LIVIVO - Search results -

Search results

Result 1 - 10 of total 144

Search options

Article: The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring.

Vorstandlechner, Vera / Copic, Dragan / Klas, Katharina / Direder, Martin / Golabi, Bahar / Radtke, Christine / Ankersmit, Hendrik J / Mildner, Michael

Pharmaceutics

2023 Volume 15, Issue 4

Abstract: Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood. Factors ... ...

Abstract	Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood. Factors secreted by peripheral blood mononuclear cells (PBMCsec) have been previously described for their beneficial effects on tissue regeneration. In this study, we investigated the effects of PBMCsec on skin scarring in mouse models and human scar explant cultures at single-cell resolution (scRNAseq). Mouse wounds and scars, and human mature scars were treated with PBMCsec intradermally and topically. The topical and intradermal application of PBMCsec regulated the expression of various genes involved in pro-fibrotic processes and tissue remodeling. We identified elastin as a common linchpin of anti-fibrotic action in both mouse and human scars. In vitro, we found that PBMCsec prevents TGFβ-mediated myofibroblast differentiation and attenuates abundant elastin expression with non-canonical signaling inhibition. Furthermore, the TGFβ-induced breakdown of elastic fibers was strongly inhibited by the addition of PBMCsec. In conclusion, we conducted an extensive study with multiple experimental approaches and ample scRNAseq data demonstrating the anti-fibrotic effect of PBMCsec on cutaneous scars in mouse and human experimental settings. These findings point at PBMCsec as a novel therapeutic option to treat skin scarring.
Language	English
Publishing date	2023-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15041065
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Investigating how economic and national identity loss messages impact climate change policy support

Klas, Anna / Clarke, Edward J. R. / Fielding, Kelly / Mackay, Matthew / Lohmann, Susanne / Ling, Mathew

Climatic Change. 2022 Dec., v. 175, no. 3-4 p.17-17

2022

Abstract: As climate change continues to be politically divisive, developing communications that align with right-leaning beliefs may increase bipartisan support for climate policy. In two experimental studies (Study 1, Australia, N = 558; Study 2, USA, N = 939), ... ...

Abstract	As climate change continues to be politically divisive, developing communications that align with right-leaning beliefs may increase bipartisan support for climate policy. In two experimental studies (Study 1, Australia, N = 558; Study 2, USA, N = 939), we tested whether an economic or national identity loss message would elicit greater support for mitigation and adaptation policies when compared to one another and to a control message. We also tested whether the direct effects of these loss-orientated messages were conditional on political orientation (specifically, identifying as politically right-leaning). In both studies, preliminary analyses indicated that there was a high level of support for both types of climate policy, but when compared to their left-wing counterparts, right-wing adherents were less likely to support mitigation and adaptation policies in either sample. Australian (Study 1) identification—although not American identity (Study 2)—also uniquely predicted adaptation support (but not mitigation support). There were no significant message frame or interaction effects in the Australian (Study 1) or US sample (Study 2). This suggests that neither an economic nor national identity loss message may be effective in overcoming the political polarization of climate change in Australia or the USA. Nevertheless, national identity could still play a useful role in Australian climate communications given its positive relationship to adaptation policy support and therefore warrants further investigation.
Keywords	climate ; climate change ; environmental policy ; politics ; Australia
Language	English
Dates of publication	2022-12
Size	p. 17.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	751086-x
ISSN	0165-0009
ISSN	0165-0009
DOI	10.1007/s10584-022-03472-2
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Einzelsign.: Show issues
Z 2010/701: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ultraviolet dual comb spectroscopy: a roadmap.

Schuster, Vittoria / Liu, Chang / Klas, Robert / Dominguez, Pablo / Rothhardt, Jan / Limpert, Jens / Bernhardt, Birgitta

Optics express

2021 Volume 29, Issue 14, Page(s) 21859–21875

Abstract: Dual Comb Spectroscopy proved its versatile capabilities in molecular fingerprinting in different spectral regions, but not yet in the ultraviolet (UV). Unlocking this spectral window would expand fingerprinting to the electronic energy structure of ... ...

Abstract	Dual Comb Spectroscopy proved its versatile capabilities in molecular fingerprinting in different spectral regions, but not yet in the ultraviolet (UV). Unlocking this spectral window would expand fingerprinting to the electronic energy structure of matter. This will access the prime triggers of photochemical reactions with unprecedented spectral resolution. In this research article, we discuss the milestones marking the way to the first UV dual comb spectrometer. We present experimental and simulated studies towards UV dual comb spectroscopy, directly applied to planned absorption measurements of formaldehyde (centered at 343 nm, 3.6 eV) and argon (80 nm, 16 eV). This will enable an unparalleled relative resolution of up to 10
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.424940
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Screen-Printed Corrosion-Resistant and Long-Term Stable Stretchable Electronics Based on AgAu Microflake Conductors.

