can further improve correct biopsy choices beyond clinical and dermoscopic evaluation for melanoma (MM), severe dysplastic nevi (SDN) and benign PSLs. Images of 49 MMs, SDNs and benign ... ...

    Abstract The purpose of this study was to investigate whether EIS technology can further improve correct biopsy choices beyond clinical and dermoscopic evaluation for melanoma (MM), severe dysplastic nevi (SDN) and benign PSLs. Images of 49 MMs, SDNs and benign PSLs were randomly selected from a prior study and were provided in a reader-type survey study to dermatologists to evaluate for biopsy. A total of 33,957 biopsy decisions were analyzed. Respondents significantly improved on the correct biopsy choice with the addition of dermoscopy versus clinical image alone for melanoma and severely dysplastic nevi. Respondents also showed a statistically significant improvement in correct biopsy choice beyond their dermoscopic evaluation when integrating the EIS score versus dermoscopy with clinical images for MM, SDN and benign lesions. Respondents also made fewer incorrect biopsy choices with the addition of the EIS score versus dermoscopy and clinical image for MM and benign lesions. Sub-analyses of biopsy choices were also conducted based on experience and practice type. The findings from this study demonstrate that the integration of EIS technology into PSL biopsy decisions has the potential to significantly improve the accuracy of lesion selection for biopsy beyond clinical and dermoscopic evaluation alone.
    MeSH term(s) Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Dysplastic Nevus Syndrome ; Dermoscopy/methods ; Dielectric Spectroscopy ; Biopsy ; Diagnosis, Differential
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1095779-0
    ISSN 1473-5636 ; 0960-8931
    ISSN (online) 1473-5636
    ISSN 0960-8931
    DOI 10.1097/CMR.0000000000000859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3378: Show issues Location:
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  4. Article ; Online: Photoprotection for all: Current gaps and opportunities.

    Rigel, Darrell S / Lim, Henry W / Draelos, Zoe D / Weber, Teresa M / Taylor, Susan C

    Journal of the American Academy of Dermatology

    2021  Volume 86, Issue 3S, Page(s) S18–S26

    Abstract: The effects of solar radiation on human skin differ based on the skin phototype, presence or absence of photodermatoses, biologic capacity to repair DNA damage, wavelength, intensity of sun exposure, geographic latitude, and other factors, underscoring ... ...

    Abstract The effects of solar radiation on human skin differ based on the skin phototype, presence or absence of photodermatoses, biologic capacity to repair DNA damage, wavelength, intensity of sun exposure, geographic latitude, and other factors, underscoring the need for a more tailored approach to photoprotection. To date, the focus of photoprotection guidelines has been to prevent sunburn and DNA damage induced by UV radiation, both UVB and UVA; however, several recent studies have shown that visible light also generates reactive oxygen and nitrogen species that can contribute to skin damage and pigmentation on the skin, particularly in people with skin of color. Therefore, individuals with dark skin, while naturally better protected against UVB radiation by virtue of the high eumelanin content in melanocytes, may need additional protection from visible light-induced skin damage. The current options for photoprotection products need to expand, and potential strategies against visible light include the addition of iron oxide, titanium dioxide, and biologically relevant antioxidants to sunscreen formulations as well as supplementation with orally active antioxidants.
    MeSH term(s) Antioxidants ; Humans ; Skin ; Sunburn/prevention & control ; Sunscreening Agents/pharmacology ; Sunscreening Agents/therapeutic use ; Ultraviolet Rays/adverse effects
    Chemical Substances Antioxidants ; Sunscreening Agents
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.12.023
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  6. Article ; Online: Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication.

    Nakajima, Shogo / Ohashi, Hirofumi / Akazawa, Daisuke / Torii, Shiho / Suzuki, Rigel / Fukuhara, Takasuke / Watashi, Koichi

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin ...

    Abstract Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin and its derivatives and analyzed their antiviral activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The micafungin derivatives Mi-2 and Mi-5 showed higher antiviral activity than micafungin, with 50% maximal inhibitory concentration (IC
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; COVID-19 ; Micafungin/pharmacology ; RNA Replication ; RNA, Viral ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Micafungin (R10H71BSWG) ; RNA, Viral
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Non-Invasive Gene Expression Testing to Rule Out Melanoma.

