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  1. Article ; Online: Cellular senescence in acute kidney injury: Target and opportunity.

    Li, Ting / Yang, Kexin / Gao, Wei / Peng, Fujun / Zou, Xiangyu

    Biochemical and biophysical research communications

    2024  Volume 706, Page(s) 149744

    Abstract: Acute kidney injury (AKI) is a common clinical disease with a high incidence and mortality rate. It typically arises from hemodynamic alterations, sepsis, contrast agents, and toxic drugs, instigating a series of events that culminate in tissue and renal ...

    Abstract Acute kidney injury (AKI) is a common clinical disease with a high incidence and mortality rate. It typically arises from hemodynamic alterations, sepsis, contrast agents, and toxic drugs, instigating a series of events that culminate in tissue and renal damage. This sequence of processes often leads to acute renal impairment, prompting the initiation of a repair response. Cellular senescence is an irreversible arrest of the cell cycle. Studies have shown that renal cellular senescence is closely associated with AKI through several mechanisms, including the promotion of oxidative stress and inflammatory response, telomere shortening, and the down-regulation of klotho expression. Exploring the role of cellular senescence in AKI provides innovative therapeutic ideas for both the prevention and treatment of AKI. Furthermore, it has been observed that targeted removal of senescent cells in vivo can efficiently postpone senescence, resulting in an enhanced prognosis for diseases associated with senescence. This article explores the effects of common anti-senescence drugs senolytics and senostatic and lifestyle interventions on renal diseases, and mentions the rapid development of mesenchymal stem cells (MSCs). These studies have taken senescence-related research to a new level. Overall, this article comprehensively summarizes the studies on cellular senescence in AKI, aiming is to elucidate the relationship between cellular senescence and AKI, and explore treatment strategies to improve the prognosis of AKI.
    MeSH term(s) Humans ; Acute Kidney Injury/metabolism ; Cellular Senescence ; Kidney/metabolism ; Mesenchymal Stem Cells/metabolism ; Oxidative Stress
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  2. Article: A Novel Variant of the

    Zhu, Lina / Peng, Fujun / Deng, Zengwen / Feng, Zhichun / Ma, Xiuwei

    Frontiers in genetics

    2022  Volume 13, Page(s) 761178

    Abstract: Pathogenic variants ... ...

    Abstract Pathogenic variants in
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.761178
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  3. Article ; Online: Prediction of Antigenic Distance in Influenza A Using Attribute Network Embedding.

    Peng, Fujun / Xia, Yuanling / Li, Weihua

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Owing to the rapid changes in the antigenicity of influenza viruses, it is difficult for humans to obtain lasting immunity through antiviral therapy. Hence, tracking the dynamic changes in the antigenicity of influenza viruses can provide a basis for ... ...

    Abstract Owing to the rapid changes in the antigenicity of influenza viruses, it is difficult for humans to obtain lasting immunity through antiviral therapy. Hence, tracking the dynamic changes in the antigenicity of influenza viruses can provide a basis for vaccines and drug treatments to cope with the spread of influenza viruses. In this paper, we developed a novel quantitative prediction method to predict the antigenic distance between virus strains using attribute network embedding techniques. An antigenic network is built to model and combine the genetic and antigenic characteristics of the influenza A virus H3N2, using the continuous distributed representation of the virus strain protein sequence (ProtVec) as a node attribute and the antigenic distance between virus strains as an edge weight. The results show a strong positive correlation between supplementing genetic features and antigenic distance prediction accuracy. Further analysis indicates that our prediction model can comprehensively and accurately track the differences in antigenic distances between vaccines and influenza virus strains, and it outperforms existing methods in predicting antigenic distances between strains.
    MeSH term(s) Humans ; Influenza, Human ; Influenza A Virus, H3N2 Subtype ; Antigens, Viral ; Influenza A virus/genetics ; Amino Acid Sequence ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Antigenic Variation ; Influenza Vaccines
    Chemical Substances Antigens, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Current drugs for HIV-1: from challenges to potential in HIV/AIDS.

    Peng, Yuan / Zong, Yanjun / Wang, Dongfeng / Chen, Junbing / Chen, Zhe-Sheng / Peng, Fujun / Liu, Zhijun

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1294966

    Abstract: The human immunodeficiency virus (HIV) persists in latently infected ... ...

    Abstract The human immunodeficiency virus (HIV) persists in latently infected CD4
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1294966
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  5. Article ; Online: A novel role of prognostic nutritional index in predicting the effectiveness of infliximab in Crohn's disease.

    Peng, Ziheng / Xu, Duo / Li, Yong / Liu, Xiaowei / Li, Fujun / Peng, Yu

    Annals of medicine

    2023  Volume 55, Issue 1, Page(s) 2236011

    Abstract: Objective: To investigate the predictive value of the prognostic nutritional index (PNI) for the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD).: Methods: All data were retrospectively collected from Xiangya Hospital, Central ...

    Abstract Objective: To investigate the predictive value of the prognostic nutritional index (PNI) for the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD).
    Methods: All data were retrospectively collected from Xiangya Hospital, Central South University between January 2016 and September 2021. Clinical remission at 52 weeks is the primary endpoint.
    Results: Altogether, 193 CD patients were enrolled. PNI can identify clinical remission (
    Conclusion: The PNI may serve as a novel and promising biomarker in predicting the effectiveness of IFX and contribute to targeted management in CD.
    MeSH term(s) Humans ; Infliximab ; Crohn Disease ; Nutrition Assessment ; Prognosis ; Retrospective Studies ; C-Reactive Protein/metabolism
    Chemical Substances Infliximab (B72HH48FLU) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2236011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: In-plane ESPI with unlimited angle of view for multi-object rotation angle determination.