Boda, Ulrika / Strandberg, Jan / Eriksson, Jens / Liu, Xianjie / Beni, Valerio / Tybrandt, Klas

ACS applied materials & interfaces

2023 Volume 15, Issue 9, Page(s) 12372–12382

Abstract: High-throughput production methods such as screen printing can bring stretchable electronics out of the lab into the market. Most stretchable conductor inks for screen printing are based on silver nanoparticles or flakes due to their favorable ... ...

Abstract	High-throughput production methods such as screen printing can bring stretchable electronics out of the lab into the market. Most stretchable conductor inks for screen printing are based on silver nanoparticles or flakes due to their favorable performance-to-cost ratio, but silver is prone to tarnishing and corrosion, thereby limiting the stability of such conductors. Here, we report on a cost-efficient and scalable approach to resolve this issue by developing screen printable inks based on silver flakes chemically coated by a thin layer of gold. The printed stretchable AgAu conductors reach a conductivity of 8500 S cm
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c22199
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene.

Palomar-Siles, Mireia / Yurevych, Viktor / Bykov, Vladimir J N / Wiman, Klas G

PloS one

2023 Volume 18, Issue 11, Page(s) e0292468

Abstract: The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors. A significant fraction (25.9%) of somatic RB1 mutations are ... ...

Abstract	The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors. A significant fraction (25.9%) of somatic RB1 mutations are nonsense substitutions leading to a premature termination codon (PTC) in the RB1 coding sequence and expression of truncated inactive Rb protein. Here we show that aminoglycoside G418, a known translational readthrough inducer, can induce full-length Rb protein in SW1783 astrocytoma cells with endogenous R579X nonsense mutant RB1 as well as in MDA-MB-436 breast carcinoma cells transiently transfected with R251X, R320X, R579X or Q702X nonsense mutant RB1 cDNA. Readthrough was associated with increased RB1 mRNA levels in nonsense mutant RB1 cells. Induction of full-length Rb protein was potentiated by the cereblon E3 ligase modulator CC-90009. These results suggest that pharmacological induction of translational readthrough could be a feasible strategy for therapeutic targeting of tumors with nonsense mutant RB1.
MeSH term(s)	Humans ; Retinoblastoma/genetics ; Codon, Nonsense/genetics ; Retinoblastoma Protein/genetics ; Protein Biosynthesis ; Retinal Neoplasms/pathology ; Ubiquitin-Protein Ligases/genetics ; Retinoblastoma Binding Proteins/genetics
Chemical Substances	Codon, Nonsense ; Retinoblastoma Protein ; RB1 protein, human ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Retinoblastoma Binding Proteins
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292468
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Discovery of Selective Inhibitors of Na

Pajouhesh, Hassan / Delwig, Anton / Beckley, Jacob T / Klas, Sheri / Monteleone, Dennis / Zhou, Xiang / Luu, George / Du Bois, J / Hunter, John C / Mulcahy, John V

ACS medicinal chemistry letters

2022 Volume 13, Issue 11, Page(s) 1763–1768

Abstract: The voltage-gated sodium channel isoform ... ...

Abstract	The voltage-gated sodium channel isoform Na
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.2c00378
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Table-top interferometry on extreme time and wavelength scales.

Skruszewicz, S / Przystawik, A / Schwickert, D / Sumfleth, M / Namboodiri, M / Hilbert, V / Klas, R / Gierschke, P / Schuster, V / Vorobiov, A / Haunhorst, C / Kip, D / Limpert, J / Rothhardt, J / Laarmann, T

Optics express

2021 Volume 29, Issue 24, Page(s) 40333–40344

Abstract: Short-pulse metrology and dynamic studies in the extreme ultraviolet (XUV) spectral range greatly benefit from interferometric measurements. In this contribution a Michelson-type all-reflective split-and-delay autocorrelator operating in a quasi ... ...

Abstract	Short-pulse metrology and dynamic studies in the extreme ultraviolet (XUV) spectral range greatly benefit from interferometric measurements. In this contribution a Michelson-type all-reflective split-and-delay autocorrelator operating in a quasi amplitude splitting mode is presented. The autocorrelator works under a grazing incidence angle in a broad spectral range (10 nm - 1 μm) providing collinear propagation of both pulse replicas and thus a constant phase difference across the beam profile. The compact instrument allows for XUV pulse autocorrelation measurements in the time domain with a single-digit attosecond precision and a useful scan length of about 1 ps enabling a decent resolution of E/ΔE = 2000 at 26.6 eV. Its performance for selected spectroscopic applications requiring moderate resolution at short wavelengths is demonstrated by characterizing a sharp electronic transition at 26.6 eV in Ar gas. The absorption of the 11
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.446563
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Increasing intention to reduce fossil fuel use: a protection motivation theory-based experimental study

Kothe, Emily J. / Ling, Mathew / Mullan, Barbara A. / Rhee, Joshua J. / Klas, Anna

Climatic Change. 2023 Mar., v. 176, no. 3 p.19-19

2023

Abstract: Reducing individual fossil fuel use is an important component of climate change mitigation, but motivating behaviour change to achieve this is difficult. Protection motivation theory (PMT) is a psychological framework that outlines the conditions under ... ...

