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Book: Shi ke ke gong yan jiu

Cheng, Zhangcan

(Zhongguo dian ji yu wen hua yan jiu cong shu ; 3 ; 中国典籍与文化研究丛书 ; 3)

2008

Author's details	Cheng Zhangcan
Series title	Zhongguo dian ji yu wen hua yan jiu cong shu ; 3 中国典籍与文化研究丛书 ; 3
Language	Chinese
Size	2, 3, 710 p
Edition	Di 1 ban
Publisher	Shanghai guji chubanshe
Publishing place	Shanghai
Document type	Book
ISBN	9787532551095 ; 7532551091
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Bibliometric and visualized analysis of hydrogels in organoids research.

Wang, Jia-Bo / Wu, Jie / Zhang, Jian / Guan, Li-An / Feng, Hai-Bo / Zhu, Ke-Yan / Zhang, Yu / Zhao, Wen-Jie / Peng, Qing / Meng, Bo / Yang, Sheng / Sun, Hua / Cheng, Ye-Dong / Zhang, Liang

Regenerative therapy

2024 Volume 25, Page(s) 395–404

Abstract: Over the past decades, there has been ongoing effort to develop complex biomimetic tissue engineering strategies for in vitro cultivation and maintenance of organoids. The defined hydrogels can create organoid models for various organs by changing their ... ...

Abstract	Over the past decades, there has been ongoing effort to develop complex biomimetic tissue engineering strategies for in vitro cultivation and maintenance of organoids. The defined hydrogels can create organoid models for various organs by changing their properties and various active molecules. An increasing number of researches has been done on the application of hydrogels in organoids, and a large number of articles have been published on the topic. Although there have been existing reviews describing the application of hydrogels in the field of organoids, there is still a lack of comprehensive studies summarizing and analyzing the overall research trends in this field. The citation can be used as an indicator of the scientific influence of an article in its field. This study aims to evaluate the application of hydrogels in organoids through bibliometric analysis, and to predict the hotspots and developing trends in this field.
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2835333-X
ISSN	2352-3204 ; 2352-3204
ISSN (online)	2352-3204
ISSN	2352-3204
DOI	10.1016/j.reth.2024.02.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Investigation of an inherited PCGF2: p.Pro65Leu mutation causing Turnpenny-Fry syndrome.

Qi, Ke-Yan / Shen, Ming / Yang, Kai / Yan, You-Sheng / Wu, Jue / Wang, Yi-Peng / Yin, Cheng-Hong

American journal of translational research

2022 Volume 14, Issue 8, Page(s) 5591–5597

Abstract: Background: Turnpenny-Fry syndrome (TPFS) has recently been defined as an uncommon monogenic disease and is characterized by global developmental delay (GDD), intellectualdisability (ID), facial dysmorphology, and skeletal abnormality. : Methods: The ...

Abstract	Background: Turnpenny-Fry syndrome (TPFS) has recently been defined as an uncommon monogenic disease and is characterized by global developmental delay (GDD), intellectualdisability (ID), facial dysmorphology, and skeletal abnormality. Methods: The present study included the clinical evaluation of a 2.5-year-old boy with GDD and ID using cerebral MRI and the genetic testing with whole-exome sequencing. Additionally, the Results: A recurrent missense variant, namely Conclusion: Our results indicated that PCGF2: p.Pro65Leu might be a hotspot for GDD and highlighted the effect of this variant on protein function.
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells.

Cheng, Ke-Yan / Hao, Min

Medical science monitor : international medical journal of experimental and clinical research

2017 Volume 23, Page(s) 2017–2028

Abstract: BACKGROUND Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. Transforming growth factor β1 (TGF-β1) can induced EMT, which could increase tumor migration and invasion. Moreover, recent studies have been proven that ... ...

