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Article ; Online: Errol Friedberg: A life in writing.

Wood, Richard D / Walker, Graham C

2023 Volume 128, Page(s) 103516

Abstract: Errol Clive Friedberg, who died at the end of March 2023, was the first Editor-in-Chief of the journal DNA Repair. He was an influential DNA repair scientist, a synthesizer of ideas, and an accomplished historian. In addition to the research ... ...

Abstract	Errol Clive Friedberg, who died at the end of March 2023, was the first Editor-in-Chief of the journal DNA Repair. He was an influential DNA repair scientist, a synthesizer of ideas, and an accomplished historian. In addition to the research accomplishments of his laboratory groups, Errol Friedberg provided enormous service to the DNA repair community though organizing major conferences, journal editing, and writing. His many books include texts about DNA repair, histories of the field, and biographies of several pioneers of molecular biology.
MeSH term(s)	History, 20th Century ; DNA Repair ; Molecular Biology ; Writing
Language	English
Publishing date	2023-06-05
Publishing country	Netherlands
Document type	Historical Article ; Journal Article
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2023.103516
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Article ; Online: Retraction Notice to: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair.

Zahn, Karl E / Jensen, Ryan B / Wood, Richard D / Doublie, Sylvie

Molecular cell

2024 Volume 84, Issue 8, Page(s) 1626

Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.03.024
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Article ; Online: Genome Protection by DNA Polymerase θ.

Wood, Richard D / Doublié, Sylvie

Annual review of genetics

2022 Volume 56, Page(s) 207–228

Abstract: DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants. Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by theta-mediated end joining. The DNA polymerase domain of Pol θ is at the C ... ...

Abstract	DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants. Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by theta-mediated end joining. The DNA polymerase domain of Pol θ is at the C terminus and is connected to an N-terminal DNA helicase-like domain by a central linker. Pol θ is crucial for maintenance of damaged genomes during development, protects DNA against extensive deletions, and limits loss of heterozygosity. The cost of using Pol θ for genome protection is that a few nucleotides are usually deleted or added at the repair site. Inactivation of Pol θ often enhances the sensitivity of cells to DNA strand-breaking chemicals and radiation. Since some homologous recombination-defective cancers depend on Pol θ for growth, inhibitors of Pol θ may be useful in treating such tumors.
MeSH term(s)	Animals ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; DNA End-Joining Repair/genetics ; DNA ; DNA Damage/genetics ; Neoplasms/genetics ; DNA Polymerase theta
Chemical Substances	DNA-Directed DNA Polymerase (EC 2.7.7.7) ; DNA (9007-49-2)
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	207928-8
ISSN	1545-2948 ; 0066-4170 ; 0066-4197
ISSN (online)	1545-2948
ISSN	0066-4170 ; 0066-4197
DOI	10.1146/annurev-genet-072920-041046
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Zs.A 1109: Show issues

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Article ; Online: Human DNA polymerase θ does not harbor intrinsic nuclease activity.

Carvajal-Maldonado, Denisse / Zahn, Karl / Jensen, Ryan / Wood, Richard D / Doublié, Sylvie

Molecular cell

2024 Volume 84, Issue 8, Page(s) 1394–1395

MeSH term(s)	Humans ; DNA Polymerase theta ; DNA-Directed DNA Polymerase/genetics ; Mutation
Chemical Substances	DNA Polymerase theta (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; POLQ protein, human (EC 2.7.7.-)
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Letter
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.03.009
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Article ; Online: Fifty years since DNA repair was linked to cancer.

Wood, Richard D

Nature

2018 Volume 557, Issue 7707, Page(s) 648–649

MeSH term(s)	DNA Damage ; DNA Repair ; Humans ; Neoplasms
Language	English
Publishing date	2018-06-29
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-018-05255-1
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Center for the Polyurethanes Industry summary of unpublished industrial hygiene studies related to the evaluation of emissions of spray polyurethane foam insulation.

Wood, Richard D

Journal of occupational and environmental hygiene

2017 Volume 14, Issue 9, Page(s) 681–693

Abstract: Spray polyurethane foam (SPF) insulation is used as thermal insulation for residential and commercial buildings. It has many advantages over other forms insulation; however, concerns have been raised related to chemical emissions during and after ... ...

