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  1. Article ; Online: Ed Zigler as mentor: Lessons for a new generation of intellectual disability researchers.

    Hodapp, R M / Burack, J A / Evans, D W / Iarocci, G

    Journal of intellectual disability research : JIDR

    2023  Volume 67, Issue 3, Page(s) 289–293

    MeSH term(s) Humans ; Intellectual Disability ; Mentors
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Editorial
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13019
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  2. Article ; Online: Ed Zigler's legacy and the developmental approach to the study of persons with intellectual disability.

    Evans, D W / Burack, J A / Hodapp, R M / Iarocci, G

    Journal of intellectual disability research : JIDR

    2023  Volume 67, Issue 3, Page(s) 183–185

    MeSH term(s) Humans ; Child ; Persons with Mental Disabilities ; Developmental Disabilities ; Intellectual Disability
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Editorial
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13017
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  3. Article ; Online: Health Topics Emerged From Brief Motivational Interviewing: A randomized clinical trial.

    Arnett, Michelle / Paulson, Danna R / Evans, Michael D / Blue, Christine / Reibel, Yvette G

    Journal of dental hygiene : JDH

    2023  Volume 97, Issue 5, Page(s) 116–127

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Humans ; Motivational Interviewing/methods ; Health Behavior ; Motivation ; Communication
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1035719-1
    ISSN 1553-0205 ; 1043-254X
    ISSN (online) 1553-0205
    ISSN 1043-254X
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  4. Article ; Online: Revealing uncertainty in the status of biodiversity change.

    Johnson, T F / Beckerman, A P / Childs, D Z / Webb, T J / Evans, K L / Griffiths, C A / Capdevila, P / Clements, C F / Besson, M / Gregory, R D / Thomas, G H / Delmas, E / Freckleton, R P

    Nature

    2024  Volume 628, Issue 8009, Page(s) 788–794

    Abstract: Biodiversity faces unprecedented threats from rapid global ... ...

    Abstract Biodiversity faces unprecedented threats from rapid global change
    MeSH term(s) Biodiversity ; Uncertainty ; Phylogeny ; Animals ; Conservation of Natural Resources/trends ; Datasets as Topic ; Time Factors ; Spatio-Temporal Analysis
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07236-z
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  5. Article ; Online: QCM-D Investigations on Cholesterol-DNA Tethering of Liposomes to Microbubbles for Therapy.

    Armistead, Fern J / Batchelor, Damien V B / Johnson, Benjamin R G / Evans, Stephen D

    The journal of physical chemistry. B

    2023  Volume 127, Issue 11, Page(s) 2466–2474

    Abstract: ... used for the attachment of liposomes to a supported lipid bilayer (SLB) as measured via QCM-D ... Importantly, we show, for the first time, that QCM-D can be used to study the tethering of microbubbles ...

    Abstract Lipid-shelled microbubbles (MBs) offer potential as theranostic agents, capable of providing both contrast enhancement in ultrasound imaging as well as a route for triggered drug release and improved localized drug delivery. A common motif in the design of such therapeutic vehicles is the attachment of the drug carrier, often in the form of liposomes, to the microbubble. Traditionally, such attachments have been based around biotin-streptavidin and maleimide-PDP chemistries. Comparatively, the use of DNA-lipid tethers offers potential advantage. First, their specificity permits the construction of more complex architectures that might include bespoke combinations of different drug-loaded liposomes and/or targeting groups, such as affimers or antibodies. Second, the use of dual-lipid tether strategies should increase the strength of the individual tethers tethering the liposomes to the bubbles. The ability of cholesterol-DNA (cDNA) tethers for conjugation of liposomes to supported lipid bilayers has previously been demonstrated. For in vivo applications, bubbles and liposomes often contain a proportion of polyethylene glycol (PEG) to promote stealth-like properties and increase lifetimes. However, the associated steric effects may hinder tethering of the drug payload. We show that while the presence of PEG reduced the tethering affinity, cDNA can still be used for the attachment of liposomes to a supported lipid bilayer (SLB) as measured via QCM-D. Importantly, we show, for the first time, that QCM-D can be used to study the tethering of microbubbles to SLBs using cDNA, signified by a decrease in the magnitude of the frequency shift compared to liposomes alone due to the reduced density of the MBs. We then replicate this tethering interaction in the bulk and observe attachment of liposomes to the shell of a central MB and hence formation of a model therapeutic microbubble.
    MeSH term(s) Liposomes ; Microbubbles ; DNA, Complementary ; Polyethylene Glycols ; Lipid Bilayers ; Cholesterol
    Chemical Substances Liposomes ; DNA, Complementary ; Polyethylene Glycols (3WJQ0SDW1A) ; Lipid Bilayers ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c07256
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  6. Article ; Online: Health topics emerged from brief-motivational interviewing: A randomized clinical trial.

