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Article ; Online: Rediscovering AMD with Swept-Source OCT Imaging: The 2022 Charles L. Schepens, MD, Lecture.

Rosenfeld, Philip J / Shen, Mengxi / Trivizki, Omer / Liu, Jeremy / Herrera, Gissel / Hiya, Farhan E / Li, Jianqing / Berni, Alessandro / Wang, Liang / El-Mulki, Omar S / Cheng, Yuxuan / Lu, Jie / Zhang, Qinqin / O'Brien, Robert C / Gregori, Giovanni / Wang, Ruikang K

Ophthalmology. Retina

2024

Abstract: ... sectional and en face imaging strategies.: Design: Presented at the 2022 Charles L. Schepens, MD, Lecture ...

Abstract	Purpose: Swept-source optical coherence tomography angiography (SS-OCTA) scans of eyes with age-related macular degeneration (AMD) were used to replace color, autofluorescence, infrared reflectance, and dye-based fundus angiographic imaging for the diagnosis and staging of AMD. Through the use of different algorithms with the SS-OCTA scans, both structural and angiographic information can be viewed and assessed using both cross-sectional and en face imaging strategies. Design: Presented at the 2022 Charles L. Schepens, MD, Lecture at the American Academy of Ophthalmology Retina Subspecialty Day, Chicago, Illinois, on September 30, 2022 PARTICIPANTS: Patients with AMD METHODS: Review of published literature and ongoing clinical research using SS-OCTA imaging in AMD. Main outcome measures: SS-OCTA imaging of AMD at different stages of disease progression. Results: Volumetric SS-OCTA dense raster scans were used to diagnose and stage both exudative and nonexudative AMD. In eyes with nonexudative AMD, a single SS-OCTA scan was used to detect and measure structural features in the macula such as the area and volume of both typical soft drusen and calcified drusen, the presence and location of hyperreflective foci, the presence of reticular pseudodrusen, also known as subretinal drusenoid deposits, the thickness of the outer retinal layer, the presence and thickness of basal laminar deposits, the presence and area of persistent choroidal hypertransmission defects, and the presence of treatment-naïve nonexudative macular neovascularization. In eyes with exudative AMD, the same SS-OCTA scan pattern was used to detect and measure the presence of macular fluid, the presence and type of macular neovascularization, and the response of exudation to treatment with vascular endothelial growth factor inhibitors. In addition, the same scan pattern was used to quantitate choriocapillaris (CC) perfusion, CC thickness, choroidal thickness, and the vascularity of the choroid. Conclusions: Compared with using several different instruments to perform multimodal imaging, a single SS-OCTA scan provides a convenient, comfortable, and comprehensive approach for obtaining qualitative and quantitative anatomic and angiographic information to monitor the onset, progression, and response to therapies in both nonexudative and exudative AMD.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ISSN	2468-6530
ISSN (online)	2468-6530
DOI	10.1016/j.oret.2024.04.012
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Article: Dépression chez l’adolescent et multiculturalité : analyse multifactorielle de la souffrance psychique au sein d’une famille en crise.

Rosenfeld, B / Delvenne, V

Revue medicale de Bruxelles

2018 Volume 39, Issue 1, Page(s) 41–46

Abstract: The complexity of depressive diagnosis and other forms of expression of psychological suffering during adolescence explain why particular caution is required. The medico-psycho-social determinants of teenager's mental health enjoin us to support a ... ...

Title translation	Depression in adolescents and multiculturality : a multifactorial analysis of psychological suffering inside a family in crisis.
Abstract	The complexity of depressive diagnosis and other forms of expression of psychological suffering during adolescence explain why particular caution is required. The medico-psycho-social determinants of teenager's mental health enjoin us to support a holistic analysis of these situations. Different analysis spectra - symptomatic, environnemental, anthropological, cultural - allow us to understand a situation at different levels of interpretation. As we will see through a clinical case examination, the difficulty of depressive diagnosis in a multicultural background is increased by the ethnocentrical aspect of this category.
MeSH term(s)	Adolescent ; Age Factors ; Cultural Diversity ; Depression/diagnosis ; Depression/therapy ; Family/psychology ; Humans ; Identity Crisis ; Male ; Psychology, Adolescent ; Risk Factors ; Stress Disorders, Post-Traumatic ; Stress, Psychological/etiology ; Stress, Psychological/therapy
Language	French
Publishing date	2018-03-10
Publishing country	Belgium
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	760217-0
ISSN	0035-3639
ISSN	0035-3639
DOI	10.30637/2018.17-053
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Article: Correction to: Effects of temperature and salinity on the reproductive phases of Macrocystis pyrifera (L.) C. Agardh (Phaeophyceae) in the Magellan region

Rodríguez, Juan Pablo / Mansilla, A / Méndez, F / Ojeda, J / Rosenfeld, S / Terrados, J

Journal of applied phycology. 2019 Apr., v. 31, no. 2

2019

Abstract: The original version of this article unfortunately contained mistakes. ...

Abstract	The original version of this article unfortunately contained mistakes.
Keywords	Macrocystis pyrifera ; salinity ; temperature
Language	English
Dates of publication	2019-04
Size	p. 929.
Publishing place	Springer Netherlands
Document type	Article
Note	Published Erratum
ZDB-ID	1002324-0
ISSN	1573-5176 ; 0921-8971
ISSN (online)	1573-5176
ISSN	0921-8971
DOI	10.1007/s10811-019-01771-3
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of temperature and salinity on the reproductive phases of Macrocystis pyrifera (L.) C. Agardh (Phaeophyceae) in the Magellan region

Rodríguez, Juan Pablo / Mansilla, A / Méndez, F / Ojeda, J / Rosenfeld, S / Terrados, J

Journal of applied phycology. 2019 Apr., v. 31, no. 2

2019

Abstract: The region of Magallanes has the world’s largest sub-Antarctic environments, including the heterogeneous habitats of archipelagos, fjords, channels, and inlets formed by ice advancing and retreating during Quaternary glacial processes. In marine ... ...

Abstract	The region of Magallanes has the world’s largest sub-Antarctic environments, including the heterogeneous habitats of archipelagos, fjords, channels, and inlets formed by ice advancing and retreating during Quaternary glacial processes. In marine ecosystems, the temperature, salinity, and photoperiod are key parameters which delimit the survival, reproduction and development of the macroalgae and, therefore, the biogeography of numerous sub-Antarctic species. In this research, we compare the reproductive development patterns in spores of Macrocystis pyrifera coming from places with different salinities along longitudinal and latitudinal gradients in Skyring Sound, Otway Sound, the Strait of Magellan (Possession Bay and Puerto del Hambre), and the Beagle Channel (Paula Bay). Laboratory analyses included four salinities and two different temperatures, comparing the percentage of spore germination, sex ratio in females and male gametophytes, and the development of gametogenesis through the proportion of gametophytes and sporophytes, with a factorial experimental design. The best germination percentages were obtained in Puerto del Hambre; the best sex ratio, on the other hand, was in Skyring Sound; finaly, for gametogenesis development, the best results were obtained in Otway Sound and Possession Bay. We prove the temperature and salinity effect over the studied population; moreover, these results demonstrate that at the end of the cycle each population develops more effectively in their local conditions, evidence of a local adaptation in M. pyrifera populations living in contrasting sites in the same region. This is crucial to understand how these populations react to the effect of environmental stressors; furthermore, the selection of appropriate conditions is also an important factor for the future commercial cultivation management of these important macroalgae.
Keywords	biogeography ; experimental design ; females ; gametogenesis ; gametophytes ; habitats ; ice ; macroalgae ; Macrocystis pyrifera ; males ; marine ecosystems ; salinity ; sex ratio ; spore germination ; spores ; sporophytes ; temperature
Language	English
Dates of publication	2019-04
Size	p. 915-928.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1002324-0
ISSN	1573-5176 ; 0921-8971
ISSN (online)	1573-5176
ISSN	0921-8971
DOI	10.1007/s10811-018-1693-x
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Rediscovery of $B \to \phi K^{()}$ decays and measurement of the longitudinal polarization fraction $f_L$ in $B \to \phi K^{}$ decays using the Summer 2020 Belle II dataset

Abudinén, F. / Adachi, I. / Adak, R. / Adamczyk, K. / Ahlburg, P. / Ahn, J. K. / Aihara, H. / Akopov, N. / Aloisio, A. / Ameli, F. / Andricek, L. / Ky, N. Anh / Asner, D. M. / Atmacan, H. / Aulchenko, V. / Aushev, T. / Aushev, V. / Aziz, T. / Babu, V. /

Bacher, S. / Baehr, S. / Bahinipati, S. / Bakich, A. M. / Bambade, P. / Banerjee, Sw. / Bansal, S. / Barrett, M. / Batignani, G. / Baudot, J. / Beaulieu, A. / Becker, J. / Behera, P. K. / Bender, M. / Bennett, J. V. / Bernieri, E. / Bernlochner, F. U. / Bertemes, M. / Bessner, M. / Bettarini, S. / Bhardwaj, V. / Bhuyan, B. / Bianchi, F. / Bilka, T. / Bilokin, S. / Biswas, D. / Bobrov, A. / Bondar, A. / Bonvicini, G. / Bozek, A. / Bračko, M. / Branchini, P. / Braun, N. / Briere, R. A. / Browder, T. E. / Brown, D. N. / Budano, A. / Burmistrov, L. / Bussino, S. / Campajola, M. / Cao, L. / Caria, G. / Casarosa, G. / Cecchi, C. / Červenkov, D. / Chang, M. -C. / Chang, P. / Cheaib, R. / Chekelian, V. / Chen, Y. Q. / Chen, Y. -T. / Cheon, B. G. / Chilikin, K. / Chirapatpimol, K. / Cho, H. -E. / Cho, K. / Cho, S. -J. / Choi, S. -K. / Choudhury, S. / Cinabro, D. / Corona, L. / Cremaldi, L. M. / Cuesta, D. / Cunliffe, S. / Czank, T. / Dash, N. / Dattola, F. / De La Cruz-Burelo, E. / De Nardo, G. / De Nuccio, M. / De Pietro, G. / de Sangro, R. / Deschamps, B. / Destefanis, M. / Dey, S. / De Yta-Hernandez, A. / Di Canto, A. / Di Capua, F. / Di Carlo, S. / Dingfelder, J. / Doležal, Z. / Jiménez, I. Domínguez / Dong, T. V. / Dort, K. / Dossett, D. / Dubey, S. / Duell, S. / Dujany, G. / Eidelman, S. / Eliachevitch, M. / Epifanov, D. / Fast, J. E. / Ferber, T. / Ferlewicz, D. / Finocchiaro, G. / Fiore, S. / Fischer, P. / Fodor, A. / Forti, F. / Frey, A. / Friedl, M. / Fulsom, B. G. / Gabriel, M. / Gabyshev, N. / Ganiev, E. / Garcia-Hernandez, M. / Garg, R. / Garmash, A. / Gaur, V. / Gaz, A. / Gebauer, U. / Gelb, M. / Gellrich, A. / Gemmler, J. / Geßler, T. / Getzkow, D. / Giordano, R. / Giri, A. / Glazov, A. / Gobbo, B. / Godang, R. / Goldenzweig, P. / Golob, B. / Gomis, P. / Grace, P. / Gradl, W. / Graziani, E. / Greenwald, D. / Guan, Y. / Hadjivasiliou, C. / Halder, S. / Hara, K. / Hara, T. / Hartbrich, O. / Hauth, T. / Hayasaka, K. / Hayashii, H. / Hearty, C. / Heck, M. / Hedges, M. T. / de la Cruz, I. Heredia / Villanueva, M. Hernández / Hershenhorn, A. / Higuchi, T. / Hill, E. C. / Hirata, H. / Hoek, M. / Hohmann, M. / Hollitt, S. / Hotta, T. / Hsu, C. -L. / Hu, Y. / Huang, K. / Iijima, T. / Inami, K. / Inguglia, G. / Jabbar, J. Irakkathil / Ishikawa, A. / Itoh, R. / Iwasaki, M. / Iwasaki, Y. / Iwata, S. / Jackson, P. / Jacobs, W. W. / Jaegle, I. / Jaffe, D. E. / Jang, E. -J. / Jeandron, M. / Jeon, H. B. / Jia, S. / Jin, Y. / Joo, C. / Joo, K. K. / Kadenko, I. / Kahn, J. / Kakuno, H. / Kaliyar, A. B. / Kandra, J. / Kang, K. H. / Kapusta, P. / Karl, R. / Karyan, G. / Kato, Y. / Kawai, H. / Kawasaki, T. / Keck, T. / Ketter, C. / Kichimi, H. / Kiesling, C. / Kim, B. H. / Kim, C. -H. / Kim, D. Y. / Kim, H. J. / Kim, J. B. / Kim, K. -H. / Kim, K. / Kim, S. -H. / Kim, Y. -K. / Kim, Y. / Kimmel, T. D. / Kindo, H. / Kinoshita, K. / Kirby, B. / Kleinwort, C. / Knysh, B. / Kodyš, P. / Koga, T. / Kohani, S. / Komarov, I. / Konno, T. / Korpar, S. / Kovalchuk, N. / Kraetzschmar, T. M. G. / Križan, P. / Kroeger, R. / Krohn, J. F. / Krokovny, P. / Krüger, H. / Kuehn, W. / Kuhr, T. / Kumar, J. / Kumar, M. / Kumar, R. / Kumara, K. / Kumita, T. / Kunigo, T. / Künzel, M. / Kurz, S. / Kuzmin, A. / Kvasnička, P. / Kwon, Y. -J. / Lacaprara, S. / Lai, Y. -T. / La Licata, C. / Lalwani, K. / Lanceri, L. / Lange, J. S. / Lautenbach, K. / Laycock, P. J. / Diberder, F. R. Le / Lee, I. -S. / Lee, S. C. / Leitl, P. / Levit, D. / Lewis, P. M. / Li, C. / Li, L. K. / Li, S. X. / Li, Y. M. / Li, Y. B. / Libby, J. / Lieret, K. / Gioi, L. Li / Lin, J. / Liptak, Z. / Liu, Q. Y. / Liu, Z. A. / Liventsev, D. / Longo, S. / Loos, A. / Lu, P. / Lubej, M. / Lueck, T. / Luetticke, F. / Luo, T. / MacQueen, C. / Maeda, Y. / Maggiora, M. / Maity, S. / Manfredi, R. / Manoni, E. / Marcello, S. / Marinas, C. / Martini, A. / Masuda, M. / Matsuda, T. / Matsuoka, K. / Matvienko, D. / McNeil, J. / Meggendorfer, F. / Mei, J. C. / Meier, F. / Merola, M. / Metzner, F. / Milesi, M. / Miller, C. / Miyabayashi, K. / Miyake, H. / Miyata, H. / Mizuk, R. / Azmi, K. / Mohanty, G. B. / Moon, H. / Moon, T. / Grimaldo, J. A. Mora / Morda, A. / Morii, T. / Moser, H. -G. / Mrvar, M. / Mueller, F. / Müller, F. J. / Muller, Th. / Muroyama, G. / Murphy, C. / Mussa, R. / Nakagiri, K. / Nakamura, I. / Nakamura, K. R. / Nakano, E. / Nakao, M. / Nakayama, H. / Nakazawa, H. / Nanut, T. / Natkaniec, Z. / Natochii, A. / Nayak, M. / Nazaryan, G. / Neverov, D. / Niebuhr, C. / Niiyama, M. / Ninkovic, J. / Nisar, N. K. / Nishida, S. / Nishimura, K. / Nishimura, M. / Nouxman, M. H. A. / Oberhof, B. / Ogawa, K. / Ogawa, S. / Olsen, S. L. / Onishchuk, Y. / Ono, H. / Onuki, Y. / Oskin, P. / Oxford, E. R. / Ozaki, H. / Pakhlov, P. / Pakhlova, G. / Paladino, A. / Pang, T. / Panta, A. / Paoloni, E. / Pardi, S. / Park, C. / Park, H. / Park, S. -H. / Paschen, B. / Passeri, A. / Pathak, A. / Patra, S. / Paul, S. / Pedlar, T. K. / Peruzzi, I. / Peschke, R. / Pestotnik, R. / Piccolo, M. / Piilonen, L. E. / Podesta-Lerma, P. L. M. / Polat, G. / Popov, V. / Praz, C. / Prencipe, E. / Prim, M. T. / Purohit, M. V. / Rad, N. / Rados, P. / Rasheed, R. / Reif, M. / Reiter, S. / Remnev, M. / Resmi, P. K. / Ripp-Baudot, I. / Ritter, M. / Ritzert, M. / Rizzo, G. / Rizzuto, L. B. / Robertson, S. H. / Pérez, D. Rodríguez / Roney, J. M. / Rosenfeld, C. / Rostomyan, A. / Rout, N. / Rozanska, M. / Russo, G. / Sahoo, D. / Sakai, Y. / Sanders, D. A. / Sandilya, S. / Sangal, A. / Santelj, L. / Sartori, P. / Sasaki, J. / Sato, Y. / Savinov, V. / Scavino, B. / Schram, M. / Schreeck, H. / Schueler, J. / Schwanda, C. / Schwartz, A. J. / Schwenker, B. / Seddon, R. M. / Seino, Y. / Selce, A. / Senyo, K. / Seong, I. S. / Serrano, J. / Sevior, M. E. / Sfienti, C. / Shebalin, V. / Shen, C. P. / Shibuya, H. / Shiu, J. -G. / Shwartz, B. / Sibidanov, A. / Simon, F. / Singh, J. B. / Skambraks, S. / Smith, K. / Sobie, R. J. / Soffer, A. / Sokolov, A. / Soloviev, Y. / Solovieva, E. / Spataro, S. / Spruck, B. / Starič, M. / Stefkova, S. / Stottler, Z. S. / Stroili, R. / Strube, J. / Stypula, J. / Sumihama, M. / Sumisawa, K. / Sumiyoshi, T. / Summers, D. J. / Sutcliffe, W. / Suzuki, K. / Suzuki, S. Y. / Svidras, H. / Tabata, M. / Takahashi, M. / Takizawa, M. / Tamponi, U. / Tanaka, S. / Tanida, K. / Tanigawa, H. / Taniguchi, N. / Tao, Y. / Taras, P. / Tenchini, F. / Tonelli, D. / Torassa, E. / Trabelsi, K. / Tsuboyama, T. / Tsuzuki, N. / Uchida, M. / Ueda, I. / Uehara, S. / Ueno, T. / Uglov, T. / Unger, K. / Unno, Y. / Uno, S. / Urquijo, P. / Ushiroda, Y. / Usov, Y. / Vahsen, S. E. / van Tonder, R. / Varner, G. S. / Varvell, K. E. / Vinokurova, A. / Vitale, L. / Vorobyev, V. / Vossen, A. / Waheed, E. / Wakeling, H. M. / Wan, K. / Abdullah, W. Wan / Wang, B. / Wang, C. H. / Wang, M. -Z. / Wang, X. L. / Warburton, A. / Watanabe, M. / Watanuki, S. / Watson, I. / Webb, J. / Wehle, S. / Welsch, M. / Wessel, C. / Wiechczynski, J. / Wieduwilt, P. / Windel, H. / Won, E. / Wu, L. J. / Xu, X. P. / Yabsley, B. / Yamada, S. / Yan, W. / Yang, S. B. / Ye, H. / Yelton, J. / Yeo, I. / Yin, J. H. / Yonenaga, M. / Yook, Y. M. / Yoshinobu, T. / Yuan, C. Z. / Yuan, G. / Yuan, W. / Yusa, Y. / Zani, L. / Zhang, J. Z. / Zhang, Y. / Zhang, Z. / Zhilich, V. / Zhou, Q. D. / Zhou, X. Y. / Zhukova, V. I. / Zhulanov, V. / Zupanc, A.

2020

Abstract: ... K^*$ modes, we also perform a measurement of the longitudinal polarization fraction $f_L$. ... Comment ...

Abstract	We utilize a sample of 34.6 fb$^{-1}$, collected by the Belle II experiment at the SuperKEKB asymmetric energy $e^+e^-$ collider, to search for the $B^+ \to \phi K^+$, $B^+ \to \phi K^{+}$, $B^0 \to \phi K^0_S$, and $B^0 \to \phi K^{0}$ decays. Charmless hadronic $B$ decays represent an important part of the Belle II physics program, and are an ideal benchmark to test the detector capabilities in terms of tracking efficiency, charged particle identification, vertexing, and advanced analysis techniques. Each channel is observed with a significance that exceeds 5 standard deviations, and we obtain measurements of their branching ratios that are in good agreement with the world averages. For the $B \to \phi K^*$ modes, we also perform a measurement of the longitudinal polarization fraction $f_L$. Comment: 19 pages, 6 figures
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2020-08-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: To achieve equitable, integrated care for children, family-centered work must focus on systems.

Rosenfeld, Lindsay / Litt, Jonathan S

Families, systems & health : the journal of collaborative family healthcare

2024 Volume 41, Issue 4, Page(s) 547–549

Abstract: Child health inequities are largely the result of entrenched, structural barriers created by racism, sexism, xenophobia, classism, and ableism that generally persist across the life course (Braveman & Gottlieb, 2014). The impact of such inequities may be ...

Abstract	Child health inequities are largely the result of entrenched, structural barriers created by racism, sexism, xenophobia, classism, and ableism that generally persist across the life course (Braveman & Gottlieb, 2014). The impact of such inequities may be magnified for those with complex needs who face considerable challenges in adulthood (Bethell et al., 2014), such as preterm infants, who experience threats to both short- and longterm health and development. Challenges in integrated care remain for all children, especially this population, despite extensive work across many decades to address such issues. The family-centered medical home has been the dominant pediatric care model in the United States for the last four decades (Stille et al., 2010). Despite emphasizing cultural humility and placing family at the care team core, the medical home model has not been able to deliver on securing equitable, integrated care for all (Bennett et al., 2012). (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Infant, Newborn ; Child ; Infant ; Humans ; Infant, Premature ; Databases, Factual ; Disability Discrimination ; Patient-Centered Care ; Delivery of Health Care, Integrated
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1326859-4
ISSN	1939-0602 ; 1091-7527 ; 0736-1718
ISSN (online)	1939-0602
ISSN	1091-7527 ; 0736-1718
DOI	10.1037/fsh0000809
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Article: Surgical pancreatic complications induced by L-asparaginase.

Sadoff, J / Hwang, S / Rosenfeld, D / Ettinger, L / Spigland, N

Journal of pediatric surgery

1997 Volume 32, Issue 6, Page(s) 860–863

Abstract: ... treatment with L-asparaginase for a variety of pediatric neoplasms, but rarely has surgical intervention ... been necessary. The authors present two fulminant cases of L-asparaginase-induced pancreatitis and ... induction chemotherapy with L-asparaginase for non-Hodgkin's lymphoma with bone marrow involvement. He presented ...

Abstract	Pancreatitis has been noted to be a potential complication in 2% to 16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms, but rarely has surgical intervention been necessary. The authors present two fulminant cases of L-asparaginase-induced pancreatitis and review the current literature. The first patient is a 15-year-old boy who underwent induction chemotherapy with L-asparaginase for non-Hodgkin's lymphoma with bone marrow involvement. He presented with diffuse patchy necrosis of the pancreas as well as a large infected pancreatic pseudocyst. He subsequently required operative debridement of the pancreas and external drainage of the pseudocyst. He is currently doing well. The second patient is a 5-year-old boy who was treated with L-asparaginase for a diagnosis of acute lymphocytic leukemia. Within 3 weeks of initiation of therapy, fulminant pancreatitis developed, which progressed to multisystem organ failure. Computed tomography scan demonstrated extensive pancreatic necrosis involving 90% of the gland. He underwent surgical debridement of his necrotic pancreas and wide drainage of the lesser sac. Postoperatively he improved but subsequently multiple complications developed including erosion of his gastroduodenal artery with significant intraabdominal bleeding, which was controlled with angiographic embolization. Subsequently erosion of his endotracheal tube into the innominate vein developed, and he died. L-asparaginase-induced pancreatitis has been described after therapy for various pediatric neoplasms, and the reported cases have usually been self-limiting. However, our cases demonstrate potentially fatal sequelae of this complication and mandate early diagnosis with appropriate surgical intervention in this setting.
MeSH term(s)	Adolescent ; Antineoplastic Agents/adverse effects ; Asparaginase/adverse effects ; Child, Preschool ; Fatal Outcome ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Male ; Pancreatic Pseudocyst/chemically induced ; Pancreatic Pseudocyst/surgery ; Pancreatitis, Acute Necrotizing/chemically induced ; Pancreatitis, Acute Necrotizing/surgery ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Chemical Substances	Antineoplastic Agents ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	1997-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/s0022-3468(97)90636-9
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Article ; Online: Toward consumer acceptance of cultured meat.