Abstract	BACKGROUND Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. Transforming growth factor β1 (TGF-β1) can induced EMT, which could increase tumor migration and invasion. Moreover, recent studies have been proven that mammalian target of rapamycin (mTOR) is a critical regulator of EMT. We investigated the mechanisms of mTOR in transforming growth factor β1 (TGF-β1)-induced EMT in cervical cancer cells. MATERIAL AND METHODS HeLa and SiHa cells were treated with 10 ng/ml TGF-β1 to induce EMT. Then, they were treated with or without rapamycin. CCK8 assay was performed to determine cell proliferation. Cell migration was detected by wound-healing assay; apoptosis was analyzed by flow cytometry; mTOR inhibitors inhibited mTOR pathway to assess the expression of E-cadherin, Vimentin STAT3, Snail2, p-p70s6k, and PKM2 expression. RESULTS TGF-β1 promoted proliferation and migration, and attenuated apoptosis in cervical carcinoma cells. Rapamycin abolished TGF-β1-induced EMT cell proliferation and migration and reversed TGF-β1-induced EMT. E-cadherin were suppressed, whereas Vimentin and PKM2 were increased in HeLa and SiHa cells after stimulation with TGF-β1. Moreover, mTOR was activated in the process of TGF-β1-induced EMT. Rapamycin inhibited the phosphorylation of p70s6k. Furthermore, inhibition of the mTOR pathway decreased PKM2 expression. CONCLUSIONS Inhibition of the mTOR pathway abolished TGF-β1-induced EMT and reduced mTOR/p70s6k signaling, which downregulated PKM2 expression. Our results provide novel mechanistic insight into the anti-tumor effects of inhibition of mTOR.
MeSH term(s)	Apoptosis/drug effects ; Cadherins/metabolism ; Carrier Proteins/biosynthesis ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; HeLa Cells ; Humans ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Thyroid Hormones/biosynthesis ; Thyroid Hormones/genetics ; Thyroid Hormones/metabolism ; Transforming Growth Factor beta1/pharmacology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Thyroid Hormone-Binding Proteins
Chemical Substances	Cadherins ; Carrier Proteins ; Membrane Proteins ; Thyroid Hormones ; Transforming Growth Factor beta1 ; MTOR protein, human (EC 2.7.1.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2017-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/msm.901542
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Article ; Online: NRF2 mutation enhances the immune escape of hepatocellular carcinoma by reducing STING activation.

Li, Cheng / Liang, Gang / Yan, Ke / Wang, Yongheng

Biochemical and biophysical research communications

2024 Volume 698, Page(s) 149536

Abstract: The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor usually hyperactivated in hepatocellular carcinoma (HCC). In addition, about 14 % of HCC patients carry mutation in NRF2 or Kelch-like ECH-associated protein 1 (Keap1), a ... ...

Abstract	The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor usually hyperactivated in hepatocellular carcinoma (HCC). In addition, about 14 % of HCC patients carry mutation in NRF2 or Kelch-like ECH-associated protein 1 (Keap1), a NRF2 inhibitor, both of which lead to constitutive activation of NRF2. It has been widely reported that NRF2 plays important roles in the proliferation, differentiation and metastasis of tumor cells. But as an important gene involved in antioxidation and anti-inflammation, little studies have focused on its role in tumor immune escape. Here we found that NRF2 gain-of-function mutation leads to reduced expression of STING and decreased infiltration of peripheral immune cells through which way it helps the tumor cells to evade from immune surveillance. This phenomenon can be reversed by STING overexpression. Our study also revealed that NRF2 mutation greatly reduced the effect of STING activating based immunotherapy. It is important to simultaneously inhibit the activity of NRF2 when using STING agonist for the treatment of HCC patients carrying NRF2 mutation.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Liver Neoplasms/pathology ; Mutation ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Signal Transduction ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Tumor Escape
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; STING1 protein, human ; Membrane Proteins ; NFE2L2 protein, human
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149536
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Article: Construction of Evaluation Index System for Training Quality of High-Level Tennis Team.

Cai, Qian / Cheng, Yan / Ke, Yong

Frontiers in psychology

2022 Volume 13, Page(s) 902516

Abstract: The paper established the evaluation index system of training quality of high-level tennis team, which comprising five first-class indexes: work planning evaluation index ( ...

Abstract	The paper established the evaluation index system of training quality of high-level tennis team, which comprising five first-class indexes: work planning evaluation index (
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.902516
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Article ; Online: Diamide-linked imidazolyl Poly(dicationic ionic liquid)s for the conversion of CO

Zou, Yizhen / Amuti, Qimanguli / Zou, Zhongwei / Xu, Yuping / Yan, Chong / Cheng, Guoe / Ke, Hanzhong

Journal of colloid and interface science

2023 Volume 656, Page(s) 47–57

Abstract: The ionic active centers and hydrogen-bond donors (HBDs) in heterogeneous catalytic materials are highly beneficial for enhancing the interaction between solid-liquid-gas three-phase interfaces and promoting effective fixation of carbon dioxide ( ... ...

Abstract	The ionic active centers and hydrogen-bond donors (HBDs) in heterogeneous catalytic materials are highly beneficial for enhancing the interaction between solid-liquid-gas three-phase interfaces and promoting effective fixation of carbon dioxide (CO
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.11.084
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Article ; Online: Prenatal PM2.5 exposure increases the risk of adverse pregnancy outcomes: evidence from meta-analysis of cohort studies.