    Arnett, Michelle C / Paulson, Danna R / Evans, Michael D / Blue, Christine M / Reibel, Yvette G

    International journal of dental hygiene

    2023  Volume 21, Issue 4, Page(s) 738–746

    Abstract: Objective: The goal of this study was to analyse transcription of audio recordings to determine health topics that emerged from brief-motivational interviewing (MI) compared to traditional oral hygiene instructions (OHI).: Methods: Fifty-eight ... ...

    Abstract Objective: The goal of this study was to analyse transcription of audio recordings to determine health topics that emerged from brief-motivational interviewing (MI) compared to traditional oral hygiene instructions (OHI).
    Methods: Fifty-eight periodontal maintenance patients were randomized to a brief-MI or traditional OHI group for a longitudinal 1-year clinical trial. Both groups received four patient education sessions per their assigned group. Audio recordings were transcribed and coded. The overarching themes and subthemes emerged were quantified and reported as the number of instances per participant. Global scores and behavioural counts were compared across baseline, 4, 8, and 12-month research visits using mixed-effect models.
    Results: Of the six overarching themes, the brief-MI group evoked more topics toward total health. Oral home care behaviours (15 vs. 10.2) and oral diseases/conditions (3.3 vs. 1.9) were discussed more in the brief-MI group compared to the traditional OHI group. This positive outcome for the average number of times a health topic was discussed in the brief-MI group compared to the traditional OHI group continued for the remaining major themes: lifestyle behaviours (1.0 vs. 0.4), nutrition (2.6 vs. 0.8), emotional/mental health (1.8 vs. 0.8) and general health (1.2 vs. 0.4).
    Conclusion: This study identified that brief-MI was a more successful communication approach to increase discussions of oral home care behaviours, oral diseases/conditions, lifestyle behaviours, nutrition, emotional/mental health and general health compared to traditional OHI in individuals with periodontitis.
    MeSH term(s) Humans ; Motivational Interviewing ; Motivation
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2252118-5
    ISSN 1601-5037 ; 1601-5029
    ISSN (online) 1601-5037
    ISSN 1601-5029
    DOI 10.1111/idh.12739
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  7. Article ; Online: Guiding epitaxial crystallization of amorphous solids at the nanoscale: Interfaces, stress, and precrystalline order.

    Janicki, T D / Wan, Z / Liu, R / Evans, P G / Schmidt, J R

    The Journal of chemical physics

    2022  Volume 157, Issue 10, Page(s) 100901

    Abstract: The crystallization of amorphous solids impacts fields ranging from inorganic crystal growth to biophysics. Promoting or inhibiting nanoscale epitaxial crystallization and selecting its final products underpin applications in cryopreservation, ... ...

    Abstract The crystallization of amorphous solids impacts fields ranging from inorganic crystal growth to biophysics. Promoting or inhibiting nanoscale epitaxial crystallization and selecting its final products underpin applications in cryopreservation, semiconductor devices, oxide electronics, quantum electronics, structural and functional ceramics, and advanced glasses. As precursors for crystallization, amorphous solids are distinguished from liquids and gases by the comparatively long relaxation times for perturbations of the mechanical stress and for variations in composition or bonding. These factors allow experimentally controllable parameters to influence crystallization processes and to drive materials toward specific outcomes. For example, amorphous precursors can be employed to form crystalline phases, such as polymorphs of Al
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0098043
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    Z 4' 49/16: Show issues

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  8. Article ; Online: Novel trial designs for patients with gastrointestinal stromal tumor.