    Rivers, J K / Copley, M R / Svoboda, R / Rigel, D S

    Skin therapy letter

    2018  Volume 23, Issue 5, Page(s) 1–4

    Abstract: The Pigmented Lesion Assay (PLA) is a gene expression test that helps rule out melanoma and has the potential to reduce the need for surgical biopsies of atypical pigmented skin lesions. Utilizing a new technological platform for the non-invasive ... ...

    Abstract The Pigmented Lesion Assay (PLA) is a gene expression test that helps rule out melanoma and has the potential to reduce the need for surgical biopsies of atypical pigmented skin lesions. Utilizing a new technological platform for the non-invasive profiling of skin, the assay analyzes samples collected from adhesive patches for expression of two key genes (PRAME and LINC00518) known to be overexpressed in melanoma. The test result is binary (positive/negative) based on the detection of one or both genes. PLA positive cases are generally biopsied to establish the histopathologic diagosis, while PLA negative cases are considered for ongoing monitoring. The combination of visual inspection with histopathology, the current gold standard for melanoma diagnosis, has a relatively low negative predictive value (NPV) of approximately 83%, meaning that 17% of melanomas will be interpreted as benign lesions. In contrast, the PLA has a very high NPV (>99%). Further, with its high specificity (69-91%), use of the PLA can reduce the number of false positive samples subjected to histopathology review. By adding the PLA to the current care pathway, the number of surgical biopsies needed to find a melanoma (number needed to biopsy) is markedly reduced from 20-25 biopsies for dermatologists and 39 biopsies for physician assistants, to an average of 2.7. To date, unnecessary surgical procedures of benign lesions have been reduced by 88% based on a sample of more than 20,000 analyzed cases. This has resulted in fewer missed melanomas and significant cost savings to health care systems.
    MeSH term(s) Gene Expression Profiling/methods ; Humans ; Melanoma/diagnosis ; Melanoma/genetics ; Melanoma/pathology ; Reproducibility of Results ; Sensitivity and Specificity ; Skin/metabolism ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
    Language English
    Publishing date 2018-10-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2065394-3
    ISSN 1201-5989
    ISSN 1201-5989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5605: Show issues Location:
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  8. Article: Successful Treatment of Generalized Essential Telangiectasia With 6-Mercaptopurine.

    Glazer, Alex M / Sofen, Bryan D / Rigel, Darrell S / Shupack, Jerome L

    Journal of drugs in dermatology : JDD

    2017  Volume 16, Issue 3, Page(s) 280–282

    Abstract: ... Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET. Moreover, we show ... ...

    Abstract

    Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET. Moreover, we show that GET may represent a state of increased angiogenesis, a paradigm shift from the current understanding that these telangiectasias represent dilatations of only pre-existing vessels. This new view of GET may drive others to look at novel agents for treatment.

    <em>J Drugs Dermatol. 2017;16(3):280-282.</em>

    .
    MeSH term(s) Antigens, CD34/metabolism ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/therapeutic use ; Biomarkers/urine ; Colitis, Ulcerative/drug therapy ; Collagen Type IV/metabolism ; Endothelial Cells/metabolism ; Female ; Fibrinogen/urine ; Humans ; Lasers, Dye/therapeutic use ; Low-Level Light Therapy ; Mercaptopurine/administration & dosage ; Mercaptopurine/therapeutic use ; Metalloproteases/urine ; Middle Aged ; Neovascularization, Pathologic/urine ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Telangiectasis/drug therapy ; Telangiectasis/pathology ; Telangiectasis/psychology ; Telangiectasis/radiotherapy
    Chemical Substances Antigens, CD34 ; Antimetabolites, Antineoplastic ; Biomarkers ; Collagen Type IV ; Platelet Endothelial Cell Adhesion Molecule-1 ; Fibrinogen (9001-32-5) ; Mercaptopurine (E7WED276I5) ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5931: Show issues Location:
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  9. Article: Telemedicine Versus Teledermatology Usage and Perception Among US-Based Physicians: A Survey Study.

    Ahmad, Maham / Marson, Justin W / Litchman, Graham H / Zakria, Danny / Kong, Clarence / Perkins, Sara / Bepple, Jennifer / Berger, Reed / DuRant, James / Hagerich, Kelly / Kahl, Nicolas / Simeon-Thompson, Laika / McSteen, Brian / Okesanya, Adesuwa / Yung, Nathan / Rigel, Darrell S

    Journal of drugs in dermatology : JDD

    2023  Volume 22, Issue 11, Page(s) e4–e8

    Abstract: ... examines telehealth use 2 years after the beginning of the COVID pandemic from a physician’s ...

    Abstract The COVID-19 pandemic has sparked an increase in focus and use of telemedicine in several patient care settings. This survey study was distributed to actively practicing US-based physicians and examines telehealth use 2 years after the beginning of the COVID pandemic from a physician’s perspective. Notable findings include telehealth benefits which include increased patient access and the ability to work from home. A continued drawback in telehealth visits is the limitations on a complete physical examination, a drawback that was emphasized by the dermatology community. While this study sheds light on the developing nature of telehealth, it is limited by its retrospective nature and sample size. Future research with larger sample sizes focusing on economic incentives and telemedicine training may help to overcome barriers to using telehealth.  J Drugs Dermatol. 2023;22(11):e4-e8    doi:10.36849/JDD.7386e.
    MeSH term(s) Humans ; Pandemics ; Retrospective Studies ; Physicians ; Telemedicine ; Perception
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.7386
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  10. Article ; Online: SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual use: Results of a randomized, double-blind, split-face, natural sunlight exposure clinical trial.

    Williams, Joshua D / Maitra, Prithwiraj / Atillasoy, Evren / Wu, Mei-Miau / Farberg, Aaron S / Rigel, Darrell S

    Journal of the American Academy of Dermatology

    2017  Volume 78, Issue 5, Page(s) 902–910.e2

    Abstract: Background: The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.: Objective: To compare the sunburn protection provided by SPF 100+ and SPF 50+ ... ...

    Abstract Background: The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.
    Objective: To compare the sunburn protection provided by SPF 100+ and SPF 50+ sunscreen in conditions of actual use.
    Methods: A total of 199 healthy men and women (≥18 years) participated in a natural sunlight, single-exposure, split-face, randomized, double-blind study in Vail, Colorado. Each participant wore both sunscreens simultaneously during activities, with no use restrictions other than designation of the treatment area. Erythema was clinically assessed on the day following exposure. Comparative efficacy was evaluated through bilateral comparison of sunburn between treatment areas and erythema score, as evaluated separately for each treatment area.
    Results: Following an average 6.1 ± 1.3 hours of sun exposure, investigator-blinded evaluation identified 55.3% of the participants (110 of 199) as more sunburned on the SPF 50+ protected side and 5% (10 of 199) on the SPF 100+ protected side. After exposure, 40.7% of the participants (81 of 199) exhibited increased erythema scores (by ≥1) on the SPF 50+ protected side as compared with 13.6% (27 of 199) on the SPF 100+ protected side.
    Limitations: Single-day exposure may not extrapolate to benefits of longer-term protection.
    Conclusion: SPF 100+ sunscreen was significantly more effective in protecting against sunburn than SPF 50+ sunscreen in actual use conditions.
    MeSH term(s) Adult ; Double-Blind Method ; Female ; Humans ; Male ; Prospective Studies ; Risk Assessment ; Sensitivity and Specificity ; Sun Protection Factor/methods ; Sunburn/prevention & control ; Sunscreening Agents/chemistry ; Sunscreening Agents/therapeutic use ; Time Factors ; Treatment Outcome ; Ultraviolet Rays/adverse effects
    Chemical Substances Sunscreening Agents
    Language English
    Publishing date 2017-12-29
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2017.12.062
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