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  1. Article ; Online: Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.

    Zheng, Yuan / Ren, Xueyang / Qi, Xiaodan / Song, Ruolan / Zhao, Chongjun / Ma, Jiamu / Li, Xianxian / Deng, Qingyue / He, Yingyu / Kong, Lingmei / Qian, Liyan / Zhang, Feng / Li, Mingxia / Sun, Mengyu / Liu, Wei / Liu, Haibin / She, Gaimei

    Journal of ethnopharmacology

    2024  Volume 328, Page(s) 118058

    Abstract: Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to ...

    Abstract Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to anti-fatigue effects, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in anti-fatigue mechanism, while it has not yet been revealed. Therefore, we elucidated the anti-fatigue mechanism of BYD through AMPK/CRY2/PER1 pathway.
    Aim of the study: To investigate the effect and mechanism of BYD in reducing fatigue, using pharmacodynamics, network pharmacology and transcriptomics through the AMPK/CRY2/PER1 signaling pathway.
    Materials and methods: Firstly, the chemical constituents of BYD were qualitatively identified by UHPLC-Q-Exactive Orbitrap/MS, establishing a comprehensive strategy with an in-house library, Xcalibur software and Pubchem combined. Secondly, a Na
    Results: In total, 114 compounds from the water extract of BYD were identified as major compounds. Na₂SO₃-induced fatigue model and AAPH-induced oxidative stress model indicated that BYD has significant anti-fatigue and antioxidant effects. Meanwhile, BYD showed significant anti-inflammatory effects on CuSO
    Conclusion: Herein, we identified 114 chemical constituents of BYD, performed zebrafish activity validation, while demonstrated that BYD can relieve fatigue by AMPK/CRY2/PER1 signaling pathway through network pharmacology and transcriptome.
    MeSH term(s) Animals ; AMP-Activated Protein Kinases ; Zebrafish ; Oxidative Stress ; Fatigue/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation/drug therapy ; Antioxidants ; Signal Transduction ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Amidines
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; 2,2'-azobis(2-amidinopropane) (7381JDR72F) ; Drugs, Chinese Herbal ; Antioxidants ; Anti-Inflammatory Agents ; Amidines
    Language English
    Publishing date 2024-03-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Das Yuan-Ming-Yuan-Ensemble

    Zhang, Shuang

    der kaiserliche "Park der vollkommenen Klarheit" in Beijing ; Zeitschichtkarten als Instrument der Gartendenkmalpflege

    (Materialien zur Geschichte der Gartenkunst ; 7)

    2004  

    Author's details Shuang Zhang. Technische Universität Berlin
    Series title Materialien zur Geschichte der Gartenkunst ; 7
    Collection
    Subject code 712.50951156
    Language German
    Size 20 S., Kt., 30 cm, 97 gr.
    Edition Kurzfassung
    Publisher TU, Univ.-Bibliothek, Abt. Publ
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT015328324
    ISBN 978-3-7983-1940-0 ; 3-7983-1940-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    064/1222 available for loan (reading room) Freihandmagazin (U1)

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  3. Book ; Audio / Video ; Thesis: Das Yuan-Ming-Yuan-Ensemble

    Zhang, Shuang

    der kaiserliche "Park der vollkommenen Klarheit" in Beijing ; Zeitschichtkarten als Instrument der Gartendenkmalpflege

    (Materialien zur Geschichte der Gartenkunst ; 7)

    2004  

    Author's details Shuang Zhang
    Series title Materialien zur Geschichte der Gartenkunst ; 7
    Collection
    Subject code 712.50951156
    Language German
    Size 1 CD-ROM, 12 cm
    Publisher TU, Univ.-Bibliothek, Abt. Publ
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Berlin, Techn., Diss., 2002
    Note Titel vom Label
    HBZ-ID HT015328318
    ISBN 978-3-7983-1940-0 ; 3-7983-1940-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  4. Book ; Online: YUAN 2.0

    Wu, Shaohua / Zhao, Xudong / Wang, Shenling / Luo, Jiangang / Li, Lingjun / Chen, Xi / Zhao, Bing / Wang, Wei / Yu, Tong / Zhang, Rongguo / Zhang, Jiahua / Wang, Chao

    A Large Language Model with Localized Filtering-based Attention

    2023  

    Abstract: In this work, we develop and release Yuan 2.0, a series of large language models with parameters ... in large-scale distributed training. Yuan 2.0 models display impressive ability in code generation, math ... problem-solving, and chatting compared with existing models. The latest version of YUAN 2.0, including model ...