Wang, Wanrong / Mu, Siqi / Yan, Weizhen / Ke, Naiyu / Cheng, Han / Ding, Rui

Environmental science and pollution research international

2023 Volume 30, Issue 48, Page(s) 106145–106197

Abstract: Adverse pregnancy outcomes (APOs) are a significant cause of fetal death. A wide range of maternal psychological, social, and environmental factors may contribute to these outcomes. Mounting epidemiological studies have indicated that ... ...

Abstract	Adverse pregnancy outcomes (APOs) are a significant cause of fetal death. A wide range of maternal psychological, social, and environmental factors may contribute to these outcomes. Mounting epidemiological studies have indicated that PM
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Premature Birth/epidemiology ; Pregnancy Outcome/epidemiology ; Stillbirth/epidemiology ; Infant, Low Birth Weight ; Particulate Matter
Chemical Substances	Particulate Matter
Language	English
Publishing date	2023-09-19
Publishing country	Germany
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29700-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radar Micro-Doppler Signature Generation Based on Time-Domain Digital Coding Metasurface.

Wang, Si Ran / Dai, Jun Yan / Ke, Jun Chen / Chen, Zhan Ye / Zhou, Qun Yan / Qi, Zhen Jie / Lu, Ying Juan / Huang, Yan / Sun, Meng Ke / Cheng, Qiang / Cui, Tie Jun

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 , Page(s) e2306850

Abstract: Micro-Doppler effect is a vital feature of a target that reflects its oscillatory motions apart from bulk motion and provides an important evidence for target recognition with radars. However, establishing the micro-Doppler database poses a great ... ...

Abstract	Micro-Doppler effect is a vital feature of a target that reflects its oscillatory motions apart from bulk motion and provides an important evidence for target recognition with radars. However, establishing the micro-Doppler database poses a great challenge, since plenty of experiments are required to get the micro-Doppler signatures of different targets for the purpose of analyses and interpretations with radars, which are dramatically limited by high cost and time-consuming. Aiming to overcome these limits, a low-cost and powerful simulation platform of the micro-Doppler effects is proposed based on time-domain digital coding metasurface (TDCM). Owing to the outstanding capabilities of TDCM in generating and manipulating nonlinear harmonics during wave-matter interactions, it enables to supply rich and high-precision electromagnetic signals with multiple micro-Doppler frequencies to describe the micro-motions of different objects, which are especially favored for the training of artificial intelligence algorithms in automatic target recognition and benefit a host of applications like imaging and biosensing.
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202306850
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Right ventricle-pulmonary artery coupling in pulmonary artery hypertension its measurement and pharmacotherapy.

Sandeep, Bhushan / Cheng, Han / Yan, Yifan / Huang, Xin / Wu, Qinghui / Gao, Ke / Xiao, Zongwei

Current problems in cardiology

2024 Volume 49, Issue 4, Page(s) 102425

Abstract: The right ventricular (RV) function correlates with prognosis in severe pulmonary artery hypertension (PAH) but which metric of it is most clinically relevant is still uncertain. Clinical methods to estimate RV function from simplified pressure volume ... ...

Abstract	The right ventricular (RV) function correlates with prognosis in severe pulmonary artery hypertension (PAH) but which metric of it is most clinically relevant is still uncertain. Clinical methods to estimate RV function from simplified pressure volume loops correlate with disease severity but the clinical relevance has not been assessed. Evaluation of right ventricle pulmonary artery coupling in pulmonary hypertensive patients may help to elucidate the mechanisms of right ventricular failure and may also help to identify patients at risk or guide the timing of therapeutic interventions in pulmonary hypertension. Complete evaluation of RV failure requires echocardiographic or magnetic resonance imaging, and right heart catheterization measurements. Treatment of RV failure in PAH relies on decreasing afterload with drugs targeting pulmonary circulation; fluid management to optimize ventricular diastolic interactions; and inotropic interventions to reverse cardiogenic shock. The ability to relate quantitative metrics of RV function in pulmonary artery hypertension to clinical outcomes can provide a powerful tool for management. Such metrics could also be utilized in the future as surrogate endpoints for outcomes and evaluation of response to therapies. This review of literature gives an insight on RV-PA coupling associated with PAH, its types of measurement and pharmacological treatment.
MeSH term(s)	Humans ; Pulmonary Artery/diagnostic imaging ; Heart Ventricles/diagnostic imaging ; Pulmonary Arterial Hypertension/diagnosis ; Pulmonary Arterial Hypertension/drug therapy ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Heart Failure
Language	English
Publishing date	2024-02-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	441230-8
ISSN	1535-6280 ; 0146-2806
ISSN (online)	1535-6280
ISSN	0146-2806
DOI	10.1016/j.cpcardiol.2024.102425
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