Abstract	Spray polyurethane foam (SPF) insulation is used as thermal insulation for residential and commercial buildings. It has many advantages over other forms insulation; however, concerns have been raised related to chemical emissions during and after application. The American Chemistry Council's (ACC's) Center for the Polyurethanes Industry (CPI) has gathered previously unpublished industrial hygiene air sampling studies submitted by member companies that were completed during an eight-year period from 2007-2014. These studies address emissions from medium density closed cell and low density open cell formulations. This article summarizes the results of personal and area air samples collected during application and post application of SPF to interior building surfaces in both laboratory and field environments. Chemicals of interest included: Volatile Organic Compounds (VOCs), methylene diphenyl diisocyanate (MDI), flame retardants, amine catalysts, blowing agents, and aldehydes. Overall, the results indicate that SPF applicators and workers in close proximity to the application are potentially exposed to MDI in excess of recommended and governmental occupational exposure limits and should use personal protective equipment (PPE) consisting of air supplied respirators and full-body protective clothing to reduce exposure. Catalyst emissions can be reduced by using reactive catalysts in SPF formulations, and mechanical ventilation is important in controlling emissions during and after application.
MeSH term(s)	Air Pollutants, Occupational/analysis ; Aldehydes/analysis ; Construction Industry ; Environmental Monitoring/methods ; Flame Retardants/analysis ; Isocyanates/analysis ; Occupational Exposure/analysis ; Occupational Health ; Polyurethanes ; Volatile Organic Compounds/analysis
Chemical Substances	Air Pollutants, Occupational ; Aldehydes ; Flame Retardants ; Isocyanates ; Polyurethanes ; Volatile Organic Compounds ; polyurethane foam (9009-54-5) ; 4,4'-diphenylmethane diisocyanate (B0LO6BBS8C)
Language	English
Publishing date	2017-06-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131820-7
ISSN	1545-9632 ; 1545-9624
ISSN (online)	1545-9632
ISSN	1545-9624
DOI	10.1080/15459624.2017.1320562
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Zs.A 5821: Show issues

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Article ; Online: Regulating Polθ in Breast Cancer.

Carvajal-Maldonado, Denisse / Wood, Richard D

Cancer research

2021 Volume 81, Issue 6, Page(s) 1441–1442

Abstract: DNA polymerase θ, a protein encoded by ... ...

Abstract	DNA polymerase θ, a protein encoded by the
MeSH term(s)	Breast Neoplasms/genetics ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; Female ; Humans ; Mutagens ; Transcription Factors ; Zinc Finger E-box-Binding Homeobox 1
Chemical Substances	Mutagens ; Transcription Factors ; ZEB1 protein, human ; Zinc Finger E-box-Binding Homeobox 1
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-20-4253
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Article ; Online: Sequential requirements for distinct Polθ domains during theta-mediated end joining.

Fijen, Carel / Drogalis Beckham, Lea / Terino, Dante / Li, Yuzhen / Ramsden, Dale A / Wood, Richard D / Doublié, Sylvie / Rothenberg, Eli

Molecular cell

2024 Volume 84, Issue 8, Page(s) 1460–1474.e6

Abstract: DNA polymerase θ (Polθ) plays a central role in a DNA double-strand break repair pathway termed theta-mediated end joining (TMEJ). TMEJ functions by pairing short-sequence "microhomologies" (MHs) in single-stranded DNA at each end of a break and ... ...

Abstract	DNA polymerase θ (Polθ) plays a central role in a DNA double-strand break repair pathway termed theta-mediated end joining (TMEJ). TMEJ functions by pairing short-sequence "microhomologies" (MHs) in single-stranded DNA at each end of a break and subsequently initiating DNA synthesis. It is not known how the Polθ helicase domain (HD) and polymerase domain (PD) operate to bring together MHs and facilitate repair. To resolve these transient processes in real time, we utilized in vitro single-molecule FRET approaches and biochemical analyses. We find that the Polθ-HD mediates the initial capture of two ssDNA strands, bringing them in close proximity. The Polθ-PD binds and stabilizes pre-annealed MHs to form a synaptic complex (SC) and initiate repair synthesis. Individual synthesis reactions show that Polθ is inherently non-processive, accounting for complex mutational patterns during TMEJ. Binding of Polθ-PD to stem-loop-forming sequences can substantially limit synapsis, depending on the available dNTPs and sequence context.
MeSH term(s)	DNA-Directed DNA Polymerase/metabolism ; DNA Breaks, Double-Stranded ; DNA Replication ; DNA, Single-Stranded/genetics ; DNA Helicases/genetics ; DNA End-Joining Repair
Chemical Substances	DNA-Directed DNA Polymerase (EC 2.7.7.7) ; DNA, Single-Stranded ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.03.010
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Article ; Online: Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study.

