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Article ; Online: An Unusual Asymptomatic Case of Unilateral Parotid Gland Agenesis.

Barca, Ida / Della Torre, Attilio / Cristofaro, Maria Giulia

2023 Volume 34, Issue 8, Page(s) e812–e814

Abstract: Congenital absence of the major salivary glands, especially of the parotid gland, is a very infrequent condition of poorly understood etiology. This condition may be unilateral or bilateral and may occur alone or in association with the absence of other ... ...

Abstract	Congenital absence of the major salivary glands, especially of the parotid gland, is a very infrequent condition of poorly understood etiology. This condition may be unilateral or bilateral and may occur alone or in association with the absence of other salivary glands or with other developmental craniofacial deformities of maxillofacial first and second branchial arch. Only 24 cases are documented in the literature. The authors present a case of a 79-year-old female who was referred to the Neurosurgery Department for neurocognitive impairment. The brain computed tomography with contrast enhancement incidentally showed a complete absence of the left parotid gland. The medical history and physical and radiographic examinations were indicative of nonsyndromic and nonfamilial asymptomatic unilateral aplasia of the parotid gland.
MeSH term(s)	Female ; Humans ; Aged ; Parotid Gland/diagnostic imaging ; Parotid Gland/surgery ; Salivary Glands ; Tomography, X-Ray Computed ; Neuroimaging ; Physical Examination
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009711
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Article ; Online: Efficacy of Pulsed Electromagnetic Field Therapy for Pain Management After Impacted Mandibular Third Molar Surgery. A Randomized Clinical Trial.

Ferragina, Francesco / Caruso, Davide / Barca, Ida / Kallaverja, Elvis / Arrotta, Antonella / Cristofaro, Maria Giulia

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2024

Abstract: Background: Postoperative pain and swelling associated with the removal of the third molar (M3) adversely affect the patient's quality of life.: Purpose: The study aims to measure pain reduction and analgesic use in patients treated with pulsed ... ...

Abstract	Background: Postoperative pain and swelling associated with the removal of the third molar (M3) adversely affect the patient's quality of life. Purpose: The study aims to measure pain reduction and analgesic use in patients treated with pulsed electromagnetic field (PEMF) therapy following M3 removal and compares it to patients who did not receive PEMF. Study design, setting, sample: The single-center study was designed as a randomized, prospective, controlled, double-blinded trial on a sample of patients with impacted mandibular M3 ascertained by x-ray orthopantomography and computed tomography. Predictor/exposure/independent variables: The predictor variable is postoperative pain management. It was assigned randomly to each subject who received either PEMF or standard therapy. Main outcome variables: The pain was quantified using a 100 mm visual analog scale and the number of analgesics taken. Each subject kept a daily clinical diary for 7 days, recording the amount of pain using the visual analog scale and the number of analgesic tablets taken. Covariates: The study covariates were age, sex, tobacco use, and Pell and Gregory's classification of M3s. Analyses: Student t test was used, placing the statistical significance for P value < .05. The primary planned analysis was a 2-group, continuity-corrected, χ Results: The study sample included 90 patients, 47 men and 43 women, with an average age of 32.43 ± 8.80 years. PEMF was statistically associated with improved pain reduction (2.08 vs 5.04 with a P value = .0002) and consumption of fewer analgesics than the control group (2.6 vs 5.8 with a P value = .0062). Conclusions and relevance: The study's results attest to the effectiveness of PEMF therapy in pain control after M3 surgery.
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2024.02.011
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Article ; Online: A rare case of secondary ameloblastic carcinoma in a young Man.

Barca, Ida / Ferragina, Francesco / Kallaverja, Elvis / Cristofaro, Maria Giulia

Annali italiani di chirurgia

2023 Volume 93

Abstract: Ameloblastic carcinoma is a rare and aggressive malignant odontogenic tumour that can arise de novo or from a preexisting benign lesion. It most frequently involves the mandible, and its clinical course is aggressive with extensive local destruction. ... ...

Abstract	Ameloblastic carcinoma is a rare and aggressive malignant odontogenic tumour that can arise de novo or from a preexisting benign lesion. It most frequently involves the mandible, and its clinical course is aggressive with extensive local destruction. Although rare, these lesions have been known to metastasize, mostly to regional lymph nodes or lungs. Surgical therapy, eventually followed by radiotherapy, is the treatment modality most frequently used, while the role of chemotherapy remains unclear. Here we present a case of secondary ameloblastic carcinoma of the mandible in a 33-year-old male patient with typical aggressiveness and extensive local destruction and metastasis with a follow-up period of 93 months. KEY WORDS: Ameloblastic Carcinoma, Head and Neck Cancer, Maxillofacial Surgery, Oncological Surgery.
MeSH term(s)	Male ; Humans ; Adult ; Ameloblastoma/surgery ; Ameloblastoma/pathology ; Odontogenic Tumors ; Mouth Neoplasms ; Lymph Nodes/pathology ; Carcinoma ; Mandibular Neoplasms/surgery
Language	English
Publishing date	2023-04-18
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article: Design and Simulate Intracranial Support to Guide Maxillo Surgery: A Study Based on Bioengineering.

Cristofaro, Maria Giulia / Kallaverja, Elvis / Ferragina, Francesco / Barca, Ida

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 24

Abstract: Background: Intraoperative navigation allows for the creation of a real-time relationship between the anatomy imagined during diagnosis/planning and the site of surgical interest. This procedure takes place by identifying and registering trustworthy ... ...

Abstract	Background: Intraoperative navigation allows for the creation of a real-time relationship between the anatomy imagined during diagnosis/planning and the site of surgical interest. This procedure takes place by identifying and registering trustworthy anatomical markers on planning images and using a point locator during the operation. The locator is calibrated in the workspace by placing a Dynamic Reference Frame (DRF) sensor. Objective: This study aims to calculate the localization accuracy of an electromagnetic locator of neuro-maxillofacial surgery, moving the standard sensor position to a different position more suitable for maxillofacial surgery. Materials and methods: The upper dental arch was chosen as an alternative fixed point for the positioning of the sensor. The prototype of a bite support device was designed and generated via 3D printing. CT images of a skull phantom with 10 anatomical landmarks were acquired. The testing procedure consisted of 10 measurements for each position of the sensor: precisely 10 measurements with the sensor placed on the forehead and 10 measurements with the sensor placed on the bite support device. It also evaluated the localization error by comparing the two procedures. Results: The localization error, when the sensor was placed on the bite support device, was lower in the sphere located on the temporal bone. It was the same in the spheres located on the maxillary bone. The test analysis of the data of the new device showed that it is reliable; the tests are reproducible and can be considered as accurate as the traditional ones. In addition, the sensor mounted on this device has proven to be slightly superior in terms of accuracy and accuracy in areas such as the middle third of the face and jaw. Discussion and conclusion: The realization of the bite support device allowed the sensor to change position concerning its natural site. This procedure allows us to explore structures, such as the frontal site, which were initially difficult to approach with neuronavigation and improves the approach to midface structures, already studied with neuronavigation. The new calibration, with the position of the sensor on the support device in the same reference points sphere, highlighted the reduction in the location error. We can say that the support proposed in this study lays the foundations for a new navigation approach for patients in maxillofacial surgery, by changing the position of the sensor. It has strong points in improving the localization error for some reference points without determining disadvantages both in the calibration and in the surgical impediment.
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13243672
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Article ; Online: Design and Simulate Intracranial Support to Guide Maxillo Surgery

Maria Giulia Cristofaro / Elvis Kallaverja / Francesco Ferragina / Ida Barca

Diagnostics, Vol 13, Iss 24, p

A Study Based on Bioengineering

2023 Volume 3672

Abstract	Background: Intraoperative navigation allows for the creation of a real-time relationship between the anatomy imagined during diagnosis/planning and the site of surgical interest. This procedure takes place by identifying and registering trustworthy anatomical markers on planning images and using a point locator during the operation. The locator is calibrated in the workspace by placing a Dynamic Reference Frame (DRF) sensor. Objective: This study aims to calculate the localization accuracy of an electromagnetic locator of neuro-maxillofacial surgery, moving the standard sensor position to a different position more suitable for maxillofacial surgery. Materials and Methods: The upper dental arch was chosen as an alternative fixed point for the positioning of the sensor. The prototype of a bite support device was designed and generated via 3D printing. CT images of a skull phantom with 10 anatomical landmarks were acquired. The testing procedure consisted of 10 measurements for each position of the sensor: precisely 10 measurements with the sensor placed on the forehead and 10 measurements with the sensor placed on the bite support device. It also evaluated the localization error by comparing the two procedures. Results: The localization error, when the sensor was placed on the bite support device, was lower in the sphere located on the temporal bone. It was the same in the spheres located on the maxillary bone. The test analysis of the data of the new device showed that it is reliable; the tests are reproducible and can be considered as accurate as the traditional ones. In addition, the sensor mounted on this device has proven to be slightly superior in terms of accuracy and accuracy in areas such as the middle third of the face and jaw. Discussion and Conclusion: The realization of the bite support device allowed the sensor to change position concerning its natural site. This procedure allows us to explore structures, such as the frontal site, which were initially difficult to approach with neuronavigation and ...
Keywords	navigation system ; electromagnetic navigation ; image-guided surgery ; sinus surgery ; Medicine (General) ; R5-920
Subject code	600
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Apocrine adenocarcinoma of the head and neck district: Our experience with two cases.

Ferragina, Francesco / Barca, Ida / Sorrentino, Alfonso / Sottile, Angelo Ruggero / Cristofaro, Maria Giulia

International journal of surgery case reports

2023 Volume 112, Page(s) 109017

Abstract: Introduction: Apocrine adenocarcinoma (AA) is a rare gland cancer that appears in the elderly, especially males. Surgery is considered the first option for the management of this tumor.: Case presentation: We report two cases of AA that occurred at ... ...

Abstract	Introduction: Apocrine adenocarcinoma (AA) is a rare gland cancer that appears in the elderly, especially males. Surgery is considered the first option for the management of this tumor. Case presentation: We report two cases of AA that occurred at our Unit of Maxillofacial Surgery. Precisely a case of a woman with AA with a usual presence at the eyelid level and a case of a man with AA with an unusual presence at the neck level. Discussion: This cancer generally arises in some specific areas of the body that present high concentrations of apocrine glands (such as in Case No.2). But it can also occur in less typical areas, such as the neck (such as in Case No.1). Conclusion: We discuss the surgical management of our cases: both based on our experience and literature data, we recommend extensive surgical excision.
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2023.109017
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Article: The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population.

Piloni, Sara / Ferragina, Francesco / Barca, Ida / Kallaverja, Elvis / Cristofaro, Maria Giulia

European journal of dentistry

2023

Abstract: Objectives: The association between oral lichen planus and thyroid disorders, especially hypothyroidism and Hashimoto's thyroiditis, has been discussed in current literature with conflicting outcomes.: Materials and methods: The study ... ...

Abstract	Objectives: The association between oral lichen planus and thyroid disorders, especially hypothyroidism and Hashimoto's thyroiditis, has been discussed in current literature with conflicting outcomes. Materials and methods: The study retrospectively evaluated the thyroid status in patients diagnosed with oral lichen planus and oral lichenoid lesions. A case-control approach was used to prove that thyroid disorders were statistically significant risk factors for oral lichen planus and oral lichenoid lesions. Statistical analysis: To evaluate these associations, odds ratios (ORs) were used. ORs precision and statistical significance were estimated using a 95% confidence interval (CI) and Results: A total of 307 patients were involved in the study: 158 females and 149 males. OR, 95% CIs, and Conclusion: Even if further investigations are needed, the association between oral lichen planus and oral lichenoid lesions with thyroid pathologies should be taken into consideration by endocrinologists due to the potential malignancy of these disorders.
Language	English
Publishing date	2023-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2491711-4
ISSN	1305-7464 ; 1305-7456
ISSN (online)	1305-7464
ISSN	1305-7456
DOI	10.1055/s-0043-1772247
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Article ; Online: Electrochemotherapy as an Effective Alternative in the Treatment of Local Advanced Oral Squamous Cell Carcinoma: A Retrospective Analysis of Treated Cases.

Barca, Ida / Ferragina, Francesco / Kallaverja, Elvis / Arrotta, Antonella / Cristofaro, Maria Giulia

International journal of environmental research and public health

2023 Volume 20, Issue 6

Abstract: Advanced oral squamous cell carcinomas represent a major challenge for maxillofacial surgeons, oncologists and radiation therapists. They also account for a large share of healthcare costs. They respond little and/or poorly to conventional therapies ( ... ...

Abstract	Advanced oral squamous cell carcinomas represent a major challenge for maxillofacial surgeons, oncologists and radiation therapists. They also account for a large share of healthcare costs. They respond little and/or poorly to conventional therapies (surgery, radiotherapy and chemotherapy). Electrochemotherapy is a new method used as a palliative treatment in patients with advanced cancer of the neck/head region who are not eligible for standard therapies. It combines the use of cytotoxic drugs with the physical principle of electroporation; it effectively controls the tumour locally and preserves organ function. To date, ECT has been little used for oral mucosal tumours, as this is difficult to access for electrodes. We report six cases of advanced oral squamous cell carcinoma treated with electrochemotherapy. This study aims to assess the debulking effect of cancer via ECT in patients with advanced oral squamous cell carcinoma. It also aims to assess the safety and tolerability of this treatment.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Mouth Neoplasms/drug therapy ; Mouth Neoplasms/pathology ; Retrospective Studies ; Electrochemotherapy/methods ; Head and Neck Neoplasms ; Bleomycin/therapeutic use ; Treatment Outcome ; Skin Neoplasms
Chemical Substances	Bleomycin (11056-06-7)
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20065170
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Article ; Online: A case of kuttner tumour misdiagnosed as malignant neoplasia with a review of the literature.