    Abstract In this work, we develop and release Yuan 2.0, a series of large language models with parameters ranging from 2.1 billion to 102.6 billion. The Localized Filtering-based Attention (LFA) is introduced to incorporate prior knowledge of local dependencies of natural language into Attention. A data filtering and generating system is presented to build pre-training and fine-tuning dataset in high quality. A distributed training method with non-uniform pipeline parallel, data parallel, and optimizer parallel is proposed, which greatly reduces the bandwidth requirements of intra-node communication, and achieves good performance in large-scale distributed training. Yuan 2.0 models display impressive ability in code generation, math problem-solving, and chatting compared with existing models. The latest version of YUAN 2.0, including model weights and source code, is accessible at Github.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence ; Computer Science - Human-Computer Interaction
    Subject code 004
    Publishing date 2023-11-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Exploring the Mechanisms of Traditional Chinese Herbal Therapy in Gastric Cancer: A Comprehensive Network Pharmacology Study of the Tiao-Yuan-Tong-Wei decoction.

    Chen, Juan / Kang, Jingdong / Yuan, Shouli / O'Connell, Peter / Zhang, Zizhu / Wang, Lina / Liu, Junying / Chen, Rongfeng

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: ... proposes a comprehensive exploratory analysis of the Tiao-Yuan-Tong-Wei decoction (TYTW), utilizing ...

    Abstract The use of herbal medicine as an adjuvant therapy in the management of gastric cancer has yielded encouraging outcomes, notably in enhancing overall survival rates and extending periods of disease remission. Additionally, herbal medicines have demonstrated potential anti-metastatic effects in gastric cancer. Despite these promising findings, there remains a significant gap in our understanding regarding the precise pharmacological mechanisms, the identification of specific herbal compounds, and their safety and efficacy profiles in the context of gastric cancer therapy. In addressing this knowledge deficit, the present study proposes a comprehensive exploratory analysis of the Tiao-Yuan-Tong-Wei decoction (TYTW), utilizing an integrative approach combining system pharmacology and molecular docking techniques. This investigation aims to elucidate the pharmacological actions of TYTW in gastric pathologies. It is hypothesized that the therapeutic efficacy of TYTW in counteracting gastric diseases stems from its ability to modulate key signaling pathways, thereby influencing PIK3CA activity and exerting anti-inflammatory effects. This modulation is observed predominantly in pathways such as PI3K/AKT, MAPK, and those directly associated with gastric cancer. Furthermore, the study explores how TYTW's metabolites (agrimoniin, baicalin, corosolic acid, and luteolin) interact with molecular targets like AKT1, CASP3, ESR1, IL6, PIK3CA, and PTGS2, and their subsequent impact on these critical pathways and biological processes. Therefore, this study represents preliminary research on the anticancer molecular mechanism of TYTW by performing network pharmacology and providing theoretical evidence for further experimental investigations.
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Da-Yuan-Yin decoction polyphenol fraction attenuates acute lung injury induced by lipopolysaccharide.

    Guo, Lengqiu / Yang, Yun / Yuan, Jie / Ren, Huiling / Huang, Xiaolei / Li, Meng / Xia, Long / Jiang, Xiaogang / Chen, Daofeng / Zhang, Jian

    Pharmaceutical biology

    2023  Volume 61, Issue 1, Page(s) 228–240

    Abstract: Context: Da-Yuan-Yin is a Chinese traditional prescription.: Objective: This study explores ... the therapeutic effects of the Da-Yuan-Yin decoction polyphenol fraction (DYY-4) on acute lung injury (ALI ...

