Article ; Online: The 21st century revolution in CLL: Why this matters to patients.
Best practice & research. Clinical haematology
2016 Volume 29, Issue 1, Page(s) 122–132
Abstract: The 21st century has seen rapid, positive changes in the management of chronic lymphocytic leukaemia from the patient's perspective. New prognostic and predictive markers have ushered in the start of more precise and individualized therapy. For the first ...
| Abstract | The 21st century has seen rapid, positive changes in the management of chronic lymphocytic leukaemia from the patient's perspective. New prognostic and predictive markers have ushered in the start of more precise and individualized therapy. For the first time, combined therapy [fludarabine, cyclophosphamide and rituximab] has been shown to prolong life significantly. Clinical trials have become more adaptive, faster and more patient friendly. Perhaps the greatest change of all is the development of novel oral agents (ibrutinib and idelalisib) and powerful monoclonal antibodies that offer robust and durable disease control. Finally, access to and understanding of these changes through an empowered and educated patient population has grown through live education forums and the Internet. |
|---|---|
| MeSH term(s) | Antibodies, Neoplasm/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/history ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Clinical Trials as Topic ; History, 21st Century ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/history ; Precision Medicine/history ; Precision Medicine/methods ; Prognosis ; Purines/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; Quinazolinones/therapeutic use |
| Chemical Substances | Antibodies, Neoplasm ; Purines ; Pyrazoles ; Pyrimidines ; Quinazolinones ; ibrutinib (1X70OSD4VX) ; idelalisib (YG57I8T5M0) |
| Language | English |
| Publishing date | 2016-08-11 |
| Publishing country | Netherlands |
| Document type | Historical Article ; Journal Article ; Review |
| ZDB-ID | 2048027-1 |
| ISSN | 1532-1924 ; 1521-6926 |
| ISSN (online) | 1532-1924 |
| ISSN | 1521-6926 |
| DOI | 10.1016/j.beha.2016.08.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Se 1029: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.