Barca, Ida / Ferragina, Francesco / Mignogna, Chiara / Cristofaro, Maria Giulia

Annali italiani di chirurgia

2022 Volume 11

Abstract: Aim: The aim of this study is to demonstrate how surgery is fundamental in case of Kuttner Tumour (KT). In literature, there are few reported cases of KT and for this reason, diagnostic errors could occur with subsequent underestimation of the disease.!# ...

Abstract	Aim: The aim of this study is to demonstrate how surgery is fundamental in case of Kuttner Tumour (KT). In literature, there are few reported cases of KT and for this reason, diagnostic errors could occur with subsequent underestimation of the disease. Materials of the study: We review cases of KT published from 1976 to today in order not to run into diagnostic errors. It was carried out a systematic review of the literature on chronic sclerosing sialadenitis, also known as KT. Results: KT is an immune-mediated localized fibro inflammatory condition that often mimics other pathological processes, such as neoplasms. Discussion: The variables analysed in each article included in this review were the age and gender of the patients, the location of the disease, the type of study; clinical presentation, instrumental tests performed, presence of IgG4, surgery performed and the evolution of patients after treatment were also assessed. Diagnosis should be based on clinical, serological and pathological findings, but in a small percentage of cases (just as in the case presented) the cytological data provided by FNAB and serum IgG4 levels do not allow a diagnosis. Conclusions: Our experience shows that only surgery with subsequent histological examination makes it possible to correctly diagnose the disease. Key words: Kuttner Tumour, Salivary glands, Immunoglobulin G4-related disease, Maxillofacial surgery.
MeSH term(s)	Chronic Disease ; Diagnostic Errors ; Humans ; Immunoglobulin G ; Neoplasms ; Sialadenitis/diagnosis ; Sialadenitis/pathology
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2022-04-08
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article ; Online: Efficacy of SMAS flap technique to prevent Frey's syndrome and aesthetic outcomes. A retrospective cohort analysis.

Cristofaro, Maria Giulia / Cordaro, Raffaella / Barca, Ida / Giudice, Amerigo

Annali italiani di chirurgia

2022 Volume 92, Page(s) 683–690

Abstract: Aim: The aim of this retrospective cohort study was to evaluate the efficacy of Superficial Musculoaponeurotic System (SMAS) flap technique to prevent Frey's Syndrome (FS) and improve aesthetic outcomes following superficial parotidectomy.: Materials ... ...

Abstract	Aim: The aim of this retrospective cohort study was to evaluate the efficacy of Superficial Musculoaponeurotic System (SMAS) flap technique to prevent Frey's Syndrome (FS) and improve aesthetic outcomes following superficial parotidectomy. Materials and methods: A total of 140 patients were treated between January 2003 and December 2018 at the Maxillofacial Unit of Magna Graecia University of Catanzaro with Superficial Parotidectomy (SP) for benign tumor and divided in two groups: Group 1 (78 patients) underwent SMAS flap reconstruction of the parotid lodge through a modified facelift incision and Group 2 (62 patients) underwent to SP without the use of SMAS interposition through a Redon type incision. Results: Significant statistical difference concerning FS, transient facial nerve injury, facial paralysis, salivary fistula, haematoma and skin deepness were found between Group 1 and Group 2, (0,00% vs 6,45% [p < 0,036], 2,56% vs 16,12% [p = 0,005], 0,00% vs 9,67% [p= 0,006], 1,28% vs 9,67% [p= 0,044], 1,28% vs 19,35% [p = 0,0002]) respectively. No significant statistical differences between the two groups were observed about wound infections (3,84% vs 8,06% [p= 0,466]). Discussion: SP represents the gold standard for the surgical treatment of benign tumors of the parotid gland greater than 3,5 cm in size involving superficial portion of the gland, for the low rate of recurrences over time and lower incidence of transient or permanent facial paralysis to which this technique leads. However, SP is not free from other complications such as FS, haematoma, salivary fistula and aesthetic results like facial contour deformity due to surgical site depression and visible scar. A reconstructive technique to reduce the impact of complications after SP is the SMAS flap because its preparation is easy, contextual to the parotidectomy and increases a little the surgical time. Conclusions: This study highlights the advantages of SMAS flap technique in reducing complications following parotid surgery, particularly FS, and in improving the quality of life. Key words: Frey's Syndrome, Minor test, Parotid benign tumor, SMAS flap, Superficial parotidectomy.
MeSH term(s)	Cohort Studies ; Esthetics ; Humans ; Parotid Gland/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Quality of Life ; Retrospective Studies ; Superficial Musculoaponeurotic System ; Sweating, Gustatory/etiology ; Sweating, Gustatory/prevention & control
Language	English
Publishing date	2022-02-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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