Levesque, Marianne / Wood, Richard / Carter, Michael D / Brock, Jo-Ann / Kieser, Katharina

CMAJ open

2023 Volume 11, Issue 5, Page(s) E1012–E1019

Abstract: Background: Identifying people with Lynch syndrome, a genetic condition predisposing those affected to colorectal, endometrial and other cancers, allows for implementation of risk-reducing strategies for patients and their families. The goal of this ... ...

Abstract	Background: Identifying people with Lynch syndrome, a genetic condition predisposing those affected to colorectal, endometrial and other cancers, allows for implementation of risk-reducing strategies for patients and their families. The goal of this study was to describe screening and testing practices for this condition among people with endometrial cancer in Nova Scotia, Canada, and to determine the prevalence of Lynch syndrome in this population. Methods: All patients diagnosed with endometrial cancer in Nova Scotia between May 1, 2017, and Apr. 30, 2020 were identified through a provincial gynecologic oncology database. Patients from out of province were excluded. We collected age, body mass index, tumour mismatch repair protein immunohistochemistry results, personal and family histories, and germline testing information for all patients. Results: We identified 465 people diagosed with endometrial cancer during the study period. Most were aged 51 years or older, and had obesity and low-grade early-stage endometrioid tumours. Tumour immunohistochemistry testing was performed in 444 cases (95.5%). Based on local criteria, 189 patients were eligible for genetic counselling, of whom 156 (82.5%) were referred to medical genetics. Of the 98 patients who underwent germline testing, 9 (9.2%) were diagnosed with Lynch syndrome. Interpretation: The prevalence of Lynch syndrome was at least 1.9% (9/465) in this population. Our results illustrate successful implementation of universal tumour testing; however, there remains a gap in access to genetic counselling.
Language	English
Publishing date	2023-10-31
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2701622-5
ISSN	2291-0026 ; 2291-0026
ISSN (online)	2291-0026
ISSN	2291-0026
DOI	10.9778/cmajo.20220136
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Article: Quadratus Lumborum Blockade for Postoperative Analgesia in Infants and Children Following Colorectal Surgery.

Manupipatpong, Katherine / Ghimire, Anuranjan / Tram, Nguyen K / Wood, Richard / Tobias, Joseph D / Veneziano, Giorgio

Journal of clinical medicine research

2023 Volume 15, Issue 2, Page(s) 84–89

Abstract: Background: Adult studies have indicated that the quadratus lumborum block (QLB) may provide superior analgesia compared to single-shot neuraxial and other truncal peripheral nerve blocks. The technique is being increasingly used for postoperative ... ...

Abstract	Background: Adult studies have indicated that the quadratus lumborum block (QLB) may provide superior analgesia compared to single-shot neuraxial and other truncal peripheral nerve blocks. The technique is being increasingly used for postoperative analgesia in children undergoing lower abdominal surgery. To date, these pediatric reports have been limited by small sample sizes, which may hinder the interpretation of results and assessment of safety. In this study, we retrospectively examined QLBs performed at a large tertiary care hospital for evidence of effectiveness and safety in the pediatric colorectal surgery population. Methods: Patients less than 21 years of age who underwent abdominal surgery and received a unilateral or bilateral QLB over a 4-year period were identified in the electronic medical record. Patient demographics, surgery type, and QLB characteristics were retrospectively examined. Pain scores and opioid consumption were tabulated over the first 72-h postoperative period. QLB procedural complications or adverse events attributable to the regional anesthetic were obtained. Results: The study cohort included 204 QLBs in 163 pediatric-aged patients (2 days to 19 years of age, median age of 2.4 years). The most common indication was unilateral blockade for ostomy creation or reversal. The majority of QLBs were performed using ropivacaine 0.2% with a median volume of 0.6 mL/kg. The median opioid requirement in oral morphine milligram equivalents (MMEs) was 0.7, 0.5, and 0.3 MME/kg on the first, second, and third postoperative days, respectively. Median pain scores were less than 2 over each time period. Aside from block failure (incidence 1.2%), there were no complications or postoperative adverse events related to the QLBs. Conclusion: This retrospective review in a large cohort of pediatric patients demonstrates that the QLB can be performed safely and efficiently in children undergoing colorectal surgery. The QLB provides adequate postoperative analgesia, has a high success rate, may limit postoperative opioid consumption, and is associated with a limited adverse effect profile.
Language	English
Publishing date	2023-02-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4833
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