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Article ; Online: Brief Report: Risk of Recurrent Interstitial Lung Disease From Osimertinib Versus Erlotinib Rechallenge After Symptomatic Osimertinib-Induced Interstitial Lung Disease.

Li, Molly S C / Lee, Kirsty W C / Mok, Kevin K S / Loong, Herbert H F / Lam, K C / Mok, Florence S T / Chan, Landon L / Lau, Y M / Chan, K P / Ng, Joyce T Y / Wong, Wesley K Y / Lam, Benjamin H W / Chen, Allen C C / Lee, Matthew M P / Chen, Olivia H / Mok, Tony S K

JTO clinical and research reports

2024 Volume 5, Issue 4, Page(s) 100648

Abstract: Introduction: Interstitial lung disease (ILD) is the most frequent cause of drug-related mortality from EGFR tyrosine kinase inhibitors (TKIs). Yet, for patients with symptomatic osimertinib-induced ILD, the risk of recurrent ILD associated with EGFR ... ...

Abstract	Introduction: Interstitial lung disease (ILD) is the most frequent cause of drug-related mortality from EGFR tyrosine kinase inhibitors (TKIs). Yet, for patients with symptomatic osimertinib-induced ILD, the risk of recurrent ILD associated with EGFR TKI rechallenge, either with osimertinib or another TKI, such as erlotinib, is unclear. Methods: Retrospective study of 913 patients who received osimertinib treatment for Results: Of 913 patients, 35 (3.8%) had symptomatic osimertinib-induced ILD, of which 12 (34%), 15 (43%), and eight (23%) had grade 2, 3 to 4, and 5 ILD, respectively. On ILD recovery, 17 patients had EGFR TKI rechallenge with eight received osimertinib and nine received erlotinib. The risk of recurrent ILD was higher with osimertinib rechallenge than erlotinib ( Conclusions: The risk of recurrent ILD was considerably higher with osimertinib rechallenge than erlotinib. Osimertinib rechallenge should be avoided, whereas erlotinib may be considered in patients with symptomatic osimertinib-induced ILD.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2024.100648
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Article ; Online: A survey of characteristics and current educational needs of hemophilia treatment centers within Asia Pacific.

Lam, Joyce C M / John, M Joseph / Street, Alison

Research and practice in thrombosis and haemostasis

2018 Volume 2, Issue 3, Page(s) 508–517

Abstract: Background: Poor disease understanding and gaps in expertise regarding hemophilia care have been identified at all levels in Asia Pacific. Continued education for involved healthcare professionals (HCPs) is crucial for improved delivery.: Objectives: ...

Abstract	Background: Poor disease understanding and gaps in expertise regarding hemophilia care have been identified at all levels in Asia Pacific. Continued education for involved healthcare professionals (HCPs) is crucial for improved delivery. Objectives: To identify training and educational needs of hemophilia HCPs in Asia Pacific. Methods: Clinicians working at hemophilia treatment centers (HTCs), identified from the World Federation of Hemophilia Directory, were contacted by the Asia Pacific Hemophilia Working Group (APHWG). An electronic survey was sent to 161 centers from 15 countries for which HTC identification was complete to assess HTC characteristics, educational status, and needs. Responses were stratified by national economic capacity. Results: From March 23 to June 6, 2016, clinicians from 58 HTCs completed the survey. Most reported availability of specialists to serve core patient requirements, although availability of trained nurses and geneticists was low in lower-middle income countries (LMICs). Although 98.3% of HTCs had laboratory facilities, 8.8% do not participate in any quality assessment schemes. The most common limitations of current initiatives were infrequency and lack of local language content. Education is currently mostly received via internet, particularly among LMICs and upper-middle income countries (UMICs), though there is strong preference for meetings. Main barriers to receiving education were funding and time constraints. Unique priority topics were musculoskeletal management, quality of life and management by non-hematologists (high-income countries), inhibitor management and research (UMICs), and outcomes assessment (LMICs). Conclusion: In Asia Pacific, training programs should be tailored according to unique needs of differing economic capacities and resource settings.
Language	English
Publishing date	2018-05-24
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1002/rth2.12108
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Article ; Online: No increased risk of flare in ulcerative colitis patients in corticosteroid-free remission after stopping 5-aminosalicylic acid: A territory-wide population-based study.