    Abstract Context: Da-Yuan-Yin is a Chinese traditional prescription.
    Objective: This study explores the therapeutic effects of the Da-Yuan-Yin decoction polyphenol fraction (DYY-4) on acute lung injury (ALI) in mice induced by lipopolysaccharide (LPS).
    Materials and methods: The mice (
    Results: DYY-4 (30, 60 mg/kg,
    Discussion and conclusions: Network pharmacology combined with animal experiments revealed the targets of DYY-4 alleviating ALI.
    MeSH term(s) Mice ; Animals ; NF-kappa B/metabolism ; Lipopolysaccharides/toxicity ; Polyphenols/adverse effects ; Cyclooxygenase 2/genetics ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/prevention & control ; Lung ; Superoxide Dismutase ; RNA, Messenger
    Chemical Substances NF-kappa B ; Lipopolysaccharides ; Polyphenols ; Cyclooxygenase 2 (EC 1.14.99.1) ; Superoxide Dismutase (EC 1.15.1.1) ; RNA, Messenger
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2023.2166085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Protective Effect of the Eluting Fraction of Da-Yuan-Yin Decoction on Acute Lung Injury.

    Yang, Yun / Chen, Jinglei / Ren, Huiling / Wei, Lan / Huang, Xiaolei / Li, Meng / Yuan, Jie / Wang, Lu / Jiang, Xiaogang / Guo, Lengqiu / Zhang, Jian

    Alternative therapies in health and medicine

    2023  Volume 29, Issue 5, Page(s) 242–254

    Abstract: Context: The Da-yuan-yin (DYY) decoction is a classical prescription ...