Abstract	Reducing individual fossil fuel use is an important component of climate change mitigation, but motivating behaviour change to achieve this is difficult. Protection motivation theory (PMT) is a psychological framework that outlines the conditions under which people are more likely to be persuaded to take a specific response or action. This experimental study investigated the impact six different protection motivation theory-based messages had on intention to reduce fossil fuel use in a sample 3803 US adults recruited via Amazon Mechanical (MTurk). Only messages targeting self-efficacy and response efficacy increased intention to reduce fossil fuel use relative to the control message. However, only the self-efficacy message had an impact on its target construct (i.e. self-efficacy). As such, the mechanism for action for the response efficacy message is unclear. Furthermore, while the current study demonstrates that many of the PMT-related messages did not achieve changes in intention, this it is still possible that messages targeting these constructs could still lead to changes in intention in other modalities and when other message content is used. Given the urgency of responding to climate change, the potential for additive benefits of combining effective PMT-based messages should be considered irrespective of their mechanism as should research focused on how to effectively target other key PMT constructs.
Keywords	behavior change ; climate change ; fossil fuels ; motivation ; people ; self-efficacy
Language	English
Dates of publication	2023-03
Size	p. 19.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	751086-x
ISSN	0165-0009
ISSN	0165-0009
DOI	10.1007/s10584-023-03489-1
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Einzelsign.: Show issues
Z 2010/701: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Agile spectral tuning of high order harmonics by interference of two driving pulses.

Schuster, Vittoria / Hilbert, Vinzenz / Klas, Robert / Liu, Chang / Tschernajew, Maxim / Bernhardt, Birgitta / Rothhardt, Jan / Limpert, Jens

Optics express

2021 Volume 29, Issue 14, Page(s) 22117–22126

Abstract: In this work, the experimental realization of a tunable high photon flux extreme ultraviolet light source is presented. This is enabled by high harmonic generation of two temporally delayed driving pulses with a wavelength of 1030 nm, resulting in a ... ...

Abstract	In this work, the experimental realization of a tunable high photon flux extreme ultraviolet light source is presented. This is enabled by high harmonic generation of two temporally delayed driving pulses with a wavelength of 1030 nm, resulting in a tuning range of 0.8 eV at the 19
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.424024
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Gas-Phase Potassium Effects and the Role of the Support on the Tar Reforming of Biomass-Derived Producer Gas Over Sulfur-Equilibrated Ni/MgAl₂O₄

Hernandez, Asbel / Andersson, Klas J / Engvall, Klas / Kantarelis, Efthymios

Energy & fuels. 2020 Aug. 17, v. 34, no. 9

2020

Abstract: Biomass gasification is a sustainable way to convert biomass residues into valuable fuels and chemicals via syngas production. However, several gas impurities need to be removed before the final synthesis. Understanding of the interactions and effects of ...

Abstract	Biomass gasification is a sustainable way to convert biomass residues into valuable fuels and chemicals via syngas production. However, several gas impurities need to be removed before the final synthesis. Understanding of the interactions and effects of biomass-derived producer gas contaminants (S and K) on the performance of reforming catalysts is of great importance when it comes to process reliability and development. In the present study, the steam reforming activity at 800 °C of a sulfur-equilibrated nickel catalyst during controlled exposure to alkali species (∼2 ppmv K) and in its absence was investigated using real producer gas from a 5 kWₜₕ O₂-blown fluidized-bed gasifier. Conversions of CH₄, C₂H₄, and C₁₀H₈ were used to evaluate the performance of the Ni/MgAl₂O₄ catalyst and MgAl₂O₄ support. A significant and positive effect on the catalyst activity is observed with addition of gas-phase KCl. This is assigned primarily to the observed K-induced reduction in sulfur coverage (θS) on Ni—an effect which is reversible. The catalytic contribution of the K-modified pure MgAl₂O₄ support was found to be significant in the conversion of naphthalene but not for light hydrocarbons. The product and catalyst analyses provided evidence to elucidate the preferential adsorption site for S and K on the catalyst as well as the role of the support. Whereas S, as expected, was found to preferentially adsorb on the surface of Ni particles, forming S-Ni sites, K was found to preferentially adsorb on the MgAl₂O₄ support. A low but still significant K adsorption on S–Ni sites, or an effect on only the fraction of exposed Ni surface area near the metal–support interface, can, however, not be excluded. The result suggests that an improved Ni/MgAl₂O₄ catalyst activity and an essentially carbon-free operation can be achieved in the presence of controlled amount of gas-phase potassium and high sulfur coverages on Ni. Based on the results, a mechanism of the possible K–S interactions is proposed.
Keywords	adsorption ; biogasification ; biomass ; catalysts ; catalytic activity ; energy ; fluidized beds ; naphthalene ; nickel ; potassium ; producer gas ; steam ; sulfur ; surface area ; synthesis gas
Language	English
Dates of publication	2020-0817
Size	p. 11103-11111.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1483539-3
ISSN	1520-5029 ; 0887-0624
ISSN (online)	1520-5029
ISSN	0887-0624
DOI	10.1021/acs.energyfuels.0c02069
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito