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  1. Article ; Online: Inhibiting TGF-β to increase response rates to chemoradiotherapy in rectal cancer.

    Romesser, Paul B / Smith, J Joshua

    The Lancet. Oncology

    2022  Volume 23, Issue 9, Page(s) 1116–1118

    MeSH term(s) Chemoradiotherapy ; Humans ; Neoadjuvant Therapy ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Retrospective Studies ; Transforming Growth Factor beta/therapeutic use ; Treatment Outcome
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00504-6
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    Zs.A 5696: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  2. Article ; Online: Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies.

    Miller, Eric D / Hitchcock, Kathryn E / Romesser, Paul B

    Journal of gastrointestinal cancer

    2023  Volume 54, Issue 4, Page(s) 1116–1127

    Abstract: Purpose: Nearly one-third of patients diagnosed with colorectal cancer (CRC) will ultimately develop metastatic disease. While a small percentage of patients can be considered for curative resection, more patients have limited disease that can be ... ...

    Abstract Purpose: Nearly one-third of patients diagnosed with colorectal cancer (CRC) will ultimately develop metastatic disease. While a small percentage of patients can be considered for curative resection, more patients have limited disease that can be considered for local therapy. Challenges remain in defining oligometastatic CRC as well as developing treatment strategies guided by high level evidence.
    Methods: In this review, we present the challenges in defining oligometastatic CRC and summarize the current literature on treatment and outcomes of local therapy in patients with metastatic CRC.
    Results: For patients with liver- and/or lung-confined CRC metastases, surgical resection is the standard of care given the potential for long-term progression-free and overall survival. For patients with liver- or lung-confined disease not amenable to surgical resection, non-surgical local therapies, such as thermal ablation, hepatic arterial infusion pump (HAIP), or stereotactic body radiation therapy (SBRT), should be considered. For patients with more advanced disease, such as lymph node or bony metastases, the role of metastasis-directed therapy is controversial. Emerging data suggests that SBRT to ablate all metastases can improve progression-free and overall survival.
    Conclusion: Multidisciplinary management is critical for patients with metastatic CRC due to the complexity of their cases and the nuanced patient, tumor, biological, and anatomical factors that must be weighed when considering local therapy. High-quality prospective randomized data in CRC are needed to further clarify the role of local ablative therapy in patients with unresectable oligometastatic CRC with ongoing studies including the RESOLUTE trial (ACTRN12621001198819) and the upcoming NCTN ERASur trial (NCT05673148).
    MeSH term(s) Humans ; Prospective Studies ; Patient Selection ; Lung Neoplasms/secondary ; Colonic Neoplasms ; Rectal Neoplasms ; Radiosurgery ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/pathology
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-022-00900-5
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    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Chemo-Re-Irradiation and Salvage Surgery for Locally Recurrent Rectal Cancer.

    Romesser, Paul B / Crane, Christopher H

    Annals of surgical oncology

    2021  Volume 28, Issue 9, Page(s) 4769–4771

    MeSH term(s) Humans ; Neoplasm Recurrence, Local ; Re-Irradiation ; Rectal Neoplasms/surgery ; Rectum ; Salvage Therapy
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10198-5
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    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Local Therapies in Advanced Colorectal Cancer.

    Hitchcock, Kathryn E / Romesser, Paul B / Miller, Eric D

    Hematology/oncology clinics of North America

    2022  Volume 36, Issue 3, Page(s) 553–567

    Abstract: Curative intent surgical resection of colorectal metastases to the liver and lungs in eligible patients results in improved disease control and prolonged overall survival with the potential for cure in a subset of patients. Additional ablative and local ... ...

    Abstract Curative intent surgical resection of colorectal metastases to the liver and lungs in eligible patients results in improved disease control and prolonged overall survival with the potential for cure in a subset of patients. Additional ablative and local therapies for use in the liver, lungs, and other body sites have been developed with emerging data on the utility and toxicity of these treatments. Future studies should focus on identification of appropriate candidates for treatment and determining the optimal modality and timing of treatment accounting for both patient and disease factors.
    MeSH term(s) Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2022.02.007
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    Se 1077: Show issues Location:
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  5. Article ; Online: A methylation-based prognostic signature in stage II colorectal patients: Considerations for clinical adoption.

    Romesser, Paul B / Sanchez-Vega, Francisco / Joshua Smith, J

    Journal of the National Cancer Institute

    2022  Volume 115, Issue 1, Page(s) 8–11

    MeSH term(s) Humans ; Prognosis ; Neoplasm Staging ; DNA Methylation ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djac184
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    Uh III Zs.131: Show issues Location:
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  6. Article: Magnetic Resonance Imaging-Guided Adaptive Radiotherapy for Colorectal Liver Metastases.