    Abstract Context: The Da-yuan-yin (DYY) decoction is a classical prescription of traditional Chinese medicine that has antipyretic and anti-inflammatory effects. Network Pharmacology (NP) is an emerging discipline based on system-biology theory and biosystem network analysis that researchers can use to predict drug-action targets and mechanisms.
    Objective: The study intended to use NP evaluate the protective effects of the fifth eluting fraction of the supernatant of the DYY decoction (DYY-5) for mice induced with acute lung injury (ALI) using lipopolysaccharide (LPS) and to explore DYY-5's mechanisms.
    Design: The research team performed an animal study.
    Setting: The study took place at the College of Pharmaceutical Science at Soochow University in Suzhou, China.
    Animals: The animals were 42 male Balb/c mice, about 20 to 25 g in weight.
    Intervention: The research team: instilled 2 mg/kg of LPS intratracheally (i.t.) to induce ALI. The team divided the mice into seven groups of six mice: (1) a control group; (2) a negative control group-the DYY-5 group with mice treated only with a high dosage, 60 mg/kg, of DYY-5 to investigate the effects of DYY-5 on normal mice; (3) the positive control group, the LPS group, with induced ALI but no treatments; (4) the LPS+60 mg/kg-DYY-5 group with induced ALI treated with a high dosage of DYY-5; (5) the LPS+30 mg/kg-DYY-5 group with induced ALI treated with a medium dosage of DYY-5; (6) the LPS+15 mg/kg-DYY-5 group with induced ALI treated with a low dosage of DYY-5; and (7) a reference drug control group, the LPS+DXM group, with induced ALI treated with 5 mg/kg of dexamethasone (DXM).
    Outcome measures: The research team: (1) determined the chemical components of DYY; (2) identified the anticomplementary activities of DYY-5; (3) took lung specimens, serum, and bronchoalveolar lavage fluid (BALF) from the mice for histopathological examination, Western blot, and biochemical analysis; (4) measured total protein concentrations and lung W/D ratios; (5) measured the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) using quantitative real-time polymerase chain reaction (PCR); (6) measured the levels of pro-inflammatory and anti-inflammatory factors, the activity of myeloperoxidase (MPO) and superoxide dismutase (SOD), and the levels of complements, including complements 3 (C3), C3c, C5a, C5aR1, and C5b-9, using kits; (7) analyzed the levels of nuclear factor-kappa B (NF-κB) and IkB kinase (IKK) using Western blot; and (8) used network pharmacology (NP) to predict DYY-5's mechanisms and potential targets.
    Results: The study's results were consistent with the NP analysis, which reflected the multitarget and multipathway characteristics of DYY-5 in alleviating ALI. The LPS+30 mg/kg-DYY-5 group had significantly lower lung wet-to-dry (W/D) ratios and total protein concentrations in BALF than the LPS group did, with P < .01 and P < .0001, respectively as did the LPS+60 mg/kg-DYY-5 group (both P < .0001). The 60 mg/kg of DYY-5 compared to the LPS group: (1) regulated the levels tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and interleukin-1 beta (IL-1β), with all P < .0001, anti-inflammatory factors-IL-4 (P < .05), IL-10 (P < .001), and IL-13 (P < .001); (2) increased the activity of SOD (P < .0001) and decreased the activity of MPO (P < .0001) and the expressions of iNOS and COX-2 mRNA (both P < .01); (3) blocked the activation of NF-κB and IKK; and (4) alleviated the pathological changes in the lung tissue, by reducing the depositions of C3c and decreasing the levels of C3, C5a and C5aR1 (all P < .0001), C5b-9 (P < .001) and C3c (P < .01) in serum.
    Conclusions: The protective effects of DYY-5 on ALI were related to antioxidation, anti-complementary activities, and regulation of inflammatory factors through the IKK/NF-κB signal pathway. DYY-5 may be useful as a potential therapeutic agent for treating ALI in clinics.
    MeSH term(s) Male ; Mice ; Animals ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Lipopolysaccharides ; Cyclooxygenase 2/adverse effects ; Complement Membrane Attack Complex/adverse effects ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Mice, Inbred BALB C ; RNA, Messenger ; Superoxide Dismutase
    Chemical Substances NF-kappa B ; Lipopolysaccharides ; Cyclooxygenase 2 (EC 1.14.99.1) ; Complement Membrane Attack Complex ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; RNA, Messenger ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4504: Show issues Location:
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  8. Article: [The terms in the Jiu Zhen Shi Er Yuan in Ling Shu].

    Zhang, L

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2023  Volume 53, Issue 3, Page(s) 131–135

    Abstract: This paper examined unearthed and handed down documents through terms and relative words in the section ... ...

    Abstract This paper examined unearthed and handed down documents through terms and relative words in the section of
    MeSH term(s) Acupuncture ; Acupuncture Therapy ; China
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.cn112155-20221007-00138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4688: Show issues Location:
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  9. Article ; Online: Assembly and comparative analysis of the first complete mitochondrial genome of a traditional Chinese medicine Angelica biserrata (Shan et Yuan) Yuan et Shan.

    Wang, Le / Liu, Xue / Xu, Yuanjiang / Zhang, Zhiwei / Wei, Yongsheng / Hu, Ying / Zheng, Changbing / Qu, Xianyou

    International journal of biological macromolecules

    2023  Volume 257, Issue Pt 1, Page(s) 128571

    Abstract: Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has ... ...

    Abstract Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has revealed. Nevertheless, the mtDNA of Angelica species remains relatively unexplored. To address this gap, we sequenced and assembled the mtDNA of A. biserrata to shed light on its genetic mechanisms and evolutionary pathways. Our investigation indicated a distinctive multi-branched conformation in the A. biserrata mtDNA. A comprehensive analysis of protein-coding sequences (PCGs) across six closely related species revealed the presence of 11 shared genes in their mitochondrial genomes. Intriguingly, positive selection emerged as a significant factor in the evolution of the atp4, matR, nad3, and nad7 genes. In addition, our data highlighted a recurring trend of homologous fragment migration between chloroplast and mitochondrial organelles. We identified 13 homologous fragments spanning both chloroplast and mitochondrial genomes. The phylogenetic tree established a close relationship between A. biserrata and Saposhnikovia divaricata. To sum up, our research would contribute to the application of population genetics and evolutionary studies in the genus Acanthopanax and other genera in the Araliaceae family.
    MeSH term(s) Medicine, Chinese Traditional ; Angelica/genetics ; Phylogeny ; Genome, Mitochondrial/genetics ; DNA, Mitochondrial
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128571
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  10. Article ; Online: Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.

