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  1. Article ; Online: A Consistent Vision During Changing Times.

    Mazzone, Peter J

    Chest

    2023  Volume 164, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CHEST Journal Portfolio.

    Mazzone, Peter J

    Chest

    2023  Volume 163, Issue 3, Page(s) 465–466

    MeSH term(s) Humans ; Thorax ; Educational Measurement
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gratitude for the Year, Excitement for the Future.

    Mazzone, Peter J

    Chest

    2022  Volume 162, Issue 1, Page(s) 1–3

    MeSH term(s) Attitude ; Emotions ; Humans
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.05.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Year of Progress and Learning.

    Mazzone, Peter J

    Chest

    2021  Volume 160, Issue 1, Page(s) 1–2

    MeSH term(s) Biomedical Research/methods ; Humans ; Learning ; Periodicals as Topic ; Pulmonary Medicine
    Language English
    Publishing date 2021-07-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.05.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The CHEST Team: Working Towards Our Goals.

    Mazzone, Peter J

    Chest

    2020  Volume 158, Issue 1, Page(s) 1–2

    MeSH term(s) Critical Care ; Humans ; Organizational Objectives ; Periodicals as Topic ; Pulmonary Medicine ; Sleep Medicine Specialty
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.05.537
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  6. Article ; Online: The CHEST Editorial Team: Serving Our Contributors and Readers.

    Mazzone, Peter J

    Chest

    2019  Volume 156, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2019-07-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.05.010
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  7. Article ; Online: Molecular biomarkers for the evaluation of lung nodules.

    Mazzone, Peter J

    The Lancet. Respiratory medicine

    2019  Volume 7, Issue 4, Page(s) 297–298

    MeSH term(s) Biomarkers, Tumor ; Humans ; Lung Neoplasms/diagnosis ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(18)30528-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lung Cancer Screening.

    Choi, Humberto K / Mazzone, Peter J

    The Medical clinics of North America

    2022  Volume 106, Issue 6, Page(s) 1041–1053

    Abstract: Lung cancer screening with low-dose computed tomography (LDCT) reduces lung cancer deaths by early detection. The United States Preventive Services Task Force recommends lung cancer screening with LDCT in adults of age 50 years to 80 years who have at ... ...

    Abstract Lung cancer screening with low-dose computed tomography (LDCT) reduces lung cancer deaths by early detection. The United States Preventive Services Task Force recommends lung cancer screening with LDCT in adults of age 50 years to 80 years who have at least a 20 pack-year smoking history and are currently smoking or have quit within the past 15 years. The implementation of a lung-cancer-screening program is complex. High-quality screening requires the involvement of a multidisciplinary team. The aim of a screening program is to find balance between mortality reduction and avoiding potential harms related to false-positive findings, overdiagnosis, invasive procedures, and radiation exposure. Components and processes of a high-quality lung-cancer-screening program include the identification of eligible individuals, shared decision-making, performing and reporting LDCT results, management of screen-detected lung nodules and non-nodule findings, smoking cessation, ensuring adherence, data collection, and quality improvement.
    MeSH term(s) Humans ; United States/epidemiology ; Middle Aged ; Early Detection of Cancer/methods ; Lung Neoplasms/diagnostic imaging ; Mass Screening/methods ; Smoking/adverse effects ; Smoking/epidemiology ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2022.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluating the Patient With a Pulmonary Nodule: A Review.

    Mazzone, Peter J / Lam, Louis

    JAMA

    2022  Volume 327, Issue 3, Page(s) 264–273

    Abstract: Importance: Pulmonary nodules are identified in approximately 1.6 million patients per year in the US and are detected on approximately 30% of computed tomographic (CT) images of the chest. Optimal treatment of an individual with a pulmonary nodule can ... ...

    Abstract Importance: Pulmonary nodules are identified in approximately 1.6 million patients per year in the US and are detected on approximately 30% of computed tomographic (CT) images of the chest. Optimal treatment of an individual with a pulmonary nodule can lead to early detection of cancer while minimizing testing for a benign nodule.
    Observations: At least 95% of all pulmonary nodules identified are benign, most often granulomas or intrapulmonary lymph nodes. Smaller nodules are more likely to be benign. Pulmonary nodules are categorized as small solid (<8 mm), larger solid (≥8 mm), and subsolid. Subsolid nodules are divided into ground-glass nodules (no solid component) and part-solid (both ground-glass and solid components). The probability of malignancy is less than 1% for all nodules smaller than 6 mm and 1% to 2% for nodules 6 mm to 8 mm. Nodules that are 6 mm to 8 mm can be followed with a repeat chest CT in 6 to 12 months, depending on the presence of patient risk factors and imaging characteristics associated with lung malignancy, clinical judgment about the probability of malignancy, and patient preferences. The treatment of an individual with a solid pulmonary nodule 8 mm or larger is based on the estimated probability of malignancy; the presence of patient comorbidities, such as chronic obstructive pulmonary disease and coronary artery disease; and patient preferences. Management options include surveillance imaging, defined as monitoring for nodule growth with chest CT imaging, positron emission tomography-CT imaging, nonsurgical biopsy with bronchoscopy or transthoracic needle biopsy, and surgical resection. Part-solid pulmonary nodules are managed according to the size of the solid component. Larger solid components are associated with a higher risk of malignancy. Ground-glass pulmonary nodules have a probability of malignancy of 10% to 50% when they persist beyond 3 months and are larger than 10 mm in diameter. A malignant nodule that is entirely ground glass in appearance is typically slow growing. Current bronchoscopy and transthoracic needle biopsy methods yield a sensitivity of 70% to 90% for a diagnosis of lung cancer.
    Conclusions and relevance: Pulmonary nodules are identified in approximately 1.6 million people per year in the US and approximately 30% of chest CT images. The treatment of an individual with a pulmonary nodule should be guided by the probability that the nodule is malignant, safety of testing, the likelihood that additional testing will be informative, and patient preferences.
    MeSH term(s) Biopsy, Needle ; Bronchoscopy ; Comorbidity ; Early Detection of Cancer/methods ; Humans ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/epidemiology ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/epidemiology ; Multiple Pulmonary Nodules/pathology ; Multiple Pulmonary Nodules/therapy ; Patient Preference ; Risk Factors ; Single Photon Emission Computed Tomography Computed Tomography ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/epidemiology ; Solitary Pulmonary Nodule/pathology ; Solitary Pulmonary Nodule/therapy ; Tomography, X-Ray Computed/statistics & numerical data ; Tumor Burden
    Language English
    Publishing date 2022-01-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.24287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rebuttal From Dr Mazzone.

    Mazzone, Peter J

    Chest

    2018  Volume 153, Issue 6, Page(s) 1306–1308

    MeSH term(s) Aged ; Aged, 80 and over ; Early Detection of Cancer/standards ; Female ; Guideline Adherence ; Humans ; Lung Neoplasms/diagnosis ; Male ; Mass Screening/organization & administration ; Medical Oncology ; Societies, Medical ; United States
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2018.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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