    Romesser, Paul B / Tyagi, Neelam / Crane, Christopher H

    Cancers

    2021  Volume 13, Issue 7

    Abstract: Technological advances have enabled well tolerated and effective radiation treatment for small liver metastases. Stereotactic ablative radiation therapy (SABR) refers to ablative dose delivery (>100 Gy BED) in five fractions or fewer. For larger tumors, ... ...

    Abstract Technological advances have enabled well tolerated and effective radiation treatment for small liver metastases. Stereotactic ablative radiation therapy (SABR) refers to ablative dose delivery (>100 Gy BED) in five fractions or fewer. For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs such as the stomach, duodenum, and large intestine. In addition to stereotactic treatment delivery, controlling respiratory motion, the use of image guidance, adaptive planning and increasing the number of radiation fractions are sometimes necessary for the safe delivery of SABR in these situations. Magnetic Resonance (MR) image-guided adaptive radiation therapy (MRgART) is a new and rapidly evolving treatment paradigm. MR imaging before, during and after treatment delivery facilitates direct visualization of both the tumor target and the adjacent normal healthy organs as well as potential intrafraction motion. Real time MR imaging facilitates non-invasive tumor tracking and treatment gating. While daily adaptive re-planning permits treatment plans to be adjusted based on the anatomy of the day. MRgART therapy is a promising radiation technology advance that can overcome many of the challenges of liver SABR and may facilitate the safe tumor dose escalation of colorectal liver metastases.
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13071636
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  7. Article ; Online: In Defense of TNT: A Dynamite Strategy.

    Cercek, Andrea / Romesser, Paul B / Crane, Christopher H / Saltz, Leonard B

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 10, Page(s) 1185–1186

    MeSH term(s) Humans ; Nitroglycerin ; Trinitrotoluene
    Chemical Substances Trinitrotoluene (118-96-7) ; Nitroglycerin (G59M7S0WS3)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.20.03412
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    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 650: Show issues

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  8. Article ; Online: Nonoperative Management of Rectal Cancer Shows Cost-Effectiveness, but Can Comparative Effectiveness Be Established?

    Romesser, Paul B / Smith, Grace / Crane, Christopher H

    Journal of the National Cancer Institute

    2020  Volume 112, Issue 8, Page(s) 771–772

    MeSH term(s) Chemoradiotherapy ; Cost-Benefit Analysis ; Humans ; Quality-Adjusted Life Years ; Rectal Neoplasms/therapy ; Remission Induction
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djaa005
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  9. Article ; Online: External Beam Radiation Therapy for Liver Metastases.

    Romesser, Paul B / Neal, Brian P / Crane, Christopher H

    Surgical oncology clinics of North America

    2020  Volume 30, Issue 1, Page(s) 159–173

    Abstract: Stereotactic ablative radiotherapy (SABR) commonly is used for small liver metastases. Modern conformal radiotherapy techniques, including 3-dimensional conformal radiotherapy and intensity-modulated radiation therapy, enable the safe delivery of SABR to ...

    Abstract Stereotactic ablative radiotherapy (SABR) commonly is used for small liver metastases. Modern conformal radiotherapy techniques, including 3-dimensional conformal radiotherapy and intensity-modulated radiation therapy, enable the safe delivery of SABR to small liver volumes. For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs, such as the stomach, duodenum, and large intestine. Controlling respiratory motion, the use of image guidance, and increasing the number of radiation fractions sometimes are necessary for the safe delivery of SABR in these situations.
    MeSH term(s) Humans ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/surgery ; Radiosurgery ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Conformal ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2020.08.006
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  10. Article: Pursuit of the Abscopal Effect

    Romesser, Paul B. / Crane, Christopher H.

    Digestive Disease Interventions

    (Immuno-Oncology and Interventional Oncology)

    2020  Volume 04, Issue 04, Page(s) 369–372

    Abstract: Evasion of immune recognition is a hallmark of cancer that facilitates tumorigenesis, maintenance, and progression. Systemic immune activation can incite tumor recognition and stimulate potent antitumor responses. While the concept of antitumor immunity ... ...

    Series title Immuno-Oncology and Interventional Oncology
    Abstract Evasion of immune recognition is a hallmark of cancer that facilitates tumorigenesis, maintenance, and progression. Systemic immune activation can incite tumor recognition and stimulate potent antitumor responses. While the concept of antitumor immunity is not new, there is renewed interest in tumor immunology given the clinical success of immune modulators in a wide range of cancer subtypes over the past decade. One particularly interesting, yet exceedingly rare phenomenon, is the abscopal response, characterized by a potent systemic antitumor response following localized tumor irradiation presumably attributed to reactivation of antitumor immunity.
    Keywords abscopal response ; radiation therapy ; immune modulation
    Language English
    Publishing date 2020-11-30
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2472-873X ; 2472-8721
    ISSN (online) 2472-873X
    ISSN 2472-8721
    DOI 10.1055/s-0040-1718905
    Database Thieme publisher's database

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