    Serrano, C / Rothschild, S / Villacampa, G / Heinrich, M C / George, S / Blay, J-Y / Sicklick, J K / Schwartz, G K / Rastogi, S / Jones, R L / Rutkowski, P / Somaiah, N / Navarro, V / Evans, D / Trent, J C

    ESMO open

    2024  Volume 9, Issue 1, Page(s) 102218

    MeSH term(s) Humans ; Gastrointestinal Stromal Tumors ; Patients
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Letter
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1016/j.esmoop.2023.102218
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  9. Article: Diagnostic and Prognostic Performance of Metabolic Signatures in Pancreatic Ductal Adenocarcinoma: The Clinical Application of Quantitative NextGen Mass Spectrometry.

    D'Amora, Paulo / Silva, Ismael D C G / Evans, Steven S / Nagourney, Adam J / Kirby, Katharine A / Herrmann, Brett / Cavalheiro, Daniela / Francisco, Federico R / Bernard, Paula J / Nagourney, Robert A

    Metabolites

    2024  Volume 14, Issue 3

    Abstract: With 64,050 new diagnoses and 50,550 deaths in the US in 2023, pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all human malignancies. Early detection and improved prognostication remain critical unmet needs. We applied next- ... ...

    Abstract With 64,050 new diagnoses and 50,550 deaths in the US in 2023, pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all human malignancies. Early detection and improved prognostication remain critical unmet needs. We applied next-generation metabolomics, using quantitative tandem mass spectrometry on plasma, to develop biochemical signatures that identify PDAC. We first compared plasma from 10 PDAC patients to 169 samples from healthy controls. Using metabolomic algorithms and machine learning, we identified ratios that incorporate amino acids, biogenic amines, lysophosphatidylcholines, phosphatidylcholines and acylcarnitines that distinguished PDAC from normal controls. A confirmatory analysis then applied the algorithms to 30 PDACs compared with 60 age- and sex-matched controls. Metabolic signatures were then analyzed to compare survival, measured in months, from date of diagnosis to date of death that identified metabolite ratios that stratified PDACs into distinct survival groups. The results suggest that metabolic signatures could provide PDAC diagnoses earlier than tumor markers or radiographic measures and offer insights into disease severity that could allow more judicious use of therapy by stratifying patients into metabolic-risk subgroups.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14030148
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  10. Article ; Online: Differential responses of cerebral and renal oxygenation to altered perfusion conditions during experimental cardiopulmonary bypass in sheep.

    Evans, Roger G / Cochrane, Andrew D / Hood, Sally G / Marino, Bruno / Iguchi, Naoya / Bellomo, Rinaldo / McCall, Peter R / Okazaki, Nobuki / Jufar, Alemayehu H / Miles, Lachlan F / Furukawa, Taku / Ow, Connie P C / Raman, Jaishankar / May, Clive N / Lankadeva, Yugeesh R

    Clinical and experimental pharmacology & physiology

    2024  Volume 51, Issue 4, Page(s) e13852

    Abstract: We tested whether the brain and kidney respond differently to cardiopulmonary bypass (CPB) and to changes in perfusion conditions during CPB. Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation ( ... ...

    Abstract We tested whether the brain and kidney respond differently to cardiopulmonary bypass (CPB) and to changes in perfusion conditions during CPB. Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation (rSO
    MeSH term(s) Sheep ; Animals ; Cardiopulmonary Bypass/adverse effects ; Metaraminol ; Oxygen ; Kidney ; Vasoconstrictor Agents ; Perfusion ; Hemoglobins
    Chemical Substances Metaraminol (818U2PZ2EH) ; Oxygen (S88TT14065) ; Vasoconstrictor Agents ; Hemoglobins
    Language English
    Publishing date 2024-02-22
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189277-0
    ISSN 1440-1681 ; 0305-1870 ; 0143-9294
    ISSN (online) 1440-1681
    ISSN 0305-1870 ; 0143-9294
    DOI 10.1111/1440-1681.13852
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