Mak, Joyce W Y / Yuen, Nobel T K / Yip, Terry C F / Lam, Ray H M / Lam, Brian K H / Cheng, Cherry T Y / Wong, Grace L H / Chan, Francis K L / Ng, Siew C

Journal of gastroenterology and hepatology

2022 Volume 37, Issue 7, Page(s) 1284–1289

Abstract: ... 2 g daily for ≥ 1 year with C-reactive protein (CRP) < 10 mg/dL and no 5-ASA dosage escalation, UC ...

Abstract	Background and aim: Whether 5-aminosalicylic acid (ASA) can be stopped in patients with stable ulcerative colitis (UC) remains unclear. We aimed to examine whether 5-ASA can be safely withdrawn in UC patients who have been in corticosteroid-free clinical remission for ≥ 1 year. Methods: This is a retrospective cohort study using territory-wide healthcare database in Hong Kong. Primary outcome was development of UC flare, defined as new corticosteroid use or UC-related hospitalizations within 5 years. UC patients on oral 5-ASA ≥ 2 g daily for ≥ 1 year with C-reactive protein (CRP) < 10 mg/dL and no 5-ASA dosage escalation, UC-related hospitalization or corticosteroid use in the past year were included. Patients on biological agents were excluded. Patients were classified as "stopping" if 5-ASA was withdrawn for ≥ 90 days within follow-up period. We performed multivariable Cox regression models adjusting for demographics, blood parameters and immunosuppressants used. Adjusted hazard ratio (aHR) with 95% confidence interval (CI) was reported comparing stopping and continuous-use groups. Results: A total of 1408 patients were included with a median follow-up duration of 41.8 months (interquartile range [IQR]: 17.2-60.0 months). Stopping 5-ASA was not associated with an increased risk of UC flare (aHR 0.91; 95% CI 0.64-1.31; P = 0.620). A higher CRP levels at the time of stopping 5-ASA (aHR 1.15; 95% CI: 1.01-1.30; P = 0.037) were associated with increased risk of flare. Conclusion: Stopping 5-ASA in UC patients in corticosteroid-free remission for ≥ 1 year was not associated with increased risk of flare. Future prospective trials should evaluate the role of stopping 5-ASA in stable UC patients.
MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Humans ; Mesalamine ; Remission Induction ; Retrospective Studies
Chemical Substances	Adrenal Cortex Hormones ; Anti-Inflammatory Agents, Non-Steroidal ; Mesalamine (4Q81I59GXC)
Language	English
Publishing date	2022-04-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.15838
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management of COVID-19-related paediatric blood samples in a clinical haematology laboratory.

Lam, Joyce C M / Moshi, Grace B / Ang, Soh H / Chew, Hui M / Ng, Qing H / Madjukie, Andrew / Logeswary, Muthiah

British journal of haematology

2020 Volume 189, Issue 5, Page(s) 848–851

MeSH term(s)	Adolescent ; Betacoronavirus/metabolism ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/blood ; Coronavirus Infections/transmission ; Coronavirus Infections/urine ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/transmission ; Pneumonia, Viral/urine ; RNA, Viral/blood ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-09
Publishing country	England
Document type	Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16721
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Uh III Zs.182: Show issues

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Article ; Online: Risk of alanine aminotransferase flare in patients with previous hepatitis B virus exposure on biological modifier therapies-A population-based study.

Ho, Jacky C L / Mak, Joyce W Y / Yip, Terry C F / Lam, Hong Man / Cheng, Tsz Yan / Lam, Tsz On / Tam, Lai Shan / Law, Man Fai / Cheung, Carmen K M / Ng, Siew C / Wong, Vincent W S / Wong, Grace L H

Liver international : official journal of the International Association for the Study of the Liver

2022 Volume 43, Issue 3, Page(s) 588–598

Abstract: Background: It is uncertain whether biological therapies would increase the risk of hepatitis among patients with past hepatitis B virus (HBV) infection. This study aimed to evaluate the risk of alanine aminotransferase (ALT) flare in patients with past ...