    Jiang, Hanyang / Wang, Jingwei / Yang, Boshuo / Dai, Meiling / Peng, Guangjian / Yang, Fujun / He, Xiaoyuan

    Optics letters

    2023  Volume 48, Issue 22, Page(s) 5827–5830

    Abstract: The in-plane electronic speckle pattern interferometry (ESPI), implemented in a Michelson stellar interferometer-like configuration, offers high sensitivity and dynamic measurement. However, its limited angle of view (AOV) remains a major challenge for ... ...

    Abstract The in-plane electronic speckle pattern interferometry (ESPI), implemented in a Michelson stellar interferometer-like configuration, offers high sensitivity and dynamic measurement. However, its limited angle of view (AOV) remains a major challenge for the rotation angle determination of multiple objects. In this Letter, we analyze the main factors that influence the AOV of the in-plane ESPI and propose an "image transmitting" approach to enlarge the AOV. With the aid of a folded dual-telescope imaging system, we develop an AOV-unlimited interferometer that can determine multi-object rotation angles in real time. The practicability of the interferometer is demonstrated by the application in real-time measuring of the rotation angles of the disks within a 2D granular system.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.504508
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  7. Article: Causal Effects of Genetically Predicted Cystatin C on Osteoporosis: A Two-Sample Mendelian Randomization Study.

    Yuan, Jiaqin / Peng, Lipeng / Luan, Fujun / Li, Jie / Zhang, Jinglin / Jiang, Wei / Wang, Wenting

    Frontiers in genetics

    2022  Volume 13, Page(s) 849206

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.849206
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  8. Article ; Online: A novel role of prognostic nutritional index in predicting the effectiveness of infliximab in Crohn's disease

    Ziheng Peng / Duo Xu / Yong Li / Xiaowei Liu / Fujun Li / Yu Peng

    Annals of Medicine, Vol 55, Iss

    2023  Volume 1

    Abstract: AbstractObjective To investigate the predictive value of the prognostic nutritional index (PNI) for the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD).Methods All data were retrospectively collected from Xiangya Hospital, Central ...

    Abstract AbstractObjective To investigate the predictive value of the prognostic nutritional index (PNI) for the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD).Methods All data were retrospectively collected from Xiangya Hospital, Central South University between January 2016 and September 2021. Clinical remission at 52 weeks is the primary endpoint.Results Altogether, 193 CD patients were enrolled. PNI can identify clinical remission (p = 0.004), and the optimal cut-off value of the PNI was 39.2. 92/116 (79.3%) and 44/77 (57.1%) in the high- and low-PNI groups were in clinical remission at week 52 (p = 0.001). Patients with low PNI have poor general health at baseline. The body mass index, hemoglobin, platelet (PLT), serum creatinine, fibrinogen, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Crohn's disease activity index (CDAI), and location of disease significantly differed between the two groups (p < 0.05). PNI was negatively correlated with CRP, ESR, PLT and CDAI (p < 0.05). The lower PNI, smoking history, and higher CDAI at baseline were the independent risk factors of disease activity at 52 weeks (p < 0.05). The high-PNI group is less likely to develop poor outcomes (p = 0.033).Conclusion The PNI may serve as a novel and promising biomarker in predicting the effectiveness of IFX and contribute to targeted management in CD.
    Keywords Prognostic nutritional index ; infliximab ; Crohn's disease ; clinical remission ; biomarker ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Failure diagnosis of the steam generator based on improved BP network and Particle

    Qi Fujun / Niu Qingsong / Peng Jing / Tian Zhiguang

    E3S Web of Conferences, Vol 256, p

    2021  Volume 02041

    Abstract: In order to overcome the problems of slow rate of convergence and falling easily into local minimum in BP algorithm, this paper introduces the adaptive particle swarm optimization algorithm and combining model. The paper applies it to steam turbine- ... ...

    Abstract In order to overcome the problems of slow rate of convergence and falling easily into local minimum in BP algorithm, this paper introduces the adaptive particle swarm optimization algorithm and combining model. The paper applies it to steam turbine-generators fault diagnosis. The experiment data shows that the algorithm converges quickly and recognizes faults efficiently; it has a reference value for faults diagnosis.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Ligands and receptors in human cytomegalovirus entry: Current therapies and new directions.

    Zhang, Min / Wang, Xiaochen / Li, Jianshe / Peng, Fujun / Liu, Zhijun / Chen, Zhe-Sheng

    Drug discovery today

    2023  Volume 29, Issue 1, Page(s) 103833

    Abstract: The demand for human cytomegalovirus (HCMV) vaccines was first raised by a committee convened during the 1990s. A comprehensive investigation into the mechanism of viral infection supports the prioritization of developing drugs or vaccines that ... ...

    Abstract The demand for human cytomegalovirus (HCMV) vaccines was first raised by a committee convened during the 1990s. A comprehensive investigation into the mechanism of viral infection supports the prioritization of developing drugs or vaccines that specifically target receptors and ligands involved in the infection process. As primary targets for neutralizing antibodies to combat HCMV, viral ligands (trimer, pentamer, and glycoprotein B) have crucial roles and exhibit substantial antiviral potential, which could be exploited for breakthroughs in antiviral research.
    MeSH term(s) Humans ; Cytomegalovirus ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/prevention & control ; Membrane Glycoproteins ; Viral Envelope Proteins ; Vaccines ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
    Chemical Substances Membrane Glycoproteins ; Viral Envelope Proteins ; Vaccines ; Antiviral Agents
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103833
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    Zs.A 4725: Show issues Location:
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