    Xia, Tian-Ji / Jin, Su-Wei / Liu, Yong-Guang / Zhang, Shan-Shan / Wang, Zhi / Liu, Xin-Min / Pan, Rui-Le / Jiang, Ning / Liao, Yong-Hong / Yan, Ming-Zhu / Chang, Qi

    Journal of ethnopharmacology

    2024  Volume 326, Page(s) 117992

    Abstract: ... Traditional Chinese medicine prescriptions composed of Ginseng Radix et Rhizoma and Polygalae Radix (Shen Yuan, SY) are ...

    Abstract Ethnopharmacological relevance: Sleep plays a critical role in several physiologic processes, and sleep disorders increase the risk of depression, dementia, stroke, cancer, and other diseases. Stress is one of the main causes of sleep disorders. Ginseng Radix et Rhizoma and Polygalae Radix have been reported to have effects of calming the mind and intensifying intelligence in Chinese Pharmacopoeia. Traditional Chinese medicine prescriptions composed of Ginseng Radix et Rhizoma and Polygalae Radix (Shen Yuan, SY) are commonly used to treat insomnia, depression, and other psychiatric disorders in clinical practice. Unfortunately, the underlying mechanisms of the SY extract's effect on sleep are still unknown.
    Aim of the study: This study aimed to investigate the hypnotic effect of the SY extract in normal mice and mice with chronic restraint stress (CRS)-induced sleep disorders and elucidate the underlying mechanisms.
    Materials and methods: The SY extract (0.5 and 1.0 g/kg) was intragastrically administered to normal mice for 1, 14, and 28 days and to CRS-treated mice for 28 days. The open field test (OFT) and pentobarbital sodium-induced sleep test (PST) were used to evaluate the hypnotic effect of the SY extract. Liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay were utilized to detect the levels of neurotransmitters and hormones. Molecular changes at the mRNA and protein levels were determined using real-time quantitative polymerase chain reaction and Western blot analysis to identify the mechanisms by which SY improves sleep disorders.
    Results: The SY extract decreased sleep latency and increased sleep duration in normal mice. Similarly, the sleep duration of mice subjected to CRS was increased by administering SY. The SY extract increased the levels of tryptophan (Trp) and 5-hydroxytryptamine (5-HT) and the expression of tryptophan hydroxylase 2 (TPH2) in the cortex of normal mice. The SY extract increased the Trp level, transcription and expression of estrogen receptor beta and TPH2 in the cortex in mice with sleep disorders by decreasing the serum corticosterone level, which promoted the synthesis of 5-HT. Additionally, the SY extract enhanced the expression of arylalkylamine N-acetyltransferase, which increased the melatonin level and upregulated the expressions of melatonin receptor-2 (MT2) and Cryptochrome 1 (Cry1) in the hypothalamus of mice with sleep disorders.
    Conclusions: The SY extract exerted a hypnotic effect via the Trp/5-HT/melatonin pathway, which augmented the synthesis of 5-HT and melatonin and further increased the expressions of MT2 and Cry1.
    MeSH term(s) Humans ; Mice ; Animals ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use ; Tryptophan ; Serotonin/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Melatonin/pharmacology ; Sleep Initiation and Maintenance Disorders/drug therapy
    Chemical Substances Hypnotics and Sedatives ; Tryptophan (8DUH1N11BX) ; Serotonin (333DO1RDJY) ; Drugs, Chinese Herbal ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2024-02-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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