Abstract	Background: It is uncertain whether biological therapies would increase the risk of hepatitis among patients with past hepatitis B virus (HBV) infection. This study aimed to evaluate the risk of alanine aminotransferase (ALT) flare in patients with past HBV infection while using biological therapies. Methodology: Patients who received biological therapies for ≥3 months from 2000 to 2019 were identified from a population-based database in Hong Kong. Patients with past HBV infection were compared with a control group without prior HBV exposure. The primary endpoint was development of ALT flare within 5 years of starting biological therapies, defined as ALT >80 IU/L. Results: There were 2471 and 2394 patients with and without past HBV infection respectively. There was a non-significant increase in risk of ALT flare among the HBV-exposed group (27.6% vs. 23.7%, p = .055). In multivariable analysis, using prednisolone-equivalent dose of >20 mg daily, male sex and concomitant immunosuppressants were risk factors for ALT flare. The risk of ALT flare was significantly higher with anti-CD20 when compared to other biological agents (36.1% vs. 14.5%, p < .01), but was not significantly different among anti-tumour necrosis factor, anti-cytokine, Janus kinase inhibitors and T cell/B cell inhibitors or anti-integrin (15.2% vs. 14.6% vs. 11.7% vs. 11.1%, p = .82). Among patients with documented hepatitis B surface antigen seroreversion, 96% were on anti-CD20. Conclusions: Our study further supports the current suggestion of prophylactic anti-viral before starting anti-CD20 in HBV-exposed patients. While other biological therapies appear to have a lower risk for ALT flare, this result needs further confirmation.
MeSH term(s)	Humans ; Male ; Hepatitis B virus/genetics ; Alanine Transaminase ; Hepatitis B, Chronic/drug therapy ; Hepatitis B/complications ; Antiviral Agents/therapeutic use ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Biological Therapy ; DNA, Viral
Chemical Substances	Alanine Transaminase (EC 2.6.1.2) ; Antiviral Agents ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; DNA, Viral
Language	English
Publishing date	2022-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15499
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Zs.A 1632: Show issues

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Article ; Online: Predicting Psychiatric Rehospitalization in Adolescents.

Joyce, Victoria W / King, Christopher D / Nash, Carol C / Lebois, Lauren A M / Ressler, Kerry J / Buonopane, Ralph J

Administration and policy in mental health

2019 Volume 46, Issue 6, Page(s) 807–820

Abstract: Adolescent psychiatric rehospitalizations are common, cause patients and their families severe psychological distress, and use tremendous healthcare resources. This study sought to identify predictors of rehospitalization in 783 adolescents in the 2 year ...

Abstract	Adolescent psychiatric rehospitalizations are common, cause patients and their families severe psychological distress, and use tremendous healthcare resources. This study sought to identify predictors of rehospitalization in 783 adolescents in the 2 year period following psychiatric hospitalization at a major treatment facility in a large urban area. A current diagnosis of posttraumatic stress disorder, greater severity of lifetime suicidal ideation (SI) and stronger treatment alliance prior to hospitalization were associated with a greater likelihood of rehospitalization. Overall, severe lifetime SI was the strongest predictor of rehospitalization; although, within the first 4 months post-discharge, moderate lifetime SI was the strongest predictor. Future research should continue to identify additional factors that may influence rehospitalization, such as the intensity of post-discharge services.
MeSH term(s)	Adolescent ; Boston ; Child ; Electronic Health Records ; Female ; Forecasting ; Hospitalization ; Humans ; Male ; Mental Disorders ; Patient Discharge ; Patient Readmission/trends ; Risk Factors ; Stress Disorders, Post-Traumatic ; Suicidal Ideation
Language	English
Publishing date	2019-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025319-1
ISSN	1573-3289 ; 0894-587X
ISSN (online)	1573-3289
ISSN	0894-587X
DOI	10.1007/s10488-019-00982-7
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Article ; Online: RARE CASE OF POTT'S DISEASE CAUSED BY BACILLUS-CALMETTE GUÉRIN VACCINE.

Mahtani, Simran / Tan, Joanne M C / Low, Sharon Y Y / Nolan, Colum P / Ong, Rina Y L / Lam, Joyce C M / Yeo, Tong H / Sng, L H / Chang, Kenneth T E / Chong, Chia Yin / Tan, Natalie W H

Journal of paediatrics and child health

2020 Volume 56, Issue 10, Page(s) 1655–1656

MeSH term(s)	BCG Vaccine ; Bacillus ; Humans ; Tuberculosis, Spinal
Chemical Substances	BCG Vaccine
Keywords	covid19
Language	English
Publishing date	2020-10-25
Publishing country	Australia
Document type	Letter
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15082
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Article ; Online: Life-threatening infections during treatment for acute lymphoblastic leukemia on the Malaysia-Singapore 2003 and 2010 clinical trials: A risk prediction model.

Oh, Bernice L Z / Fan, Lijia / Lee, Shawn H R / Foo, Koon Mian / Chiew, Kean Hui / Seeto, Zelia Z L / Chen, Zhi Wei / Neoh, Cheryl C C / Liew, Germaine S M / Eng, Jing Jia / Lam, Joyce C M / Quah, Thuan Chong / Tan, Ah Moy / Chan, Yiong Huak / Yeoh, Allen E J

Asia-Pacific journal of clinical oncology

2022 Volume 18, Issue 5, Page(s) e456–e468

Abstract: Aim: Life-threatening infections significantly impact the care of children undergoing therapy for acute lymphoblastic leukemia (ALL) who are at risk of severe sepsis due to both host and treatment factors. Our aim was to develop a life-threatening ... ...

Abstract	Aim: Life-threatening infections significantly impact the care of children undergoing therapy for acute lymphoblastic leukemia (ALL) who are at risk of severe sepsis due to both host and treatment factors. Our aim was to develop a life-threatening infection risk prediction model that would allow remote rapid triage of patients to reduce time to first dose of antibiotics and sepsis-related mortality. Methods: A retrospective analysis of 2068 fever episodes during ALL therapy was used for model building and subsequent internal validation. Results: Three hundred and seventy-seven patients were treated for ALL in two institutions with comparable critical and supportive care resources. A total of 55 patients accounted for 71 admissions to the critical care unit for sepsis that led to eight septic deaths during a 16-year study period. A retrospective analysis of risk factors for sepsis enabled us to build a model focused on 13 variables that discriminated admissions requiring critical care well: area under the receiver operating characteristic curve of .82; 95% CI .76-.87, p<.001, and Brier score of .033. Significant univariate predictors included neutropenia, presence of symptoms of abdominal pain, diarrhea, fever during induction or steroid-based phases, and the lack of any localizing source of infection at time of presentation. Conclusion: We have developed a risk prediction model that can reliably identify ALL patients undergoing treatment who are at a higher risk of life-threatening sepsis. Clinical applicability can potentially be extended to low-middle income settings, and its utility should be further studied in real-world settings.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Child ; Clinical Trials as Topic ; Fever ; Humans ; Malaysia/epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Retrospective Studies ; Sepsis/chemically induced ; Sepsis/diagnosis ; Sepsis/drug therapy ; Singapore
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-02-08
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2187409-8
ISSN	1743-7563 ; 1743-7555
ISSN (online)	1743-7563
ISSN	1743-7555
DOI	10.1111/ajco.13756
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Article ; Online: Prospective Randomized Phase II Study of Stereotactic Body Radiotherapy (SBRT) vs. Conventional Fractionated Radiotherapy (CFRT) for Chinese Patients with Early-Stage Localized Prostate Cancer.

Poon, Darren M C / Lam, Daisy / Wong, Kenneth C W / Chu, Cheuk-Man / Cheung, Michael / Mo, Frankie / Suen, Joyce / Ng, Chi-Fai / Chan, Anthony T C

Current oncology (Toronto, Ont.)

2021 Volume 29, Issue 1, Page(s) 27–37

Abstract: Background: Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). This study aimed to compare the effects of these two distinct ... ...

Abstract	Background: Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). This study aimed to compare the effects of these two distinct fractionations on patient-reported quality of life (PRQOL) and tolerability. Methods: In this prospective phase II study, patients with low- and intermediate-risk localized PC were randomly assigned in a 1:1 ratio to the SBRT (36.25 Gy/5 fractions/2 weeks) or CFRT (76 Gy/38 fractions/7.5 weeks) treatment groups. The primary endpoint of variation in PRQOL at 1 year was assessed by changes in the Expanded Prostate Cancer Index Composite (EPIC) questionnaire scores and analysed by z-tests and Results: Sixty-four eligible Chinese men were treated (SBRT, Conclusion: SBRT offered similar PRQOL and less toxicity compared with CFRT in Chinese men with localized PC.
MeSH term(s)	China ; Dose Fractionation, Radiation ; Humans ; Male ; Prospective Studies ; Prostatic Neoplasms/radiotherapy ; Quality of Life ; Radiosurgery
Language	English
Publishing date	2021-12-22
Publishing country	Switzerland
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29010003
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Zs.A 4305: Show issues

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Article: Management of COVID-19-related paediatric blood samples in a clinical haematology laboratory

Lam, Joyce C M / Moshi, Grace B / Ang, Soh H / Chew, Hui M / Ng, Qing H / Madjukie, Andrew / Logeswary, Muthiah

Br J Haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #66438
Database	COVID19

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