Rosenfeld, Daniel L / Tomiyama, A Janet

Trends in cognitive sciences

2023 Volume 27, Issue 8, Page(s) 689–691

Abstract: Cultured meat is an alternative protein that offers health and environmental advantages over conventional meat, yet many consumers are resistant to eating cultured meat. In this article, we review reasons for consumer resistance and suggest that proper ... ...

Abstract	Cultured meat is an alternative protein that offers health and environmental advantages over conventional meat, yet many consumers are resistant to eating cultured meat. In this article, we review reasons for consumer resistance and suggest that proper communication about the production and benefits of cultured meat can improve consumer acceptance.
MeSH term(s)	Humans ; Consumer Behavior ; Food Preferences ; Meat
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2010989-1
ISSN	1879-307X ; 1364-6613
ISSN (online)	1879-307X
ISSN	1364-6613
DOI	10.1016/j.tics.2023.05.002
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Article: Ex vivo purging of allogeneic marrow with L-Leucyl-L-leucine methyl ester. A phase I study.

Rosenfeld, C S / Thiele, D L / Shadduck, R K / Zeigler, Z R / Schindler, J

Transplantation

1995 Volume 60, Issue 7, Page(s) 678–683

Abstract: L-Leucyl-L-leucine methyl ester (LLME) is a lysosomatropic compound that is converted by dipeptidyl ...

Abstract	L-Leucyl-L-leucine methyl ester (LLME) is a lysosomatropic compound that is converted by dipeptidyl peptidase I to metabolites that are membranolytic for cytotoxic T cells, NK cells, and LAK cells. Ex vivo treatment of murine marrow with LLME ameliorates acute graft-versus-host-disease (GVHD), which led to consideration of a clinical study. A phase I study design was initiated to evaluate the effects of ex vivo purging of allogeneic marrow on engraftment, since LLME also suppresses human progenitor cells. All patients received a preparative regimen of cyclophosphamide plus total body irradiation. GVHD prophylaxis consisted of cyclosporine +/- corticosteroids. This study included 19 patients with high risk disease undergoing allogeneic transplantation from an HLA-identical sibling (n = 12) or a partially HLA-matched family donor (n = 7). Marrow mononuclear cells were treated ex vivo in a dosage escalation study with LLME concentrations of 0.25 mM, 0.375 mM, and 0.5 mM. Marrow NK and LAK activities were essentially eliminated at concentrations > or = 0.375 mM LLME. CD8+ cells were also reduced. Granulocyte macrophage colony-forming unit recovery was 3% at 0.5 mM LLME. The median time to an absolute neutrophil count of 500/microliters was 17 days after transplantation (95% confidence interval = 14-18 days). One patient that received marrow treated with 0.5 mM LLME died of secondary graft failure. Complete donor chimerism was documented in each evaluable case. NK recovery was delayed at LLME concentrations > or = 0.375 mM LLME. Grade II/IV GVHD occurred in 4/18 evaluable patients. Ex vivo treatment of human marrow with LLME diminishes NK activity, LAK activity, CD8+ cells, and granulocyte macrophage colony-forming units, but does not totally prevent acute GVHD.
MeSH term(s)	Acute Disease ; Adolescent ; Adult ; Bone Marrow/drug effects ; Bone Marrow Cells ; Bone Marrow Purging ; Bone Marrow Transplantation/immunology ; Cytotoxicity, Immunologic/drug effects ; Dipeptides ; Dose-Response Relationship, Immunologic ; Female ; Graft Rejection/immunology ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/immunology ; Hematopoiesis/drug effects ; Hematopoiesis/physiology ; Humans ; Immunosuppressive Agents ; Leukemia/therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Male ; Middle Aged ; Risk Factors
Chemical Substances	Dipeptides ; Immunosuppressive Agents ; leucyl-leucine-methyl ester (13022-42-9)
Language	English
Publishing date	1995-10-15
Publishing country	United States
Document type	Clinical Trial ; Clinical Trial, Phase I ; Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/00007890-199510150-00011
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Participation of children with disabilities across the life course: using socio-ecological perspectives to guide research and practice.

Rosenfeld, Lindsay

Developmental medicine and child neurology

2019 Volume 62, Issue 4, Page(s) 406

MeSH term(s)	Child ; Disabled Children ; Humans
Language	English
Publishing date	2019-12-26
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.14442
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